Project: Research project

Project Details


DESCRIPTION (Adapted from the applicant's abstract): C. elegans has been
selected as a "high connectivity" animal model for cellular development.
This very small, simple animal has been widely adopted for experimental
study due to extensive genetic resources and accessible cell biology. The
complete genome of the worm is being sequenced by the Worm Genome
Consortium. Much of the animal's adult anatomy has been reconstructed from
electron micrographs of serial thin sections. However, EM techniques are
not widely utilized by the C. elegans community, and most data from previous
EM studies are not easily accessed. The C. elegans Anatomy Center will
concentrate on extending these EM methods in C. elegans, particularly to
study cellular changes during normal development and in mutant animals, and
to conduct EM-immunocytochemical studies to localize antigens at the
ultrastructural level. Such studies will be conducted in close
collaboration with NIH- and NSF-funded laboratories, as a directed component
of their ongoing research efforts. In addition, the Center will publish
much more detailed information regarding the anatomy of the nematode in the
form of annotated electron micrographs. This information will be supplied
on CD-ROMs, over the World Wide Web, and possibly in book form. Where
necessary, the Center will conduct additional EM surveys of the wild type
anatomy at several developmental stages to supplement the Atlas,
particularly to fill gaps in general knowledge. This pre-resource
application will build the capabilities of the Center over an initial three
year period. The applicants intend to request a P40 or P41 grant later for
continued support of the Center.
Effective start/end date2/1/982/29/12


  • Anatomy
  • Cell Biology
  • Genetics
  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Molecular Biology


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