• 6138 Citations
  • 40 h-Index
1969 …2019
If you made any changes in Pure, your changes will be visible here soon.

Publications 1969 2019

  • 6138 Citations
  • 40 h-Index
  • 163 Article
  • 4 Conference contribution
  • 2 Chapter
  • 2 Conference article
Filter
Article
2019
1 Citation (Scopus)

Active-Site Glu165 Activation in Triosephosphate Isomerase and Its Deprotonation Kinetics

Deng, H., Dyer, R. B. & Callender, R., May 16 2019, In : Journal of Physical Chemistry B. 123, 19, p. 4230-4241 12 p.

Research output: Contribution to journalArticle

Triose-Phosphate Isomerase
Deprotonation
Catalytic Domain
phosphates
Phosphates

Computational Studies of Catalytic Loop Dynamics in Yersinia Protein Tyrosine Phosphatase Using Pathway Optimization Methods

Deng, H., Ke, S., Callender, R., Balakrishnan, G., Spiro, T. G., May, E. R. & Brooks, C. L., Jan 1 2019, (Accepted/In press) In : Journal of Physical Chemistry B.

Research output: Contribution to journalArticle

Protein Tyrosine Phosphatases
phosphatases
tyrosine
Energy barriers
Phosphatases

Effect of Protein Isotope Labeling on the Catalytic Mechanism of Lactate Dehydrogenase

Egawa, T., Deng, H., Chang, E. & Callender, R., Jan 1 2019, (Accepted/In press) In : Journal of Physical Chemistry B.

Research output: Contribution to journalArticle

lactates
dehydrogenases
L-Lactate Dehydrogenase
Isotopes
Labeling
Enzyme kinetics
enzymatic reactions
Enzymes
Kinetics
kinetics
2018
3 Citations (Scopus)
pyruvates
tryptophan
Solvation
conjugation
Pyruvic Acid
2017
2 Citations (Scopus)

Difference FTIR Studies of Substrate Distribution in Triosephosphate Isomerase

Deng, H., Vedad, J., Desamero, R. Z. B. & Callender, R., Nov 2 2017, In : Journal of Physical Chemistry B. 121, 43, p. 10036-10045 10 p.

Research output: Contribution to journalArticle

Dihydroxyacetone Phosphate
Triose-Phosphate Isomerase
Fourier Transform Infrared Spectroscopy
phosphates
Phosphates
5 Citations (Scopus)
nicotinamide
lactates
dehydrogenases
adenines
L-Lactate Dehydrogenase
4 Citations (Scopus)

Resolution of Submillisecond Kinetics of Multiple Reaction Pathways for Lactate Dehydrogenase

Reddish, M. J., Callender, R. & Dyer, R. B., May 9 2017, In : Biophysical Journal. 112, 9, p. 1852-1862 11 p.

Research output: Contribution to journalArticle

L-Lactate Dehydrogenase
Temperature
Enzymes
Microfluidics
Signal-To-Noise Ratio
6 Citations (Scopus)

Thermodynamic and Structural Adaptation Differences between the Mesophilic and Psychrophilic Lactate Dehydrogenases

Khrapunov, S., Chang, E. & Callender, R., Jul 18 2017, In : Biochemistry. 56, 28, p. 3587-3595 9 p.

Research output: Contribution to journalArticle

Lactate Dehydrogenases
Thermodynamics
Substrates
Enzymes
Perciformes
2016
3 Citations (Scopus)

Active-Loop Dynamics within the Michaelis Complex of Lactate Dehydrogenase from Bacillus stearothermophilus

Nie, B., Lodewyks, K., Deng, H., Desamero, R. Z. B. & Callender, R., Jul 12 2016, In : Biochemistry. 55, 27, p. 3803-3814 12 p.

Research output: Contribution to journalArticle

Geobacillus stearothermophilus
Bacilli
L-Lactate Dehydrogenase
Catalytic Domain
NAD
2015
6 Citations (Scopus)

Mechanism of Thermal Adaptation in the Lactate Dehydrogenases

Peng, H. L., Egawa, T., Chang, E., Deng, H. & Callender, R., Dec 10 2015, In : Journal of Physical Chemistry B. 119, 49, p. 15256-15262 7 p.

Research output: Contribution to journalArticle

Lactate Dehydrogenases
lactates
dehydrogenases
swine
L-Lactate Dehydrogenase
45 Citations (Scopus)

The dynamical nature of enzymatic catalysis

Callender, R. & Dyer, R. B., Feb 17 2015, In : Accounts of Chemical Research. 48, 2, p. 407-413 7 p.

Research output: Contribution to journalArticle

Catalysis
Conformations
Proteins
Vibrational spectroscopy
Enzymes
2014
22 Citations (Scopus)

Direct evidence of catalytic heterogeneity in lactate dehydrogenase by temperature jump infrared spectroscopy

Reddish, M. J., Peng, H. L., Deng, H., Panwar, K. S., Callender, R. & Dyer, R. B., Aug 22 2014, In : Journal of Physical Chemistry B. 118, 37, p. 10854-10862 9 p.

Research output: Contribution to journalArticle

lactates
dehydrogenases
L-Lactate Dehydrogenase
enzymes
Infrared spectroscopy
21 Citations (Scopus)

Energy landscape of the michaelis complex of lactate dehydrogenase: Relationship to catalytic mechanism

Peng, H. L., Deng, H., Dyer, R. B. & Callender, R., Mar 25 2014, In : Biochemistry. 53, 11, p. 1849-1857 9 p.

Research output: Contribution to journalArticle

Pyruvic Acid
L-Lactate Dehydrogenase
NAD
Lactic Acid
Observation
2013
14 Citations (Scopus)

Large scale dynamics of the michaelis complex in Bacillus stearothermophilus lactate dehydrogenase revealed by a single-tryptophan mutant study

Nie, B., Deng, H., Desamero, R. & Callender, R., Mar 19 2013, In : Biochemistry. 52, 11, p. 1886-1892 7 p.

Research output: Contribution to journalArticle

Geobacillus stearothermophilus
Bacilli
L-Lactate Dehydrogenase
Tryptophan
Catalytic Domain
2012
5 Citations (Scopus)
Protein Tyrosine Phosphatases
phosphatases
tyrosine
Phosphatases
Enzymes
2011
20 Citations (Scopus)

Conformational heterogeneity within the Michaelis complex of lactate dehydrogenase

Deng, H., Vu, D. V., Clinch, K., Desamero, R., Dyer, R. B. & Callender, R., Jun 16 2011, In : Journal of Physical Chemistry B. 115, 23, p. 7670-7678 9 p.

Research output: Contribution to journalArticle

lactates
dehydrogenases
L-Lactate Dehydrogenase
pyruvates
Pyruvic Acid
22 Citations (Scopus)

Effect of osmolytes on protein dynamics in the lactate dehydrogenase- catalyzed reaction

Zhadin, N. & Callender, R., Mar 15 2011, In : Biochemistry. 50, 10, p. 1582-1589 8 p.

Research output: Contribution to journalArticle

L-Lactate Dehydrogenase
Urea
Pyruvic Acid
Hydrides
Enthalpy
2010
12 Citations (Scopus)

Pyrophosphate activation in hypoxanthine-guanine phosphoribosyltransferase with transition state analogue

Deng, H., Callender, R., Schramm, V. L. & Grubmeyer, C., Mar 30 2010, In : Biochemistry. 49, 12, p. 2705-2714 10 p.

Research output: Contribution to journalArticle

Hypoxanthine Phosphoribosyltransferase
Chemical activation
Phosphates
Conformations
Oxygen
2009
13 Citations (Scopus)

Loop-tryptophan human purine nucleoside phosphorylase reveals submillisecond protein dynamics

Ghanem, M., Zhadin, N., Callender, R. & Schramm, V. L., Apr 28 2009, In : Biochemistry. 48, 16, p. 3658-3668 11 p.

Research output: Contribution to journalArticle

Purine-Nucleoside Phosphorylase
Tryptophan
Catalytic Domain
Fluorescence
Ligands
2008
26 Citations (Scopus)

On the pathway of forming enzymatically productive ligand-protein complexes in lactate dehydrogenase

Deng, H., Brewer, S., Vu, D. M., Clinch, K., Callender, R. & Dyery, R. B., Jul 15 2008, In : Biophysical Journal. 95, 2, p. 804-813 10 p.

Research output: Contribution to journalArticle

L-Lactate Dehydrogenase
NAD
Ligands
Proteins
Isotopes
24 Citations (Scopus)

Probing the role of dynamics in hydride transfer catalyzed by lactate dehydrogenase

Zhadin, N., Gulotta, M. & Callender, R., Aug 15 2008, In : Biophysical Journal. 95, 4, p. 1974-1984 11 p.

Research output: Contribution to journalArticle

Pyruvic Acid
L-Lactate Dehydrogenase
Lactic Acid
NAD
Spectrum Analysis
24 Citations (Scopus)

Tryptophan-free human PNP reveals catalytic site interactions

Ghanem, M., Saen-oon, S., Zhadin, N., Wing, C., Cahill, S. M., Schwartz, S. D., Callender, R. & Schramm, V. L., Mar 11 2008, In : Biochemistry. 47, 10, p. 3202-3215 14 p.

Research output: Contribution to journalArticle

Purine-Nucleoside Phosphorylase
Tryptophan
Catalytic Domain
Guanine
Phosphates
2007
18 Citations (Scopus)

Effects of cell volume regulating osmolytes on glycerol 3-phosphate binding to triosephosphate isomerase

Gulotta, M., Qiu, L., Desamero, R., Rösgen, J., Bolen, D. W. & Callender, R., Sep 4 2007, In : Biochemistry. 46, 35, p. 10055-10062 8 p.

Research output: Contribution to journalArticle

Triose-Phosphate Isomerase
Cell Size
Urea
Salts
Substrates
31 Citations (Scopus)

Lactate dehydrogenase undergoes a substantial structural change to bind its substrate

Qiu, L., Gulotta, M. & Callender, R., Sep 2007, In : Biophysical Journal. 93, 5, p. 1677-1686 10 p.

Research output: Contribution to journalArticle

L-Lactate Dehydrogenase
Temperature
Thermodynamics
NAD
Urea
45 Citations (Scopus)

Ligand binding and protein dynamics in lactate dehydrogenase

Pineda, J. R. E. T., Callender, R. & Schwartz, S. D., Sep 2007, In : Biophysical Journal. 93, 5, p. 1474-1483 10 p.

Research output: Contribution to journalArticle

L-Lactate Dehydrogenase
Carrier Proteins
Ligands
NAD
Protein Conformation
31 Citations (Scopus)

Loop dynamics and ligand binding kinetics in the reaction catalyzed by the Yersinia protein tyrosine phosphatase

Khajehpour, M., Wu, L., Liu, S., Zhadin, N., Zhang, Z. Y. & Callender, R., Apr 10 2007, In : Biochemistry. 46, 14, p. 4370-4378 9 p.

Research output: Contribution to journalArticle

Yersinia
Protein Tyrosine Phosphatases
Ligands
Kinetics
Catalytic Domain
2006
67 Citations (Scopus)

Advances in time-resolved approaches to characterize the dynamical nature of enzymatic catalysis

Callender, R. & Dyer, R. B., Aug 2006, In : Chemical Reviews. 106, 8, p. 3031-3042 12 p.

Research output: Contribution to journalArticle

Catalysis
Lasers
Triose-Phosphate Isomerase
ras Proteins
Enzyme kinetics
2005
24 Citations (Scopus)

Structural transformations in the dynamics of Michaelis complex formation in lactate dehydrogenase

McClendon, S., Vu, D. M., Clinch, K., Callender, R. & Dyer, R. B., Jul 2005, In : Biophysical Journal. 89, 1

Research output: Contribution to journalArticle

L-Lactate Dehydrogenase
Spectrum Analysis
Niacinamide
Isotopes
NAD
43 Citations (Scopus)

The approach to the Michaelis complex in lactate dehydrogenase: The substrate binding pathway

McClendon, S., Zhadin, N. & Callender, R., Sep 2005, In : Biophysical Journal. 89, 3, p. 2024-2032 9 p.

Research output: Contribution to journalArticle

L-Lactate Dehydrogenase
Hydrogen Bonding
NAD
Niacinamide
Enzymes
2004
37 Citations (Scopus)
Purine-Nucleoside Phosphorylase
Nucleophiles
Fourier Transform Infrared Spectroscopy
Catalytic Domain
Phosphates
18 Citations (Scopus)

Active site contacts in the purine nucleoside phosphorylase-hypoxanthine complex by NMR and ab initio calculations

Deng, H., Cahill, S. M., Abad, J. L., Lewandowicz, A., Callender, R., Schramm, V. L. & Jones, R. A., Dec 21 2004, In : Biochemistry. 43, 50, p. 15966-15974 9 p.

Research output: Contribution to journalArticle

Purine-Nucleoside Phosphorylase
Hypoxanthine
Chemical shift
Catalytic Domain
Hydrogen Bonding
11 Citations (Scopus)

Assignment of Downfield Proton Resonances in Purine Nucleoside Phosphorylase·Immucillin-H Complex by Saturation-Transferred NOEs

Deng, H., Lewandowicz, A., Cahill, S. M., Furneaux, R. H., Tyler, P. C., Girvin, M. E., Callender, R. & Schramm, V. L., Feb 24 2004, In : Biochemistry. 43, 7, p. 1980-1987 8 p.

Research output: Contribution to journalArticle

Purine Nucleosides
Protons
Purine-Nucleoside Phosphorylase
Hydrogen bonds
Hydrogen
5 Citations (Scopus)
Enzyme Inhibitors
Protons
Enzymes
Adenosine Deaminase
Hydrogen
2003
79 Citations (Scopus)

Active site loop motion in triosephosphate isomerase: T-jump relaxation spectroscopy of thermal activation

Desamero, R., Rozovsky, S., Zhadin, N., McDermott, A. & Callender, R., Mar 18 2003, In : Biochemistry. 42, 10, p. 2941-2951 11 p.

Research output: Contribution to journalArticle

Triose-Phosphate Isomerase
Enthalpy
Catalytic Domain
Spectrum Analysis
Hot Temperature
26 Citations (Scopus)

Primary folding dynamics of sperm whale apomyoglobin: Core formation

Gulotta, M., Rogatsky, E., Callender, R. & Dyer, R. B., Mar 1 2003, In : Biophysical Journal. 84, 3, p. 1909-1918 10 p.

Research output: Contribution to journalArticle

Sperm Whale
Burial
Temperature
Fluorescence
Circular Dichroism
2002
13 Citations (Scopus)

Determination of the ionization state and catalytic function of Glu-133 in peptide deformylase by difference FTIR spectroscopy

Deng, H., Callender, R., Zhu, J., Nguyen, K. T. & Pei, D., Aug 20 2002, In : Biochemistry. 41, 33, p. 10563-10569 7 p.

Research output: Contribution to journalArticle

peptide deformylase
Fourier Transform Infrared Spectroscopy
Ionization
Spectrum Analysis
Spectroscopy
44 Citations (Scopus)

Environmental effects on phosphoryl group bonding probed by vibrational spectroscopy: Implications for understanding phosphoryl transfer and enzymatic catalysis

Cheng, H., Nikolic-Hughes, I., Wang, J. H., Deng, H., O'Brien, P. J., Wu, L., Zhang, Z. Y., Herschlag, D. & Callender, R., Sep 25 2002, In : Journal of the American Chemical Society. 124, 38, p. 11295-11306 12 p.

Research output: Contribution to journalArticle

Vibrational spectroscopy
Catalysis
Environmental impact
Spectrum Analysis
Dimethyl sulfoxide
1 Citation (Scopus)

Interactions of amidated acids with heparin

Desamero, R. Z. B., Cheng, H., Cahill, S. M., Girvin, M., Deng, H., Callender, R., Rath, P., Variano, B. & Smart, J. E., 2002, In : Biopolymers - Biospectroscopy Section. 67, 1, p. 41-48 8 p.

Research output: Contribution to journalArticle

Heparin
Acids
Point contacts
Drug delivery
Monomers
24 Citations (Scopus)

Is the PTPase - Vanadate complex a true transition state analogue?

Deng, H., Callender, R., Huang, Z. & Zhang, Z. Y., May 7 2002, In : Biochemistry. 41, 18, p. 5865-5872 8 p.

Research output: Contribution to journalArticle

Protein Tyrosine Phosphatases
Vanadates
Enzymes
Yersinia
Kinetics
4 Citations (Scopus)

Physical properties of compounds promoting oral delivery of macromolecular drugs

Desamero, R. Z. B., Cheng, H., Cahill, S. M., Girvin, M., Deng, H., Callender, R., Rath, P., Variano, B. & Smart, J. E., 2002, In : Biopolymers - Biospectroscopy Section. 67, 1, p. 26-40 15 p.

Research output: Contribution to journalArticle

Raman Spectrum Analysis
Amides
Solubility
Biological Availability
Heparin
72 Citations (Scopus)

Probing protein dynamics using temperature jump relaxation spectroscopy

Callender, R. & Dyer, R. B., Oct 1 2002, In : Current Opinion in Structural Biology. 12, 5, p. 628-633 6 p.

Research output: Contribution to journalArticle

Spectrum Analysis
Temperature
Lasers
Proteins
Heating
48 Citations (Scopus)

Toward an understanding of the role of dynamics on enzymatic catalysis in lactate dehydrogenase

Gulotta, M., Deng, H., Deng, H., Dyer, R. B. & Callender, R., Mar 12 2002, In : Biochemistry. 41, 10, p. 3353-3363 11 p.

Research output: Contribution to journalArticle

Catalysis
L-Lactate Dehydrogenase
NAD
Substrates
Catalytic Domain
3 Citations (Scopus)

Vibrational analysis of NADH cofactors bound to glycerol-3-phosphate dehydrogenase and dogfish lactate dehydrogenase

Van Beek, J., Deng, H., Callender, R. & Burgner, J., 2002, In : Journal of Raman Spectroscopy. 33, 5, p. 397-403 7 p.

Research output: Contribution to journalArticle

Glycerolphosphate Dehydrogenase
Glycerol
L-Lactate Dehydrogenase
NAD
Phosphates
12 Citations (Scopus)

Vibrational structure of NAD(P) cofactors bound to three NAD(P) dependent enzymes: An investigation of ground state activation

Chen, Y. Q., Van Beek, J., Deng, H., Burgner, J. & Callender, R., Oct 17 2002, In : Journal of Physical Chemistry B. 106, 41, p. 10733-10740 8 p.

Research output: Contribution to journalArticle

dehydrogenases
NAD
Ground state
enzymes
Hydrogen
2001
39 Citations (Scopus)

Core formation in apomyoglobin: Probing the upper reaches of the folding energy landscape

Gulotta, M., Gilmanshin, R., Buscher, T. C., Callender, R. & Dyer, R. B., May 1 2001, In : Biochemistry. 40, 17, p. 5137-5143 7 p.

Research output: Contribution to journalArticle

Relaxation time
Fluorescence
Burial
Kinetics
Infrared radiation
41 Citations (Scopus)

Dynamics of protein ligand binding on multiple time scales: NADH binding to lactate dehydrogenase

Deng, H., Zhadin, N. & Callender, R., Apr 3 2001, In : Biochemistry. 40, 13, p. 3767-3773 7 p.

Research output: Contribution to journalArticle

L-Lactate Dehydrogenase
Protein Binding
NAD
Ligands
Proteins
27 Citations (Scopus)

Femtosecond dynamics of rhodopsin photochemistry probed by a double pump spectroscopic approach

Yan, M., Rothberg, L. & Callender, R., Feb 1 2001, In : Journal of Physical Chemistry B. 105, 4, p. 856-859 4 p.

Research output: Contribution to journalArticle

Rhodopsin
Photochemical reactions
photochemical reactions
Pumps
pumps
34 Citations (Scopus)

Structures of apomyoglobin's various acid-destabilized forms

Gilmanshin, R., Gulotta, M., Dyer, R. B. & Callender, R., May 1 2001, In : Biochemistry. 40, 17, p. 5127-5136 10 p.

Research output: Contribution to journalArticle

Freezing
Melting
Acids
Fourier Transform Infrared Spectroscopy
Thermodynamics
12 Citations (Scopus)

Vibrational Structure of Dihydrofolate Bound to R67 Dihydrofolate Reductase

Deng, H., Callender, R. & Howell, E., Dec 28 2001, In : Journal of Biological Chemistry. 276, 52, p. 48956-48960 5 p.

Research output: Contribution to journalArticle

Tetrahydrofolate Dehydrogenase
Hydrides
Escherichia coli
Trimethoprim
Enzymes