Project Details
Description
Project Abstract
This project is a pilot clinical trial of a new brain stimulation treatment for obsessive-compulsive disorder. OCD
is a mental illness that affects 4-7 million people in the US. Of those, 50-70% still have substantial symptoms
after being treated with medication or talk therapy. Recently, clinicians have started trying to treat OCD with
deep brain stimulation (DBS). DBS involves surgically placing electrodes into the brain, then sending electrical
stimulation currents through those electrodes. Most investigators think that DBS for OCD works by affecting
brain circuits called the cortico-striato-thalamo-cortical loops, or CSTC loops. The belief is that OCD is caused
by the CSTC loops being too strongly connected, so that signals get "stuck" in them and become the stuck,
perseverative, obsessional thinking of OCD. To interrupt these loops, investigators have placed DBS into the
ventral capsule/ventral striatum (VC/VS), the "S" of CSTC.
VC/VS DBS has helped several patient who had very treatment-resistant OCD. However, about half do not get
better. We hypothesize that this is because DBS does not always influence cortico-striatal loops correctly,
because it only affects a single area in this multi-area circuit. Our main objective (Aim 1) is to test a stimulator
that affects the deep brain and the cortex (brain surface) at once and tries to break the abnormal CSTC
synchrony. It drives two brain areas at slightly different frequencies, keeping them "out of sync". Our second
objective is to test whether activity in the CSTC loop correlates to the symptoms of OCD. No study has proven
that these two are linked in humans, because it is difficult to record from the human brain, especially over long
periods of time and from deep brain areas. We will use a novel technology, the Medtronic PC+S "sensing
DBS", to record the brain's activity while delivering the stimulation treatment (Aim 2a). As patients' symptoms
improve, we expect to see that connectivity and synchrony between the surface and deep brain decreases
along the same trajectory. We will also capture recordings during symptom flares and as patients participate in
symptom-triggering activities such as exposure therapy sessions. This will help us further determine how well
this brain activity correlates to symptoms. Finally, to help capture clearer signals, we will also collect those
recordings while patients do a fear task that is linked to OCD severity, using EEG to further understand the
cortico-striatal response to DBS (Aim 2b). This study leverages a broad interdisciplinary team of psychiatrists,
statisticians, a neurosurgeon, and electrophysiologists, all with experience in OCD and brain stimulation.
Status | Finished |
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Effective start/end date | 9/30/16 → 11/30/23 |
Funding
- National Institute of Neurological Disorders and Stroke: $181,221.00
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