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HEMOGLOBIN--A WORKBENCH TO STUDY PROTEIN ALLOSTERY

Friedman, J. M., Englander, S., Noble, R., Hoffman, B., Armone, A., Arnone, A. & Englander, S.

National Institutes of Health

1/1/9912/31/05

Project: Research project

Plasticity
Hemoglobins
Heme
Biophysics
Ligands

PATHOGENESIS OF CRYPTOCOCCAL MENINGOENCEPHALITIS

Lee, S. C.

National Institutes of Health

12/16/9811/30/03

Project: Research project

Cryptococcus neoformans
Meningoencephalitis
Microglia
Astrocytes
Cryptococcal Meningitis
Borderline Personality Disorder
Valproic Acid
Placebos
Anger
Psychiatry
Fires
Smoke
Fumes
Miners

PRINCIPAL NIH RESEARCH RESOURCE X RAY BEAMLINE AT NSLS: WIGGLER BEAMLINE X25

Almo, S. C., Almo, S. C., Flanagan, J., Phillips, W., Berendzen, J., Moore, P. B., Berman, L., Ealick, S., Capel, M., Ruiming, X., Reinherz, E., Terwilliger, T. O. M., Ellenberger, T. E., Sweet, R., Lewis, H. A. L., Sanghani, P., Ohlendorf, D., Chen, L. I. N., Mariuzza, R., Bahnson, B., Honglin, L., Beese, L., Ha, Y. A., Hill, C. P., Doublie, S., van Roey, P., Brown, B. A., Patel, D., Crane, B., Lu, Y. I., Wolberger, C., Kantrowitz, E., Lambright, D., Kull, F., Churchill, M., Becker, M., Amzel, L. M., Reinisch, K., Steitz, T. A., Crane, A., Gouaux, J. E., MacKinnon, R., Schneider, D. K., Swaminathan, S., Robinson, H., Gehring, K., Leahy, D., Marcotrigiano, J., Quan, H., Agbandje-McKenna, M., Stock, A. M., Bohm, A. A., Sondek, J., Muniz, J. R. C., Lawson, C., Marmorstein, R., Varughese, K., Wang, J., Wucherpfennig, K., Richter-Addo, G. B., Dashuang, S., Izard, T., Parry, C., Jiang, J., Pollard, T. D., Boriack-Sjodin, A., Kong, X., Silvaggi, N., Kissinger, C., Schulman, B., Neiditch, M., Coulombe, R., Lolis, E., Ferguson, K., Clarke, T., Birrane, G., Verdine, G., Cygler, M., Murakami, K., Bruner, S., Hengming, K., Parris, K. D., Arnold, E. D., Strobel, S., Sygusch, J., Ippolito, J., Zhao, Y., Mallett, T. C., Williams, L. D., Cordes, M., Blacklow, S. C., Jianhua, F., Soares, A. S., Colman, P., Zhaohui, X., McDonough, M., Kobe, B., Yili, L., Loll, P., Serganov, A., Braddock, D., Gallagher, T., Morstein, R., Delbaere, L., Paetzel, M. W., Samanta, U., Mariuzza, R., Moore, P. B., Cohen, C., Rould, M., van Den Akker, F., Huang, Z., Merithew, E., Heroux, A., Goldberg, J., Liu, C., Miller, C., Schlessinger, J., Berman, L. E., Jayaraman, S., Yigong, S., Hong, L., Hill, C. P., Birktoft, J., Junop, M., Martucci, W. E., Radisky, E., Howell, P. L., Song, J., Hunt, J. F., Quan, H., Zhao, R. U. I., Royer, W., Fu, D. A. X., Wang, Z., Schroeder, S., Kielkopf, C., Ha, Y. A., Vivien, Y., Kissinger, C., Bohm, A. A., Vicens, C. N., Wucherpfennig, K., Morais Cabral, J., Smith, P., Blaber, M., Pata, J., Bussiere, D., Reinisch, K., Hart, P. J., Allen, K. N., Vedula, L. S., Blobel, G., Schindelin, H., Zhou, M., Buchanan, S. K., Wang, Q. I., Zhou, Z., Simmons, C. R., Lowther, W. T., Gallagher, D., Zhaohui, X., Krasilnikov, A. S., Robinson, V., Silvaggi, N., Park, R., Huang, M., Hughson, F., McMillan, M., Agbandje-McKenna, M., Lawson, C., Allen, C., Hollis, T., vandenberg, L. N., Eckenroth, B., Anderson, A. C., Stern, L., Zongchao, J., Tang, L., Joseph, L., Parsons, J., Christopher Charles, L., Tremblay, L., Serganov, A., Neiditch, M., Xiong, Y., Acharya, R., Modis, Y., Jiang-Yong, M., Furukawa, H., Aggarwal, A. K., Khangulov, S., Morrison, J., Z Helen, W., Eathiraj, S., Boudker, O., Orville, A., Jiang, J., Yuan, Y. U., Sanghani, P., Czyzewski, B. K., Soares, A. S., Quan, H., Pavletich, N., Jogl, G., Akey, C., Stock, A. M., Riedl, S., Beglova, N., Long, S. B., Boriack-Sjodin, P., Richter-Addo, G. B., Pata, J., Oldfield, E., Wuxian, S., Lolis, E., Heldwein, E., Schiffer, C. A., Liu, C., Joshua, L., Radisky, E., Howell, P. L., Garcia-Diaz, M., MacKinnon, R., McKeever, B. M., Huang, Z., Blaber, M., Pascal, J., Page, R., Sliz, P., vandemark, A. P., Smith, P. B., Reinisch, K., Christensen, H. E., Schlessinger, J., Mariuzza, R., Allen, K., Mangel, W. F., Hardy, J., Vedula, L. S., Feklistov, A., Bowman, G. D., Everse, S., Bing, H., Armache, K. J., Steitz, T. A., Bruner, S., Huang, M., Sherman, D., Bohm, A. A., Jian, H., Hubbard, S. R., Blobel, G., Nimigean, C., Hang, S., Lawson, C., Lu, Y. I., Simanshu, D., Seeliger, M. A., Fromme, J. C., Gerratana, B., Moore, P. B., Terwilliger, T. O. M., Ellenberger, T. E., Lewis, H. A. L., Chen, L. I. N., Hill, C. P., Lu, Y. I., Ha, Y. A., Kull, F., Amzel, L. M., Schneider, D. K., Stock, A. M., Pollard, T. D., Arnold, E. D., Mallett, T. C., Williams, L. D., Blacklow, S. C., Moore, P. B., Berman, L. E., Hill, C. P., Martucci, W. E., Zhao, R. U. I., Fu, D. A. X., Vicens, C. N., Ha, Y. A., Allen, K. N., Buchanan, S. K., Wang, Q. I., Lowther, W. T., Krasilnikov, A. S., vandenberg, L. N., Anderson, A. C., Aggarwal, A. K., Yuan, Y. U., Czyzewski, B. K., Stock, A. M., Boriack-Sjodin, P., Schiffer, C. A., Mangel, W. F., Hubbard, S. R., Lu, Y. I. & Fromme, J. C.

National Institutes of Health

9/30/986/30/13

Project: Research project

available personnel
technical development
development project
hardware
supervision
Apoptosis
AIDS-Related Complex
Caspases
Cardiac Myocytes
Striated Muscle

NEW METHODOLOGY FOR VEGF MEDIATED GENE DELIVERY

Backer, J. M.

9/30/988/31/02

Project: Research project

GENETIC ENGINEERING OF BETA CELLS FOR TRANSPLANTATION

Brownlee, M. A.

9/30/989/29/01

Project: Research project

Astrocytes
Extracellular Fluid
Glutamic Acid
Ethanol
Excitatory Amino Acids
Cardiac Myocytes
AIDS-Related Complex
Apoptosis
Reperfusion Injury
Myocardial Infarction
Uterine Cervical Neoplasms
Papillomavirus Infections
Natural History
Vaccines
Microbiota
Breast Diseases
Vitamin D
Diet Therapy
Dietary Calcium
Dietary Fats

MASS SPECTROMETERS

Angeletti, R. H.

National Institutes of Health

7/15/987/14/99

Project: Research project

Mass spectrometers
Mass spectrometry
Immunology
Signal transduction
Ion sources
Mycobacterium
Tuberculosis
Bacteriophages
Molecular Biology
Mycobacteriophages
coenzymes
biochemical pathways
enzymology
enzymes
canes
Cryptococcus neoformans
Melanins
Monoclonal Antibodies
Peptides
Virulence

MECHANISMS OF INTERCELLULAR COMMUNICATION

Verselis, V., Bennett, M. V. & Bennett, M. V.

National Institutes of Health

7/1/986/30/15

Project: Research project

Communication
Connexins
Neuronal Plasticity
Neurosciences
Synaptic Transmission
Lead Poisoning
Iron
Vulnerable Populations
National Institute of Environmental Health Sciences (U.S.)
Chelation Therapy
Tuberculosis
Mycolic Acids
Ethionamide
Pharmaceutical Preparations
HIV
Hyperinsulinism
Insulin Resistance
Lipids
Muscles
Type 2 Diabetes Mellitus

GENERAL CLINICAL RESEARCH CENTER

Wagshul, M. E., Arbeit, L., Carlson, H., Gorevic, P., Palmer, L., Berelowitz, M., Goligorsky, M., Luft, B., La Gamma, E., Hurst, L., Schindler, R., Wilson, T., McNurlan, M. A., Cohn, P., Delisi, L. E., Cersosimo, E., Krupp, L., Cersomino, E., Nachman, S., Volkow, N., Gruber, B., Garlick, P. J., Vincent, R., Lane, D., Gelato, M., Younas, A., Madajewicz, S., Hultin, M., Diaz, A., Edelman, N., Fine, R., Gerber, O., Belman, A., Kaushansky, K., Coyle, P., Badalamente, M., Barraco, R., Parkinson, D., Trilling, J., Vitkun, S., Cohn, P., Adsumelli, R., Carlson, H., Glass, P., Lane, A., Lydic, M. L., Singer, A. J., Perrotta, P., Sheynkin, Y., Ricotta, J., Chang, L., Chen, J., Ding, Y., Langenback, E., Brand, D., Ernst, T., Smith, B., Canli, T., Lawson, W. B., Volkow, N., Ray-Mazumder, S., Steigbigel, R. O. Y., Sedler, M., Coyle, P., Rooney, W., Garry, D. J., Ryan, M., Kovach, J. S., Madajewicz, S., Pomeroy, J., Friedberg, F., Badalamente, M., Wilson, T. H., McNurlan, M. A., Krupp, L., Hurst, L., Wang, G., Perkins, C., Nachman, S., Chen, W., Fowler, J., Goldstein, R., Gelato, M., Tomasi, D. G., Jabar, R., Anderson, J., Dagum, A., Blader, J., Parodi-Mujica, L. R., De Leon, M. J., Whyte, D., Schwartz, J. E., Chawla, A., Baker, D., Maletic-Savatic, M., Saunders, T., Anschel, D., Rigas, B., Carlson, H., Christodoulou, C., Gold, A., Klein, D., Bahou, W., O'Hea, E., Schlyer, D., Kurland, I. J., Weiming, X., Stone, A. A., Caparelli, E. D. C., Biegon, A., Ricotta, J., Lydic, M. L., Jurgens, C., Skopicki, H., Richard, L., Jaber, R., Shumay, E., Dixon, D., Broderick, J. B., Chitkata, M., Bahou, W., Kiefer, D., Morelli, P., Tassiopoulus, A., Lane, A., Mynarcik, D., Singer, A. J., Clark, R. A., Sheynkin, Y., McNurlan, M. A., Steigbigel, R. O. Y., Garry, D. J., Wilson, T. H., McNurlan, M. A., Tomasi, D. G., De Leon, M. J., Schwartz, J. E., Stone, A. A., Broderick, J. B., Smith, B., Canli, T., Lawson, W. B., Volkow, N., Ray-Mazumder, S., Steigbigel, R. O. Y., Sedler, M., Coyle, P., Rooney, W., Garry, D. J., Ryan, M., Kovach, J. S., Madajewicz, S., Pomeroy, J., Friedberg, F., Badalamente, M., Wilson, T. H., McNurlan, M. A., Krupp, L., Hurst, L., Wang, G., Perkins, C., Nachman, S., Chen, W., Fowler, J., Goldstein, R., Gelato, M. & Tomasi, D. G.

National Institutes of Health

6/4/9811/30/11

Project: Research project

Biomechanical Phenomena
Dementia
Medicine
Brain
Research

ANCHORED PROTEIN KINASE A IN SIGNAL TRANSDUCTION

Rubin, C. S.

National Institutes of Health

6/1/985/31/07

Project: Research project

A Kinase Anchor Proteins
Cyclic AMP-Dependent Protein Kinases
Signal Transduction
Phosphorylation
Epithelial Cells
Leukocytes
Macrophages
Apoptosis
Inflammation
Apoptosis Regulatory Proteins
DNA
Proteins
Genes
Joining
Molecules

MULTI EPITOPE HIV PEPTIDE AND V1/V2 PROTEIN VACCINES

Goldstein, H., Pinter, A. & Rubenstein, A.

National Institutes of Health

5/15/986/30/99

Project: Research project

SCID Mice
HIV Infections
Transgenic Mice
Vaccines
HIV
Drug Users
HIV
Viral Load
Drug Resistance
Therapeutics
Magnetic Resonance Angiography
Cerebrovascular Circulation
Magnetic Resonance Imaging
Perfusion
Research Design
Cell Survival
Genes
Growth
Neurodegenerative Diseases
Cell Division

MECHANISMS OF REDUCED PROTEIN DEGRADATION WITH AGE

Cuervo, A. M., Xiao, R. & Xiao, R.

National Institutes of Health

5/1/981/31/04

Project: Research project

Proteolysis
Research
Research Personnel
Heat-Shock Proteins
Lysosomes
Sulindac
Curcumin
Chemoprevention
Non-Steroidal Anti-Inflammatory Agents
Apoptosis
Endothelin-1
Placenta
Pre-Eclampsia
Peptides
Carboxypeptidase H
Histones
Chromatin
Genes
DNA Methylation
Erythrocytes
Histones
Chromatin
Gene Expression
DNA Methylation
Genes

TOXOPLASMA DEVELOPMENT AND CELL CYCLE

Kim, K.

4/1/983/31/03

Project: Research project

Paclitaxel
docetaxel
Carcinoma
Microtubules
Shc Signaling Adaptor Proteins
Epitopes
Allergens
IgE Receptors
Cluster Analysis
Receptor Aggregation

PRESERVATION AND REPLACEMENT OF BETA CELLS IN IDDM

Fleischer, N., Goldstein, H., Gupta, S., Efrat, S., Horwitz, M. S., Nathanson, S., Dilorenzo, T. & Horwitz, M. S.

National Institutes of Health

2/5/987/31/10

Project: Research project

Type 1 Diabetes Mellitus
Viral Genes
Inbred NOD Mouse
Insulin
Transplantation
Caenorhabditis elegans
Anatomy
electrons
Atlases
Electrons
RNA Transport
Yeasts
Messenger RNA
Parturition
Cell Nucleus Active Transport

ABO ANTIBODIES--PARADIGM FOR HUMAN REPERTOIRE EVOLUTION

Chang, T. Y.

National Institutes of Health

12/15/9711/30/02

Project: Research project

Transfusion Medicine
Anti-Idiotypic Antibodies
Antibodies
Research
Bacteriophages

MUCINS AND COLON CANCER PROGRESSION

Velcich, A.

National Institutes of Health

12/15/9711/30/01

Project: Research project

Mucins
Colonic Neoplasms
Aberrant Crypt Foci
Goblet Cells
Cyclooxygenase 2
DNA Mismatch Repair
Neoplasms
Mutation
DNA Damage
Carcinogenesis
Transgenic Mice
HIV Infections
HIV
Chemokine Receptors
Research Personnel

GENERAL CLINICAL RESEARCH CENTER

Burk, R. D., Brownlee, M. A., Schilsky, M., Nagel, R., Santoro, N. F., Fabry, M., Wozniak, R., Rieder, J., Kennan, R., Pan, J., Nagel, R., Santoro, N. F., Hetherington, H., Klein, R., Bookchin, R., Howard, A., Rieder, J., Somlo, S., Roy-Chowdhury, J., Wadler, S., Rubenstein, A., Purpura, D., Spiegel, A., Wylie-Rosett, J., Noyer, C., Kaufman, H. L., Weber, T., Roy-Chowdhury, N., Diamond, B., Segal-Isaacson, C. J., Engel, S., Alderman, M., Wylie-Rosett, J., Weber, T., Bigal, M., Pollard, J. W., Kaskel, F., Segal-Isaacson, C. J., Dimartino-Nardi, J., Ilowite, N., Eugene, F., Mossavar-Rahmani, Y., Khan, U., Rivas, Y., Morrow, B. E., Roy-Chowdhury, N., Barzilai, N., Shamoon, H., Stein, D. T., Fleischer, N., Hawkins, M. A., Ho, G. Y. F., Barzilai, N., Berk, S. I., Schoenbaum, E., Shamoon, H., Lipton, R. B., Hawkins, M. A., Stein, D. T., Crandall, J. P., Melman, A., Gupta, S., Barzilai, N., Crystal, H., Weiss, L. M., Diamond, B., Bloom, B., Rossetti, L., Frishman, W., Somlo, S., Schilsky, M., Roy-Chowdhury, J., Weiss, L. M., Santoro, N. F., Kaufman, H. L., Segal-Isaacson, C. J., Santoro, N. F., Pollard, J. W., Segal-Isaacson, C. J., Morrow, B. E., Engel, S., Pan, J., Klein, R., Alderman, M., Nagel, R., Santoro, N. F., Hetherington, H., Segal-Isaacson, C. J. & Weiss, L. M.

National Institutes of Health

9/30/9711/30/11

Project: Research project

Type 1 Diabetes Mellitus
Glucose
Type 2 Diabetes Mellitus
Prostatic Neoplasms
Hypoglycemia
Intra-Abdominal Fat
Insulin
Glucose
Liver
Body Composition
RNA-Directed DNA Polymerase
Libraries
Gene Library
HIV-1
Moloney murine leukemia virus
Bone Morphogenetic Proteins
Neural Stem Cells
Neurogenesis
Oligodendroglia
Neuroglia
Bone Morphogenetic Proteins
Bone Morphogenetic Protein Receptors
Stem Cells
Neuroglia
Lateral Ventricles
Ricin
RNA
Substrates
Molecules
Adenine
Immunoglobulin Variable Region
Mutation
Chromatin
Histones
Genes