• Vijg, Jan (PI)
  • Gwathmey, Judith (PI)
  • Wei, Jeanne (PI)
  • Boerrigter, Michael (PI)
  • Ingwall, Joanne (PI)

Project: Research project

Project Details


Our ultimate goal is to attempt to unravel the multifaceted process of
aging and reduce it to a finite number of well-defined molecular
processes that likely interact with environmental factors. This should
give us insight into the basic mechanisms of aging and provide new
possibilities for early diagnosis and medical intervention. We plan to
closely couple basic molecular studies on aging to physiological
endpoints. Indeed, to optimally apply the recent windfall of new
advanced techniques in molecular biology to the benefit of gerontology,
it is of the utmost importance to bring together basic research and
functional correlations. As a model for this we have adopted the
hypothesis that DNA damage, mutation and dysfunction contribute to
physiological decline and disease during aging. Using the latest
technology, we will study (1) somatic mutation frequency, (2) relative
DNA repair proficiency, (3) gene expression regulation, and (4)
mitochondrial energetics. This will allow us to define a role, if any,
of DNA changes in specific aging problems. The added value of the
program is that we will be able to relate the different data sets to one
another. Finally, the program project could serve as a model for future
studies on molecular parameters in conjunction with functional outcomes.
Effective start/end date9/30/936/30/99


  • Medicine(all)