• 1466 Citations
  • 17 h-Index
19982019

Research output per year

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Publications

  • 1466 Citations
  • 17 h-Index
  • 29 Article
  • 1 Short survey
  • 1 Review article
2019

The active site of the Mycobacterium tuberculosis branched-chain amino acid biosynthesis enzyme dihydroxyacid dehydratase contains a 2Fe-2S cluster

Bashiri, G., Grove, T. L., Hegde, S. S., Lagautriere, T., Gerfen, G. J., Almo, S. C., Squire, C. J., Blanchard, J. S. & Baker, E. N., Aug 30 2019, In : Journal of Biological Chemistry. 294, 35, p. 13158-13170 13 p.

Research output: Contribution to journalArticle

1 Scopus citations
2017

Identification of mycobacterial RplJ/L10 and RpsA/S1 proteins as novel targets for CD4+ T cells

Johnson, A. J., Kennedy, S. C., Arlehamn, C. S. L., Goldberg, M. F., Saini, N. K., Xu, J., Paul, S., Hegde, S. S., Blanchard, J. S., Chan, J., Jacobs, W. R., Sette, A. & Porcelli, S. A., Apr 1 2017, In : Infection and Immunity. 85, 4, e01023-16.

Research output: Contribution to journalArticle

10 Scopus citations

Mechanistic Characterization of Escherichia coli l -Aspartate Oxidase from Kinetic Isotope Effects

Chow, C., Hegde, S. & Blanchard, J. S., Aug 8 2017, In : Biochemistry. 56, 31, p. 4044-4052 9 p.

Research output: Contribution to journalArticle

1 Scopus citations
2016

Chemical Mechanism of the Branched-Chain Aminotransferase IlvE from Mycobacterium tuberculosis

Amorim Franco, T. M., Hegde, S. & Blanchard, J. S., Nov 15 2016, In : Biochemistry. 55, 45, p. 6295-6303 9 p.

Research output: Contribution to journalArticle

9 Scopus citations
2011
19 Scopus citations

Reversible acetylation and inactivation of Mycobacterium tuberculosis acetyl-CoA synthetase is dependent on cAMP

Xu, H., Hegde, S. S. & Blanchard, J. S., Jul 5 2011, In : Biochemistry. 50, 26, p. 5883-5892 10 p.

Research output: Contribution to journalArticle

70 Scopus citations

Structural and biochemical analysis of the pentapeptide repeat protein EfsQnr, a potent DNA gyrase inhibitor

Hegde, S. S., Vetting, M. W., Mitchenall, L. A., Maxwell, A. & Blanchard, J. S., Jan 1 2011, In : Antimicrobial Agents and Chemotherapy. 55, 1, p. 110-117 8 p.

Research output: Contribution to journalArticle

30 Scopus citations

Structure of QnrB1, a plasmid-mediated fluoroquinolone resistance factor

Vetting, M. W., Hegde, S. S., Wang, M., Jacoby, G. A., Hooper, D. C. & Blanchard, J. S., Jul 15 2011, In : Journal of Biological Chemistry. 286, 28, p. 25265-25273 9 p.

Research output: Contribution to journalArticle

43 Scopus citations
2010

Kinetics and inhibition of nicotinamidase from mycobacterium tuberculosis

Seiner, D. R., Hegde, S. S. & Blanchard, J. S., Nov 9 2010, In : Biochemistry. 49, 44, p. 9613-9619 7 p.

Research output: Contribution to journalArticle

22 Scopus citations

The structure and mechanism of the Mycobacterium tuberculosis cyclodityrosine synthetase

Vetting, M. W., Hegde, S. S. & Blanchard, J. S., Nov 2010, In : Nature Chemical Biology. 6, 11, p. 797-799 3 p.

Research output: Contribution to journalArticle

48 Scopus citations

Unusual structural characteristics of the Mycobacterium tuberculosis pentapeptide repeat protein MfpA

Khrapunov, S., Cheng, H., Hegde, S., Blanchard, J. & Brenowitz, M., Jul 26 2010, In : Spectroscopy. 24, 3-4, p. 339-341 3 p.

Research output: Contribution to journalArticle

2009
12 Scopus citations
2008

Mechanistic and structural analysis of aminoglycoside N-acetyltransferase AAC(6′)-Ib and its bifunctional, fluoroquinolone-active AAC(6′)-Ib-cr variant

Vetting, M. W., Chi, H. P., Hegde, S. S., Jacoby, G. A., Hooper, D. C. & Blanchard, J. S., Sep 16 2008, In : Biochemistry. 47, 37, p. 9825-9835 11 p.

Research output: Contribution to journalArticle

78 Scopus citations

Solution structure and refolding of the Mycobacterium tuberculosis pentapeptide repeat protein MfpA

Khrapunov, S., Cheng, H., Hegde, S., Blanchard, J. & Brenowitz, M., Dec 26 2008, In : Journal of Biological Chemistry. 283, 52, p. 36290-36299 10 p.

Research output: Contribution to journalArticle

8 Scopus citations
2007

Mechanistic and structural analysis of human spermidine/spermine N 1-acetyltransferase

Hegde, S. S., Chandler, J., Vetting, M. W., Yu, M. & Blanchard, J. S., Jun 19 2007, In : Biochemistry. 46, 24, p. 7187-7195 9 p.

Research output: Contribution to journalArticle

29 Scopus citations
27 Scopus citations
2006

Pentapeptide repeat proteins

Vetting, M. W., Hegde, S. S., Fajardo, J. E., Fiser, A., Roderick, S. L., Takiff, H. E. & Blanchard, J. S., Jan 10 2006, In : Biochemistry. 45, 1, p. 1-10 10 p.

Research output: Contribution to journalReview article

114 Scopus citations
2005

Biochemistry: A fluoroquinolone resistance protein from Mycobacterium tuberculosis that mimics DNA

Hegde, S. S., Vetting, M. W., Roderick, S. L., Mitchenall, L. A., Maxwell, A., Takiff, H. E. & Blanchard, J. S., Jun 3 2005, In : Science. 308, 5727, p. 1480-1483 4 p.

Research output: Contribution to journalArticle

191 Scopus citations

Structure and functions of the GNAT superfamily of acetyltransferases

Vetting, M. W., Luiz, L. P., Yu, M., Hegde, S. S., Magnet, S., Roderick, S. L. & Blanchard, J. S., Jan 1 2005, In : Archives of Biochemistry and Biophysics. 433, 1, p. 212-226 15 p.

Research output: Contribution to journalShort survey

389 Scopus citations
2003
32 Scopus citations

Structural changes enhance the activity of Chainia xylanase in low urea concentrations

Kumar, A. R., Hegde, S. S., Ganesh, K. N. & Khan, M. I., Feb 21 2003, In : Biochimica et Biophysica Acta - Proteins and Proteomics. 1645, 2, p. 164-171 8 p.

Research output: Contribution to journalArticle

6 Scopus citations

What can structure tell us about in vivo function? The case of aminoglycoside-resistance genes

Vetting, M., Roderick, S. L., Hegde, S., Magnet, S. & Blanchard, J. S., Jun 1 2003, In : Biochemical Society transactions. 31, 3, p. 520-522 3 p.

Research output: Contribution to journalArticle

8 Scopus citations
2002

Aminoglycoside 2′-n-acetyltransferase from mycobacterium tuberculosis in complex with coenzyme a and aminoglycoside substrates

Vetting, M. W., Hegde, S. S., Javid-Majd, F., Blanchard, J. S. & Roderick, S. L., Sep 2002, In : Nature structural biology. 9, 9, p. 653-658 6 p.

Research output: Contribution to journalArticle

110 Scopus citations
39 Scopus citations
2001

FemABX Family Members are Novel Nonribosomal Peptidyltransferases and Important Pathogen-specific Drug Targets

Hegde, S. S. & Shrader, T. E., Mar 9 2001, In : Journal of Biological Chemistry. 276, 10, p. 6998-7003 6 p.

Research output: Contribution to journalArticle

75 Scopus citations
65 Scopus citations
1999

Crystallization and preliminary X-ray diffraction studies of a Bowman-Birk inhibitor from Vigna unguiculata seeds

Rao, K. N., Hegde, S. S., Lewis, R. J. & Suresh, C. G., Nov 1 1999, In : Acta Crystallographica Section D: Biological Crystallography. 55, 11, p. 1920-1922 3 p.

Research output: Contribution to journalArticle

7 Scopus citations

Role of arginine in substrate binding and tryptophan microenvironment of endoxylanase from Chainia sp. (NCL 82-5-1)

Hegde, S. S., Kumar, A. R., Ganesh, K. N. & Khan, M. I., Jan 1 1999, In : Journal of Biochemistry, Molecular Biology and Biophysics. 2, 4, p. 249-258 10 p.

Research output: Contribution to journalArticle

1 Scopus citations
1998

Catalytic thiol and carboxylate: Role of cysteine and glutamic acid in the xylosidic activity of endoxylanase from Chainia sp. (NCL 82-5-1)

Subray, S. H., Ameeta, R. K., Krishna, N. G. & Khan, I. M., Jul 15 1998, In : Archives of Biochemistry and Biophysics. 355, 2, p. 153-159 7 p.

Research output: Contribution to journalArticle

7 Scopus citations

Purification and characterization of an extracellular endo-xylanase from an actinomycete Chainia sp.

Hegde, S. S., Kumar, A. R., Suresh, C. G., Kotwal, S. M., Ganesh, K. N. & Khan, M. I., Jun 10 1998, In : Journal of Biochemistry, Molecular Biology and Biophysics. 1, 3, p. 171-179 9 p.

Research output: Contribution to journalArticle

3 Scopus citations
12 Scopus citations