Find Research Projects

Search results

• Active

  Eradicating persistent M. tuberculosis by synthetic lethality of terminal respiratory oxidases

  Berney, M.

  National Institute of Allergy and Infectious Diseases

  11/13/18 → 10/31/21

  Project: Research project

  • Synthetic Lethal Mutations 100%
  • Mycobacterium tuberculosis 74%
  • Tuberculosis 72%
  • Oxidoreductases 64%
  • 6-chloro-2-ethyl-N-(4-(4-(4-(trifluoromethoxy)phenyl)piperidin-1-yl)benzyl) imidazo(1,2-a)pyridine-3-carboxamide 62%

• The Center of Excellence in Promoting LHS Operations and Research at Einstein/Montefiore (EXPLORE)

  Cunningham, C. O., Marantz, P. R. & Rinke, M. L.

  9/30/18 → 9/29/23

  Project: Research project

  • infrastructure 100%
  • health 97%
  • health care 51%
  • resources 46%
  • leader 45%

• Comprehensive Pediatric Hypertension Diagnosis and Management

  Rinke, M. L.

  9/30/18 → 7/31/21

  Project: Research project

  • Hypertension 100%
  • Pediatrics 59%
  • Primary Health Care 48%
  • Pediatricians 32%
  • Quality Improvement 20%

• DYNAMICS AND TUNING OF THE MHC II PRESENTED PEPTIDOME

  Santambrogio, L.

  9/19/18 → 8/31/23

  Project: Research project

  • dendritic cells 100%
  • lymph nodes 29%
  • insulin-dependent diabetes mellitus 27%
  • epitopes 27%
  • autoimmunity 26%

• UNDERSTANDING CELLULAR AND TRANSCRIPTIONAL REGULATORY CHANGES IN HUMAN AGING

  Greally, J. M.

  National Institute on Aging

  9/15/18 → 5/31/22

  Project: Research project

  • DNA Methylation 100%
  • Epigenomics 58%
  • T-Lymphocytes 20%
  • Glucocorticoid Receptor Deficiency 17%
  • Glucocorticoid Receptors 12%

• An immunotherapeutic strategy for the induction and stabilization of remission in type 1 diabetes

  DiLorenzo, T. P. & DiLorenzo, T. P.

  National Institute of Diabetes and Digestive and Kidney Diseases

  9/15/18 → 7/31/21

  Project: Research project

  • Remission Induction 100%
  • Type 1 Diabetes Mellitus 70%
  • T-Lymphocytes 57%
  • Antigens 29%
  • Immunological Synapses 27%

• Computational evaluation of the causal role of somatic mutations in human aging

  Dong, X.

  National Institute on Aging

  9/15/18 → 1/31/22

  Project: Research project

  • Mutation 100%
  • B-Lymphocytes 35%
  • Genomic Instability 20%
  • Genome 18%
  • Genomic Structural Variation 15%

• Social Dancing Intervention for older adults at high risk of Alzheimer's disease and other dementias: A pilot study

  Blumen, H. M., Verghese, J. & Verghese, J.

  National Institute on Aging

  9/15/18 → 8/31/21

  Project: Research project

  • Dementia 100%
  • Executive Function 80%
  • Alzheimer Disease 71%
  • Neuronal Plasticity 37%
  • Cognitive Dysfunction 31%

• The Study of Human Sulfuryl-Transfer Biology

  Leyh, T. S.

  9/8/18 → 8/31/21

  Project: Research project

  • Sulfotransferases 100%
  • monoamine-sulfating phenol sulfotransferase 29%
  • sapropterin 21%
  • Libraries 21%
  • Neurotransmitter Agents 20%

• Peer mentorship to improve outcomes in patients on maintenance hemodialysis

  Melamed, M. L., Golestaneh, L., Golestaneh, L. & Melamed, M. L.

  National Institute of Diabetes and Digestive and Kidney Diseases

  9/6/18 → 7/31/21

  Project: Research project

  • Mentors 100%
  • Renal Dialysis 63%
  • Maintenance 47%
  • Dialysis 46%
  • Self-Management 33%

• Optimizing smoking cessation interventions for PLWH in Nairobi, Kenya

  Shuter, J. & Shuter, J.

  National Cancer Institute

  9/5/18 → 8/31/21

  Project: Research project

  • Kenya 100%
  • Acquired Immunodeficiency Syndrome 91%
  • Smoking Cessation 90%
  • Methadone 76%
  • HIV 75%

• Identification and targeting of pathways separating healthy stem cell aging from malignant transformation

  Will, B.

  National Cancer Institute

  9/1/18 → 8/31/21

  Project: Research project

  • Chaperone-Mediated Autophagy 100%
  • Cellular Senescence 50%
  • Stem Cells 41%
  • Hematopoietic Stem Cells 24%
  • Genetic Models 11%

• Identifying and Reducing Disparities in Outcomes Among Economically Vulnerable and Minority Young Adults with Type 1 Diabetes

  Agarwal, S.

  National Institute of Diabetes and Digestive and Kidney Diseases

  9/1/18 → 8/31/21

  Project: Research project

  • Type 1 Diabetes Mellitus 100%
  • Young Adult 90%

• Assessing genome sequence integrity in normal human cells

  Spivack, S. D., Vijg, J. & Vijg, J.

  National Institute of Environmental Health Sciences

  8/15/18 → 5/31/22

  Project: Research project

  • Genome 100%
  • Mutation 91%
  • Smoke 47%
  • Tobacco 47%
  • DNA 41%

• Microbial Metabolite Mimics, PXR and Colitis-Induced Colorectal Cancer

  Mani, S.

  National Cancer Institute

  8/14/18 → 7/31/21

  Project: Research project

  • Pregnane 100%
  • Metabolite 38%
  • Indole 23%
  • Non Toxic 8%

• Regulation of Nuclear Functions by Drosophila Linker Histone H1

  Fyodorov, D., Skoultchi, A. I. & Skoultchi, A. I.

  National Institute of General Medical Sciences

  8/1/18 → 5/31/22

  Project: Research project

  • Histones 100%
  • Chromatin 98%
  • Drosophila 95%
  • Chromosomes 44%
  • Post Translational Protein Processing 38%

• Calcification Propensity, using Dynamic Light Scattering, to Study Vascular Calcification in Patients with Advanced Chronic Kidney Disease

  Chen, W.

  National Institute of Diabetes and Digestive and Kidney Diseases

  8/1/18 → 5/31/22

  Project: Research project

  • Vascular Calcification 100%
  • Dynamic Light Scattering 73%
  • Chronic Renal Insufficiency 56%
  • Osteocalcin 13%
  • Biomarkers 12%

• Apolipoprotein A5 and Gallstone Formation

  Wang, D. Q. H.

  7/20/18 → 4/30/22

  Project: Research project

  • apolipoproteins 100%
  • bile 58%
  • cholelithiasis 55%
  • cholesterol 30%
  • liver 26%

• Structural, Molecular and Functional Specialization in Osteocyte Mechanosensing

  Spray, D. C.

  National Institute of Arthritis and Musculoskeletal and Skin Diseases

  7/11/18 → 4/30/22

  Project: Research project

  • Osteocytes 100%
  • Integrins 13%
  • T-Type Calcium Channels 10%
  • Purinergic P2X7 Receptors 9%
  • Pharmacology 9%

• Genetic and Dietary Interactions in MMR Deficient Colon Tumorigenesis

  Edelmann, W., Augenlicht, L. H. & Edelmann, W.

  National Cancer Institute

  7/5/18 → 5/31/22

  Project: Research project

  • Hereditary Nonpolyposis Colorectal Neoplasms 100%
  • Colon 97%
  • Carcinogenesis 91%
  • villin 59%
  • Stem Cells 34%

• Novel role and mechanisms of histone deacetylases in traumatic brain injury

  Bennett, M. V. L.

  7/1/18 → 3/31/24

  Project: Research project

  • Traumatic Brain Injury 100%
  • Histone Deacetylases 55%
  • Macrophages 52%
  • Microglia 48%
  • Inflammation 27%

• Cerebellum and Mental Disorders

  Khodakhah, K.

  National Institute of Mental Health

  7/1/18 → 3/31/22

  Project: Research project

  • Cerebellum 100%
  • Mental Disorders 79%
  • Ventral Tegmental Area 51%
  • Social Behavior 49%
  • Autism Spectrum Disorder 43%

• Composition and formation of the cyst wall

  Weiss, L. M.

  National Institute of Allergy and Infectious Diseases

  6/1/18 → 5/31/22

  Project: Research project

  • Toxoplasma gondii 100%
  • toxoplasmosis 56%
  • bradyzoites 33%
  • tachyzoites 29%
  • carrier state 27%

• Thiamine as a Renal Protective Agent in Septic Shock

  Moskowitz, A. L.

  National Institute of General Medical Sciences

  6/1/18 → 5/31/22

  Project: Research project

  • Renal Agents 100%
  • Thiamine 98%
  • Protective Agents 81%
  • Septic Shock 74%
  • Sepsis 31%

• Immunoregulation by indoleamine 2,3-dioxygenases in tuberculosis

  Porcelli, S. A., Chan, J. & Porcelli, S. A.

  National Institute of Allergy and Infectious Diseases

  5/1/18 → 4/30/22

  Project: Research project

  • Indoleamine-Pyrrole 2,3,-Dioxygenase 100%
  • Tuberculosis 53%
  • Protein Isoforms 29%
  • Immunosuppressive Agents 21%
  • Kynurenine 20%

• Dissecting the dynamic interplay between p53, chromatin and transcriptional bursting in single cells

  Coleman, R. A.

  National Institute of General Medical Sciences

  4/1/18 → 3/31/22

  Project: Research project

  • Chromatin 100%
  • DNA Polymerase II 40%
  • Histones 35%
  • Histone Acetyltransferases 33%
  • Transcription Factors 28%

• CD138 Regulates Competition of Antibody Secreting Cells for Survival

  Fooksman, D. R.

  National Heart, Lung, and Blood Institute

  4/1/18 → 3/31/22

  Project: Research project

  • Antibody-Producing Cells 100%
  • Cell Survival 52%
  • Vaccines 14%
  • Immunization 10%
  • Immunity 10%

• Development of Novel MetAP2 inhibitors as potential therapeutics for Microsporidiosis

  Weiss, L. M.

  National Institute of Allergy and Infectious Diseases

  4/1/18 → 3/31/22

  Project: Research project

  • methionine aminopeptidase 2 100%
  • Microsporidiosis 54%
  • Aminopeptidases 16%
  • fumagillin 13%
  • Methionine 12%

• Use of focused ultrasound to increase melanoma immunogenicity and inhibit tumor-induced T cell tolerance

  Guha, C. & Macian-Juan, F.

  National Cancer Institute

  4/1/18 → 3/31/22

  Project: Research project

  • Neoplasm Antigens 100%
  • Melanoma 82%
  • Tumor Microenvironment 65%
  • T-Lymphocytes 61%
  • Immunosuppressive Agents 52%

• NRSA Training Core

  Marantz, P. R.

  National Center for Advancing Translational Sciences

  3/22/18 → 2/28/22

  Project: Research project

  • grant 100%
  • mentoring 65%
  • training program 57%
  • Career development 49%
  • candidacy 36%

• Institutional Career Development Core

  Marantz, P. R.

  National Center for Advancing Translational Sciences

  3/22/18 → 2/28/22

  Project: Research project

  • Career development 100%
  • educational program 19%
  • grant 18%
  • training program 17%
  • Healthcare 17%

• Stromal cell therapy as a treatment against Gastrointestinal Acute Radiation Syndrome (GI-ARS)

  Guha, C.

  National Institute of Allergy and Infectious Diseases

  3/9/18 → 2/28/22

  Project: Research project

  • Acute Radiation Syndrome 100%
  • Stromal Cells 55%
  • Cell- and Tissue-Based Therapy 52%
  • Transplants 39%
  • Bone Marrow 27%

• Molecular Basis of Early Childhood Obesity Programming by Intrauterine Growth Restriction

  Charron, M. J., Fuloria, M. & Fuloria, M.

  Eunice Kennedy Shriver National Institute of Child Health and Human Development

  3/1/18 → 2/28/22

  Project: Research project

  • Pediatric Obesity 100%
  • Fetal Growth Retardation 95%
  • T-Lymphocytes 65%
  • DNA Methylation 62%
  • Growth 37%

• A combined computational and experimental approach to the evolution and role of the DNA sequence environment in targeting mutations to antibody V regions

  Scharff, M. D.

  National Institute of Allergy and Infectious Diseases

  3/1/18 → 2/28/22

  Project: Research project

  • AICDA (activation-induced cytidine deaminase) 100%
  • Mutation 85%
  • Antibodies 69%
  • Genes 21%
  • Immunoglobulin Variable Region 19%

• Bone neuro-mechanosignaling and inflammation: New players in diabetic osteopenia

  Thi, M. M.

  National Institute of Arthritis and Musculoskeletal and Skin Diseases

  3/1/18 → 12/31/21

  Project: Research project

  • Metabolic Bone Diseases 100%
  • Bone and Bones 70%
  • Inflammation 55%
  • Nerve Growth Factor 35%
  • Type 1 Diabetes Mellitus 24%

• Cognitive-Motor Interference Assessment for Improving Neurologic and Physical Disability Outcomes (CAMINANDO) in Survivors of Severe Acute Respiratory Failure

  Hope, A. A.

  National Heart, Lung, and Blood Institute

  3/1/18 → 2/28/22

  Project: Research project

  • Respiratory Insufficiency 100%
  • Survivors 72%
  • Nervous System 67%
  • Acute Lung Injury 67%
  • Mentors 55%

• Structural, functional, and mechanistic anlaysis of autoreactive CD8 T cells

  DiLorenzo, T. P.

  National Institute of Allergy and Infectious Diseases

  2/8/18 → 1/31/22

  Project: Research project

  • T-Lymphocytes 100%
  • Alleles 65%
  • T-Cell Antigen Receptor 45%
  • Peptides 43%
  • Type 1 Diabetes Mellitus 40%

• Visual Crowding

  Kohn, A.

  NATIONAL EYE INSTITUTE

  2/1/18 → 1/31/22

  Project: Research project

  • Crowding 100%
  • Visual Cortex 10%
  • Ocular Vision 8%
  • Population 7%
  • Animals 7%

• Mechanisms regulating the aging of HSC niches

  Frenette, P. S.

  National Institute of Diabetes and Digestive and Kidney Diseases

  1/15/18 → 12/31/21

  Project: Research project

  • Stem Cell Niche 100%
  • Sympathetic Nervous System 96%
  • Hematopoietic Stem Cells 85%
  • Nestin 35%
  • Bone Marrow 31%

• Integrated analysis of CVD risk in HIV: gut microbiota, immune function and metabolites

  Kaplan, R. C. & Qi, Q.

  National Heart, Lung, and Blood Institute

  1/15/18 → 12/31/21

  Project: Research project

  • Gastrointestinal Microbiome 100%
  • HIV 76%
  • Metabolomics 36%
  • HIV Infections 28%
  • Atherosclerosis 26%

• Role of Tet proteins in epigenetic regulation of embryonic stem cell biology

  Dawlaty, M. M.

  National Institute of General Medical Sciences

  12/5/17 → 11/30/21

  Project: Research project

  • embryonic stem cells 100%
  • protein transport 91%
  • cell biology 86%
  • epigenetics 85%
  • enzymes 45%

• Mechanisms Underlying the HIV-HSV-2 Syndemic

  Herold, B.

  National Institute of Allergy and Infectious Diseases

  12/5/17 → 11/30/21

  Project: Research project

  • Syndemic 100%
  • Human Herpesvirus 2 86%
  • HIV 51%
  • T-Lymphocytes 12%
  • Blood Cells 11%

• Host-virus interactions in the control of filovirus entry

  Chandran, K.

  National Institute of Allergy and Infectious Diseases

  12/5/17 → 11/30/21

  Project: Research project

  • Filoviridae 100%
  • Host Microbial Interactions 68%
  • Membrane Fusion 34%
  • Filoviridae Infections 12%
  • Ebola Hemorrhagic Fever 9%

• Cerebellar Dysfunction in DYT1

  Khodakhah, K.

  National Institute of Neurological Disorders and Stroke

  12/1/17 → 11/30/21

  Project: Research project

  • Dystonia 100%
  • Cerebellar Diseases 92%
  • Purkinje Cells 55%
  • Basal Ganglia 24%
  • Cerebellar Nuclei 15%

• The biological underpinnings of Motoric Cognitive Risk syndrome: a multi-center study

  Verghese, J.

  National Institute on Aging

  9/30/17 → 3/31/22

  Project: Research project

  • Cognitive Dysfunction 100%
  • Dementia 46%
  • Brain 34%
  • Cerebral Small Vessel Diseases 33%
  • Gait 31%

• Cerebellum and Addiction

  Khodakhah, K.

  NATIONAL INSTITUTE ON DRUG ABUSE

  9/30/17 → 7/31/21

  Project: Research project

  • Ventral Tegmental Area 100%
  • Cerebellum 87%
  • Addictive Behavior 47%
  • Reward 22%
  • Cognition 18%

• Combinatorial Actions of Genetic Variants and Gender Bias of Alzherimer's Disease

  Suh, Y.

  9/30/17 → 5/31/22

  Project: Research project

  • Single Nucleotide Polymorphism 100%
  • Neurons 48%
  • Alleles 43%
  • Genome-Wide Association Study 41%
  • Astrocytes 36%

• From microscale structure to population coding of normal and learned behavior

  Pena, J. L., Pena, J. L. & Pena, J. L.

  National Institute of Neurological Disorders and Stroke

  9/25/17 → 7/31/21

  Project: Research project

  • Population 100%
  • Strigiformes 61%
  • Drive 60%
  • Sound Localization 56%
  • Microelectrodes 43%

• 5-Cog Battery to improve detection of cognitive impairment and dementia

  Verghese, J.

  National Institute of Neurological Disorders and Stroke

  9/25/17 → 10/31/21

  Project: Research project

  • Dementia 100%
  • Cognitive Dysfunction 88%
  • Primary Health Care 65%
  • Memory 36%
  • Population Health 36%

• PROTOZOAN PURINE PHOSPHORIBOSYLTRANSFERASES AS TARGETS TO TREAT MALARIA, AFRICAN TRYPANOSOMIASIS AND CHAGAS'S DISEASE

  Schramm, V. L. & Schramm, V. L.

  National Institute of Allergy and Infectious Diseases

  9/25/17 → 8/31/21

  Project: Research project

  • Purine 100%
  • Hypoxanthine 21%
  • Parasitic 21%
  • Nucleotide 14%
  • Transition State 14%