Chemokines in healing myocardial infarction

Project: Research project

Project Details

Description

NARRATIVE Members of the Transforming Growth Factor (TGF)- family are critically involved in regulation of inflammation and in repair following myocardial infarction; however, effective repair is dependent on timely inhibition of TGF- signaling to prevent persistent fibrogenic and hypertrophic responses The current proposal will investigate the mechanisms responsible for suppression and termination of TGF superfamily signaling cascades following infarction. In vivo experiments using cell-specific knockout mice and in vitro loss- and gain-of-function studies will be performed to dissect the molecular signals that inhibit TGF- responses in cardiomyocytes, fibroblasts and macrophages, thus protecting the infarcted heart from adverse remodeling.
StatusActive
Effective start/end date6/6/051/31/23

Funding

  • National Heart, Lung, and Blood Institute: $173,959.00
  • National Heart, Lung, and Blood Institute: $620,497.00
  • National Heart, Lung, and Blood Institute: $243,541.00
  • National Heart, Lung, and Blood Institute: $417,500.00
  • National Heart, Lung, and Blood Institute: $417,500.00
  • National Heart, Lung, and Blood Institute: $395,080.00
  • National Heart, Lung, and Blood Institute: $415,000.00
  • National Heart, Lung, and Blood Institute: $406,700.00
  • National Heart, Lung, and Blood Institute: $284,454.00
  • National Heart, Lung, and Blood Institute: $293,181.00
  • National Heart, Lung, and Blood Institute: $284,454.00
  • National Heart, Lung, and Blood Institute: $124,319.00
  • National Heart, Lung, and Blood Institute: $383,750.00
  • National Heart, Lung, and Blood Institute: $292,950.00
  • National Heart, Lung, and Blood Institute: $564,511.00
  • National Heart, Lung, and Blood Institute: $415,000.00
  • National Heart, Lung, and Blood Institute: $284,454.00
  • National Heart, Lung, and Blood Institute: $300,000.00
  • National Heart, Lung, and Blood Institute: $564,511.00

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