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  Identification and targeting of pathways separating healthy stem cell aging from malignant transformation

  Will, B.

  National Cancer Institute

  9/1/18 → 8/31/21

  Project: Research project

  • Cellular Senescence
  • Autophagy
  • Stem Cells
  • Hematopoietic Stem Cells
  • Genetic Models

• Therapeutic targeting of MDS stem cells

  Steidl, U. G. & Verma, A. K.

  National Heart, Lung, and Blood Institute

  8/20/18 → 6/30/21

  Project: Research project

  • Interleukin-8
  • Stem Cells
  • Therapeutics
  • Heterografts
  • Disease Progression

• Assessing genome sequence integrity in normal human cells

  Spivack, S. D., Vijg, J. & Vijg, J.

  National Institute of Environmental Health Sciences

  8/15/18 → 5/31/21

  Project: Research project

  • Genome
  • Mutation
  • DNA
  • Smoke
  • Tobacco

• Microbial Metabolite Mimics, PXR and Colitis-Induced Colorectal Cancer

  Mani, S.

  National Cancer Institute

  8/14/18 → 7/31/21

  Project: Research project

  • Pregnane X Receptor
  • Metabolites
  • indole
  • Toll-Like Receptor 4
  • Lead compounds

• Adapting, Scaling, and Spreading an Algorithmic Asthma Mobile Intervention to Promote Patient-Reported Outcomes Within Primary Care Settings

  Jariwala, S. P.

  National Institutes of Health

  8/1/18 → 5/31/21

  Project: Research project

  • Patient Reported Outcome Measures
  • Primary Health Care
  • Asthma
  • Patient Education
  • Education

• Regulation of Nuclear Functions by Drosophila Linker Histone H1

  Fyodorov, D. & Skoultchi, A. I.

  National Institute of General Medical Sciences

  8/1/18 → 5/31/21

  Project: Research project

  • Histones
  • Drosophila
  • Chromatin
  • Chromosomes
  • Post Translational Protein Processing

• Apolipoprotein A5 and Gallstone Formation

  Wang, D. Q. H.

  7/20/18 → 4/30/22

  Project: Research project

• A Major Nutritional Effect on Intestinal Stem Cells and Tumors

  Augenlicht, L. H.

  National Cancer Institute

  7/17/18 → 5/31/21

  Project: Research project

  • stem cells
  • neoplasms
  • carcinogenesis
  • homeostasis
  • cells

• Structural, Molecular and Functional Specialization in Osteocyte Mechanosensing

  Spray, D. C.

  National Institute of Arthritis and Musculoskeletal and Skin Diseases

  7/11/18 → 4/30/21

  Project: Research project

  • Osteocytes
  • Integrins
  • T-Type Calcium Channels
  • Purinergic P2X7 Receptors
  • Pharmacology

• Next Generation of HPV and Cervical Cancer Research in HIV+ Women

  Strickler, H. & Burk, R. D.

  National Cancer Institute

  7/11/18 → 6/30/21

  Project: Research project

  • Uterine Cervical Neoplasms
  • HIV
  • Natural History
  • Microbiota
  • Lactobacillus crispatus

• Nutritionally Driven Sporadic Intestinal Tumors: Impact on Stem Cells

  Augenlicht, L. H.

  National Cancer Institute

  7/5/18 → 5/31/21

  Project: Research project

  • stem cells
  • neoplasms
  • colorectal neoplasms
  • homeostasis
  • carcinogenesis

• Genetic and Dietary Interactions in MMR Deficient Colon Tumorigenesis

  Edelmann, W. & Augenlicht, L. H.

  National Cancer Institute

  7/5/18 → 5/31/21

  Project: Research project

  • Colon
  • Carcinogenesis
  • Hereditary Nonpolyposis Colorectal Neoplasms
  • villin
  • Stem Cells

• The Misdiagnosis of Cerebrovascular Disease in Emergent Headache Evaluations

  Liberman, A. L.

  National Institute of Neurological Disorders and Stroke

  7/1/18 → 6/30/21

  Project: Research project

  • Cerebrovascular Disorders
  • Diagnostic Errors
  • Headache
  • Hospital Emergency Service
  • Stroke

• Cerebellum and Mental Disorders

  Khodakhah, K.

  National Institute of Mental Health

  7/1/18 → 3/31/21

  Project: Research project

  • Mental Disorders
  • Cerebellum
  • Ventral Tegmental Area
  • Social Behavior
  • Autism Spectrum Disorder

• Novel role and mechanisms of histone deacetylases in traumatic brain injury

  Bennett, M. V. L.

  7/1/18 → 3/31/24

  Project: Research project

• How MeCP2 discriminates epigenetic marks is still a mystery

  Brenowitz, M. D.

  National Institute of General Medical Sciences

  7/1/18 → 6/30/21

  Project: Research project

  • Epigenomics
  • Chromatin
  • Nucleotides
  • Methyl-CpG-Binding Protein 2
  • Rett Syndrome

• Composition and formation of the cyst wall

  Weiss, L. M.

  6/1/18 → 5/31/23

  Project: Research project

• Immunoregulation by indoleamine 2,3-dioxygenases in tuberculosis

  Porcelli, S. A. & Chan, J.

  National Institute of Allergy and Infectious Diseases

  5/1/18 → 4/30/21

  Project: Research project

  • Indoleamine-Pyrrole 2,3,-Dioxygenase
  • Tuberculosis
  • Protein Isoforms
  • Immunosuppressive Agents
  • Kynurenine

• CD138 Regulates Competition of Antibody Secreting Cells for Survival

  Fooksman, D. R.

  National Heart, Lung, and Blood Institute

  4/1/18 → 3/31/21

  Project: Research project

  • Antibody-Producing Cells
  • Cell Survival
  • Vaccines
  • Immunization
  • Immunity

• Use of focused ultrasound to increase melanoma immunogenicity and inhibit tumor-induced T cell tolerance

  Guha, C. & Macian-Juan, F.

  National Cancer Institute

  4/1/18 → 3/31/21

  Project: Research project

  • Neoplasm Antigens
  • Melanoma
  • Tumor Microenvironment
  • T-Lymphocytes
  • Immunosuppressive Agents

• Development of Novel MetAP2 inhibitors as potential therapeutics for Microsporidiosis

  Weiss, L. M.

  National Institute of Allergy and Infectious Diseases

  4/1/18 → 3/31/21

  Project: Research project

  • methionine aminopeptidase 2
  • Microsporidiosis
  • fumagillin
  • Methionine
  • Microsporidia

• Dissecting the dynamic interplay between p53, chromatin and transcriptional bursting in single cells

  Coleman, R. A.

  National Institute of General Medical Sciences

  4/1/18 → 3/31/21

  Project: Research project

  • Chromatin
  • DNA Polymerase II
  • Histones
  • Histone Acetyltransferases
  • Transcription Factors

• Institutional Career Development Core

  Marantz, P. R.

  National Center for Advancing Translational Sciences

  3/22/18 → 2/28/21

  Project: Research project

  • Career development
  • educational program
  • grant
  • training program
  • Healthcare

• Clinical and Translational Science Award

  Shamoon, H.

  National Center for Advancing Translational Sciences

  3/22/18 → 2/28/21

  Project: Research project

  • Translational Medical Research
  • Implementation Science
  • National Center for Advancing Translational Sciences (U.S.)
  • Community Health Services
  • Population Health

• NRSA Training Core

  Marantz, P. R.

  National Center for Advancing Translational Sciences

  3/22/18 → 2/28/21

  Project: Research project

  • grant
  • mentoring
  • training program
  • Career development
  • candidacy

• Stromal cell therapy as a treatment against Gastrointestinal Acute Radiation Syndrome (GI-ARS)

  Guha, C.

  National Institute of Allergy and Infectious Diseases

  3/9/18 → 2/28/21

  Project: Research project

  • Acute Radiation Syndrome
  • Stromal Cells
  • Cell- and Tissue-Based Therapy
  • Transplants
  • Bone Marrow

• Bone neuro-mechanosignaling and inflammation: New players in diabetic osteopenia

  Thi, M. M.

  National Institute of Arthritis and Musculoskeletal and Skin Diseases

  3/1/18 → 12/31/20

  Project: Research project

  • Metabolic Bone Diseases
  • Bone and Bones
  • Inflammation
  • Nerve Growth Factor
  • Type 1 Diabetes Mellitus

• Mentoring Junior Investigators to Tackle the Opioid Epidemic

  Starrels, J. L.

  NATIONAL INSTITUTE ON DRUG ABUSE

  3/1/18 → 2/28/21

  Project: Research project

  • Mentoring
  • Opioid Analgesics
  • Epidemics
  • Research Personnel
  • Prescriptions

• Molecular Basis of Early Childhood Obesity Programming by Intrauterine Growth Restriction

  Charron, M. J. & Fuloria, M.

  Eunice Kennedy Shriver National Institute of Child Health and Human Development

  3/1/18 → 2/28/21

  Project: Research project

  • Fetal Growth Retardation
  • Pediatric Obesity
  • T-Lymphocytes
  • DNA Methylation
  • Growth

• Cognitive-Motor Interference Assessment for Improving Neurologic and Physical Disability Outcomes (CAMINANDO) in Survivors of Severe Acute Respiratory Failure

  Hope, A. A.

  National Heart, Lung, and Blood Institute

  3/1/18 → 2/28/21

  Project: Research project

  • Respiratory Insufficiency
  • Survivors
  • Nervous System
  • Acute Lung Injury
  • Mentors

• A combined computational and experimental approach to the evolution and role of the DNA sequence environment in targeting mutations to antibody V regions

  Scharff, M. D.

  National Institute of Allergy and Infectious Diseases

  3/1/18 → 2/28/21

  Project: Research project

  • AICDA (activation-induced cytidine deaminase)
  • Mutation
  • Antibodies
  • Genes
  • Immunoglobulin Variable Region

• Structural, functional, and mechanistic anlaysis of autoreactive CD8 T cells

  Almo, S. C. & DiLorenzo, T. P.

  National Institute of Allergy and Infectious Diseases

  2/8/18 → 1/31/21

  Project: Research project

  • T-Lymphocytes
  • Alleles
  • T-Cell Antigen Receptor
  • Peptides
  • Type 1 Diabetes Mellitus

• Defining Novel Cellular Correlates of Protection Against Human Malaria by CyTOF

  Lauvau, G.

  National Institute of Allergy and Infectious Diseases

  2/6/18 → 1/31/21

  Project: Research project

  • Malaria
  • Parasites
  • Immunity
  • T-Lymphocytes
  • Antibody Formation

• Visual Crowding

  Kohn, A.

  NATIONAL EYE INSTITUTE

  2/1/18 → 1/31/21

  Project: Research project

  • Crowding
  • Visual Cortex
  • Ocular Vision
  • Population
  • Animals

• Capture and characterize transient catalytic intermediates by X-ray crystallography

  Rousseau, D. L.

  National Institute of General Medical Sciences

  2/1/18 → 1/31/21

  Project: Research project

  • X ray crystallography
  • Microfluidics
  • Electron Transport Complex IV
  • Microcrystals
  • Reaction intermediates

• Mechanisms regulating the aging of HSC niches

  Frenette, P. S.

  National Institute of Diabetes and Digestive and Kidney Diseases

  1/15/18 → 12/31/20

  Project: Research project

  • Stem Cell Niche
  • Sympathetic Nervous System
  • Hematopoietic Stem Cells
  • Nestin
  • Cellular Senescence

• Integrated analysis of CVD risk in HIV: gut microbiota, immune function and metabolites

  Kaplan, R. C. & Qi, Q.

  National Heart, Lung, and Blood Institute

  1/15/18 → 12/31/20

  Project: Research project

  • Gastrointestinal Microbiome
  • HIV
  • Metabolomics
  • HIV Infections
  • Atherosclerosis

• Development of a genetic and molecular prediction model for cisplatin and radiation resistance in head and neck squamous cell carcinoma

  Ow, T. J.

  National Institute of Dental and Craniofacial Research

  1/1/18 → 12/31/20

  Project: Research project

  • Molecular Models
  • Squamous Cell Carcinoma of Head and Neck
  • Cisplatin
  • Radiation
  • Translational Medical Research

• Host-virus interactions in the control of filovirus entry

  Chandran, K.

  National Institute of Allergy and Infectious Diseases

  12/5/17 → 11/30/20

  Project: Research project

  • Filoviridae
  • Host Microbial Interactions
  • Membrane Fusion
  • Filoviridae Infections
  • Ebola Hemorrhagic Fever

• Combinatorial Actions of Genetic Variants and Gender Bias of Alzherimer's Disease

  Suh, Y.

  9/30/17 → 5/31/22

  Project: Research project

• Cerebellum and Addiction

  Khodakhah, K.

  NATIONAL INSTITUTE ON DRUG ABUSE

  9/30/17 → 7/31/21

  Project: Research project

  • Ventral Tegmental Area
  • Cerebellum
  • Addictive Behavior
  • Reward
  • Cognition

• The biological underpinnings of Motoric Cognitive Risk syndrome: a multi-center study

  Verghese, J.

  National Institute on Aging

  9/30/17 → 3/31/21

  Project: Research project

  • Cognitive Dysfunction
  • Dementia
  • Cerebral Small Vessel Diseases
  • Biomarkers
  • Brain

• Cortical computations underlying binocular motion integration

  Kohn, A.

  NATIONAL EYE INSTITUTE

  9/30/17 → 6/30/21

  Project: Research project

  • Binoculars
  • Networks (circuits)
  • Computer vision
  • Brain
  • Experiments

• PROTOZOAN PURINE PHOSPHORIBOSYLTRANSFERASES AS TARGETS TO TREAT MALARIA, AFRICAN TRYPANOSOMIASIS AND CHAGAS'S DISEASE

  Schramm, V. L. & Schramm, V. L.

  National Institute of Allergy and Infectious Diseases

  9/25/17 → 8/31/21

  Project: Research project

  • purine phosphoribosyltransferase
  • Protozoa
  • Lead compounds
  • Salvaging
  • Hypoxanthine Phosphoribosyltransferase

• 5-Cog Battery to improve detection of cognitive impairment and dementia

  Verghese, J.

  National Institute of Neurological Disorders and Stroke

  9/25/17 → 8/31/21

  Project: Research project

  • Dementia
  • Cognitive Dysfunction
  • Primary Health Care
  • Memory
  • Population Health

• From microscale structure to population coding of normal and learned behavior

  Pena, J. L. & Pena, J. L.

  National Institute of Neurological Disorders and Stroke

  9/25/17 → 7/31/21

  Project: Research project

  • Population
  • Strigiformes
  • Drive
  • Sound Localization
  • Microelectrodes

• Computational models for the signaling of tumor necrosis factor receptor on cell surfaces

  Wu, Y.

  National Institute of General Medical Sciences

  9/20/17 → 7/31/21

  Project: Research project

  • Tumor Necrosis Factor Receptors
  • Ligands
  • Tumor Necrosis Factor-alpha
  • Cell Surface Receptors
  • Kinetics

• Robust Predictor of Breast Cancer Risk

  Ostrer, H. & Ostrer, H.

  National Cancer Institute

  9/20/17 → 6/30/21

  Project: Research project

  • Breast Neoplasms
  • Germ-Line Mutation
  • Mutation
  • BRCA2 Protein
  • Genes

• Resilience to Alzheimer's disease in humans with exceptional longevity

  Barzilai, N. & Zhang, Z.

  National Institute on Aging

  9/15/17 → 5/31/21

  Project: Research project

  • Longevity
  • Alzheimer Disease
  • Aged, 80 and over
  • Genotype
  • Cognition

• Single cell approach to uncovering factors regulating HSC division symmetry in vivo

  Ito, K.

  National Institute of Diabetes and Digestive and Kidney Diseases

  9/15/17 → 6/30/21

  Project: Research project

  • Hematopoietic Stem Cells
  • Cell Division
  • Transplantation
  • Bone Marrow
  • Stem Cell Niche