• 3906 Citations
  • 28 h-Index
1988 …2019

Research output per year

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Publications

  • 3906 Citations
  • 28 h-Index
  • 37 Article
  • 3 Review article
  • 1 Chapter
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Article
2019
Open Access
1 Scopus citations

Optogenetic control of cofilin and αTAT in living cells using Z-lock

Stone, O. J., Pankow, N., Liu, B., Sharma, V. P., Eddy, R. J., Wang, H., Putz, A. T., Teets, F. D., Kuhlman, B., Condeelis, J. S. & Hahn, K. M., Dec 1 2019, In : Nature Chemical Biology. 15, 12, p. 1183-1190 8 p.

Research output: Contribution to journalArticle

3 Scopus citations
2017

Blood vessel endothelium-directed tumor cell streaming in breast tumors requires the HGF/C-Met signaling pathway

Leung, E., Xue, A., Wang, Y., Rougerie, P., Sharma, V. P., Eddy, R., Cox, D. & Condeelis, J., May 11 2017, In : Oncogene. 36, 19, p. 2680-2692 13 p.

Research output: Contribution to journalArticle

24 Scopus citations

Tumor Cell Invadopodia: Invasive Protrusions that Orchestrate Metastasis

Eddy, R. J., Weidmann, M. D., Sharma, V. P. & Condeelis, J. S., 2017, (Accepted/In press) In : Trends in Cell Biology.

Research output: Contribution to journalArticle

76 Scopus citations
2016

Macrophage-dependent tumor cell transendothelial migration is mediated by Notch1/Mena INV-initiated invadopodium formation

Pignatelli, J., Bravo-Cordero, J. J., Roh-Johnson, M., Gandhi, S. J., Wang, Y., Chen, X., Eddy, R. J., Xue, A., Singer, R. H., Hodgson, L., Oktay, M. H. & Condeelis, J. S., Nov 30 2016, In : Scientific Reports. 6, 37874.

Research output: Contribution to journalArticle

26 Scopus citations

MenaINV dysregulates cortactin phosphorylation to promote invadopodium maturation

Weidmann, M. D., Surve, C. R., Eddy, R. J., Chen, X., Gertler, F. B., Sharma, V. P. & Condeelis, J. S., Nov 8 2016, In : Scientific reports. 6, 36142.

Research output: Contribution to journalArticle

17 Scopus citations
2015

PTP1B-dependent regulation of receptor tyrosine kinase signaling by the actin-binding protein Mena

Hughes, S. K., Oudin, M. J., Tadros, J., Neil, J., Del Rosario, A., Joughin, B. A., Ritsma, L., Wyckoff, J., Vasile, E., Eddy, R. J., Philippar, U., Lussiez, A., Condeelis, J. S., Van Rheenen, J., White, F., Lauffenburger, D. A. & Gertler, F. B., Nov 1 2015, In : Molecular Biology of the Cell. 26, 21, p. 3867-3878 12 p.

Research output: Contribution to journalArticle

19 Scopus citations
2014
6 Scopus citations
2013

Spatial regulation of RhoC activity defines protrusion formation in migrating cells

Bravo-Cordero, J. J., Sharma, V. P., Roh-Johnson, M., Chen, X., Eddy, R., Condeelis, J. & Hodgson, L., Sep 9 2013, In : Journal of cell science. 126, 15, p. 3356-3369 14 p.

Research output: Contribution to journalArticle

35 Scopus citations

Tks5 and SHIP2 regulate invadopodium maturation, but not initiation, in breast carcinoma cells

Sharma, V. P., Eddy, R., Entenberg, D., Kai, M., Gertler, F. B. & Condeelis, J., Nov 4 2013, In : Current Biology. 23, 21, p. 2079-2089 11 p.

Research output: Contribution to journalArticle

82 Scopus citations

β1 integrin regulates Arg to promote invadopodial maturation and matrix degradation

Beaty, B. T., Sharma, V. P., Bravo-Cordero, J. J., Simpson, M. A., Eddy, R. J., Koleske, A. J. & Condeelis, J., Jun 1 2013, In : Molecular biology of the cell. 24, 11, p. 1661-1675 15 p.

Research output: Contribution to journalArticle

80 Scopus citations
2011

A novel spatiotemporal RhoC activation pathway locally regulates cofilin activity at invadopodia

Bravo-Cordero, J. J., Oser, M., Chen, X., Eddy, R., Hodgson, L. & Condeelis, J., Apr 26 2011, In : Current Biology. 21, 8, p. 635-644 10 p.

Research output: Contribution to journalArticle

111 Scopus citations
2009

N-WASP and cortactin are involved in invadopodium-dependent chemotaxis to EGF in breast tumor cells

DesMarais, V., Yamaguchi, H., Oser, M., Soon, L., Mouneimne, G., Sarmiento, C., Eddy, R. & Condeelis, J., Jun 1 2009, In : Cell motility and the cytoskeleton. 66, 6, p. 303-316 14 p.

Research output: Contribution to journalArticle

79 Scopus citations

Unbalancing the phosphatidylinositol-4,5-bisphosphate-cofilin interaction impairs cell steering

Leyman, S., Sidani, M., Ritsma, L., Waterschoot, D., Eddy, R., Dewitte, D., Debeir, O., Decaestecker, C., Vandekerckhove, J., Van Rheenen, J., Ampe, C., Condeelis, J. & Van Troys, M., Dec 1 2009, In : Molecular biology of the cell. 20, 21, p. 4509-4523 15 p.

Research output: Contribution to journalArticle

23 Scopus citations
2008

Cofilin is a pH sensor for actin free barbed end formation: role of phosphoinositide binding

Frantz, C., Barreiro, G., Dominguez, L., Chen, X., Eddy, R., Condeelis, J., Kelly, M. J. S., Jacobson, M. P. & Barber, D. L., Dec 1 2008, In : Journal of Cell Biology. 183, 5, p. 865-879 15 p.

Research output: Contribution to journalArticle

125 Scopus citations

Quantification of PtdIns(3,4,5)P3 dynamics in EGF-stimulated carcinoma cells: A comparison of PH-domain-mediated methods with immunological methods

Yip, S. C., Eddy, R. J., Branch, A. M., Pang, H., Wu, H., Yan, Y., Drees, B. E., Neilsen, P. O., Condeelis, J. & Backer, J. M., Apr 15 2008, In : Biochemical Journal. 411, 2, p. 441-448 8 p.

Research output: Contribution to journalArticle

24 Scopus citations
2007

Cofilin determines the migration behavior and turning frequency of metastatic cancer cells

Sidani, M., Wessels, D., Mouneimne, G., Ghosh, M., Goswami, S., Sarmiento, C., Wang, W., Kuhl, S., El-Sibai, M., Backer, J. M., Eddy, R., Soll, D. & Condeelis, J., Nov 19 2007, In : Journal of Cell Biology. 179, 4, p. 777-791 15 p.

Research output: Contribution to journalArticle

132 Scopus citations

EGF-induced PIP2 hydrolysis releases and activates cofilin locally in carcinoma cells

Van Rheenen, J., Song, X., Van Roosmalen, W., Cammer, M., Chen, X., DesMarais, V., Yip, S. C., Backer, J. M., Eddy, R. J. & Condeelis, J. S., Dec 17 2007, In : Journal of Cell Biology. 179, 6, p. 1247-1259 13 p.

Research output: Contribution to journalArticle

179 Scopus citations

The distinct roles of Ras and Rac in PI 3-kinase-dependent protrusion during EGF-stimulated cell migration

Yip, S. C., El-Sibai, M., Coniglio, S. J., Mouneimne, G., Eddy, R. J., Drees, B. E., Neilsen, P. O., Goswami, S., Symons, M., Condeelis, J. S. & Backer, J. M., Sep 1 2007, In : Journal of cell science. 120, 17, p. 3138-3146 9 p.

Research output: Contribution to journalArticle

51 Scopus citations
2006

Initiation of cofilin activity in response to EGF is uncoupled from cofilin phosphorylation and dephosphorylation in carcinoma cells

Song, X., Chen, X., Yamaguchi, H., Mouneimne, G., Condeelis, J. S. & Eddy, R. J., Jul 15 2006, In : Journal of cell science. 119, 14, p. 2871-2881 11 p.

Research output: Contribution to journalArticle

79 Scopus citations

Spatial and Temporal Control of Cofilin Activity Is Required for Directional Sensing during Chemotaxis

Mouneimne, G., DesMarais, V., Sidani, M., Scemes, E., Wang, W., Song, X., Eddy, R. & Condeelis, J., Nov 21 2006, In : Current Biology. 16, 22, p. 2193-2205 13 p.

Research output: Contribution to journalArticle

131 Scopus citations
2005

A neural Wiskott-Aldrich syndrome protein-mediated pathway for localized activation of actin polymerization that is regulated by cortactin

Kempiak, S. J., Yamaguchi, H., Sarmiento, C., Sidani, M., Ghosh, M., Eddy, R. J., DesMarais, V., Way, M., Condeelis, J. & Segall, J. E., Feb 18 2005, In : Journal of Biological Chemistry. 280, 7, p. 5836-5842 7 p.

Research output: Contribution to journalArticle

50 Scopus citations

Cofilin takes the lead

DesMarais, V., Ghosh, M., Eddy, R. & Condeelis, J., Jan 1 2005, In : Journal of cell science. 118, 1, p. 19-26 8 p.

Research output: Contribution to journalArticle

231 Scopus citations

Molecular mechanisms of invadopodium formation: The role of the N-WASP-Arp2/3 complex pathway and cofilin

Yamaguchi, H., Lorenz, M., Kempiak, S., Sarmiento, C., Coniglio, S., Symons, M., Segall, J., Eddy, R., Miki, H., Takenawa, T. & Condeelis, J., Jan 31 2005, In : Journal of Cell Biology. 168, 3, p. 441-452 12 p.

Research output: Contribution to journalArticle

468 Scopus citations
2004

Phospholipase C and cofilin are required for carcinoma cell directionality in response to EGF stimulation

Mouneimne, G., Soon, L., DesMarais, V., Sidani, M., Song, X., Yip, S. C., Ghosh, M., Eddy, R., Backer, J. M. & Condeelis, J., Aug 30 2004, In : Journal of Cell Biology. 166, 5, p. 697-708 12 p.

Research output: Contribution to journalArticle

191 Scopus citations
2003

Membrane lipid organization is critical for human neutrophil polarization

Pierini, L. M., Eddy, R. J., Fuortes, M., Seveau, S., Casulo, C. & Maxfield, F. R., Mar 21 2003, In : Journal of Biological Chemistry. 278, 12, p. 10831-10841 11 p.

Research output: Contribution to journalArticle

122 Scopus citations
2002

Microtubule asymmetry during neutrophil polarization and migration

Eddy, R. J., Pierini, L. M. & Maxfield, F. R., Dec 1 2002, In : Molecular biology of the cell. 13, 12, p. 4470-4483 14 p.

Research output: Contribution to journalArticle

58 Scopus citations
2001

Cytoskeleton-dependent membrane domain segregation during neutrophil polarization

Seveau, S., Eddy, R. J., Maxfield, F. R. & Pierini, L. M., Jan 1 2001, In : Molecular biology of the cell. 12, 11, p. 3550-3562 13 p.

Research output: Contribution to journalArticle

100 Scopus citations

The Uptake and Degradation of Matrix-bound Lipoproteins by Macrophages Require an Intact Actin Cytoskeleton, Rho Family GTPases, and Myosin ATPase Activity

Sakr, S. W., Eddy, R. J., Barth, H., Wang, F., Greenberg, S., Maxfield, F. R. & Tabas, I., Oct 5 2001, In : Journal of Biological Chemistry. 276, 40, p. 37649-37658 10 p.

Research output: Contribution to journalArticle

51 Scopus citations
2000

Ca2+-dependent myosin II activation is required for uropod retraction during neutrophil migration

Eddy, R. J., Pierini, L. M., Matsumura, F. & Maxfield, F. R., Jan 1 2000, In : Journal of cell science. 113, 7, p. 1287-1298 12 p.

Research output: Contribution to journalArticle

166 Scopus citations
1997

Capping protein terminates but does not initiate chemoattractant- induced actin assembly in Dictyostelium

Eddy, R. J., Han, J. & Condeelis, J. S., Dec 1 1997, In : Journal of Cell Biology. 139, 5, p. 1243-1253 11 p.

Research output: Contribution to journalArticle

55 Scopus citations
1996

A major agonist-regulated capping activity in Dictyostelium is due to the capping protein, cap32/34

Eddy, R. J., Jinghua, H., Sauterer, R. A. & Condeelis, J. S., Dec 12 1996, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1314, 3, p. 247-259 13 p.

Research output: Contribution to journalArticle

9 Scopus citations
1993

Aginactin, an agonist-regulated F-actin capping activity is associated with an Hsc70 in Dictyostelium

Eddy, R. J., Sauterer, R. A. & Condeelis, J. S., Jan 1 1993, In : Journal of Biological Chemistry. 268, 31, p. 23267-23274 8 p.

Research output: Contribution to journalArticle

16 Scopus citations
1992

Fibroblast contraction occurs on release of tension in attached collagen lattices: Dependency on an organized actin cytoskeleton and serum

Tomasek, J. J., Haaksma, C. J., Eddy, R. J. & Vaughan, M. B., Mar 1992, In : The Anatomical Record. 232, 3, p. 359-368 10 p.

Research output: Contribution to journalArticle

192 Scopus citations
1991

Purification and characterization of aginactin, a newly identified agonist-regulated actin-capping protein from Dictyostelium amoebae

Sauterer, R. A., Eddy, R. J., Hall, A. L. & Condeelis, J. S., Dec 1 1991, In : Journal of Biological Chemistry. 266, 36, p. 24533-24539 7 p.

Research output: Contribution to journalArticle

26 Scopus citations
1990

Mechanisms of amoeboid chemotaxis: An evaluation of the cortical expansion model

Condeelis, J., Bresnick, A., Demma, M., Dharmawardhane, S., Eddy, R., Hall, A. L., Sauterer, R. & Warren, V., 1990, In : Developmental Genetics. 11, 5-6, p. 333-340 8 p.

Research output: Contribution to journalArticle

53 Scopus citations
1988

Evidence for the nonmuscle nature of the 'myofibroblast' of granulation tissue and hypertropic scar: An immunofluorescence study

Eddy, R. J., Petro, J. A. & Tomasek, J. J., Jan 1 1988, In : American Journal of Pathology. 130, 2, p. 252-260 9 p.

Research output: Contribution to journalArticle

112 Scopus citations