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• Emergence of bedaquiline and clofazimine resistance after interruption of drug-resistant TB therapy in a high HIV prevalence setting

  Brust, J. C. M.

  12/26/19 → 11/30/24

  Project: Research project

  • bedaquiline 100%
  • Clofazimine 63%
  • Multidrug-Resistant Tuberculosis 23%
  • Extensively Drug-Resistant Tuberculosis 11%
  • HIV 10%

• Geographic Medicine and Emerging Infections

  Tanowitz, H. B., Kim, K. & Weiss, L. M.

  7/1/06 → 8/31/24

  Project: Research project

  • Medicine 100%
  • Translational Medical Research 66%
  • Education 36%
  • Mycology 29%
  • Parasitology 28%

• Virtual Reality-Enhanced Haptic Simulation to Improve Self-Regulation of Applied Delivery Force During Shoulder Dystocia

  Gurewitsch Allen, E. D.

  9/1/19 → 7/31/24

  Project: Research project

  • Obstetrics 100%
  • Virtual reality 27%
  • Biomedical engineering 20%
  • Force measurement 18%
  • Medicine 15%

• Novel role and mechanisms of histone deacetylases in traumatic brain injury

  Bennett, M. V. L.

  7/1/18 → 3/31/24

  Project: Research project

  • Traumatic Brain Injury 100%
  • Histone Deacetylases 55%
  • Macrophages 52%
  • Microglia 48%
  • Inflammation 27%

• Early Phase Pain Investigation Clinical Network: Greater New York Clinical Center

  Lipton, R. B.

  9/30/19 → 3/31/24

  Project: Research project

  • Pain 100%
  • Chronic Pain 62%
  • Acute Pain 36%
  • Clinical Trials 33%
  • Biomarkers 33%

• FOOD-BASED BIOMARKERS, DIET QUALITY, AND CARDIOMETABOLIC HEALTH

  Qi, Q.

  4/15/19 → 3/31/24

  Project: Research project

  • biomarkers 100%
  • Ireland 73%
  • nutritional adequacy 53%
  • novel foods 43%
  • coronary disease 42%

• Hypothalamic autophagy and metabolic regulation in aging

  Singh, R. & Rose, S. A.

  National Institute on Aging

  4/1/13 → 3/31/24

  Project: Research project

  • Macroautophagy 100%
  • Autophagy 62%
  • Pro-Opiomelanocortin 48%
  • Melanocyte-Stimulating Hormones 31%
  • Neurons 26%

• Novel effectors of insulin action in the liver

  Yang, F.

  1/3/20 → 11/30/23

  Project: Research project

  • ST 679 100%
  • Mediator Complex 58%
  • Liver 46%
  • Insulin Resistance 41%
  • Sterol Regulatory Element Binding Protein 1 34%

• The Center of Excellence in Promoting LHS Operations and Research at Einstein/Montefiore (EXPLORE)

  Cunningham, C. O., Marantz, P. R. & Rinke, M. L.

  9/30/18 → 9/29/23

  Project: Research project

  • infrastructure 100%
  • health 97%
  • health care 51%
  • resources 46%
  • leader 45%

• Migraine Clinical Outcome Assessment System (MiCOAS)

  Lipton, R. B.

  9/10/19 → 8/31/23

  Project: Research project

  • Migraine Disorders 100%
  • Health Care Outcome Assessment 40%
  • Organized Financing 27%
  • Gold 23%
  • Qualitative Research 17%

• Developmental Impact of NICU Exposures (DINE)

  Aschner, J. L.

  9/21/16 → 8/31/23

  Project: Research project

  • Neonatal Intensive Care Units 100%
  • phthalic acid 83%
  • Premature Infants 37%
  • Manganese 27%
  • Third Pregnancy Trimester 24%

• DYNAMICS AND TUNING OF THE MHC II PRESENTED PEPTIDOME

  Santambrogio, L.

  9/19/18 → 8/31/23

  Project: Research project

  • dendritic cells 100%
  • lymph nodes 29%
  • insulin-dependent diabetes mellitus 27%
  • epitopes 27%
  • autoimmunity 26%

• Cellular mechanisms by which Neisseria gonorrhoeae infects the female reproductive tract

  Stein, D. T.

  7/5/19 → 6/30/23

  Project: Research project

  • Sexually Transmitted Diseases 100%
  • Infections 78%
  • Cervix Uteri 50%
  • opacity proteins 47%
  • Epithelial Cells 45%

• Head-mounted Photoacoustic Imaging of Deep-brain Neural Activities in Freely Behaving Animals

  Verkhusha, V.

  5/1/20 → 4/30/23

  Project: Research project

  • image analysis 100%
  • brain 84%
  • animals 75%
  • electrodes 57%
  • electric potential difference 55%

• NCI ET-CTN with Phase i Emphasis at UPCI

  Chu, E. & Rose, S. A.

  National Cancer Institute

  3/25/14 → 2/28/23

  Project: Research project

  • Clinical Trials 100%
  • Drug Development 49%
  • Therapeutics 25%
  • Neoplasms 25%
  • Organizations 22%

• Understanding the Exopher: A Novel Mechanism for Extrusion of Neurotoxic Content

  Hall, D. H.

  9/30/13 → 11/30/22

  Project: Research project

  • Neurons 100%
  • Protein Aggregates 68%
  • Healthy Aging 67%
  • Brain 53%
  • Organelles 51%

• Leveraging the electronic health record to reduce opioid analgesic prescriptions

  Bachhuber, M. A.

  8/15/17 → 7/31/22

  Project: Research project

  • Opioid Analgesics 100%
  • Prescriptions 41%
  • Electronic Health Records 28%
  • Implementation Science 10%
  • Research Personnel 9%

• Effect of drugs of abuse on CNS HIV-1 reservoirs and neuropathogenesis

  Kalpana, G. V., Prasad, V. R. & Prasad, V. R.

  NATIONAL INSTITUTE ON DRUG ABUSE

  9/1/16 → 7/31/22

  Project: Research project

  • HIV-1 100%
  • Substance-Related Disorders 98%
  • HIV 37%
  • Cannabis 34%
  • Cocaine 32%

• Structure and Function of Neonatal Social Communication in Genetic Mouse Models of Autism

  Hiroi, N.

  8/1/17 → 7/31/22

  Project: Research project

  • Autism Spectrum Disorder 100%
  • Communication 27%
  • Mothers 23%
  • Genetic Models 16%
  • Epigenomics 12%

• rhMFG-E8 as an Effective Adjuvant Therapy for Hemorrhagic Shock

  Yang, W.

  National Heart, Lung, and Blood Institute

  1/8/16 → 7/30/22

  Project: Research project

  • milk fat globule 100%
  • Hemorrhagic Shock 80%
  • Factor VIII 71%
  • Human Milk 70%
  • Epidermal Growth Factor 62%

• Advanced Glycation Endproducts and Cardio-Renal Disease

  Kizer, J.

  7/15/17 → 6/30/22

  Project: Research project

  • Advanced Glycation End Products 100%
  • imidazolone 49%
  • Mentors 34%
  • Research Personnel 28%
  • 3-deoxyglucosone 24%

• INDUCIBLE DNA REPAIR IN CEREBRAL ISCHEMIA

  Bennett, M. V. L.

  6/16/97 → 6/30/22

  Project: Research project

  • DNA Repair 100%
  • Ischemia 34%
  • DNA Repair Enzymes 32%
  • DNA Damage 26%
  • Brain Ischemia 22%

• AIF1/Iba1 in microglial function and stroke

  Sibinga, N. E. S.

  7/1/20 → 6/30/22

  Project: Research project

  • Stroke 100%
  • Microglia 89%
  • Wounds and Injuries 42%
  • Inflammation Mediators 18%
  • Cell Lineage 15%

• Systems Modeling of Alzheimers Disease in C. elegans

  Suh, Y.

  9/15/17 → 6/30/22

  Project: Research project

  • Gene Regulatory Networks 100%
  • Longevity 82%
  • Amyloid Plaques 66%
  • Amyloid 58%
  • Cognitive Dysfunction 50%

• mTORC1-dependent regulation of the CycC/CDK8 complex

  Pessin, J. E., Yang, F., Rose, S. A. & Yang, F.

  National Institute of Diabetes and Digestive and Kidney Diseases

  6/1/13 → 5/31/22

  Project: Research project

  • Cyclin C 100%
  • Cyclin-Dependent Kinase 8 43%
  • Brown Adipose Tissue 41%
  • Brown Adipocytes 25%
  • Beige Adipocytes 20%

• Small Molecule Activators of Pro-apoptotic BAX for Cancer Therapy

  Gavathiotis, E. & Rose, S. A.

  National Cancer Institute

  7/1/14 → 5/31/22

  Project: Research project

  • Cell Death 100%
  • Apoptotic 71%
  • Antiapoptotic 64%
  • Molecule 41%
  • Pharmacological Property 23%

• Impact of illicit drugs, HIV, and ART on neuroinflammation and BBB disruption

  Berman, J. W., Goldstein, H. & Goldstein, H.

  NATIONAL INSTITUTE ON DRUG ABUSE

  7/1/17 → 5/31/22

  Project: Research project

  • Illicit Drugs 100%
  • Blood-Brain Barrier 94%
  • HIV 73%
  • Methamphetamine 70%
  • Monocytes 56%

• Assessing genome sequence integrity in normal human cells

  Spivack, S. D., Vijg, J. & Vijg, J.

  National Institute of Environmental Health Sciences

  8/15/18 → 5/31/22

  Project: Research project

  • Genome 100%
  • Mutation 91%
  • Smoke 47%
  • Tobacco 47%
  • DNA 41%

• Composition and formation of the cyst wall

  Weiss, L. M.

  National Institute of Allergy and Infectious Diseases

  6/1/18 → 5/31/22

  Project: Research project

  • Toxoplasma gondii 100%
  • toxoplasmosis 56%
  • bradyzoites 33%
  • tachyzoites 29%
  • carrier state 27%

• UNDERSTANDING CELLULAR AND TRANSCRIPTIONAL REGULATORY CHANGES IN HUMAN AGING

  Greally, J. M.

  National Institute on Aging

  9/15/18 → 5/31/22

  Project: Research project

  • DNA Methylation 100%
  • Epigenomics 58%
  • T-Lymphocytes 20%
  • Glucocorticoid Receptor Deficiency 17%
  • Glucocorticoid Receptors 12%

• Genetic and Dietary Interactions in MMR Deficient Colon Tumorigenesis

  Edelmann, W., Augenlicht, L. H. & Edelmann, W.

  National Cancer Institute

  7/5/18 → 5/31/22

  Project: Research project

  • Hereditary Nonpolyposis Colorectal Neoplasms 100%
  • Colon 97%
  • Carcinogenesis 91%
  • villin 59%
  • Stem Cells 34%

• Mechanisms of Radiation-induced Vascular Endothelial Cell Injury and Its Correction

  Yang, W. & Yang, W.

  National Institute of Allergy and Infectious Diseases

  6/7/17 → 5/31/22

  Project: Research project

  • Ghrelin 100%
  • Endothelial Cells 55%
  • Radiation 54%
  • Pyroptosis 50%
  • Whole-Body Irradiation 44%

• Regulation of Nuclear Functions by Drosophila Linker Histone H1

  Fyodorov, D., Skoultchi, A. I. & Skoultchi, A. I.

  National Institute of General Medical Sciences

  8/1/18 → 5/31/22

  Project: Research project

  • Histones 100%
  • Chromatin 98%
  • Drosophila 95%
  • Chromosomes 44%
  • Post Translational Protein Processing 38%

• Utility of Centrally Acting Angiotensin Converting Enzyme Inhibitors to slow the progression of Dementia

  George, C. J.

  9/15/20 → 5/31/22

  Project: Research project

  • Cognitive Dysfunction 100%
  • Angiotensin-Converting Enzyme Inhibitors 85%
  • Gait 66%
  • Retirement 41%
  • Organized Financing 41%

• Thiamine as a Renal Protective Agent in Septic Shock

  Moskowitz, A. L.

  National Institute of General Medical Sciences

  6/1/18 → 5/31/22

  Project: Research project

  • Renal Agents 100%
  • Thiamine 98%
  • Protective Agents 81%
  • Septic Shock 74%
  • Sepsis 31%

• Development of thrombopoietin mimetic (TPOm) as a mitigator against Radiation-induced endovascular injuries

  Guha, C., Kulkarni, S., Guha, C. & Kulkarni, S.

  National Institute of Allergy and Infectious Diseases

  6/8/17 → 5/31/22

  Project: Research project

  • Acute Radiation Syndrome 100%
  • Thrombopoietin 81%
  • Radiation 41%
  • Bone Marrow 34%
  • Vascular System Injuries 29%

• Combinatorial Actions of Genetic Variants and Gender Bias of Alzherimer's Disease

  Suh, Y.

  9/30/17 → 5/31/22

  Project: Research project

  • Single Nucleotide Polymorphism 100%
  • Neurons 48%
  • Alleles 43%
  • Genome-Wide Association Study 41%
  • Astrocytes 36%

• CCL2-CCR2b signaling in HIV-1 fitness and disease; Role of host genetic polymorphisms

  Prasad, V. R.

  7/1/20 → 5/31/22

  Project: Research project

  • HIV-1 100%
  • Endosomal Sorting Complexes Required for Transport 70%
  • Actins 48%
  • HIV 47%
  • Viruses 46%

• Calcification Propensity, using Dynamic Light Scattering, to Study Vascular Calcification in Patients with Advanced Chronic Kidney Disease

  Chen, W.

  National Institute of Diabetes and Digestive and Kidney Diseases

  8/1/18 → 5/31/22

  Project: Research project

  • Vascular Calcification 100%
  • Dynamic Light Scattering 73%
  • Chronic Renal Insufficiency 56%
  • Osteocalcin 13%
  • Biomarkers 12%

• Structure-based Vaccine Design for CCHFV

  Chandran, K.

  6/25/20 → 5/31/22

  Project: Research project

  • Crimean-Congo hemorrhagic fever virus 100%
  • National Institute of Allergy and Infectious Diseases (U.S.) 27%
  • Glycoproteins 23%
  • Ticks 21%
  • Vaccines 20%

• Dysregulation of mTOR Signaling in Fragile X Syndrome

  Zukin, R. S.

  1/1/11 → 4/30/22

  Project: Research project

  • TOR Serine-Threonine Kinases 100%
  • Fragile X Syndrome 83%
  • Neuronal Plasticity 36%
  • Autistic Disorder 31%
  • Fragile X Mental Retardation Protein 29%

• Training in Aging Research

  Barzilai, N., Rossetti, L., Rose, S. A., Rose, S. A. & Rose, S. A.

  National Institute on Aging

  5/1/04 → 4/30/22

  Project: Research project

  • Longevity 100%
  • Autophagy 53%
  • Immunosenescence 40%
  • Academic Success 37%
  • Mentors 34%

• Activation of Endogenous Transposable Elements by Myc During Aging

  Secombe, J. & Secombe, J.

  National Institute on Aging

  9/30/16 → 4/30/22

  Project: Research project

  • DNA Transposable Elements 100%
  • Longevity 16%
  • Diptera 14%
  • Genome 6%
  • Single-Cell Analysis 6%

• Monocyte CNS HIV entry & neurodegeneration: Translational studies in the CART era

  Berman, J. W.

  National Institute of Mental Health

  7/19/17 → 4/30/22

  Project: Research project

  • Monocytes 100%
  • HIV 83%
  • Activated-Leukocyte Cell Adhesion Molecule 35%
  • Cognitive Dysfunction 17%
  • TAK-652 13%

• Thyroglobulin Peptide Presentation by HLA-DR in Thyroiditis

  Tomer, Y., Rose, S. A. & Rose, S. A.

  National Institute of Diabetes and Digestive and Kidney Diseases

  3/1/06 → 4/30/22

  Project: Research project

  • Thyroiditis 100%
  • HLA-DR Antigens 83%
  • Thyroid Diseases 72%
  • Autoimmune Diseases 57%
  • Peptides 49%

• Comparative genomes of longevity

  Vijg, J., Seluanov, A., Gladyshev, V. N., Gorbunova, V. & Zhang, Z.

  National Institute on Aging

  5/1/14 → 4/30/22

  Project: Research project

  • somatic mutation 100%
  • rodents 82%
  • mutation rate 81%
  • mutation 44%
  • DNA damage 41%

• Apolipoprotein A5 and Gallstone Formation

  Wang, D. Q. H.

  7/20/18 → 4/30/22

  Project: Research project

  • apolipoproteins 100%
  • bile 58%
  • cholelithiasis 55%
  • cholesterol 30%
  • liver 26%

• Immunoregulation by indoleamine 2,3-dioxygenases in tuberculosis

  Porcelli, S. A., Chan, J. & Porcelli, S. A.

  National Institute of Allergy and Infectious Diseases

  5/1/18 → 4/30/22

  Project: Research project

  • Indoleamine-Pyrrole 2,3,-Dioxygenase 100%
  • Tuberculosis 53%
  • Protein Isoforms 29%
  • Immunosuppressive Agents 21%
  • Kynurenine 20%

• Mechanisms of opioid- mediated HIV neuropathogenesis

  Berman, J. W. & Goldstein, H.

  NATIONAL INSTITUTE ON DRUG ABUSE

  5/1/19 → 4/30/22

  Project: Research project

  • HIV 100%
  • Opioid Analgesics 92%
  • Monocytes 59%
  • Small Cytoplasmic RNA 42%
  • Morphine 37%

• Neurobiological Substrates of Visual-Somatosensory Integration in Aging

  Mahoney, J. R.

  National Institute on Aging

  9/1/16 → 4/30/22

  Project: Research project

  • Gait 100%
  • Accidental Falls 83%
  • Cognitive Remediation 79%
  • Cognitive Neuroscience 70%
  • Vision Disorders 57%