• Kaufman, Howard L. (PI)

Project: Research project

Project Details


The purpose of this research study is to evaluate a new experimental treatment using a vaccine to treat cancer. The vaccine is a canarypox virus (ALVAC) that co-expresses the human carcinoembryonic antigen (CEA) and the so-stimulatory molecule B7-1. This is expected to activate T-cell responses against CEA-expressing tumor cells. This protocol is a phase I trial designed to determine the optimal dose of vaccine, side effects, clinical and immune responses. Increasing doses of virus will be used in patients with advanced CEA-expressing tumors by monthly intramuscular injections over 3 months. This study proposes to treat six patients at each dose of virus and will analyze immune responses after each immunization by in vitro T-cell assays and clinical responses after the 3 month treatment period. Patients without progression may be re-vaccinated.
Effective start/end date10/1/989/30/01


  • National Center for Research Resources


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    Spiegel, A. M., Purpura, D., Spiegel, A. A. M., Howard, A. A. A., Melman, A. A., Bloom, B. B. R., Diamond, B. B., Segal-isaacson, C. C., Stein, D. D. C., Purpura, D. D., Schoenbaum, E., Kaskel, F. F., Ho, G. G. Y., Shamoon, H., Hetherington, H. H. P., Crystal, H. H., Roy-chowdhury, J. J., Pollard, J. J. W., Rieder, J. J., Crandall, J. J. P., Wylie-Rosett, J., Pan, J. J. W., Rossetti, L. L., Weiss, L. M., Bigal, M. M., Hawkins, M. A., Brownlee, M. M. A., Alderman, M. M. H., Schilsky, M. M. L., Fabry, M. M. E., Roy-chowdhury, N. N., Barzilai, N. N. J., Fleischer, N. N. S., Santoro, N. N. F., Kennan, R. R. P., Bookchin, R. R. M., Klein, R. R. M., Lipton, R. B., Burk, R. R. D., Nagel, R. R. L., Engel, S. S. S., Gupta, S. S., Somlo, S. S., Berk, S. S., Weber, T. T. J., Frishman, W. W. H., Noyer, C. C., Barzilai, N., Burk, R. D., Fabry, M. E., Fleischer, N., Hawkins, M. A., Ho, G. Y., Kaufman, H. L., Nagel, R. L., Roy-Chowdhury, J., Rubenstein, A., Santoro, N. F., Schilsky, M. L., Shamoon, H., Somlo, S., Stein, D. T., Wadler, S. H., Wozniak, R. & Wylie-Rosett, J.

    National Center for Research Resources


    Project: Research project