BASIC MECHANISMS IN AUTOIMMUNE DISEASE

Project: Research project

Project Details

Description

Four investigators from one clinical and two basic science departments will
explore aspects of autoantibody formation and regulation in autoimmune
disease and of cell mediated immunity. The first two projects focus on
anti-DNA antibodies in systemic lupus, the structural basis for antigen
binding and pathogenicity and the regulation of expression DNA binding
antibodies. The third project is an exploits an idiotypic approach to
understand the molecular genetics of rheumatoid factors in rheumatoid
arthritis. The fourth project exploits a novel methodology for studying
self peptides associated with MHC antigens to identify tissue specific self
peptides.

The investigators will share 3 core facilities funded by this grant, an
administrative core, an oligonucleotide synthesis core, and an animal core,
as well as additional core facilities supported by other sources. The
investigators in this program are highly interactive. This application
reflects the continuing commitment of some of the investigators to the
study of human disease and the new focus of others on issues relevant to
human pathobiology.
StatusFinished
Effective start/end date5/1/934/30/94

Funding

  • National Institute of Allergy and Infectious Diseases
  • National Institute of Allergy and Infectious Diseases

ASJC

  • Drug Discovery
  • Microbiology (medical)
  • Medical Laboratory Technology
  • Materials Chemistry
  • Molecular Biology
  • Biophysics
  • Biochemistry
  • Cancer Research
  • Rheumatology
  • Nuclear Energy and Engineering
  • Ecology
  • Immunology
  • Organic Chemistry

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