CHANGES IN PLASMA GLUCOSE EFFECT PER SE ON HEPATIC GLUCOSE METABOLISM

  • Schilsky, Michael (PI)
  • Nagel, Ronald (PI)
  • Santoro, Nanette F. (PI)
  • Fabry, Mary (PI)
  • Wozniak, Robert (PI)
  • Rieder, Jessica (PI)
  • Kennan, Richard (PI)
  • Pan, Jullie (PI)
  • Nagel, Ronald (PI)
  • Santoro, Nanette F. (PI)
  • Hetherington, Hoby (PI)
  • Klein, Robert (PI)
  • Bookchin, Robert (PI)
  • Howard, Andrea (PI)
  • Rieder, Jessica (PI)
  • Somlo, Stefan (PI)
  • Roy-Chowdhury, Jayanta (PI)
  • Wadler, Scott (PI)
  • Rubenstein, Arye (PI)
  • Purpura, Dominick (PI)
  • Spiegel, Allen (PI)
  • Wylie-Rosett, Judith (PI)
  • Noyer, Charles (PI)
  • Kaufman, Howard L. (PI)
  • Weber, Thomas (PI)
  • Roy-Chowdhury, Namita (PI)
  • Diamond, Betty (PI)
  • Segal-Isaacson, C.J. (PI)
  • Engel, Samuel (PI)
  • Alderman, Michael (PI)
  • Wylie-Rosett, Judith (PI)
  • Weber, Thomas (PI)
  • Bigal, Marcelo (PI)
  • Pollard, Jeffrey W. (PI)
  • Kaskel, Frederick (PI)
  • Segal-Isaacson, C.J. (PI)
  • Dimartino-Nardi, Joan (PI)
  • Ilowite, Norman (PI)
  • Eugene, Fine (PI)
  • Mossavar-Rahmani, Yasmin (PI)
  • Khan, Unab (PI)
  • Rivas, Yolanda (PI)
  • Morrow, Bernice E. (PI)
  • Roy-Chowdhury, Namita (PI)
  • Barzilai, Nir (PI)
  • Shamoon, Harry (PI)
  • Crystal, Howard (PI)
  • Weiss, Louis M. (PI)
  • Diamond, Betty (PI)
  • Bloom, Barry (PI)
  • Rossetti, Luciano (PI)
  • Frishman, William (PI)
  • Somlo, Stefan (PI)
  • Schilsky, Michael (PI)
  • Roy-Chowdhury, Jayanta (PI)
  • Weiss, Louis M. (PI)
  • Santoro, Nanette F. (PI)
  • Kaufman, Howard L. (PI)
  • Segal-Isaacson, C.J. (PI)
  • Santoro, Nanette F. (PI)
  • Pollard, Jeffrey W. (PI)
  • Segal-Isaacson, C.J. (PI)
  • Morrow, Bernice E. (PI)
  • Engel, Samuel (PI)
  • Pan, Jullie (PI)
  • Klein, Robert (PI)
  • Alderman, Michael (PI)
  • Nagel, Ronald (PI)
  • Santoro, Nanette F. (PI)
  • Hetherington, Hoby (PI)
  • Segal-Isaacson, C.J. (PI)
  • Ho, Gloria Yuen Fun (PI)
  • Melman, Arnold (PI)
  • Berk, Steven Ira (PI)
  • Wylie-Rosett, Judith (PI)
  • Kaskel, Frederick J. (PI)
  • Stein, Daniel T. (PI)
  • Rivas, Yolanda (PI)
  • Mossavar-Rahmani, Yasmin (PI)
  • Hawkins, Meredith A. (PI)
  • Ilowite, Norman Todd (PI)
  • Khan, Unab I. (PI)

Project: Research project

Project Details

Description

Activation of endogenous glucose production (EGP) was examined in non-diabetic (N=12) and type 1 diabetic (DM1, N=8) subjects while lowering plasma glucose (PG) from clamped euglycemia (~100 mg/dl; 5.6 mmol/L) to values just above the threshold for epinephrine (EPI) and glucagon secretion (~70 mg/dl; 3.9 mmol/L). To induce physiologic hyperinsulinemia (HIns), insulin infusions were fixed at 20% above the rate previously established that maintained euglycemia during somatostatin (250 5g/hr), glucagon (1.0 ng.kg-1.min-1), and GH (3.0 ng.kg-1.min-1) infusions without need for glucose infusion. In nondiabetic subjects, PG was reduced from 5.410.1 mmol/L to 3.910.1 mmol/L in the Experimental protocol, and held constant (5.310.2 mmol/L and 5.5mmol/L) in Control protocol. In the latter, with constant Hins (plasma insulin=12616 pmol/L) and euglycemia, EGP (estimated by [3H-3]-glucose) fell to values 40% of basal (p
StatusFinished
Effective start/end date1/1/015/31/08

Funding

  • National Center for Research Resources
  • National Center for Research Resources
  • National Center for Research Resources
  • National Center for Research Resources
  • National Center for Research Resources
  • National Center for Research Resources
  • National Center for Research Resources
  • National Center for Research Resources
  • National Center for Research Resources
  • National Center for Research Resources
  • National Center for Research Resources
  • National Center for Research Resources
  • National Center for Research Resources
  • National Center for Research Resources
  • National Center for Research Resources
  • National Center for Research Resources

ASJC

  • Clinical Neurology
  • Endocrinology, Diabetes and Metabolism
  • Medicine(all)
  • Biotechnology
  • Demography
  • Cardiology and Cardiovascular Medicine
  • Nephrology
  • Neurology
  • Infectious Diseases
  • Transplantation
  • Genetics
  • Speech and Hearing
  • Radiology Nuclear Medicine and imaging
  • Pulmonary and Respiratory Medicine
  • Pharmacy
  • Virology
  • Surgery
  • Immunology and Allergy
  • Rheumatology
  • Microbiology
  • Immunology
  • Hepatology
  • Neuroscience(all)
  • Nursing(all)
  • Psychiatry and Mental health
  • Pathophysiology
  • Gastroenterology
  • Spectroscopy
  • Oncology
  • Cancer Research
  • Epidemiology
  • Pediatrics, Perinatology, and Child Health
  • Cell Biology
  • Pathology and Forensic Medicine
  • Pharmacology
  • Pharmaceutical Science

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