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19992020

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7 Scopus citations

A Brugia malayi homolog of macrophage migration inhibitory factor reveals an important link between macrophages and eosinophil recruitment during nematode infection

Falcone, F. H., Loke, P., Zang, X., MacDonald, A. S., Maizels, R. M. & Allen, J. E., Nov 1 2001, In : Journal of Immunology. 167, 9, p. 5348-5354 7 p.

Research output: Contribution to journalArticle

Open Access
102 Scopus citations

A genetic library screen for signaling proteins that interact with phosphorylated T cell costimulatory receptors

Zang, X., Loke, P., Kim, J., Wojnoonski, K., Kusdra, L. & Allison, J. P., Dec 1 2006, In : Genomics. 88, 6, p. 841-845 5 p.

Research output: Contribution to journalArticle

9 Scopus citations

Alternative activation is an innate response to injury that requires CD4+ T cells to be sustained during chronic infection

Loke, PN., Gallagher, I., Nair, M. G., Zang, X., Brombacher, F., Mohrs, M., Allison, J. P. & Allen, J. E., Sep 15 2007, In : Journal of Immunology. 179, 6, p. 3926-3936 11 p.

Research output: Contribution to journalArticle

Open Access
199 Scopus citations

An Immunoscore Using PD-L1, CD68, and Tumor-infiltrating Lymphocytes (TILs) to Predict Response to Neoadjuvant Chemotherapy in Invasive Breast Cancer

McLemore, L. E., Janakiram, M., Albanese, J., Shapiro, N., Lo, Y., Zang, X. & Fineberg, S., Oct 1 2018, In : Applied Immunohistochemistry and Molecular Morphology. 26, 9, p. 611-619 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

A novel serpin expressed by blood-borne microfilariae of the parasitic nematode Brugia malayi inhibits human neutrophil serine proteinases

Zang, X., Yazdanbakhsh, M., Jiang, H., Kanost, M. R. & Maizels, R. M., Aug 15 1999, In : Blood. 94, 4, p. 1418-1428 11 p.

Research output: Contribution to journalArticle

92 Scopus citations

B7-H3 and B7x are highly expressed in human prostate cancer and associated with disease spread and poor outcome

Zang, X., Thompson, R. H., Al-Ahmadie, H. A., Serio, A. M., Reuter, V. E., Eastham, J. A., Scardino, P. T., Sharma, P. & Allison, J. P., Dec 4 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 49, p. 19458-19463 6 p.

Research output: Contribution to journalArticle

240 Scopus citations

B7-H4(B7x)-mediated cross-talk between glioma-initiating cells and macrophages via the IL6/JAK/STAT3 pathway lead to poor prognosis in glioma patients

Yao, Y., Ye, H., Qi, Z., Mo, L., Yue, Q., Baral, A., Hoon, D. S. B., Vera, J. C., Heiss, J. D., Chen, C. C., Hua, W., Zhang, J., Jin, K., Wang, Y., Mao, Y., Zang, X. & Zhou, L., Jun 1 2016, In : Clinical Cancer Research. 22, 11, p. 2778-2790 13 p.

Research output: Contribution to journalArticle

42 Scopus citations

B7x: A widely expressed B7 family member that inhibits T cell activation

Zang, X., Loke, PN., Kim, J., Murphy, K., Waitz, R. & Allison, J. P., Sep 2 2003, In : Proceedings of the National Academy of Sciences of the United States of America. 100, 18, p. 10388-10392 5 p.

Research output: Contribution to journalArticle

273 Scopus citations

B7x/B7-H4 modulates the adaptive immune response and ameliorates renal injury in antibody-mediated nephritis

Pawar, R. D., Goilav, B., Xia, Y., Herlitz, L., Doerner, J., Chalmers, S., Ghosh, K., Zang, X. & Putterman, C., Feb 1 2015, In : Clinical and Experimental Immunology. 179, 2, p. 329-343 15 p.

Research output: Contribution to journalArticle

10 Scopus citations

B7x and myeloid-derived suppressor cells in the tumor microenvironment a tale of two cities

Jeon, H., Ohaegbulam, K. C., Abadi, Y. M. & Zang, X., Sep 4 2013, In : OncoImmunology. 2, 7, e24744.

Research output: Contribution to journalArticle

17 Scopus citations

B7x in the periphery abrogates pancreas-specific damage mediated by self-reactive CD8 T cells

Lee, J. S., Scandiuzzi, L., Ray, A., Wei, J., Hofmeyer, K. A., Abadi, Y. M., Loke, P., Lin, J., Yuan, J., Serreze, D. V., Allison, J. P. & Zang, X., Oct 15 2012, In : Journal of Immunology. 189, 8, p. 4165-4174 10 p.

Research output: Contribution to journalArticle

23 Scopus citations

Blockade of CTLA-4 and Tim-3 pathways induces fetal loss with altered cytokine profiles by decidual CD4 + T cells

Wang, S., Chen, C., Li, M., Qian, J., Sun, F., Li, Y., Yu, M., Wang, M., Zang, X., Zhu, R., Li, D. & Du, M., Jan 1 2019, In : Cell Death and Disease. 10, 1, 15.

Research output: Contribution to journalArticle

1 Scopus citations

BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1

Watanabe, N., Gavrieli, M., Sedy, J. R., Yang, J., Fallarino, F., Loftin, S. K., Hurchla, M. A., Zimmerman, N., Sim, J., Zang, X., Murphy, T. L., Russell, J. H., Allison, J. P. & Murphy, K. M., Jul 1 2003, In : Nature Immunology. 4, 7, p. 670-679 10 p.

Research output: Contribution to journalArticle

544 Scopus citations

Cell–cell contact with proinflammatory macrophages enhances the immunotherapeutic effect of mesenchymal stem cells in two abortion models

Li, Y., Zhang, D., Xu, L., Dong, L., Zheng, J., Lin, Y., Huang, J., Zhang, Y., Tao, Y., Zang, X., Li, D. & Du, M., Dec 1 2019, In : Cellular and Molecular Immunology. 16, 12, p. 908-920 13 p.

Research output: Contribution to journalArticle

9 Scopus citations

Clinical outcome of various regimens of gonadotropin-releasing hormone analogues after conservative surgery in patients with endometriosis

Liu, W., Chen, C., Shi, J., Zang, X. X. & Zhao, A. M., Oct 30 2016, In : International Journal of Clinical and Experimental Medicine. 9, 10, p. 19935-19943 9 p., IJCEM0027833.

Research output: Contribution to journalArticle

Cloning and characterisation of mmc-1, a microfilarial-specific gene, from Brugia pahangi

Emes, R., Thompson, F., Moore, J., Zang, X. & Devaney, E., Feb 28 2002, In : International Journal for Parasitology. 32, 4, p. 415-424 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

Curcumin improves the therapeutic efficacy of Listeriaat-Mage-b vaccine in correlation with improved T-cell responses in blood of a triple-negative breast cancer model 4T1

Singh, M., Ramos, I., Asafu-Adjei, D., Quispe-Tintaya, W., Chandra, D., Jahangir, A., Zang, X., Aggarwal, B. B. & Gravekamp, C., Aug 2013, In : Cancer Medicine. 2, 4, p. 571-582 12 p.

Research output: Contribution to journalArticle

37 Scopus citations

Donor and host B7-H4 expression negatively regulates acute graft-versus-host disease lethality

Saha, A., Taylor, P. A., Lees, C. J., Panoskaltsis-Mortari, A., Osborn, M. J., Feser, C. J., Thangavelu, G., Melchinger, W., Refaeli, Y., Hill, G. R., Munn, D. H., Murphy, W. J., Serody, J. S., Maillard, I., Kreymborg, K., van den Brink, M., Dong, C., Huang, S., Zang, X., Allison, J. P. & 2 others, Zeiser, R. & Blazar, B. R., 2019, In : JCI Insight. 4, 19, e127716.

Research output: Contribution to journalArticle

Downregulation of nicotinamide N-methyltransferase inhibits migration and epithelial-mesenchymal transition of esophageal squamous cell carcinoma via Wnt/β-catenin pathway

Cui, Y., Zhang, L., Wang, W., Ma, S., Liu, H., Zang, X., Zhang, Y. & Guan, F., Oct 1 2019, In : Molecular and Cellular Biochemistry. 460, 1-2, p. 93-103 11 p.

Research output: Contribution to journalArticle

1 Scopus citations

Expression, clinical significance, and receptor identification of the newest B7 family member HHLA2 protein

Janakiram, M., Chinai, J. M., Fineberg, S., Fiser, A., Montagna, C., Medavarapu, R., Castano, E., Jeon, H., Ohaegbulam, K. C., Zhao, R., Zhao, A., Almo, S. C., Sparano, J. A. & Zang, X., May 15 2015, In : Clinical Cancer Research. 21, 10, p. 2359-2366 8 p.

Research output: Contribution to journalArticle

51 Scopus citations

HDAC1 silence promotes neuroprotective effects of human umbilical cord-derived mesenchymal stem cells in a mouse model of traumatic brain injury via PI3K/AKT pathway

Xu, L., Xing, Q., Huang, T., Zhou, J., Liu, T., Cui, Y., Cheng, T., Wang, Y., Zhou, X., Yang, B., Yang, G. L., Zhang, J., Zang, X., Ma, S. & Guan, F., Jan 4 2019, In : Frontiers in Cellular Neuroscience. 12, 498.

Research output: Contribution to journalArticle

10 Scopus citations

HHLA2, a member of the B7 family, is expressed in human osteosarcoma and is associated with metastases and worse survival

Koirala, P., Roth, M. E., Gill, J., Chinai, J. M., Ewart, M. R., Piperdi, S., Geller, D. S., Hoang, B. H., Fatakhova, Y. V., Ghorpade, M., Zang, X. & Gorlick, R., Aug 17 2016, In : Scientific Reports. 6, 31154.

Research output: Contribution to journalArticle

29 Scopus citations

HHLA2, a new immune checkpoint member of the B7 family, is widely expressed in human lung cancer and associated with EGFR mutational status

Cheng, H., Janakiram, M., Borczuk, A., Lin, J., Qiu, W., Liu, H., Chinai, J. M., Halmos, B., Perez-Soler, R. & Zang, X., Feb 1 2017, In : Clinical Cancer Research. 23, 3, p. 825-832 8 p.

Research output: Contribution to journalArticle

30 Scopus citations

HHLA2 and TMIGD2: new immunotherapeutic targets of the B7 and CD28 families

Janakiram, M., Chinai, J. M., Zhao, A., Sparano, J. A. & Zang, X., Aug 3 2015, In : OncoImmunology. 4, 8

Research output: Contribution to journalArticle

23 Scopus citations

HHLA2 is a member of the B7 family and inhibits human CD4 and CD8 T-cell function

Zhao, R., Chinai, J. M., Buhl, S., Scandiuzzi, L., Ray, A., Jeon, H., Ohaegbulam, K. C., Ghosh, K., Zhao, A., Scharff, M. D. & Zang, X., Jun 11 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 24, p. 9879-9884 6 p.

Research output: Contribution to journalArticle

67 Scopus citations

HHLA2 is expressed in pancreatic and ampullary cancers and increased expression is associated with better post-surgical prognosis

Boor, P. P. C., Sideras, K., Biermann, K., Hosein Aziz, M., Levink, I. J. M., Mancham, S., Erler, N. S., Tang, X., van Eijck, C. H., Bruno, M. J., Sprengers, D., Zang, X. & Kwekkeboom, J., Apr 14 2020, In : British Journal of Cancer. 122, 8, p. 1211-1218 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Histone deacetylases inhibitor MS-275 suppresses human esophageal squamous cell carcinoma cell growth and progression via the PI3K/Akt/mTOR pathway

Ma, S., Liu, T., Xu, L., Wang, Y., Zhou, J., Huang, T., Li, P., Liu, H., Zhang, Y., Zhou, X., Cui, Y., Zang, X., Wang, Y. & Guan, F., Jan 1 2019, In : Journal of Cellular Physiology. 234, 12, p. 22400-22410 11 p.

Research output: Contribution to journalArticle

5 Scopus citations

Homologues of human macrophage migration inhibitory factor from a parasitic nematode: Gene cloning, protein activity, and crystal structure

Zang, X., Taylor, P., Wang, J. M., Meyer, D. J., Scott, A. L., Walkinshaw, M. D. & Maizels, R. M., Nov 15 2002, In : Journal of Biological Chemistry. 277, 46, p. 44261-44267 7 p.

Research output: Contribution to journalArticle

86 Scopus citations

Host B7x promotes pulmonary metastasis of breast cancer

Abadi, Y. M., Jeon, H., Ohaegbulam, K. C., Scandiuzzi, L., Ghosh, K., Hofmeyer, K. A., Lee, J. S., Ray, A., Gravekamp, C. & Zang, X., Apr 1 2013, In : Journal of Immunology. 190, 7, p. 3806-3814 9 p.

Research output: Contribution to journalArticle

43 Scopus citations

Identification of chimeric RNAs in human infant brains and their implications in neural differentiation

Tang, Y., Ma, S., Wang, X., Xing, Q., Huang, T., Liu, H., Li, Q., Zhang, Y., Zhang, K., Yao, M., Yang, G. L., Li, H., Zang, X., Yang, B. & Guan, F., Jun 2019, In : International Journal of Biochemistry and Cell Biology. 111, p. 19-26 8 p.

Research output: Contribution to journalArticle

Immune checkpoint B7x (B7-H4/B7S1/VTCN1) is over expressed in spontaneous canine bladder cancer: the first report and its implications in a preclinical model

Chand, D., Dhawan, D., Sankin, A., Ren, X., Lin, J., Schoenberg, M., Knapp, D. W. & Zang, X., Jan 1 2019, In : Bladder Cancer. 5, 1, p. 63-71 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

Immune evasion genes from filarial nematodes

Maizels, R. M., Gomez-Escobar, N., Gregory, W. F., Murray, J. & Zang, X., Jun 23 2001, In : International Journal for Parasitology. 31, 9, p. 889-898 10 p.

Research output: Contribution to journalArticle

131 Scopus citations

Immune infiltration and PD-L1 expression in the tumor microenvironment are prognostic in osteosarcoma

Koirala, P., Roth, M. E., Gill, J., Piperdi, S., Chinai, J. M., Geller, D. S., Hoang, B. H., Park, A., Fremed, M. A., Zang, X. & Gorlick, R., Jul 26 2016, In : Scientific Reports. 6, 30093.

Research output: Contribution to journalArticle

82 Scopus citations

Inducible costimulator is required for type 2 antibody isotype switching but not T helper cell type 2 responses in chronic nematode infection

Loke, P., Zang, X., Hsuan, L., Waitz, R., Locksley, R. M., Allen, J. E. & Allison, J. P., Jul 12 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 28, p. 9872-9877 6 p.

Research output: Contribution to journalArticle

19 Scopus citations

Molecular pathways: Targeting B7-H3 (CD276) for human cancer immunotherapy

Picarda, E., Ohaegbulam, K. C. & Zang, X., Jul 15 2016, In : Clinical Cancer Research. 22, 14, p. 3425-3431 7 p.

Research output: Contribution to journalArticle

101 Scopus citations

Mouse mast cell protease-4 deteriorates renal function by contributing to inflammation and fibrosis in immune complex-mediated glomerulonephritis

Scandiuzzi, L., Beghdadi, W., Daugas, E., Åbrink, M., Tiwari, N., Brochetta, C., Claver, J., Arouche, N., Zang, X., Pretolani, M., Monteiro, R. C., Pejler, G. & Blank, U., Jul 1 2010, In : Journal of Immunology. 185, 1, p. 624-633 10 p.

Research output: Contribution to journalArticle

50 Scopus citations

NF-κB RelA renders tumor-associated macrophages resistant to and capable of directly suppressing CD8+ T cells for tumor promotion

Li, L., Han, L., Sun, F., Zhou, J., Ohaegbulam, K. C., Tang, X., Zang, X., Steinbrecher, K. A., Qu, Z. & Xiao, G., Jun 3 2018, In : OncoImmunology. 7, 6, e1435250.

Research output: Contribution to journalArticle

4 Scopus citations

Over-Expression and Prognostic Significance of HHLA2, a New Immune Checkpoint Molecule, in Human Clear Cell Renal Cell Carcinoma

Zhang, Z., Liu, J., Zhang, C., Li, F., Li, L., Wang, D., Chand, D., Guan, F., Zang, X. & Zhang, Y., May 19 2020, In : Frontiers in Cell and Developmental Biology. 8, 280.

Research output: Contribution to journalArticle

Open Access

PAK kinase inhibition has therapeutic activity in novel preclinical models of adult T-Cell leukemia/lymphoma

Chung, E. Y., Mai, Y., Shah, U. A., Wei, Y., Ishida, E., Kataoka, K., Ren, X., Pradhan, K., Bartholdy, B., Wei, X., Zou, Y., Zhang, J., Ogawa, S., Steidl, U., Zang, X., Verma, A., Janakiram, M. & Ye, B. H., Jun 15 2019, In : Clinical Cancer Research. 25, 12, p. 3589-3601 13 p.

Research output: Contribution to journalArticle

2 Scopus citations

PD-L1 expression is a prognostic factor in subgroups of gastric cancer patients stratified according to their levels of CD8 and FOXP3 immune markers

Ying, L., Yan, F., Meng, Q., Yu, L., Yuan, X., Gantier, M. P., Williams, B. R. G., Chan, D. W., Shi, L., Tu, Y., Ni, P., Wang, X., Chen, W., Zang, X., Xu, D. & Hu, Y., Jun 3 2018, In : OncoImmunology. 7, 6, e1433520.

Research output: Contribution to journalArticle

11 Scopus citations

Rapid progression of adult T-cell leukemia/lymphoma as tumor-infiltrating Tregs after PD-1 blockade

Rauch, D. A., Conlon, K. C., Janakiram, M., Brammer, J. E., Harding, J. C., Ye, B. H., Zang, X., Ren, X., Olson, S., Cheng, X., Miljkovic, M. D., Sundaramoorthi, H., Joseph, A., Skidmore, Z. L., Griffith, O., Griffith, M., Waldmann, T. A. & Ratner, L., Oct 24 2019, In : Blood. 134, 17, p. 1406-1414 9 p.

Research output: Contribution to journalArticle

11 Scopus citations

Serum-soluble B7x is elevated in renal cell carcinoma patients and is associated with advanced stage

Thompson, R. H., Zang, X., Lohse, C. M., Leibovich, B. C., Slovin, S. F., Reuter, V. E., Cheville, J. C., Blute, M. L., Russo, P., Kwon, E. D. & Allison, J. P., Aug 1 2008, In : Cancer research. 68, 15, p. 6054-6058 5 p.

Research output: Contribution to journalArticle

56 Scopus citations

Structure and cancer immunotherapy of the B7 family member B7x

Jeon, H., Vigdorovich, V., Garrett-Thomson, S. C., Janakiram, M., Ramagopal, U. A., Abadi, Y. M., Lee, J. S., Scandiuzzi, L., Ohaegbulam, K. C., Chinai, J. M., Zhao, R., Yao, Y., Mao, Y., Sparano, J. A., Almo, S. C. & Zang, X., Jan 1 2014, In : Cell Reports. 9, 3, p. 1089-1098 10 p.

Research output: Contribution to journalArticle

36 Scopus citations

Structure and t cell inhibition properties of b7 family member, B7-H3

Vigdorovich, V., Ramagopal, U. A., Lázár-Molnár, E., Sylvestre, E., Lee, J. S., Hofmeyer, K. A., Zang, X., Nathenson, S. G. & Almo, S. C., May 7 2013, In : Structure. 21, 5, p. 707-717 11 p.

Research output: Contribution to journalArticle

37 Scopus citations

Substituting threonine 187 with alanine in p27Kip1 prevents pituitary tumorigenesis by two-hit loss of RB1 and enhances humoral immunity in old age

Zhao, H., Bauzon, F., Bi, E., Yu, J. J., Fu, H., Lu, Z., Cui, J., Jeon, H., Zang, X., Ye, B. H. & Zhu, L., Feb 27 2015, In : Journal of Biological Chemistry. 290, 9, p. 5797-5809 13 p.

Research output: Contribution to journalArticle

7 Scopus citations

T Cell Immunoglobulin Mucin-3 Crystal Structure Reveals a Galectin-9-Independent Ligand-Binding Surface

Cao, E., Zang, X., Ramagopal, U. A., Mukhopadhaya, A., Fedorov, A., Fedorov, E., Zencheck, W. D., Lary, J. W., Cole, J. L., Deng, H., Xiao, H., DiLorenzo, T. P., Allison, J. P., Nathenson, S. G. & Almo, S. C., Mar 23 2007, In : Immunity. 26, 3, p. 311-321 11 p.

Research output: Contribution to journalArticle

114 Scopus citations

The appropriate frequency and function of decidual Tim-3+CTLA-4+CD8+ T cells are important in maintaining normal pregnancy

Wang, S., Sun, F., Li, M., Qian, J., Chen, C., Wang, M., Zang, X., Li, D., Yu, M. & Du, M., Jun 1 2019, In : Cell Death and Disease. 10, 6, 407.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations
3 Scopus citations