Autophagy mediated immune stimulation by reovirus in KRAS mutated colorectal cancer

Project Narrative A clinical gap exists for patients with KRAS mutated CRC with fewer treatment options and lack of appropriate responsiveness to newly emerging immune therapy. We will explore the immune stimulation characteristics of reovirus and further follow the contribution of autophagic pathway in the process. Results will provide valuable insight that can be utilized to strategize an effective immune therapy for immune deserted KRAS mutated CRC patients.