Research output per year
Research output per year
- 20 results
Search results
-
2020
Nanoluciferase reporter mycobacteriophage for sensitive and rapid detection of mycobacterium tuberculosis drug susceptibility
Jain, P., Garing, S., Verma, D., Saranathan, R., Clute-Reinig, N., Gadwa, J., Peterson, C., Hermansky, G., Fernandez, A. A., Asare, E., Weisbrod, T. R., Spencer, E., Mulholland, C. V., Berney, M., Bell, D., Nichols, K. P., Le Ny, A. L. M., Ordway, D., Jacobs, W. R., Somoskovi, A., & 1 others, Nov 2020, In: Journal of Bacteriology. 202, 22, e00411-20.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations -
2018
Rational design of biosafety level 2-approved, multidrug-resistant strains of Mycobacterium tuberculosis through nutrient auxotrophy
Vilchèze, C., Copeland, J., Keiser, T. L., Weisbrod, T., Washington, J., Jain, P., Malek, A., Weinrick, B. & Jacobs, W. R., May 1 2018, In: mBio. 9, 3, e00938-18.Research output: Contribution to journal › Article › peer-review
Open Access25 Scopus citations -
2017
Enhanced respiration prevents drug tolerance and drug resistance in Mycobacterium tuberculosis
Vilchèze, C., Hartman, T., Weinrick, B., Jain, P., Weisbrod, T. R., Leung, L. W., Freundlich, J. S. & Jacobs, W. R., Apr 25 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 17, p. 4495-4500 6 p.Research output: Contribution to journal › Article › peer-review
Open Access125 Scopus citations -
2016
Dual-reporter mycobacteriophages (Φ2DRMS) reveal preexisting mycobacterium tuberculosis persistent cells in human sputum
Jain, P., Weinrick, B. C., Kalivoda, E. J., Yang, H., Munsamy, V., Vilcheze, C., Weisbrod, T. R., Larsen, M. H., O’Donnell, M. R., Pym, A. & Jacobs, W. R., Sep 1 2016, In: mBio. 7, 5, e01023-16.Research output: Contribution to journal › Article › peer-review
Open Access58 Scopus citations -
Fluorescent reporter DS6A mycobacteriophages reveal unique variations in infectibility and phage production in mycobacteria
Mayer, O., Jain, P., Weisbrod, T. R., Biro, D., Ho, L., Jacobs-Sera, D., Hatfull, G. F. & Jacobs, W. R., 2016, In: Journal of Bacteriology. 198, 23, p. 3220-3232 13 p.Research output: Contribution to journal › Article › peer-review
Open Access29 Scopus citations -
Targeting Mycobacterium tuberculosis tumor necrosis factor alpha-downregulating genes for the development of antituberculous vaccines
Olsen, A., Chen, Y., Ji, Q., Zhu, G., De Silva, A. D., Vilchèze, C., Weisbrod, T., Li, W., Xu, J., Larsen, M., Zhang, J., Porcelli, S. A., Jacobs, W. R. & Chan, J., 2016, In: mBio. 7, 3, e01023-15.Research output: Contribution to journal › Article › peer-review
Open Access34 Scopus citations -
2009
Protection of Mycobacterium tuberculosis from reactive oxygen species conferred by the mel2 locus impacts persistence and dissemination
Cirillo, S. L. G., Subbian, S., Chen, B., Weisbrod, T. R., Jacobs, W. R. & Cirillo, J. D., Jun 2009, In: Infection and immunity. 77, 6, p. 2557-2567 11 p.Research output: Contribution to journal › Article › peer-review
Open Access49 Scopus citations -
2006
Transfer of a point mutation in Mycobacterium tuberculosis inhA resolves the target of isoniazid
Vilchèze, C., Wang, F., Arai, M., Hazbón, M. H., Colangeli, R., Kremer, L., Weisbrod, T. R., Alland, D., Sacchettini, J. C. & Jacobs, W. R., Sep 2006, In: Nature Medicine. 12, 9, p. 1027-1029 3 p.Research output: Contribution to journal › Article › peer-review
272 Scopus citations -
2005
Altered NADH/NAD+ ratio mediates coresistance to isoniazid and ethionamide in mycobacteria
Vilchèze, C., Weisbrod, T. R., Chen, B., Kremer, L., Hazbón, M. H., Wang, F., Alland, D., Sacchettini, J. C. & Jacobs, W. R., Feb 2005, In: Antimicrobial agents and chemotherapy. 49, 2, p. 708-720 13 p.Research output: Contribution to journal › Article › peer-review
Open Access211 Scopus citations -
2000
Characterization of the Mycobacterium tuberculosis iniBAC promoter, a promoter that responds to cell wall biosynthesis inhibition
Alland, D., Steyn, A. J., Weisbrod, T., Aldrich, K. & Jacobs, W. R., Apr 2000, In: Journal of Bacteriology. 182, 7, p. 1802-1811 10 p.Research output: Contribution to journal › Article › peer-review
Open Access122 Scopus citations -
Inactivation of the inhA-encoded fatty acid synthase II (FASII) enoyl- acyl carrier protein reductase induces accumulation of the FASI end products and cell lysis of Mycobacterium smegmatis
Vilchèze, C., Morbidoni, H. R., Weisbrod, T. R., Iwamoto, H., Kuo, M., Sacchettini, J. C. & Jacobs, W. R., Jul 2000, In: Journal of Bacteriology. 182, 14, p. 4059-4067 9 p.Research output: Contribution to journal › Article › peer-review
Open Access249 Scopus citations -
1998
Identification of differentially expressed mRNA in prokaryotic organisms by customized amplification libraries (DECAL): The effect of isoniazid on gene expression in Mycobacterium tuberculosis
Alland, D., Kramnik, I., Weisbrod, T. R., Otsubo, L., Cerny, R., Miller, L. P., Jacobs, W. R. & Bloom, B. R., Oct 27 1998, In: Proceedings of the National Academy of Sciences of the United States of America. 95, 22, p. 13227-13232 6 p.Research output: Contribution to journal › Article › peer-review
Open Access98 Scopus citations -
NADH dehydrogenase defects confer isoniazid resistance and conditional- lethality in Mycobacterium smegmatis
Miesel, L., Weisbrod, T. R., Marcinkeviciene, J. A., Bittman, R. & Jacobs, W. R., May 1998, In: Journal of Bacteriology. 180, 9, p. 2459-2467 9 p.Research output: Contribution to journal › Article › peer-review
Open Access137 Scopus citations -
1997
Cloning of the dapB gene, encoding dihydrodipicolinate reductase, from Mycobacterium tuberculosis
Pavelka, M. S., Weisbrod, T. R. & Jacobs, W. R., 1997, In: Journal of Bacteriology. 179, 8, p. 2777-2782 6 p.Research output: Contribution to journal › Article › peer-review
Open Access21 Scopus citations -
Erratum: Genetic determination of the meso-diaminopimelate biosynthetic pathway of mycobacteria (Journal of Bacteriology 176:14 (4424-4429))
Cirillo, J. D., Weisbrod, T. R., Banerjee, A., Bloom, B. R. & Jacobs, J., 1997, In: Journal of Bacteriology. 179, 8, p. 2792 1 p.Research output: Contribution to journal › Comment/debate › peer-review
Open Access -
1996
Allelic exchange in Mycobacterium tuberculosis with long linear recombination substrates
Balasubramanian, V., Pavelka, M. S., Bardarov, S. S., Martin, J., Weisbrod, T. R., Mcadam, R. A., Bloom, B. R. & Jacobs, W. R., Jan 1996, In: Journal of Bacteriology. 178, 1, p. 273-279 7 p.Research output: Contribution to journal › Article › peer-review
Open Access135 Scopus citations -
Efflux pump of the proton antiporter family confers low-level fluoroquinolone resistance in Mycobacterium smegmatis
Takiff, H. E., Cimino, M., Musso, M. C., Weisbrod, T., Martinez, R., Delgado, M. B., Salazar, L., Bloom, B. R. & Jacobs, W. R., Jan 9 1996, In: Proceedings of the National Academy of Sciences of the United States of America. 93, 1, p. 362-366 5 p.Research output: Contribution to journal › Article › peer-review
Open Access174 Scopus citations -
1995
In vivo growth characteristics of leucine and methionine auxotrophic mutants of Mycobacterium bovis BCG generated by transposon mutagenesis
McAdam, R. A., Weisbrod, T. R., Martin, J., Scuderi, J. D., Brown, A. M., Cirillo, J. D., Bloom, B. R. & Jacobs, W. R., 1995, In: Infection and immunity. 63, 3, p. 1004-1012 9 p.Research output: Contribution to journal › Article › peer-review
Open Access178 Scopus citations -
1994
Genetic determination of the meso-diaminopimelate biosynthetic pathway of mycobacteria
Cirillo, J. D., Weisbrod, T. R., Banerjee, A., Bloom, B. R. & Jacobs, W. R., 1994, In: Journal of Bacteriology. 176, 14, p. 4424-4429 6 p.Research output: Contribution to journal › Article › peer-review
Open Access24 Scopus citations -
Isolation and characterization of the aspartokinase and aspartate semialdehyde dehydrogenase operon from mycobacteria
Cirillo, J. D., Weisbrod, T. R., Pascopella, L., Bloom, B. R. & Jacobs, W. R., Feb 1994, In: Molecular Microbiology. 11, 4, p. 629-639 11 p.Research output: Contribution to journal › Article › peer-review
53 Scopus citations