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  MOLECULAR BIOLOGIC STUDIES ON THE CAUSE OF PARATHYROID NEOPLASIA

  Spiegel, A. M.

  Project: Research project

  • Parathyroid Glands 100%
  • Neoplasms 78%
  • Parathyroid Neoplasms 69%
  • Primary Hyperparathyroidism 32%
  • Germ-Line Mutation 30%

• GUANINE NUCLEOTIDE BINDING PROTEINS AS RECEPTOR-EFFECTOR COUPLERS

  Spiegel, A. M.

  National Institute of Diabetes and Digestive and Kidney Diseases

  Project: Research project

  • Guanine Nucleotides 100%
  • Carrier Proteins 68%
  • GTP-Binding Proteins 16%
  • Potassium Channels 13%
  • Mutation 13%

• GUANINE NUCLEOTIDE BINDING PROTEINS AS RECEPTOR-EFFECTOR COUPLERS

  Spiegel, A. M.

  Project: Research project

  • Guanine Nucleotides 100%
  • Carrier Proteins 68%
  • G-protein Beta gamma 17%
  • Signal Transduction 13%
  • Potassium Channels 10%

• PEDIATRIC HYDROXYUREA PHASE III CLINICAL TRIAL

  Minniti, C. P.

  Project: Research project

• STUDIES ON A CALCIUM SENSING RECEPTOR

  Spiegel, A. M., Spiegel, A. M. & Spiegel, A. M.

  Project: Research project

  • Calcium-Sensing Receptors 100%
  • Familial Hypercalciuric Hypocalcemia 27%
  • GTP-Binding Protein alpha Subunits 21%
  • Complement System Proteins 19%
  • Metabotropic Glutamate Receptors 18%

• Structure/Function Of Men1 Gene And Its Protein Product

  Spiegel, A. M., Wackym, P. A., Morell, R., Dibello, P. & Wackym, P. A.

  Project: Research project

  • neoplasms 100%
  • Drosophila 55%
  • mice 47%
  • genes 45%
  • proteins 27%

• Cervical cancer and human papillomavirus (HPV) infection

  Castle, P. E.

  Project: Research project

  • Uterine Cervical Neoplasms 100%
  • Cohort Studies 74%
  • Papillomavirus Infections 60%
  • Nigeria 57%
  • Natural History 54%

• GUANINE NUCLEOTIDE BINDING PROTEINS AS RECEPTOR-EFFECTOR COUPLERS

  Spiegel, A. M.

  Project: Research project

  • GTP-Binding Proteins 100%
  • Guanine Nucleotides 41%
  • Carrier Proteins 28%
  • Transducin 24%
  • Rhodopsin 21%

• HUMORAL HYPERCALCEMIA OF MALIGNANCY

  Spiegel, A. M.

  Project: Research project

  • Humoral Hypercalcemia Of Malignancy 100%
  • Hypercalcemia 68%
  • Leydig Cell Tumor 44%
  • Wells syndrome 42%
  • Inbred F344 Rats 34%

• MOLECULAR BIOLOGIC STUDIES ON THE CAUSE OF PARATHYROID NEOPLASIA

  Spiegel, A. M.

  Project: Research project

  • neoplasms 100%
  • parathyroid glands 42%
  • hyperparathyroidism 32%
  • oncogenes 24%
  • hyperplasia 21%

• STUDIES ON PSEUDOHYPOPARATHYROIDISM AND RELATED DISORDERS

  Spiegel, A. M.

  Project: Research project

  • Pseudohypoparathyroidism 100%
  • Parathyroid Hormone 43%
  • Hormones 22%
  • Adenylyl Cyclases 22%
  • Albright's hereditary osteodystrophy 18%

• MAINTENANCE OF THE NHLBI BIOLOGIC SPECIMEN REPOSITORY

  Kaplan, R. C. & Kaplan, R. C.

  Project: Research project

  • Blood 100%

• PSEUDOHYPOPARATHYROIDISM AND RELATED DISORDERS

  Spiegel, A. M.

  Project: Research project

  • Pseudohypoparathyroidism 100%
  • Adenylyl Cyclases 26%
  • Albright's hereditary osteodystrophy 21%
  • Hormones 18%
  • Hypoparathyroidism 16%

• GUANINE NUCLEOTIDE BINDING PROTEINS AS RECEPTOR-EFFECTOR COUPLERS

  Spiegel, A. M.

  Project: Research project

  • GTP-Binding Proteins 100%
  • Guanine Nucleotides 49%
  • Carrier Proteins 34%
  • Transducin 29%
  • Rhodopsin 25%

• RESEARCH TRIANGLE INSTITUTE/PROGRAMMING AND ANALYTICAL SUPPORT

  Guha, C.

  National Cancer Institute

  Project: Research project

  • Heavy Ion Radiotherapy 100%
  • neoplasms 48%
  • applied research 27%
  • research programs 23%
  • morbidity 22%

• Hispanic Community Health Study

  Kaplan, R. C.

  National Heart, Lung, and Blood Institute

  Project: Research project

  • audiometry 100%
  • health 86%
  • examination 73%
  • population group 70%
  • health care 67%
• Finished

  Cell fate choices by Tbx1 in forming the mammalian heart

  Morrow, B. E. & Zheng, D.

  8/20/20 → 4/30/21

  Project: Research project

  • DiGeorge Syndrome 100%
  • Stem Cells 44%
  • Mesoderm 39%
  • Chromatin Immunoprecipitation Sequencing 31%
  • Embryonic Structures 29%

• Predictive analytics for cognitive decline and Alzheimer?s disease

  Ezzati, A.

  8/1/20 → 4/30/21

  Project: Research project

  • Machine Learning 100%
  • Cognitive Dysfunction 96%
  • Dementia 74%
  • Secondary Prevention 57%
  • Biostatistics 44%

• A Randomized Clinical Trial to Assess the Effectiveness of Ablative Treatments for Cervical-Cancer Risk Reduction in HIV+ Women living in Mozambique

  Castle, P. E.

  5/12/20 → 4/30/21

  Project: Research project

  • Uterine Cervical Neoplasms 100%
  • Triage 85%
  • HIV 85%
  • Acetic Acid 66%
  • Treatment Failure 60%

• Novel Strategies for the Discovery of Microbial Metabolic Pathways

  Almo, S. C.

  5/1/20 → 4/30/21

  Project: Research project

  • Solute 100%
  • Metabolic 79%
  • Ligand 74%
  • Protein 70%
  • Enzyme Activity 40%

• IMPACT OF PRENATAL VITAMIN A DEFICIENCY ON CELL FATE ALTERATIONS IN ADULT AIRWAY HYPERRESPONSIVENESS

  Suzuki, M.

  4/1/20 → 3/31/21

  Project: Research project

  • Cellular Reprogramming 100%
  • Tretinoin 80%
  • Vitamin A Deficiency 70%
  • Epigenomics 68%
  • Lung 55%

• Analytical and/or Clinical Validation of Candidate Biomarkers for Curative Therapies in Sickle Cell Disease

  Manwani, D. G.

  National Heart, Lung, and Blood Institute

  9/20/19 → 2/17/20

  Project: Research project

  • Sickle Cell Anemia 100%
  • Neutrophil Activation 67%
  • Biomarkers 66%
  • Hydroxyurea 13%
  • Inflammation 12%

• Development of a nanotechnology resource center to advance urological research

  Davies, K. & Friedman, J. M.

  9/17/19 → 6/30/21

  Project: Research project

  • Nanoparticles 100%
  • Nanotechnology 89%
  • Research Personnel 26%
  • Urologic Diseases 17%
  • Resource Allocation 14%

• Optimization of microparticle-based topical treatments for treating erectile dysfunction in patients refractory to oral PDE5 inhibitors

  Davies, K.

  National Institute of Diabetes and Digestive and Kidney Diseases

  9/13/19 → 9/12/20

  Project: Research project

  • Erectile Dysfunction 100%
  • Nitric Oxide 95%
  • Phosphodiesterase 5 Inhibitors 82%
  • Prostatectomy 40%
  • lead oxide 16%

• Zeiss Confocal Microscope with Airyscan for Einstein Neural Cell Engineering and Imaging Core

  Dobrenis, K.

  NIH Office of the Director

  9/2/19 → 8/31/20

  Project: Research project

  • Cell Engineering 100%
  • cell engineering 90%
  • Huntington Disease 83%
  • image analysis 62%
  • Schizophrenia 61%

• Cytek Aurora Multiparameter Flow Cytometer

  Porcelli, S. A.

  8/1/19 → 7/31/20

  Project: Research project

  • Flow cytometry 100%
  • Fluorescence 38%
  • Dyes 37%
  • Semiconductor detectors 29%
  • Fluorophores 27%

• Treat All and beyond: addressing methods, data and capacity building challenges in the African regions of IeDEA

  Anastos, K.

  National Institute of Allergy and Infectious Diseases

  8/1/19 → 7/31/20

  Project: Research project

  • Capacity Building 100%
  • Africa South of the Sahara 30%
  • Research Personnel 28%
  • National Institute of Allergy and Infectious Diseases (U.S.) 21%
  • Rwanda 19%

• Impact of multiple stigmas on HIV care continuum outcomes for key populations

  Patel, V. V.

  National Institute of Mental Health

  7/17/19 → 6/30/21

  Project: Research project

  • HIV 100%
  • Continuity of Patient Care 96%
  • India 40%
  • Population 34%
  • Retention in Care 34%

• New Biosensor Tools for Diaphanous Related Formin MD1A and 2, Useful for Multiplex Imaging

  Hodgson, L.

  National Institute of General Medical Sciences

  7/1/19 → 3/31/21

  Project: Research project

  • Formins 100%
  • Biosensing Techniques 71%
  • rho GTP-Binding Proteins 67%
  • Energy Transfer 46%
  • Wiskott-Aldrich Syndrome Protein Family 30%

• Functional role of IP3 receptors in the regulation of cardiac myofibroblasts

  Santulli, G.

  National Heart, Lung, and Blood Institute

  7/1/19 → 6/30/21

  Project: Research project

  • Inositol 1,4,5-Trisphosphate Receptors 100%
  • Fibroblasts 91%
  • Myofibroblasts 78%
  • Fibrosis 71%
  • Myocardial Infarction 39%

• Age associated genomic instability and brain tumor risk

  Montagna, C.

  National Cancer Institute

  7/1/19 → 6/30/21

  Project: Research project

  • Genomic Instability 100%
  • Brain Neoplasms 65%
  • Cerebellum 51%
  • Cerebral Cortex 39%
  • Astrocytes 38%

• Plasmodium phospholipase A2s as potential novel drug targets

  Daily, J. P.

  National Institute of Allergy and Infectious Diseases

  6/21/19 → 5/31/21

  Project: Research project

  • Cerebral Malaria 100%
  • Brain Edema 80%
  • Endothelial Cells 53%
  • Permeability 52%
  • Phospholipases 51%

• Dynamic visualization of polyribosomes

  Yoon, Y. J.

  National Institute of Mental Health

  6/13/19 → 5/31/21

  Project: Research project

  • Fragile X Mental Retardation Protein 100%
  • Polyribosomes 62%
  • Microscopy 27%
  • Optical Imaging 26%
  • Ribosome Subunits 22%

• Clinical Research Sites for the MACS/WIHS Combined Cohort Study (MACS/WIHS-CCS)

  Sharma, A. & Anastos, K.

  National Heart, Lung, and Blood Institute

  4/1/19 → 3/31/21

  Project: Research project

  • HIV 100%
  • Acquired Immunodeficiency Syndrome 94%
  • Cohort Studies 81%
  • Cardiovascular Diseases 30%
  • Comorbidity 19%

• NIH Support for Conferences and Scientific Meetings

  Larsen, M. H.

  National Institute of Allergy and Infectious Diseases

  3/1/19 → 2/29/20

  Project: Research project

  • Mycobacterium 100%
  • mycobacterial diseases 86%
  • leprosy 41%
  • tuberculosis 34%
  • researchers 24%

• Studies on Pol III-Associated Leukodystrophy

  Moir, R. D. & Willis, I. M.

  Eunice Kennedy Shriver National Institute of Child Health and Human Development

  3/1/19 → 2/28/21

  Project: Research project

  • Mutation 100%
  • Anodontia 87%
  • Genetic Suppression 83%
  • RNA Polymerase III 82%
  • Developmental Disabilities 74%

• Investigating the CDC42 pathway as a novel pathway for pediatric non-atopic obesity-related asthma

  Rastogi, D.

  2/1/19 → 1/31/20

  Project: Research project

  • Cell Cycle 100%
  • Asthma 91%
  • Obesity 50%
  • Steroids 33%
  • Pediatrics 23%

• Identification of new regulators of autophagy in T cells

  Macian-Juan, F., Botbol, Y. M. & Macian-Juan, F.

  National Institute of Allergy and Infectious Diseases

  1/16/19 → 12/31/20

  Project: Research project

  • Autophagy 100%
  • T-Lymphocytes 59%
  • Macroautophagy 23%
  • Autophagosomes 20%
  • Organ Specificity 10%

• Cooperative Research Agreements Related to the World Trade Center Health Program (U01)

  Hall, C. B.

  1/1/19 → 8/31/20

  Project: Research project

• Cooperative Research Agreements Related to the World Trade Center Health Program (U01)

  Verma, A. K.

  1/1/19 → 6/30/20

  Project: Research project

• Effective immunity against Trypanosoma cruzi infection induced by immunization

  Huang, H.

  11/9/18 → 10/31/20

  Project: Research project

  • Trypanosoma cruzi 100%
  • infection 56%
  • mice 19%
  • vaccine development 16%
  • Chagas disease 16%

• Gene and Stem Cell-Based Treatment for Tendinopathy

  Sun, H. (.

  9/30/18 → 8/31/20

  Project: Research project

  • Stem Cells 79%
  • Tendinopathy 70%
  • Pain 20%
  • Rotator Cuff 16%
  • Inbred F344 Rats 16%

• A Novel Therapeutic that Harnesses MIcrotubules to Enhance Corneal Wound Healing Following an Alkaline Burn

  Chuck, R. S.

  NATIONAL EYE INSTITUTE

  9/30/18 → 9/29/19

  Project: Research project

  • Microtubules 100%
  • Wound Healing 94%
  • Wounds and Injuries 61%
  • Burns 43%
  • Corneal Epithelium 35%

• Role of autophagy in manganese-induced neurotoxicity

  Zhang, Z.

  9/30/18 → 8/31/20

  Project: Research project

  • Manganese 100%
  • Autophagy 55%
  • Transcription Factors 11%
  • Lysosomes 10%
  • Neurodegenerative Diseases 9%

• Crosstalk Between T Cells and Airway Smooth Muscle in Obesity-Related Asthma

  Rastogi, D.

  9/21/18 → 12/31/18

  Project: Research project

  • Smooth Muscle 100%
  • Asthma 80%
  • Obesity 50%
  • Weights and Measures 32%
  • Cell Adhesion 29%

• A Novel Therapeutic that Harnesses Microtubules to Promote Cavernous Nerve Regeneration after Radical Prostatectomy

  Sharp, D. J.

  National Institute of Diabetes and Digestive and Kidney Diseases

  9/20/18 → 8/31/19

  Project: Research project

  • Prostatectomy 100%
  • Erectile Dysfunction 86%
  • Small Interfering RNA 67%
  • Nerve Regeneration 65%
  • Microtubules 58%

• Impact of HIV, oral microbiome and mycobiome on oral HPV

  Burk, R. D. & Schlecht, N. F.

  National Institute of Dental and Craniofacial Research

  9/18/18 → 9/17/20

  Project: Research project

  • Mycobiome 100%
  • HIV 55%
  • Microbiota 54%
  • Papillomavirus Infections 19%
  • Natural History 8%

• Robust Predictor of Colon Cancer Risk

  Ostrer, H.

  National Cancer Institute

  9/13/18 → 8/31/20

  Project: Research project

  • Colonic Neoplasms 100%
  • Hereditary Nonpolyposis Colorectal Neoplasms 75%
  • Mutation 40%
  • DNA Mismatch Repair 34%
  • Risk Assessment 24%

• TREAT ECARDS: Translating Evidence into Action: Electronic Clinical Decision Support in ARDS

  Gong, M. N.

  9/1/18 → 6/30/21

  Project: Research project

  • Adult Respiratory Distress Syndrome 100%
  • Clinical Decision Support Systems 28%
  • Practice Guidelines 12%
  • Professional Practice 10%
  • Workflow 9%

• Integration of RhoGTPase signaling during macrophage migration

  Cox, D., Hodgson, L. & Hodgson, L.

  National Institute of General Medical Sciences

  9/1/18 → 8/31/20

  Project: Research project

  • rho GTP-Binding Proteins 100%
  • Cell Movement 39%
  • Macrophage Colony-Stimulating Factor 38%
  • Macrophages 27%
  • GTP Phosphohydrolases 27%