COCAINE SELF ADMINISTRATION--ACCUMBENS CELL ACTIVITY

  • Nicola, Saleem M. (PI)
  • Cabral, Guy A. (PI)
  • Cabral, Guy A. (PI)
  • Cabral, Guy A. (PI)
  • Cabral, Guy A. (PI)

Project: Research project

Project Details

Description

The proposed research seeks to determine the contribution of dopamine to
the firing of neurons in the rat nucleus accumbens while the aimal
self-administers cocaine. Dopamine. Psychostimulants, dopaine agonists
and dopamine antagonists will be iontoporetically applied to recorded
accumbens cell during the performance of a lever-pressing task that
results in the delivery of a cocaine reward to the animal. Locailized
iontophoretic application of drugs allows for their effects on
individual neurons to be observed while the behavior of the the animals
continues unchanges by the drug. The effects of these drugs on the
firing of these cells during the lever-press and between repsonse will
be analyzed to determine what role dopamine plays in the emergence,
timing and shing of patterns of firing that are specifically associated
with the lever-press. The results of these studies will indicate how
dopamine modifies information processing in the accumbers, and will
asuggest mechanisms by hopaminergic modulation of accumberns cell firing
leads to the motivation to obtain the drug.
StatusFinished
Effective start/end date2/1/981/31/99

Funding

  • National Institutes of Health: $25,472.00
  • NATIONAL INSTITUTE ON DRUG ABUSE

ASJC

  • Biological Psychiatry
  • Cellular and Molecular Neuroscience
  • Cognitive Neuroscience
  • Behavioral Neuroscience
  • Pharmacology

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