• 2194 Citations
  • 26 h-Index
1980 …2019

Research output per year

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Publications

  • 2194 Citations
  • 26 h-Index
  • 77 Article
  • 2 Comment/debate
  • 2 Letter
  • 1 Review article
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Article
2019

Allosteres to regulate neurotransmitter sulfonation

Darrah, K., Wang, T., Cook, I., Cacace, M., Deiters, A. & Leyh, T. S., Feb 15 2019, In : Journal of Biological Chemistry. 294, 7, p. 2293-2301 9 p.

Research output: Contribution to journalArticle

1 Scopus citations

Isoform-specific therapeutic control of sulfonation in humans

Cook, I., Wang, T. & Leyh, T. S., Jan 2019, In : Biochemical Pharmacology. 159, p. 25-31 7 p.

Research output: Contribution to journalArticle

2017
5 Scopus citations

The NSAID allosteric site of human cytosolic sulfotransferases

Wang, T., Cook, I. & Leyh, T. S., Dec 8 2017, In : Journal of Biological Chemistry. 292, 49, p. 20305-20312 8 p.

Research output: Contribution to journalArticle

2 Scopus citations
2016

Controlling Sulfuryl-Transfer Biology

Cook, I., Wang, T., Wang, W., Kopp, F., Wu, P. & Leyh, T. S., May 19 2016, In : Cell Chemical Biology. 23, 5, p. 579-586 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

Isozyme Specific Allosteric Regulation of Human Sulfotransferase 1A1

Wang, T., Cook, I. T. & Leyh, T. S., Jul 26 2016, In : Biochemistry. 55, 29, p. 4036-4046 11 p.

Research output: Contribution to journalArticle

11 Scopus citations

Minireview design and interpretation of human sulfotransferase a1 assays

Wang, T., Cook, I. & Leyh, T. S., Apr 2016, In : Drug Metabolism and Disposition. 44, 4, p. 481-484 4 p.

Research output: Contribution to journalArticle

8 Scopus citations

The structure of the catechin-binding site of human sulfotransferase 1A1

Cook, I., Wang, T., Girvin, M. & Leyh, T. S., Dec 13 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 50, p. 14312-14317 6 p.

Research output: Contribution to journalArticle

10 Scopus citations
2015

Sulfotransferase 1A1 Substrate Selectivity: A Molecular Clamp Mechanism

Cook, I. T., Wang, T. & Leyh, T. S., Oct 6 2015, In : Biochemistry. 54, 39, p. 6114-6122 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

Synthesis of mevalonate-and fluorinated mevalonate prodrugs and their in vitro human plasma stability

Kang, S., Watanabe, M., Jacobs, J. C., Yamaguchi, M., Dahesh, S., Nizet, V., Leyh, T. S. & Silverman, R. B., Jan 27 2015, In : European Journal of Medicinal Chemistry. 90, p. 448-461 14 p.

Research output: Contribution to journalArticle

8 Scopus citations

The allosteric binding sites of sulfotransferase 1A1

Cook, I., Wang, T., Falany, C. N. & Leyh, T. S., Mar 1 2015, In : Drug Metabolism and Disposition. 43, 3, p. 418-423 6 p.

Research output: Contribution to journalArticle

10 Scopus citations

The ribosome can discriminate the chirality of amino acids within its peptidyl-transferase center

Englander, M. T., Avins, J. L., Fleisher, R. C., Liu, B., Effraim, P. R., Wang, J., Schulten, K., Leyh, T. S., Gonzalez, R. L. & Cornish, V. W., May 12 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 19, p. 6038-6043 6 p.

Research output: Contribution to journalArticle

36 Scopus citations
2014

3′-Phosphoadenosine 5′-phosphosulfate allosterically regulates sulfotransferase turnover

Wang, T., Cook, I. & Leyh, T. S., Nov 11 2014, In : Biochemistry. 53, 44, p. 6893-6900 8 p.

Research output: Contribution to journalArticle

17 Scopus citations

An enzymatic platform for the synthesis of isoprenoid precursors

Rodriguez, S. B. & Leyh, T. S., Aug 25 2014, In : PloS one. 9, 8, e105594.

Research output: Contribution to journalArticle

7 Scopus citations

Paradigms of sulfotransferase catalysis the mechanism of sult2a1

Wang, T., Cook, I., Falany, C. N. & Leyh, T. S., Sep 19 2014, In : Journal of Biological Chemistry. 289, 38, p. 26474-26480 7 p.

Research output: Contribution to journalArticle

27 Scopus citations
2013

High accuracy in silico sulfotransferase models

Cook, I., Wang, T., Falany, C. N. & Leyh, T. S., Nov 29 2013, In : Journal of Biological Chemistry. 288, 48, p. 34494-34501 8 p.

Research output: Contribution to journalArticle

28 Scopus citations

Host cell-induced components of the sulfate assimilation pathway are major protective antigens of Mycobacterium tuberculosis

Pinto, R., Leotta, L., Shanahan, E. R., West, N. P., Leyh, T. S., Britton, W. & Triccas, J. A., Mar 1 2013, In : Journal of Infectious Diseases. 207, 5, p. 778-785 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

Testing the sulfotransferase molecular pore hypothesis

Cook, I., Wang, T., Almo, S. C., Kim, J., Falany, C. N. & Leyh, T. S., Mar 22 2013, In : Journal of Biological Chemistry. 288, 12, p. 8619-8626 8 p.

Research output: Contribution to journalArticle

25 Scopus citations

The gate that governs sulfotransferase selectivity

Cook, I., Wang, T., Almo, S. C., Kim, J., Falany, C. N. & Leyh, T. S., Jan 15 2013, In : Biochemistry. 52, 2, p. 415-424 10 p.

Research output: Contribution to journalArticle

46 Scopus citations
2012

Analytical expressions for the homotropic binding of ligand to protein dimers and trimers

Lefurgy, S. T. & Leyh, T. S., Feb 15 2012, In : Analytical Biochemistry. 421, 2, p. 433-438 6 p.

Research output: Contribution to journalArticle

3 Scopus citations

A nucleotide-gated molecular pore selects sulfotransferase substrates

Cook, I., Wang, T., Falany, C. N. & Leyh, T. S., Jul 17 2012, In : Biochemistry. 51, 28, p. 5674-5683 10 p.

Research output: Contribution to journalArticle

34 Scopus citations
20 Scopus citations

Three-stage assembly of the cysteine synthase complex from Escherichia coli

Wang, T. & Leyh, T. S., Feb 3 2012, In : Journal of Biological Chemistry. 287, 6, p. 4360-4367 8 p.

Research output: Contribution to journalArticle

16 Scopus citations
2011
1 Scopus citations
2010

Channeling by proximity: The catalytic advantages of active site colocalization using brownian dynamics

Bauler, P., Huber, G., Leyh, T. & McCammon, J. A., May 6 2010, In : Journal of Physical Chemistry Letters. 1, 9, p. 1332-1335 4 p.

Research output: Contribution to journalArticle

64 Scopus citations

Lack of substrate inhibition in a monomeric form of human cytosolic SULT2A1

Cook, I. T., Leyh, T. S., Kadlubar, S. A. & Falany, C. N., Dec 1 2010, In : Hormone Molecular Biology and Clinical Investigation. 3, 1, p. 367-374 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

Mevalonate analogues as substrates of enzymes in the isoprenoid biosynthetic pathway of Streptococcus pneumoniae

Kudoh, T., Park, C. S., Lefurgy, S. T., Sun, M., Michels, T., Leyh, T. S. & Silverman, R. B., Feb 1 2010, In : Bioorganic and Medicinal Chemistry. 18, 3, p. 1124-1134 11 p.

Research output: Contribution to journalArticle

14 Scopus citations

Precise, facile initial rate measurements

Tang, Q. & Leyh, T. S., Dec 16 2010, In : Journal of Physical Chemistry B. 114, 49, p. 16131-16136 6 p.

Research output: Contribution to journalArticle

7 Scopus citations

Probing ligand-binding pockets of the mevalonate pathway enzymes from Streptococcus pneumoniae

Lefurgy, S. T., Rodriguez, S. B., Park, C. S., Cahill, S., Silverman, R. B. & Leyh, T. S., Jul 2 2010, In : Journal of Biological Chemistry. 285, 27, p. 20654-20663 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Structural rearrangement of SULT2A1: Effects on dehydroepiandrosterone and raloxifene sulfation

Cook, I. T., Falany, C. N., Leyh, T. S., Kadlubar, S. A. & Falany, C. N., Jan 1 2010, In : Hormone Molecular Biology and Clinical Investigation. 1, 2, p. 81-87 7 p.

Research output: Contribution to journalArticle

31 Scopus citations

The human estrogen sulfotransferase: A half-site reactive enzyme

Sun, M. & Leyh, T. S., Jun 15 2010, In : Biochemistry. 49, 23, p. 4779-4785 7 p.

Research output: Contribution to journalArticle

25 Scopus citations
2009

Mycobacterium tuberculosis universal stress protein Rv2623 regulates bacillary growth by ATP-binding: Requirement for establishing chronic persistent infection

Drumm, J. E., Mi, K., Bilder, P., Sun, M., Lim, J., Bielefeldt-Ohmann, H., Basaraba, R., So, M., Zhu, G., Tufariello, J. A. M., Izzo, A. A., Orme, I. M., Almo, S. C., Leyh, T. S. & Chan, J., May 2009, In : PLoS pathogens. 5, 5, e1000460.

Research output: Contribution to journalArticle

83 Scopus citations

Natural amino acids do not require their native tRNAs for efficient selection by the ribosome

Effraim, P. R., Wang, J., Englander, M. T., Avins, J., Leyh, T. S., Gonzalez, R. L. & Cornish, V. W., Dec 2009, In : Nature Chemical Biology. 5, 12, p. 947-953 7 p.

Research output: Contribution to journalArticle

26 Scopus citations

Structure of the ternary complex of phosphomevalonate kinase: The enzyme and its family

Andreassi, J. L., Vetting, M. W., Bilder, P. W., Roderick, S. L. & Leyh, T. S., Jul 14 2009, In : Biochemistry. 48, 27, p. 6461-6468 8 p.

Research output: Contribution to journalArticle

19 Scopus citations
2008

Diffusional channeling in the sulfate-activating complex: Combined continuum modeling and coarse-grained Brownian dynamics studies

Cheng, Y., Chang, C. E. A., Yu, Z., Zhang, Y., Sun, M., Leyh, T. S., Holst, M. J. & McCammon, J. A., Nov 15 2008, In : Biophysical journal. 95, 10, p. 4659-4667 9 p.

Research output: Contribution to journalArticle

18 Scopus citations
2007

Crystal structure of the Streptococcus pneumoniae mevalonate kinase in complex with diphosphomevalonate

Andreassi, J. L., Bilder, P. W., Vetting, M. W., Roderick, S. L. & Leyh, T. S., May 1 2007, In : Protein Science. 16, 5, p. 983-989 7 p.

Research output: Contribution to journalArticle

16 Scopus citations

Sulfite reduction in mycobacteria

Pinto, R., Harrison, J. S., Hsu, T., Jacobs, W. R. & Leyh, T. S., Sep 1 2007, In : Journal of Bacteriology. 189, 18, p. 6714-6722 9 p.

Research output: Contribution to journalArticle

24 Scopus citations
2006

Channeling in sulfate activating complexes

Sun, M. & Leyh, T. S., Sep 26 2006, In : Biochemistry. 45, 38, p. 11304-11311 8 p.

Research output: Contribution to journalArticle

26 Scopus citations

Sulfation of raloxifene and 4-hydroxytamoxifen by human cytosolic sulfotransferases

Falany, J. L., Pilloff, D. E., Leyh, T. S. & Falany, C. N., Mar 2006, In : Drug Metabolism and Disposition. 34, 3, p. 361-368 8 p.

Research output: Contribution to journalArticle

53 Scopus citations

Transition state of the sulfuryl transfer reaction of estrogen sulfotransferase

Hoff, R. H., Czyryca, P. G., Sun, M., Leyh, T. S. & Hengge, A. C., Oct 13 2006, In : Journal of Biological Chemistry. 281, 41, p. 30645-30649 5 p.

Research output: Contribution to journalArticle

17 Scopus citations
2005

Anatomy of an energy-coupling mechanism - The interlocking catalytic cycles of the ATP sulfurylase-GTPase system

Sun, M. & Leyh, T. S., Oct 25 2005, In : Biochemistry. 44, 42, p. 13941-13948 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

The trifunctional sulfate-activating complex (SAC) of Mycobacterium tuberculosis

Sun, M., Andreassi, J. L., Liu, S., Pinto, R., Triccas, J. A. & Leyh, T. S., Mar 4 2005, In : Journal of Biological Chemistry. 280, 9, p. 7861-7866 6 p.

Research output: Contribution to journalArticle

22 Scopus citations
2004

Molecular functions of conserved aspects of the GHMP kinase family

Andreassi, J. L. & Leyh, T. S., Nov 23 2004, In : Biochemistry. 43, 46, p. 14594-14601 8 p.

Research output: Contribution to journalArticle

44 Scopus citations

Streptococcus pneumoniae isoprenoid biosynthesis is downregulated by diphosphomevalonate: An antimicrobial target

Andreassi, J. L., Dabovic, K. & Leyh, T. S., Dec 28 2004, In : Biochemistry. 43, 51, p. 16461-16466 6 p.

Research output: Contribution to journalArticle

27 Scopus citations

The Mycobacterium tuberculosis cysD and cysNC genes form a stress-induced operon that encodes a tri-functional sulfate-activating complex

Pinto, R., Tang, Q. X., Britton, W. J., Leyh, T. S. & Triccas, J. A., Jun 2004, In : Microbiology. 150, 6, p. 1681-1686 6 p.

Research output: Contribution to journalArticle

Open Access
46 Scopus citations
2003

Allosteric and Catalytic Functions of the PPi-binding Motif in the ATP Sulfurylase-GTPase System

Pilloff, D. E. & Leyh, T. S., Dec 12 2003, In : Journal of Biological Chemistry. 278, 50, p. 50435-50441 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

Structural and functional analysis of a truncated form of Saccharomyces cerevisiae ATP sulfurylase: C-terminal domain essential for oligomer formation but not for activity

Lalor, D. J., Schnyder, T., Saridakis, V., Pilloff, D. E., Dong, A., Tang, H., Leyh, T. S. & Pai, E. F., Dec 1 2003, In : Protein Engineering. 16, 12, p. 1071-1079 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

The kinetic mechanism of phosphomevalonate kinase

Pilloff, D., Dabovic, K., Romanowski, M. J., Bonanno, J. B., Doherty, M., Burley, S. K. & Leyh, T. S., Feb 14 2003, In : Journal of Biological Chemistry. 278, 7, p. 4510-4515 6 p.

Research output: Contribution to journalArticle

42 Scopus citations
2002

Cysteine biosynthetic enzymes are the pieces of a metabolic energy pump

Wei, J., Tang, Q. X., Varlamova, O., Roche, C., Lee, R. & Leyh, T. S., Jul 2 2002, In : Biochemistry. 41, 26, p. 8493-8498 6 p.

Research output: Contribution to journalArticle

25 Scopus citations

Defining the mandate of proteomics in the post-genomics era: workshop report.

Kenyon, G. L., DeMarini, D. M., Fuchs, E., Galas, D. J., Kirsch, J. F., Leyh, T. S., Moos, W. H., Petsko, G. A., Ringe, D., Rubin, G. M. & Sheahan, L. C., Oct 2002, In : Molecular & cellular proteomics : MCP. 1, 10, p. 763-780 18 p.

Research output: Contribution to journalArticle

63 Scopus citations