• 1807 Citations
  • 24 h-Index
20082020

Research output per year

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Publications

  • 1807 Citations
  • 24 h-Index
  • 44 Article
  • 4 Review article
2020

Biological basis for efficacy of activin receptor ligand traps in myelodysplastic syndromes

Verma, A., Suragani, R. N. V. S., Aluri, S., Shah, N., Bhagat, T. D., Alexander, M. J., Komrokji, R. & Kumar, R., Feb 3 2020, In : Journal of Clinical Investigation. 130, 2, p. 582-589 8 p.

Research output: Contribution to journalReview article

Open Access
2 Scopus citations
2019

Ascorbic acid–induced TET activation mitigates adverse hydroxymethylcytosine loss in renal cell carcinoma

Shenoy, N., Bhagat, T. D., Cheville, J., Lohse, C., Bhattacharyya, S., Tischer, A., Machha, V., Gordon-Mitchell, S., Choudhary, G., Wong, L. F., Gross, L. A., Ressigue, E., Leibovich, B., Boorjian, S. A., Steidl, U., Wu, X., Pradhan, K., Gartrell, B., Agarwal, B., Pagliaro, L. & 8 others, Suzuki, M., Greally, J. M., Rakheja, D., Houston Thompson, R., Susztak, K., Witzig, T., Zou, Y. & Verma, A., Apr 1 2019, In : Journal of Clinical Investigation. 129, 4, p. 1612-1625 14 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Cytokine-regulated phosphorylation and activation of TET2 by JAK2 in hematopoiesis

Jeong, J. J., Gu, X., Nie, J., Sundaravel, S., Liu, H., Kuo, W. L., Bhagat, T. D., Pradhan, K., Cao, J., Nischal, S., McGraw, K. L., Bhattacharyya, S., Bishop, M. R., Artz, A., Thirman, M. J., Moliterno, A., Ji, P., Levine, R. L., Godley, L. A., Steidl, U. & 6 others, Bieker, J. J., List, A. F., Saunthararajah, Y., He, C., Verma, A. & Wickrema, A., Jun 2019, In : Cancer discovery. 9, 6, p. 778-795 18 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Lactate-mediated epigenetic reprogramming regulates formation of human pancreatic cancer-associated fibroblasts

Bhagat, T. D., Von Ahgrens, D., Dawlaty, M., Zou, Y., Baddour, J., Achreja, A., Zhao, H., Yang, L., Patel, B., Kwak, C., Choudhary, G. S., Gordon-Mitchell, S., Alluri, S., Bhattacharyya, S., Sahu, S., Yu, Y., Bartenstein, M., Giricz, O., Suzuki, M., Sohal, D. & 12 others, Gupta, S., Guerrero, P., Batra, S., Goggins, M., Steidl, U., Greally, J., Agarwal, B., Pradhan, K., Banerjee, D., Nagrath, D., Maitra, A. & Verma, A., Oct 2019, In : eLife. 8, e50663.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Loss of function of DOCK4 in myelodysplastic syndromes stem cells is restored by inhibitors of DOCK4 signaling networks

Sundaravel, S., Kuo, W. L., Jeong, J. J., Choudhary, G. S., Gordon-Mitchell, S., Liu, H., Bhagat, T. D., McGraw, K. L., Gurbuxani, S., List, A. F., Verma, A. & Wickrema, A., Sep 15 2019, In : Clinical Cancer Research. 25, 18, p. 5638-5649 12 p.

Research output: Contribution to journalArticle

1 Scopus citations

Misidentification of MLL3 and other mutations in cancer due to highly homologous genomic regions

Bowler, T. G., Pradhan, K., Kong, Y., Bartenstein, M., Morrone, K. A., Shridharan, A., Kessel, R. M., Shastri, A., Giricz, O., Bhagat, T. D., Gordon-Mitchell, S., Rohanizadegan, M., Hooda, L., Datt, I., Przychodzen, B. P., Parmar, S., Maqbool, S., Maciejewski, J. P., Steidl, U., Greally, J. M. & 1 others, Verma, A., Jan 1 2019, In : Leukemia and Lymphoma.

Research output: Contribution to journalArticle

Phase II study of the ALK5 inhibitor galunisertib in very low-, low-, and intermediate-risk myelodysplastic syndromes

Santini, V., Valcarcel, D., Platzbecker, U., Komrokji, R. S., Cleverly, A. L., Lahn, M. M., Janssen, J., Zhao, Y., Chiang, A., Giagounidis, A., Guba, S. C., Gueorguieva, I., Girvan, A. C., Da Silva Ferreira, M., Bhagat, T. D., Pradhan, K., Steidl, U., Sridharan, A., Will, B. & Verma, A., Dec 1 2019, In : Clinical Cancer Research. 25, 23, p. 6976-6985 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

Stem cell mutations can be detected in myeloma patients years before onset of secondary leukemias

Sridharan, A., Schinke, C. D., Georgiev, G., da Silva Ferreira, M., Thiruthuvanathan, V., MacArthur, I., Bhagat, T. D., Choudhary, G. S., Aluri, S., Chen, J., Pradhan, K., Xia, Y., Panjikaran, M., Sims, G., Bhagat, C. K., Bender, R., Keeler, L., Graber, A., Heuck, C., Fletcher, F. A. & 10 others, Alapat, D., Weinhold, N., Johnson, S. K., Wickrema, A., Barlogie, B., Morgan, G. J., Shastri, A., Steidl, U., Will, B. & Verma, A., Jan 1 2019, In : Blood Advances. 3, 23, p. 3962-3967 6 p.

Research output: Contribution to journalArticle

Open Access

U2AF1 mutations induce oncogenic IRAK4 isoforms and activate innate immune pathways in myeloid malignancies

Smith, M. A., Choudhary, G. S., Pellagatti, A., Choi, K., Bolanos, L. C., Bhagat, T. D., Gordon-Mitchell, S., Von Ahrens, D., Pradhan, K., Steeples, V., Kim, S., Steidl, U., Walter, M., Fraser, I. D. C., Kulkarni, A., Salomonis, N., Komurov, K., Boultwood, J., Verma, A. & Starczynowski, D. T., May 1 2019, In : Nature Cell Biology. 21, 5, p. 640-650 11 p.

Research output: Contribution to journalArticle

12 Scopus citations
2018

Antisense STAT3 inhibitor decreases viability of myelodysplastic and leukemic stem cells

Shastri, A., Choudhary, G., Teixeira, M., Gordon-Mitchell, S., Ramachandra, N., Bernard, L., Bhattacharyya, S., Lopez, R., Pradhan, K., Giricz, O., Ravipati, G., Wong, L. F., Cole, S., Bhagat, T. D., Feld, J., Dhar, Y., Bartenstein, M., Thiruthuvanathan, V. J., Wickrema, A., Hilda Ye, B. & 13 others, Frank, D. A., Pellagatti, A., Boultwood, J., Zhou, T., Kim, Y., Robert MacLeod, A., Epling-Burnette, P. K., Ye, M., McCoon, P., Woessner, R., Steidl, U., Will, B. & Verma, A., Dec 3 2018, In : Journal of Clinical Investigation. 128, 12, p. 5489-5504 16 p.

Research output: Contribution to journalArticle

Open Access
13 Scopus citations

North American ATLL has a distinct mutational and transcriptional profile and responds to epigenetic therapies

Shah, U. A., Chung, E. Y., Giricz, O., Pradhan, K., Kataoka, K., Gordon-Mitchel, S., Bhagat, T. D., Mai, Y., Wei, Y., Ishida, E., Choudhary, G. S., Joseph, A., Rice, R., Gitego, N., Parrish, C., Bartenstein, M., Goel, S., Mantzaris, I., Shastri, A., Derman, O. & 13 others, Binder, A., Gritsman, K., Kornblum, N., Braunschweig, I., Bhagat, C., Hall, J., Graber, A., Ratner, L., Wang, Y., Ogawa, S., Verma, A., Ye, B. H. & Janakiram, M., Oct 4 2018, In : Blood. 132, 14, p. 1507-1518 12 p.

Research output: Contribution to journalArticle

16 Scopus citations

The RUNX1/IL-34/CSF-1R axis is an autocrinally regulated modulator of resistance to BRAF-V600E inhibition in melanoma

Giricz, O., Mo, Y., Dahlman, K. B., Cotto-Rios, X. M., Vardabasso, C., Nguyen, H., Matusow, B., Bartenstein, M., Polishchuk, V., Johnson, D. B., Bhagat, T. D., Shellooe, R., Burton, E., Tsai, J., Zhang, C., Habets, G., Greally, J. M., Yu, Y., Kenny, P. A., Fields, G. B. & 8 others, Pradhan, K., Stanley, E. R., Bernstein, E., Bollag, G., Gavathiotis, E., West, B. L., Sosman, J. A. & Verma, A. K., Jul 26 2018, In : JCI Insight. 3, 14

Research output: Contribution to journalArticle

Open Access
2017

Altered hydroxymethylation is seen at regulatory regions in pancreatic cancer and regulates oncogenic pathways

Bhattacharyya, S., Pradhan, K., Campbell, N., Mazdo, J., Vasantkumar, A., Maqbool, S., Bhagat, T. D., Gupta, S., Suzuki, M., Yu, Y., Greally, J. M., Steidl, U., Bradner, J., Dawlaty, M., Godley, L., Maitra, A. & Verma, A., Nov 1 2017, In : Genome Research. 27, 11, p. 1830-1842 13 p.

Research output: Contribution to journalArticle

17 Scopus citations

Epigenetically aberrant stroma in MDS propagates disease via Wnt/β-catenin activation

Bhagat, T. D., Chen, S., Bartenstein, M., Barlowe, A. T., Von Ahrens, D., Choudhary, G. S., Tivnan, P., Amin, E., Marcondes, A. M., Sanders, M. A., Hoogenboezem, R. M., Kambhampati, S., Ramachandra, N., Mantzaris, I., Sukrithan, V., Laurence, R., Lopez, R., Bhagat, P., Giricz, O., Sohal, D. & 18 others, Wickrema, A., Yeung, C., Gritsman, K., Aplan, P., Hochedlinger, K., Yu, Y., Pradhan, K., Zhang, J., Greally, J. M., Mukherjee, S., Pellagatti, A., Boultwood, J., Will, B., Steidl, U., Raaijmakers, M. H. G. P., Deeg, H. J., Kharas, M. G. & Verma, A., Sep 15 2017, In : Cancer Research. 77, 18, p. 4846-4857 12 p.

Research output: Contribution to journalArticle

17 Scopus citations

Notch pathway is activated via genetic and epigenetic alterations and is a therapeutic target in clear cell renal cancer

Bhagat, T. D., Zou, Y., Huang, S., Park, J., Palmer, M. B., Hu, C., Li, W., Shenoy, N., Giricz, O., Choudhary, G., Yu, Y., Ko, Y. A., Izquierdo, M. C., Park, A. S. D., Vallumsetla, N., Laurence, R., Lopez, R., Suzuki, M., Pullman, J., Kaner, J. & 8 others, Gartrell, B., Hakimi, A. A., Greally, J. M., Patel, B., Benhadji, K., Pradhan, K., Verma, A. & Susztak, K., Jan 20 2017, In : Journal of Biological Chemistry. 292, 3, p. 837-846 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

The role of stromal cancer-associated fibroblasts in pancreatic cancer

Von Ahrens, D., Bhagat, T. D., Nagrath, D., Maitra, A. & Verma, A., Mar 28 2017, In : Journal of Hematology and Oncology. 10, 1, 76.

Research output: Contribution to journalReview article

86 Scopus citations

Upregulation of TET activity with ascorbic acid induces epigenetic modulation of lymphoma cells

Shenoy, N., Bhagat, T., Nieves, E., Stenson, M., Lawson, J., Choudhary, G. S., Habermann, T., Nowakowski, G., Singh, R., Wu, X., Verma, A. & Witzig, T. E., Jul 21 2017, In : Blood cancer journal. 7, 7, p. e587

Research output: Contribution to journalArticle

25 Scopus citations
2016

Pexmetinib: A novel dual inhibitor of Tie2 and p38 MAPK with efficacy in preclinical models of myelodysplastic syndromes and acute myeloid leukemia

Bachegowda, L., Morrone, K., Winski, S. L., Mantzaris, I., Bartenstein, M., Ramachandra, N., Giricz, O., Sukrithan, V., Nwankwo, G., Shahnaz, S., Bhagat, T. D., Bhattacharyya, S., Assal, A., Shastri, A., Gordon-Mitchell, S., Pellagatti, A., Boultwood, J., Schinke, C., Yu, Y., Guha, C. & 16 others, Rizzi, J., Garrus, J., Brown, S., Wollenberg, L., Hogeland, G., Wright, D., Munson, M., Rodriguez, M., Gross, S., Chantry, D., Zou, Y., Platanias, L. C., Burgess, L. E., Pradhan, K., Steidl, U. & Verma, A., Aug 15 2016, In : Cancer Research. 76, 16, p. 4841-4849 9 p.

Research output: Contribution to journalArticle

16 Scopus citations
2015

Central Role of ULK1 in Type I Interferon Signaling

Saleiro, D., Mehrotra, S., Kroczynska, B., Beauchamp, E. M., Lisowski, P., Majchrzak-Kita, B., Bhagat, T. D., Stein, B. L., McMahon, B., Altman, J. K., Kosciuczuk, E. M., Baker, D. P., Jie, C., Jafari, N., Thompson, C. B., Levine, R. L., Fish, E. N., Verma, A. K. & Platanias, L. C., Apr 28 2015, In : Cell Reports. 11, 4, p. 605-617 13 p.

Research output: Contribution to journalArticle

31 Scopus citations

Colony stimulating factor-1 receptor signaling networks inhibit mouse macrophage inflammatory responses by induction of microRNA-21

Caescu, C. I., Guo, X., Tesfa, L., Bhagat, T. D., Verma, A., Zheng, D. & Stanley, E. R., Feb 19 2015, In : Blood. 125, 8, p. e1-e13

Research output: Contribution to journalArticle

51 Scopus citations

IL8-CXCR2 pathway inhibition as a therapeutic strategy against MDS and AML stem cells

Schinke, C., Giricz, O., Li, W., Shastri, A., Gordon, S., Barreyro, L., Bhagat, T., Bhattacharyya, S., Ramachandra, N., Bartenstein, M., Pellagatti, A., Boultwood, J., Wickrema, A., Yu, Y., Will, B., Wei, S., Steidl, U. & Verma, A., Jan 1 2015, In : Blood. 125, 20, p. 3144-3152 9 p.

Research output: Contribution to journalArticle

73 Scopus citations

Reduced DOCK4 expression leads to erythroid dysplasia in myelodysplastic syndromes

Sundaravel, S., Duggan, R., Bhagat, T., Ebenezer, D. L., Liu, H., Yu, Y., Bartenstein, M., Unnikrishnan, M., Karmakar, S., Liu, T. C., Torregroza, I., Quenon, T., Anastasi, J., McGraw, K. L., Pellagatti, A., Boultwood, J., Yajnik, V., Artz, A., Le Beau, M. M., Steidl, U. & 4 others, List, A. F., Evans, T., Verma, A. & Wickrema, A., Nov 17 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 46, p. E6359-E6368

Research output: Contribution to journalArticle

14 Scopus citations
2014
8 Scopus citations

HSC commitment-associated epigenetic signature is prognostic in acute myeloid leukemia

Bartholdy, B., Christopeit, M., Will, B., Mo, Y., Barreyro, L., Yu, Y., Bhagat, T. D., Okoye-Okafor, U. C., Todorova, T. I., Greally, J. M., Levine, R. L., Melnick, A., Verma, A. & Steidl, U., Mar 3 2014, In : Journal of Clinical Investigation. 124, 3, p. 1158-1167 10 p.

Research output: Contribution to journalArticle

30 Scopus citations

Kidney cancer is characterized by aberrant methylation of tissue-specific enhancers that are prognostic for overall survival

Hu, C. Y., Mohtat, D., Yu, Y., Ko, Y. A., Shenoy, N., Bhattacharya, S., Izquierdo, M. C., Park, A. S. D., Giricz, O., Vallumsetla, N., Gundabolu, K., Ware, K., Bhagat, T. D., Suzuki, M., Pullman, J., Liu, X. S., Greally, J. M., Susztak, K. & Verma, A., Aug 15 2014, In : Clinical Cancer Research. 20, 16, p. 4349-4360 12 p.

Research output: Contribution to journalArticle

39 Scopus citations

Long non-coding RNA HNF1A-AS1 regulates proliferation and migration in oesophageal adenocarcinoma cells

Yang, X., Song, J. H., Cheng, Y., Wu, W., Bhagat, T., Yu, Y., Abraham, J. M., Ibrahim, S., Ravich, W., Roland, B. C., Khashab, M., Singh, V. K., Shin, E. J., Yang, X., Verma, A. K., Meltzer, S. J. & Mori, Y., Jun 1 2014, In : Gut. 63, 6, p. 881-890 10 p.

Research output: Contribution to journalArticle

144 Scopus citations

TET1-mediated hydroxymethylation facilitates hypoxic gene induction in neuroblastoma

Mariani, C. J., Vasanthakumar, A., Madzo, J., Yesilkanal, A., Bhagat, T., Yu, Y., Bhattacharyya, S., Wenger, R. H., Cohn, S. L., Nanduri, J., Verma, A., Prabhakar, N. R. & Godley, L. A., Jun 12 2014, In : Cell Reports. 7, 5, p. 1343-1352 10 p.

Research output: Contribution to journalArticle

73 Scopus citations
2013

Genome-wide hydroxymethylation tested using the HELP-GT assay shows redistribution in cancer

Bhattacharyya, S., Yu, Y., Suzuki, M., Campbell, N., Mazdo, J., Vasanthakumar, A., Bhagat, T. D., Nischal, S., Christopeit, M., Parekh, S., Steidl, U., Godley, L., Maitra, A., Greally, J. M. & Verma, A., Sep 1 2013, In : Nucleic Acids Research. 41, 16, p. e157

Research output: Contribution to journalArticle

47 Scopus citations

High resolution integrative analysis reveals widespread genetic and epigenetic changes after chronic in-vitro acid and bile exposure in barrett's epithelium cells

Bajpai, M., Kessel, R., Bhagat, T., Nischal, S., Yu, Y., Verma, A. & Das, K. M., Dec 1 2013, In : Genes Chromosomes and Cancer. 52, 12, p. 1123-1132 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

High resolution methylome analysis reveals widespread functional hypomethylation during adult human erythropoiesis

Yu, Y., Mo, Y., Ebenezer, D., Bhattacharyya, S., Liu, H., Sundaravel, S., Giricz, O., Wontakal, S., Cartier, J., Caces, B., Artz, A., Nischal, S., Bhagat, T., Bathon, K., Maqbool, S., Gligich, O., Suzuki, M., Steidl, U., Godley, L., Skoultchi, A. & 3 others, Greally, J., Wickrema, A. & Verma, A., Mar 29 2013, In : Journal of Biological Chemistry. 288, 13, p. 8805-8814 10 p.

Research output: Contribution to journalArticle

23 Scopus citations

Hypomethylation of noncoding DNA regions and overexpression of the long noncoding RNA, AFAP1-AS1, in Barrett's esophagus and esophageal adenocarcinoma

Wu, W., Bhagat, T. D., Yang, X., Song, J. H., Cheng, Y., Agarwal, R., Abraham, J. M., Ibrahim, S., Bartenstein, M., Hussain, Z., Suzuki, M., Yu, Y., Chen, W., Eng, C., Greally, J., Verma, A. & Meltzer, S. J., May 2013, In : Gastroenterology. 144, 5, p. 956-966.e4

Research output: Contribution to journalArticle

149 Scopus citations

Methylome profiling reveals distinct alterations in phenotypic and mutational subgroups of myeloproliferative neoplasms

Nischal, S., Bhattacharyya, S., Christopeit, M., Yu, Y., Zhou, L., Bhagat, T. D., Sohal, D., Will, B., Mo, Y., Suzuki, M., Pardanani, A., Michael McDevitt, M., Maciejewski, J. P., Melnick, A. M., Greally, J. M., Steidl, U., Moliterno, A. & Verma, A., Feb 1 2013, In : Cancer Research. 73, 3, p. 1076-1085 10 p.

Research output: Contribution to journalArticle

32 Scopus citations

MiR-21 mediates hematopoietic suppression in MDS by activating TGF-β signaling

Bhagat, T. D., Zhou, L., Sokol, L., Kessel, R., Caceres, G., Gundabolu, K., Tamari, R., Gordon, S., Mantzaris, I., Jodlowski, T., Yu, Y., Jing, X., Polineni, R., Bhatia, K., Pellagatti, A., Boultwood, J., Kambhampati, S., Steidl, U., Stein, C., Ju, W. & 5 others, Liu, G., Kenny, P., List, A., Bitzer, M. & Verma, A., Apr 11 2013, In : Blood. 121, 15, p. 2875-2881 7 p.

Research output: Contribution to journalArticle

74 Scopus citations

Myeloma is characterized by stage-specific alterations in DNA methylation that occur early during myelomagenesis

Heuck, C. J., Mehta, J., Bhagat, T., Gundabolu, K., Yu, Y., Khan, S., Chrysofakis, G., Schinke, C., Tariman, J., Vickrey, E., Pulliam, N., Nischal, S., Zhou, L., Bhattacharyya, S., Meagher, R., Hu, C., Maqbool, S., Suzuki, M., Parekh, S., Reu, F. & 4 others, Steidl, U., Greally, J., Verma, A. & Singhal, S. B., Mar 15 2013, In : Journal of Immunology. 190, 6, p. 2966-2975 10 p.

Research output: Contribution to journalArticle

54 Scopus citations

Role of DNA Methylation in the Pathogenesis and Treatment of Myelodysplastic Syndromes

Khan, H., Vale, C., Bhagat, T. & Verma, A., Jan 1 2013, In : Seminars in Hematology. 50, 1, p. 16-37 22 p.

Research output: Contribution to journalArticle

31 Scopus citations

Satb1 regulates the self-renewal of hematopoietic stem cells by promoting quiescence and repressing differentiation commitment

Will, B., Vogler, T. O., Bartholdy, B., Garrett-Bakelman, F., Mayer, J., Barreyro, L., Pandolfi, A., Todorova, T. I., Okoye-Okafor, U. C., Stanley, R. F., Bhagat, T. D., Verma, A., Figueroa, M. E., Melnick, A., Roth, M. & Steidl, U., May 1 2013, In : Nature Immunology. 14, 5, p. 437-445 9 p.

Research output: Contribution to journalArticle

58 Scopus citations
2012

Alterations in the ribosomal machinery in cancer and hematologic disorders

Shenoy, N., Kessel, R., Bhagat, T. D., Bhattacharyya, S., Yu, Y., McMahon, C. & Verma, A., Jun 20 2012, In : Journal of Hematology and Oncology. 5, 32.

Research output: Contribution to journalReview article

43 Scopus citations

Role of epigenetic alterations in the pathogenesis of Barrett's esophagus and esophageal adenocarcinoma

Agarwal, A., Polineni, R., Hussein, Z., Vigoda, I., Bhagat, T. D., Bhattacharyya, S., Maitra, A. & Verma, A., Jul 31 2012, In : International Journal of Clinical and Experimental Pathology. 5, 5, p. 382-396 15 p.

Research output: Contribution to journalReview article

35 Scopus citations

Stem and progenitor cells in myelodysplastic syndromes show aberrant stage-specific expansion and harbor genetic and epigenetic alterations

Will, B., Zhou, L., Vogler, T. O., Ben-Neriah, S., Schinke, C., Tamari, R., Yu, Y., Bhagat, T. D., Bhattacharyya, S., Barreyro, L., Heuck, C., Mo, Y., Parekh, S., McMahon, C., Pellagatti, A., Boultwood, J., Montagna, C., Silverman, L., Maciejewski, J., Greally, J. M. & 5 others, Ye, B. H., List, A. F., Steidl, C., Steidl, U. & Verma, A., Sep 6 2012, In : Blood. 120, 10, p. 2076-2086 11 p.

Research output: Contribution to journalArticle

115 Scopus citations
17 Scopus citations
2011

Aberrant epigenetic and genetic marks are seen in myelodysplastic leukocytes and reveal Dock4 as a candidate pathogenic gene on chromosome 7q

Zhou, L., Opalinska, J., Sohal, D., Yu, Y., Mo, Y., Bhagat, T., Abdel-Wahab, O., Fazzari, M., Figueroa, M., Alencar, C., Zhang, J., Kambhampati, S., Parmar, S., Nischal, S., Hueck, C., Suzuki, M., Freidman, E., Pellagatti, A., Boultwood, J., Steidl, U. & 10 others, Sauthararajah, Y., Yajnik, V., Mcmahon, C., Gore, S. D., Platanias, L. C., Levine, R., Melnick, A., Wickrema, A., Greally, J. M. & Vermaa, A., Jul 15 2011, In : Journal of Biological Chemistry. 286, 28, p. 25211-25223 13 p.

Research output: Contribution to journalArticle

29 Scopus citations

Reduced SMAD7 leads to overactivation of TGF-β signaling in MDS that can be reversed by a specific inhibitor of TGF-β receptor I kinase

Zhou, L., McMahon, C., Bhagat, T., Alencar, C., Yu, Y., Fazzari, M., Sohal, D., Heuck, C., Gundabolu, K., Ng, C., Mo, Y., Shen, W., Wickrema, A., Kong, G., Friedman, E., Sokol, L., Mantzaris, G., Pellagatti, A., Boultwood, J., Platanias, L. C. & 7 others, Steidl, U., Yan, L., Yingling, J. M., Lahn, M. M., List, A., Bitzer, M. & Verma, A., Feb 1 2011, In : Cancer Research. 71, 3, p. 955-963 9 p.

Research output: Contribution to journalArticle

81 Scopus citations

Widespread hypomethylation occurs early and synergizes with gene amplification during esophageal carcinogenesis

Alvarez, H., Opalinska, J., Zhou, L., Sohal, D., Fazzari, M. J., Yu, Y., Montagna, C., Montgomery, E. A., Canto, M., Dunbar, K. B., Wang, J., Roa, J. C., Mo, Y., Bhagat, T., Ramesh, K. H., Cannizzaro, L., Mollenhauer, J., Thompson, R. F., Suzuki, M., Meltzer, S. & 4 others, Melnick, A., Greally, J. M., Maitra, A. & Verma, A., Mar 1 2011, In : PLoS genetics. 7, 3, e1001356.

Research output: Contribution to journalArticle

83 Scopus citations
2010

Cytosine methylation dysregulation in neonates following intrauterine growth restriction

Einstein, F., Thompson, R. F., Bhagat, T. D., Fazzari, M. J., Verma, A., Barzilai, N. & Greally, J. M., Jan 26 2010, In : PloS one. 5, 1, e8887.

Research output: Contribution to journalArticle

101 Scopus citations

Design and synthesis of novel derivatives of all-trans retinoic acid demonstrate the combined importance of acid moiety and conjugated double bonds in its binding to PMLRAR-α oncogene in acute promyelocytic leukemia

Schinke, C., Goel, S., Bhagat, T. D., Zhou, L., Mo, Y., Gallagher, R., Kabalka, G. W., Platanias, L. C., Verma, A. & Das, B., Jun 2010, In : Leukemia and Lymphoma. 51, 6, p. 1108-1114 7 p.

Research output: Contribution to journalArticle

4 Scopus citations
2008

Inhibition of the TGF-β receptor I kinase promotes hematopoiesis in MDS

Zhou, L., Nguyen, A. N., Sohal, D., Ma, J. Y., Pahanish, P., Gundabolu, K., Hayman, J., Chubak, A., Mo, Y., Bhagat, T. D., Das, B., Kapoun, A. M., Navas, T. A., Parmar, S., Kambhampati, S., Pellagatti, A., Braunchweig, I., Zhang, Y., Wickrema, A., Medicherla, S. & 6 others, Boultwood, J., Platanias, L. C., Higgins, L. S., List, A. F., Bitzer, M. & Verma, A., Oct 15 2008, In : Blood. 112, 8, p. 3434-3443 10 p.

Research output: Contribution to journalArticle

107 Scopus citations

Meta-analysis of microarray studies reveals a novel hematopoietic progenitor cell signature and demonstrates feasibility of inter-platform data integration

Sohal, D., Yeatts, A., Ye, K., Pellagatti, A., Zhou, L., Pahanish, P., Mo, Y., Bhagat, T., Mariadason, J., Boultwood, J., Melnick, A., Greally, J. & Verma, A., Aug 13 2008, In : PloS one. 3, 8, e2965.

Research output: Contribution to journalArticle

22 Scopus citations