CENTER FOR MAGNETIC RESONANCE

  • Gerfen, Gary J. (PI)
  • Cheng, Hong (PI)
  • Neuringer, L.E.O. (PI)
  • Turner, Christopher (PI)
  • Holtzman, David (PI)
  • Culligan-Hensley, Patrici (PI)
  • Havel, Timothy (PI)
  • Teng, Xiaowu (PI)
  • Walsworth, Ronald (PI)
  • Del Nido, Pedro J. (PI)
  • Binello, Emanuela (PI)
  • Cloutier, Normand (PI)
  • Berger, Imre (PI)
  • Fahmy, A.M.R. (PI)
  • Dunham, Shari (PI)
  • Zhang, Wurong (PI)
  • Culligan-Hensley, P.A.T. (PI)
  • Hong, M.E.I. (PI)
  • Batey, Robert (PI)
  • Long, Joanna (PI)
  • Maus, Douglas (PI)
  • Brodsky, Alexander (PI)
  • Venkataraman, Ganesh (PI)
  • Altunata, Selen (PI)
  • Brunger, Axel (PI)
  • Sumi, Bao (PI)
  • Hongyuan, Mao (PI)
  • Souza, Kerry (PI)
  • Farrar, Margaret (PI)
  • Erlacher, Heidi (PI)
  • Gross, John (PI)
  • Sodickson, Aaron (PI)
  • Packard, Scott (PI)
  • Xuelian, Luo (PI)
  • Kutney, Michael (PI)
  • Price, Mark (PI)
  • Halkides, Christopher (PI)
  • Hatcher, Mary (PI)
  • Zhang, Guowang (PI)
  • Mueller, Leonard (PI)
  • Costa, Philip (PI)
  • Cheng, Yuan (PI)
  • Gonzalez, Ramon Gilberto (PI)
  • Rienstra, Chad (PI)
  • Connolly, Peter (PI)
  • Petkova, Aneta (PI)
  • Briinger, Axel (PI)
  • Pravia, Marco (PI)
  • Mierke, Dale (PI)
  • Gabnella, Leu (PI)
  • Gary J Gerfen, [No Value] (PI)
  • Prestegard, James (PI)
  • Redfield, Alfred Guillou (PI)
  • Baldus Marc, [No Value] (PI)
  • Kreischer, Kenneth (PI)
  • Veshtort, Mikhail (PI)
  • Schade, Markus (PI)
  • Hall, Dennis (PI)
  • Lansing, Jonathan (PI)
  • Rovnyak, David (PI)
  • Huaping, Mo (PI)
  • Bennati, Marina (PI)
  • Richert, Clemens (PI)
  • Kamath, Santharam (PI)
  • Baleja, James (PI)
  • Jenkins, Bruce (PI)
  • Weis, Volker (PI)
  • Mair, Ross (PI)
  • Czerwinski, Kenneth (PI)
  • Blacklow, Stephen C. (PI)
  • Turner, Christopher (PI)
  • Tang, Xiao- (PI)
  • Somaroo, Shyamal (PI)
  • Peled, Sharon (PI)
  • Gong, Huiling (PI)
  • Itin, Boris (PI)
  • Aivazian, Dikran (PI)
  • Sewell, William (PI)
  • Seeberger, Peter (PI)
  • Ojha, Rejadra (PI)
  • Baldus, Marc (PI)
  • Gupta, Goutam (PI)
  • Sun, Zhen-Yu (PI)
  • Gross, John (PI)
  • Kennedy, Robert (PI)
  • Tounge, Brett (PI)
  • Freund, Christian (PI)
  • Battiste, J. (PI)
  • Lees, Robert (PI)
  • Campbell, Sharon (PI)
  • Tseng, Ching- (PI)
  • Snyder, John (PI)
  • Rule, Gordon (PI)
  • Boutis, Gregory (PI)
  • Jaroniec, Christopher (PI)
  • Reif, Bernd (PI)
  • Hare, Brian (PI)
  • Stubbe, Joanne (PI)
  • Gonzalez, Juan (PI)
  • Liu, S.I.U. (PI)
  • Zhang, Jundong (PI)
  • Zhang, Yang (PI)
  • Antonelli, David (PI)
  • Dahlquist, Richard (PI)
  • Dubacq, Jean-Paul (PI)
  • Schrock, Richard (PI)
  • Sivaraja, Mohanram (PI)
  • Khait, Igor (PI)
  • Dasgupta, Sunil (PI)
  • Bennet, Andrew (PI)
  • Lansbury, P.T. (PI)
  • Warner, Kenneth (PI)
  • Sarma, Mukti (PI)
  • Feng, Tao (PI)
  • Warschawski, Dror (PI)
  • Ruben, David (PI)
  • Warren, Gregory (PI)
  • Becerra, Lino (PI)
  • Gelasco, Andrew (PI)
  • Jonas, Richard (PI)
  • Boqin, Sun (PI)
  • Millis, Kevin (PI)
  • Williamson, James (PI)
  • Gang, Wu (PI)
  • Maas, Werner (PI)
  • Hu, J.I.N. (PI)
  • Lippard, Stephen (PI)
  • Bellew, Brendan (PI)
  • Farrar, Christian (PI)
  • Tokuhiro, Tadashi (PI)
  • Cory, David (PI)
  • Sarma, Ramaswamy (PI)
  • Bennett, Andrew (PI)
  • Griffin, Robert (PI)
  • Neuringer, L.E.O. (PI)
  • Del Nido, Pedro J. (PI)
  • Fahmy, A.M.R. (PI)
  • Culligan-Hensley, P.A.T. (PI)
  • Hong, M.E.I. (PI)
  • Gary J Gerfen, [No Value] (PI)
  • Baldus Marc, [No Value] (PI)
  • Blacklow, Stephen C. (PI)
  • Battiste, J. (PI)
  • Gonzalez, Juan (PI)
  • Liu, S.I.U. (PI)
  • Zhang, Jundong (PI)
  • Zhang, Yang (PI)
  • Antonelli, David (PI)
  • Dahlquist, Richard (PI)
  • Dubacq, Jean-Paul (PI)
  • Schrock, Richard (PI)
  • Sivaraja, Mohanram (PI)
  • Khait, Igor (PI)
  • Dasgupta, Sunil (PI)
  • Bennet, Andrew (PI)
  • Lansbury, P.T. (PI)
  • Warner, Kenneth (PI)
  • Sarma, Mukti (PI)
  • Feng, Tao (PI)
  • Warschawski, Dror (PI)
  • Ruben, David (PI)
  • Warren, Gregory (PI)
  • Becerra, Lino (PI)
  • Gelasco, Andrew (PI)
  • Jonas, Richard (PI)
  • Boqin, Sun (PI)
  • Millis, Kevin (PI)
  • Williamson, James (PI)
  • Gang, Wu (PI)
  • Maas, Werner (PI)
  • Hu, J.I.N. (PI)
  • Lippard, Stephen (PI)
  • Bellew, Brendan (PI)
  • Farrar, Christian (PI)
  • Tokuhiro, Tadashi (PI)
  • Cory, David (PI)
  • Sarma, Ramaswamy (PI)
  • Bennett, Andrew (PI)
  • Griffin, Robert (PI)

Project: Research project

Project Details

Description

This proposal request continued support for the Center of Magnetic
Resonance (CMR) at the Francis Bitter National Magnet Laboratory. MIT
(Grant RR-00995-18). During the coming five year grant period we plan
significant upgrades of existing equipment, acquisition of new
instrumentation, and research initiatives in several new areas. (1) The
seven spectrometers currently operating in the facility will be upgraded
with new transmitter, receivers, pulse programmer, computer, etc. (2) The
facility will expand with the addition of nine additional instruments.
These include a new addition to the facility, the Spatial NMR Laboratory
containing five spectrometers, a new 600 MHz solution spectrometer,
eventually two 750 MHz instruments and high field solid state NMR and
EPR/DNP spectrometers. (3) New and continuing areas of interest in the
core research program include: (a) RF gradient enhanced spectroscopy, (b)
isotopic labeling and spectroscopy of RNA's and RNA/protein complexes,
(c) imaging of solids, (d) structural studies of solids via dipolar
recouping techniques (e) structural studies of large proteins including
enzyme/substrate/inhibitor complexes, Beta-amyloid, bacteriorhodopsin, and halorhodopsin (f) CW and pulsed
dynamic nuclear polarization, and (g) high frequency CW and pulsed EPR
and ENDOR studies of paramagnetic enzymes and enzyme/inhibitor complexes.
(4) The collaborative research effort will grow significantly and will
include: Solution NMR investigations of (a) drug induced DNA degradation
(Stubbe), (b) human sarcomas (Singer), (c) intermediates in protein
folding (Kemp), (d) NMA binding domain (Lippard) (e) glycoprotein folding
(Lansbury), (f) cell function and mRNA translation (Gehrke), (g) field
dependence of 13C and 15N relaxation times in proteins (Wagner). Imaging
studies will include (a) perfusion imaging (Rosen), (b) creatine kinase
and brain energetics (Holtzman), (c) metabolism in human cancer xenograph
(Jain), (d) diffusion of small solutes in cartilage (Burstein and Gray)
and (e) spectroscopy and imaging of rabbit eyes (Chen). (5) The service
component of the facility remains an important function as is evident by
the 10 proposals from outside investigators who have or plan to use the
facility frequently. (6) Plans for training and dissemination include
course work in magnetic resonance, seminars and publication in scholarly
journals.
StatusFinished
Effective start/end date5/1/764/30/04

Funding

  • National Center for Research Resources
  • National Center for Research Resources
  • National Center for Research Resources
  • National Center for Research Resources
  • National Center for Research Resources
  • National Institutes of Health
  • National Institutes of Health
  • National Center for Research Resources

ASJC

  • Medicine(all)

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