A combined computational and experimental approach to the evolution and role of the DNA sequence environment in targeting mutations to antibody V regions

Project: Research project

Project Details

Description

Project narrative The proposed research is relevant to public health because understanding the targeting of AID-mediated mutations across many human heavy chain V-regions will make it possible to develop vaccines that will lead more rapidly to better and more broadly protective antibodies to infectious agents and reveal the risk factors in the development of B-cell malignancies and gastric and other solid tumors where AID is implicated.
StatusActive
Effective start/end date3/1/182/28/23

Funding

  • National Institute of Allergy and Infectious Diseases: $537,909.00
  • National Institute of Allergy and Infectious Diseases: $578,750.00
  • National Institute of Allergy and Infectious Diseases: $67,258.00
  • National Institute of Allergy and Infectious Diseases: $585,186.00
  • National Institute of Allergy and Infectious Diseases: $591,815.00
  • National Institute of Allergy and Infectious Diseases: $65,982.00
  • National Institute of Allergy and Infectious Diseases: $587,448.00

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