BONE MORPHOGENETIC PROTEIN REGULATION--BRAIN DEVELOPMENT

Project: Research project

Project Details

Description

The long-term goal in applying for a clinical investigator development
award is to enable the applicant to develop the analytic and technical
skills necessary to become an independent investigator of clinically
relevant basic science. The scientific aim Of this proposal is to further
define mechanisms of intercellular communication in brain development.
The investigation will focus on the role of the bone morphogenetic
proteins (BMPs) in neural development. The BMPs are expressed in
embryonic, postnatal, and adult mouse brains. Further, the BMPs have
potent effects on the development of neurons and astrocytes in vitro. To
examine the hypothesis that the BMP's play a role in the lineage
commitment of neural progenitors and regulate the differentiation and
function of more mature neural cells, the effects of the BMPs will be
examined in vitro on cultured CNS progenitor cells, neurons and
astrocytes. The developmental expression profiles of BMPs 2, 4 and 7, and
the BMP receptors, activin receptor-like kinases (ALK) 3 and 6, will be
determined. These investigations are significant both for defining basic
developmental mechanisms relevant to CNS diseases, and for potentially
leading to clinical applications for neurotrophic factors.
StatusFinished
Effective start/end date7/1/965/31/01

ASJC

  • Neuroscience(all)
  • Cell Biology

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