BRAIN DEVELOPMENT &DEVELOPMENTAL NEUROLOGICAL DISORDER

  • Buschke, Herman (PI)
  • Nortion, William (PI)
  • Paldino, Albert (PI)
  • Ledeen, Robert (PI)
  • Rapin, Isabelle (PI)
  • Suzuki, Kunihiko (PI)

Project: Research project

Description

This is a multidisciplinary research program to study neurological diseases
affecting brain development, both in humans and in experimental animals, and the
basic neurobiological process in developing brain. It represents a continuation
of long-standing combined efforts of clinicians and basic scientists covering a
broad range of discplines, including pediatric neurology, clinical psychology,
histology and electron microscopy, and biochemistry. The program consists of
two major sections, one involving human patients, and the other, basic
experimental studies. The program is concerned with inherited metabolic and
developmental disorders, including sphingolipidoses, Kinky hair syndrome and
related diseases. Collaborative studies among clinicians, morphologists and
biochemists are planned for understanding the molecular basis of these diseases. The Golgi study of neuronal processes in normal and pathological brain
development is an important new component of the program. Studies of
appropriate experimental models and of fundamental processes of brain
development complement the studies of human patients. This organization is
based on our continuing and successful philosophy that meaningful understanding
of human pathological conditions cannot be achieved without suppoort of relevant
fundamental studies and that progress in studies of diseases in turn often
provides new insight into the basic normal processes.
StatusFinished
Effective start/end date6/1/763/31/87

Funding

  • National Institutes of Health

Fingerprint

Cluster Analysis
Learning
Sphingolipidoses
Menkes Kinky Hair Syndrome
Clinical Psychology
Brain
Neurology
Biochemistry
Histology
Electron Microscopy
Theoretical Models
Pediatrics
Research

ASJC

  • Medicine(all)
  • Neuroscience(all)