• 2911 Citations
  • 31 h-Index
1989 …2019

Research output per year

If you made any changes in Pure these will be visible here soon.

Publications

2019

The evolving landscape of autoantigen discovery and characterization in type 1 diabetes

Purcell, A. W., Sechi, S. & DiLorenzo, T. P., Jan 1 2019, In : Diabetes. 68, 5, p. 879-886 8 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations
2018

HLA-B*39:06 Efficiently Mediates Type 1 Diabetes in a Mouse Model Incorporating Reduced Thymic Insulin Expression

Schloss, J., Ali, R., Racine, J. J., Chapman, H. D., Serreze, D. V. & DiLorenzo, T. P., May 15 2018, In : Journal of Immunology. 200, 10, p. 3353-3363 11 p.

Research output: Contribution to journalArticle

3 Scopus citations

Improved murine MHC-deficient HLA transgenic NOD mouse models for type 1 diabetes therapy development

Racine, J. J., Stewart, I., Ratiu, J., Christianson, G., Lowell, E., Helm, K., Allocco, J., Maser, R. S., Chen, Y. G., Lutz, C. M., Roopenian, D., Schloss, J., DiLorenzo, T. P. & Serreze, D. V., May 1 2018, In : Diabetes. 67, 5, p. 923-935 13 p.

Research output: Contribution to journalArticle

4 Scopus citations
2016
1 Scopus citations

Bridging mice to men: Using HLA transgenic mice to enhance the future prediction and prevention of autoimmune type 1 diabetes in humans

Serreze, D. V., Niens, M., Kulik, J. & DiLorenzo, T. P., May 1 2016, In : Methods in Molecular Biology. 1438, p. 137-151 15 p.

Research output: Contribution to journalReview article

6 Scopus citations

Characterization of the peptide binding specificity of the HLA class I alleles B*38:01 and B*39:06

Sidney, J., Schloss, J., Moore, C., Lindvall, M., Wriston, A., Hunt, D. F., Shabanowitz, J., DiLorenzo, T. P. & Sette, A., Mar 1 2016, In : Immunogenetics. 68, 3, p. 231-236 6 p.

Research output: Contribution to journalArticle

3 Scopus citations

Delivery of siRNAs to dendritic cells using DEC205-targeted lipid nanoparticles to inhibit immune responses

Katakowski, J. A., Mukherjee, G., Wilner, S. E., Maier, K. E., Harrison, M. T., DiLorenzo, T. P., Levy, M. & Palliser, D., Feb 1 2016, In : Molecular Therapy. 24, 1, p. 146-155 10 p.

Research output: Contribution to journalArticle

17 Scopus citations

Genetically modified human CD4+ T cells can be evaluated in vivo without lethal graft-versus-host disease

Ali, R., Babad, J., Follenzi, A., Gebe, J. A., Brehm, M. A., Nepom, G. T., Shultz, L. D., Greiner, D. L. & DiLorenzo, T. P., Aug 1 2016, In : Immunology. 148, 4, p. 339-351 13 p.

Research output: Contribution to journalArticle

6 Scopus citations
2015

Generation of β cell-specific human cytotoxic T cells by lentiviral transduction and their survival in immunodeficient human leucocyte antigen-transgenic mice

Babad, J., Mukherjee, G., Follenzi, A., Ali, R., Roep, B. O., Shultz, L. D., Santamaria, P., Yang, O. O., Goldstein, H., Greiner, D. L. & Dilorenzo, T. P., Mar 1 2015, In : Clinical and Experimental Immunology. 179, 3, p. 398-413 16 p.

Research output: Contribution to journalArticle

13 Scopus citations

Glucagon-reactive islet-infiltrating CD8 T cells in NOD mice

Mukherjee, G., Chaparro, R. J., Schloss, J., Smith, C., Bando, C. D. & Dilorenzo, T. P., Apr 1 2015, In : Immunology. 144, 4, p. 631-640 10 p.

Research output: Contribution to journalArticle

4 Scopus citations
2014

Compensatory Mechanisms Allow Undersized Anchor-Deficient Class i MHC Ligands to Mediate Pathogenic Autoreactive T Cell Responses

Lamont, D., Mukherjee, G., Kumar, P. R., Samanta, D., McPhee, C. G., Kay, T. W. H., Almo, S. C., DiLorenzo, T. P. & Serreze, D. V., Sep 1 2014, In : Journal of Immunology. 193, 5, p. 2135-2146 12 p.

Research output: Contribution to journalArticle

12 Scopus citations
2013

DEC-205-mediated antigen targeting to steady-state dendritic cells induces deletion of diabetogenic CD8+ T cells independently of PD-1 and PD-L1

Mukherjee, G., Geliebter, A., Babad, J., Santamaria, P., Serreze, D. V., Freeman, G. J., Tarbell, K. V., Sharpe, A. & DiLorenzo, T. P., Nov 1 2013, In : International Immunology. 25, 11, p. 651-660 10 p., dxt031.

Research output: Contribution to journalArticle

11 Scopus citations
2012

Beyond HLA-A*0201: New HLA-transgenic nonobese diabetic mouse models of type 1 diabetes identify the insulin C-peptide as a rich source of CD8 + T cell epitopes

Antal, Z., Baker, J. C., Smith, C., Jarchum, I., Babad, J., Mukherjee, G., Yang, Y., Sidney, J., Sette, A., Santamaria, P. & DiLorenzo, T. P., Jun 1 2012, In : Journal of Immunology. 188, 11, p. 5766-5775 10 p.

Research output: Contribution to journalArticle

7 Scopus citations
2011
12 Scopus citations

Structural and functional characterization of a single-chain peptide - MHC molecule that modulates both naive and activated CD8 + T cells

Samanta, D., Mukherjee, G., Ramagopal, U. A., Chaparro, R. J., Nathenson, S. G., DiLorenzo, T. P. & Almo, S. C., Aug 16 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 33, p. 13682-13687 6 p.

Research output: Contribution to journalArticle

11 Scopus citations
2010

An update on the use of NOD mice to study autoimmune (Type 1) diabetes

Chaparro, R. J. & Dilorenzo, T. P., Nov 1 2010, In : Expert Review of Clinical Immunology. 6, 6, p. 939-955 17 p.

Research output: Contribution to journalReview article

40 Scopus citations

Bridging mice to men: Using HLA transgenic mice to enhance the future prediction and prevention of autoimmune type 1 diabetes in humans

Serreze, D. V., Niens, M., Kulik, J. & Dilorenzo, T. P., Dec 1 2010, Mouse Models for Drug Discovery: Methods and Protocols. Proetzel, G. & Wiles, M. (eds.). p. 119-134 16 p. (Methods in Molecular Biology; vol. 602).

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Scopus citations

Ins2 deficiency augments spontaneous HLA-A*0201-restricted T Cell responses to insulin

Jarchum, I. & DiLorenzo, T. P., Jan 15 2010, In : Journal of Immunology. 184, 2, p. 658-665 8 p.

Research output: Contribution to journalArticle

13 Scopus citations

Predominant occupation of the class I MHC molecule H-2Kwm7 with a single self-peptide suggests a mechanism for its diabetes-protective effect

Brims, D. R., Qian, J., Jarchum, I., Mikesh, L., Palmieri, E., Ramagopal, U. A., Malashkevich, V. N., Chaparro, R. J., Lund, T., Hattori, M., Shabanowitz, J., Hunt, D. F., Nathenson, S. G., Almo, S. C. & DiLorenzo, T. P., Jan 21 2010, In : International Immunology. 22, 3, p. 191-203 13 p., dxp127.

Research output: Contribution to journalArticle

2 Scopus citations

T-cell autoantigens in the non-obese diabetic mouse model of autoimmune diabetes

Babad, J., Geliebter, A. & DiLorenzo, T. P., Dec 1 2010, In : Immunology. 131, 4, p. 459-465 7 p.

Research output: Contribution to journalReview article

30 Scopus citations

The benefit of self-control

Santambrogio, L. & Dilorenzo, T. P., Jul 1 2010, In : Immunology and Cell Biology. 88, 5, p. 513-514 2 p.

Research output: Contribution to journalComment/debate

3 Scopus citations

The immunotherapeutic potential of dendritic cells in type 1 diabetes

Mukherjee, G. & Dilorenzo, T. P., Aug 1 2010, In : Clinical and Experimental Immunology. 161, 2, p. 197-207 11 p.

Research output: Contribution to journalReview article

21 Scopus citations
2009

Lentivectors encoding immunosuppressive proteins genetically engineer pancreatic β-cells to correct diabetes in allogeneic mice

Kojaoghlanian, T., Joseph, A., Follenzi, A., Zheng, J. H., Leiser, M., Fleischer, N., Horwitz, M. S., DiLorenzo, T. P. & Goldstein, H., Jan 1 2009, In : Gene Therapy. 16, 3, p. 340-348 9 p.

Research output: Contribution to journalArticle

6 Scopus citations
2008

Efficient culture of CD8+ T cells from the islets of NOD mice and their use for the study of autoreactive specificities

Jarchum, I., Takaki, T. & DiLorenzo, T. P., Nov 30 2008, In : Journal of Immunological Methods. 339, 1, p. 66-73 8 p.

Research output: Contribution to journalArticle

17 Scopus citations

HLA class I supertypes in type 1 diabetic children in an urban children's hospital

Antal, Z., Jarchum, I. & DiLorenzo, T. P., Dec 2008, Immunology of Diabetes V From Bench to Bedside. Blackwell Publishing Inc., p. 86-89 4 p. (Annals of the New York Academy of Sciences; vol. 1150).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Lentiviral vectors encoding human immunodeficiency virus type 1 (HIV-1)-specific T-cell receptor genes efficiently convert peripheral blood CD8 T lymphocytes into cytotoxic T lymphocytes with potent in vitro and in vivo HIV-1-specific inhibitory activity

Joseph, A., Jian, H. Z., Follenzi, A., DiLorenzo, T., Sango, K., Hyman, J., Chen, K., Piechocka-Trocha, A., Brander, C., Hooijberg, E., Vignali, D. A., Walker, B. D. & Goldstein, H., Mar 1 2008, In : Journal of virology. 82, 6, p. 3078-3089 12 p.

Research output: Contribution to journalArticle

69 Scopus citations

Rapid identification of MHC class I-restricted antigens relevant to autoimmune diabetes using retrogenic T cells

Chaparro, R. J., Burton, A. R., Serreze, D. V., Vignali, D. A. A. & DiLorenzo, T. P., Jun 1 2008, In : Journal of Immunological Methods. 335, 1-2, p. 106-115 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

Selective delivery of β cell antigen to dendritic cells in vivo leads to deletion and tolerance of autoreactive CD8+ T cells in NOD mice

Mukhopadhaya, A., Hanafusa, T., Jarchum, I., Chen, Y. G., Iwai, Y., Serreze, D. V., Steinman, R. M., Tarbell, K. V. & DiLorenzo, T. P., Apr 29 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 17, p. 6374-6379 6 p.

Research output: Contribution to journalArticle

101 Scopus citations
2007

Assembly and structural properties of glucocorticoid-induced TNF receptor ligand: Implications for function

Chattopadhyay, K., Ramagopal, U. A., Mukhopadhaya, A., Malashkevich, V. N., DiLorenzo, T. P., Brenowitz, M., Nathenson, S. G. & Almo, S. C., Dec 4 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 49, p. 19452-19457 6 p.

Research output: Contribution to journalArticle

53 Scopus citations

"Humanized" HLA transgenic NOD mice to identify pancreatic β cell autoantigens of potential clinical relevance to type 1 diabetes

Serreze, D. V., Marron, M. P. & DiLorenzo, T. P., Apr 2007, How Do We Best Employ Animal Models for Type 1 Diabetesand Multiple Sclerosis. Blackwell Publishing Inc., p. 103-111 9 p. (Annals of the New York Academy of Sciences; vol. 1103).

Research output: Chapter in Book/Report/Conference proceedingChapter

17 Scopus citations

Improved outcomes in NOD mice treated with a novel Th2 cytokine-biasing NKT cell activator

Forestier, C., Takaki, T., Molano, A., Im, J. S., Baine, I., Jerud, E. S., Illarionov, P., Ndonye, R., Howell, A. R., Santamaria, P., Besra, G. S., DiLorenzo, T. P. & Porcelli, S. A., Feb 1 2007, In : Journal of Immunology. 178, 3, p. 1415-1425 11 p.

Research output: Contribution to journalArticle

Open Access
75 Scopus citations

In vivo cytotoxicity of insulin-specific CD8+ T-cells in HLA-A*0201 transgenic NOD mice

Jarchum, I., Baker, J. C., Yamada, T., Takaki, T., Marron, M. P., Serreze, D. V. & DiLorenzo, T. P., Oct 1 2007, In : Diabetes. 56, 10, p. 2551-2560 10 p.

Research output: Contribution to journalArticle

40 Scopus citations

Structural genomics of protein phosphatases

Almo, S. C., Bonanno, J. B., Sauder, J. M., Emtage, S., Dilorenzo, T. P., Malashkevich, V., Wasserman, S. R., Swaminathan, S., Eswaramoorthy, S., Agarwal, R., Kumaran, D., Madegowda, M., Ragumani, S., Patskovsky, Y., Alvarado, J., Ramagopal, U. A., Faber-Barata, J., Chance, M. R., Sali, A., Fiser, A. & 3 others, Zhang, Z. Y., Lawrence, D. S. & Burley, S. K., Sep 1 2007, In : Journal of Structural and Functional Genomics. 8, 2-3, p. 121-140 20 p.

Research output: Contribution to journalReview article

98 Scopus citations

T Cell Immunoglobulin Mucin-3 Crystal Structure Reveals a Galectin-9-Independent Ligand-Binding Surface

Cao, E., Zang, X., Ramagopal, U. A., Mukhopadhaya, A., Fedorov, A., Fedorov, E., Zencheck, W. D., Lary, J. W., Cole, J. L., Deng, H., Xiao, H., DiLorenzo, T. P., Allison, J. P., Nathenson, S. G. & Almo, S. C., Mar 23 2007, In : Immunity. 26, 3, p. 311-321 11 p.

Research output: Contribution to journalArticle

114 Scopus citations

Translational mini-review series on type 1 diabetes: Systematic analysis of T cell epitopes in autoimmune diabetes

Di Lorenzo, T. P., Peakman, M. & Roep, B. O., Apr 1 2007, In : Clinical and Experimental Immunology. 148, 1, p. 1-16 16 p.

Research output: Contribution to journalShort survey

189 Scopus citations
2006

HLA-A*0201-restricted T cells from humanized NOD mice recognize autoantigens of potential clinical relevance to type 1 diabetes

Takaki, T., Marron, M. P., Mathews, C. E., Guttmann, S. T., Bottino, R., Trucco, M., DiLorenzo, T. P. & Serreze, D. V., Mar 1 2006, In : Journal of Immunology. 176, 5, p. 3257-3265 9 p.

Research output: Contribution to journalArticle

Open Access
88 Scopus citations
1 Scopus citations
2005

Developmental control of CD8+ T cell-avidity maturation in autoimmune diabetes

Han, B., Serra, P., Yamanouchi, J., Amrani, A., Elliott, J. F., Dickie, P., Dilorenzo, T. P. & Santamaria, P., Jul 1 2005, In : Journal of Clinical Investigation. 115, 7, p. 1879-1887 9 p.

Research output: Contribution to journalArticle

88 Scopus citations

The good turned ugly: Immunopathogenic basis for diabetogenic CD8 + T cells in NOD mice

DiLorenzo, T. P. & Serreze, D. V., Apr 1 2005, In : Immunological Reviews. 204, p. 250-263 14 p.

Research output: Contribution to journalReview article

64 Scopus citations
2004

Individual nonobese diabetic mice exhibit unique patterns of CD8 + T cell reactivity to three islet antigens, including the newly identified widely expressed dystrophia myotonica kinase

Lieberman, S. M., Takaki, T., Han, B., Santamaria, P., Serreze, D. V. & DiLorenzo, T. P., Dec 1 2004, In : Journal of Immunology. 173, 11, p. 6727-6734 8 p.

Research output: Contribution to journalArticle

Open Access
99 Scopus citations

MHC Class II Molecules Play a Role in the Selection of Autoreactive Class I-Restricted CD8 T Cells that are Essential Contributors to Type 1 Diabetes Development in Nonobese Diabetic Mice

Serreze, D. V., Holl, T. M., Marron, M. P., Graser, R. T., Johnson, E. A., Choisy-Rossi, C., Slattery, R. M., Lieberman, S. M. & DiLorenzo, T. P., Jan 15 2004, In : Journal of Immunology. 172, 2, p. 871-879 9 p.

Research output: Contribution to journalArticle

Open Access
35 Scopus citations

Requirement for both H-2Db and H-2Kd for the induction of diabetes by the promiscuous CD8+ T cell clonotype AI4

Takaki, T., Lieberman, S. M., Holl, T. M., Han, B., Santamaria, P., Serreze, D. V. & DiLorenzo, T. P., Aug 15 2004, In : Journal of Immunology. 173, 4, p. 2530-2541 12 p.

Research output: Contribution to journalArticle

Open Access
24 Scopus citations
2003

A comprehensive guide to antibody and T-cell responses in type 1 diabetes

Lieberman, S. M. & DiLorenzo, T. P., Nov 1 2003, In : Tissue Antigens. 62, 5, p. 359-377 19 p.

Research output: Contribution to journalReview article

125 Scopus citations

Identification of the β cell antigen targeted by a prevalent population of pathogenic CD8+ T cells in autoimmune diabetes

Lieberman, S. M., Evans, A. M., Han, B., Takaki, T., Vinnitskaya, Y., Caldwell, J. A., Serreze, D. V., Shabanowitz, J., Hunt, D. F., Nathenson, S. G., Santamaria, P. & DiLorenzo, T. P., Jul 8 2003, In : Proceedings of the National Academy of Sciences of the United States of America. 100, 14, p. 8384-8388 5 p.

Research output: Contribution to journalArticle

308 Scopus citations
2002

During the early prediabetic period in NOD mice, the pathogenic CD8+ T-cell population comprises multiple antigenic specificities

DiLorenzo, T. P., Lieberman, S. M., Takaki, T., Honda, S., Chapman, H. D., Santamaria, P., Serreze, D. V. & Nathenson, S. G., Dec 1 2002, In : Clinical Immunology. 105, 3, p. 332-341 10 p.

Research output: Contribution to journalArticle

33 Scopus citations
2001

Autoreactive Diabetogenic T-Cells in NOD Mice Can Efficiently Expand from a Greatly Reduced Precursor Pool

Serreze, D. V., Johnson, E. A., Chapman, H. D., Graser, R. T., Marron, M. P., DiLorenzo, T. P., Silveira, P., Yoshimura, Y., Nathenson, S. G. & Joyce, S., Sep 2001, In : Diabetes. 50, 9, p. 1992-2000 9 p.

Research output: Contribution to journalArticle

Open Access
35 Scopus citations

Hapten addition to an MHC class I-binding peptide causes substantial adjustments of the TCR structure of the responding CD8+ T cells

Honda, S., Zhang, W., Kalergis, A. M., DiLorenzo, T. P., Wang, F. & Nathenson, S. G., Oct 15 2001, In : Journal of Immunology. 167, 8, p. 4276-4285 10 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Immunobiological analysis of TCR single-chain transgenic mice reveals new possibilities for interaction between CDR3α and an antigenic peptide bound to MHC class I

Zhang, W., Honda, S., Wang, F., DiLorenzo, T. P., Kalergis, A. M., Ostrov, D. A. & Nathenson, S. G., Oct 15 2001, In : Journal of Immunology. 167, 8, p. 4396-4404 9 p.

Research output: Contribution to journalArticle

4 Scopus citations
2000

Identification of a CD8 T cell that can independently mediate autoimmune diabetes development in the complete absence of CD4 T cell helper functions

Graser, R. T., DiLorenzo, T. P., Wang, F., Christianson, G. J., Chapman, H. D., Roopenian, D. C., Nathenson, S. G. & Serreze, D. V., Apr 1 2000, In : Journal of Immunology. 164, 7, p. 3913-3918 6 p.

Research output: Contribution to journalArticle

Open Access
121 Scopus citations