• Flamm, Eugene S. (PI)
  • Sakatani, Kaoru (PI)
  • Decrescito, Vincent (PI)
  • Chesler, Mitch (PI)
  • Gruner, John (PI)
  • Young, Wise (PI)
  • Lopez, Thomas (PI)

Project: Research project

Project Details


This Proposal is for a continuation of the Clinical Research Center for
Acute Spinal Cord Injuries at New York University. The underlying theme of
this Center proposal is to study intensively experimental spinal cord
injury at a basic pathophysiologic level as a model for clinical spinal
cord injury. Major emphasis will be placed on studying the effects of
trauma to the spinal cord beyond the acute period following the injury.
Changes in the distribution of ions such as calcium, sodium and potassium
within the cord, neurophysiologic studies of ascending and descending
pathways, and the role of cellular inflammatory response as a cause of
progressive damage to the spinal cord in the weeks following the trauma
will be used to test the hypothesis that the injury to the spinal cord is
progressive beyond the first 12-24 hours. This will provide important
information about treatment regimens which may have to be utilized for
extended periods if any recovery is to be achieved. In addition to
determining these pathophysiologic changes in the spinal cord, the effect
of different treatment modalities on these parameters will be tested. The
clinical studies will examine the efficacy of opioid antagonists and
corticosteroids in the amelioration of spinal cord injury as part of a
multi-center randomized trial. Alternate therapies will also be tested in
pilot studies. Experimental treatment will test the hypothesis that the
opioid receptors play a role in spinal cord injury and that this therapy
and corticosteroids are effective even when administered more than 1 hour
after injury. The evaluation of therapy on the recovery of injured animals
will include neurologic, physiologic and morphologic outcome parameters.
This will provide a comprehensive picture of the experimentally injured
spinal cord and the response to therapy that will provide a rational basis
for selecting clinical therapies. The goal of a Center for Spinal Cord
Injury will be realized by the close integration of the component projects
of this proposal.
Effective start/end date12/31/893/31/99


  • Clinical Neurology
  • Neurology
  • Biotechnology