Project: Research project

Project Details


Four investigators from one clinical and two basic science departments will
explore aspects of autoantibody formation and regulation in autoimmune
disease and of cell mediated immunity. The first two projects focus on
anti-DNA antibodies in systemic lupus, the structural basis for antigen
binding and pathogenicity and the regulation of expression DNA binding
antibodies. The third project is an exploits an idiotypic approach to
understand the molecular genetics of rheumatoid factors in rheumatoid
arthritis. The fourth project exploits a novel methodology for studying
self peptides associated with MHC antigens to identify tissue specific self

The investigators will share 3 core facilities funded by this grant, an
administrative core, an oligonucleotide synthesis core, and an animal core,
as well as additional core facilities supported by other sources. The
investigators in this program are highly interactive. This application
reflects the continuing commitment of some of the investigators to the
study of human disease and the new focus of others on issues relevant to
human pathobiology.
Effective start/end date1/1/014/30/97


  • Molecular Biology
  • Rheumatology
  • Immunology
  • Genetics
  • Chemical Engineering(all)
  • Medicine(all)
  • Immunology and Microbiology(all)
  • Cell Biology
  • Immunology and Allergy


Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.