• 6271 Citations
  • 40 h-Index
1969 …2019

Research output per year

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Publications

2019

Active-Site Glu165 Activation in Triosephosphate Isomerase and Its Deprotonation Kinetics

Deng, H., Dyer, R. B. & Callender, R., May 16 2019, In : Journal of Physical Chemistry B. 123, 19, p. 4230-4241 12 p.

Research output: Contribution to journalArticle

3 Scopus citations

Computational Studies of Catalytic Loop Dynamics in Yersinia Protein Tyrosine Phosphatase Using Pathway Optimization Methods

Deng, H., Ke, S., Callender, R., Balakrishnan, G., Spiro, T. G., May, E. R. & Brooks, C. L., Sep 19 2019, In : Journal of Physical Chemistry B. 123, 37, p. 7840-7851 12 p.

Research output: Contribution to journalArticle

Effect of Protein Isotope Labeling on the Catalytic Mechanism of Lactate Dehydrogenase

Egawa, T., Deng, H., Chang, E. & Callender, R., Nov 21 2019, In : Journal of Physical Chemistry B. 123, 46, p. 9801-9808 8 p.

Research output: Contribution to journalArticle

2018
4 Scopus citations
2017

Difference FTIR Studies of Substrate Distribution in Triosephosphate Isomerase

Deng, H., Vedad, J., Desamero, R. Z. B. & Callender, R., Nov 2 2017, In : Journal of Physical Chemistry B. 121, 43, p. 10036-10045 10 p.

Research output: Contribution to journalArticle

3 Scopus citations
6 Scopus citations

Resolution of Submillisecond Kinetics of Multiple Reaction Pathways for Lactate Dehydrogenase

Reddish, M. J., Callender, R. & Dyer, R. B., May 9 2017, In : Biophysical journal. 112, 9, p. 1852-1862 11 p.

Research output: Contribution to journalArticle

5 Scopus citations

Thermodynamic and Structural Adaptation Differences between the Mesophilic and Psychrophilic Lactate Dehydrogenases

Khrapunov, S., Chang, E. & Callender, R., Jul 18 2017, In : Biochemistry. 56, 28, p. 3587-3595 9 p.

Research output: Contribution to journalArticle

7 Scopus citations
2016

Active-Loop Dynamics within the Michaelis Complex of Lactate Dehydrogenase from Bacillus stearothermophilus

Nie, B., Lodewyks, K., Deng, H., Desamero, R. Z. B. & Callender, R., Jul 12 2016, In : Biochemistry. 55, 27, p. 3803-3814 12 p.

Research output: Contribution to journalArticle

3 Scopus citations
2015

Mechanism of Thermal Adaptation in the Lactate Dehydrogenases

Peng, H. L., Egawa, T., Chang, E., Deng, H. & Callender, R., Dec 10 2015, In : Journal of Physical Chemistry B. 119, 49, p. 15256-15262 7 p.

Research output: Contribution to journalArticle

7 Scopus citations

The dynamical nature of enzymatic catalysis

Callender, R. & Dyer, R. B., Feb 17 2015, In : Accounts of Chemical Research. 48, 2, p. 407-413 7 p.

Research output: Contribution to journalArticle

51 Scopus citations
2014

Direct evidence of catalytic heterogeneity in lactate dehydrogenase by temperature jump infrared spectroscopy

Reddish, M. J., Peng, H. L., Deng, H., Panwar, K. S., Callender, R. & Dyer, R. B., Aug 22 2014, In : Journal of Physical Chemistry B. 118, 37, p. 10854-10862 9 p.

Research output: Contribution to journalArticle

23 Scopus citations

Energy landscape of the michaelis complex of lactate dehydrogenase: Relationship to catalytic mechanism

Peng, H. L., Deng, H., Dyer, R. B. & Callender, R., Mar 25 2014, In : Biochemistry. 53, 11, p. 1849-1857 9 p.

Research output: Contribution to journalArticle

23 Scopus citations
2013

Large scale dynamics of the michaelis complex in Bacillus stearothermophilus lactate dehydrogenase revealed by a single-tryptophan mutant study

Nie, B., Deng, H., Desamero, R. & Callender, R., Mar 19 2013, In : Biochemistry. 52, 11, p. 1886-1892 7 p.

Research output: Contribution to journalArticle

14 Scopus citations
2012
5 Scopus citations
2011

Conformational heterogeneity within the Michaelis complex of lactate dehydrogenase

Deng, H., Vu, D. V., Clinch, K., Desamero, R., Dyer, R. B. & Callender, R., Jun 16 2011, In : Journal of Physical Chemistry B. 115, 23, p. 7670-7678 9 p.

Research output: Contribution to journalArticle

21 Scopus citations

Effect of osmolytes on protein dynamics in the lactate dehydrogenase- catalyzed reaction

Zhadin, N. & Callender, R., Mar 15 2011, In : Biochemistry. 50, 10, p. 1582-1589 8 p.

Research output: Contribution to journalArticle

23 Scopus citations
2010

Pyrophosphate activation in hypoxanthine-guanine phosphoribosyltransferase with transition state analogue

Deng, H., Callender, R., Schramm, V. L. & Grubmeyer, C., Mar 30 2010, In : Biochemistry. 49, 12, p. 2705-2714 10 p.

Research output: Contribution to journalArticle

12 Scopus citations

Raman (and IR) studies of protein structure and dynamics

Deng, H. & Callender, R., Dec 14 2010, XXII International Conference on Raman Spectroscopy, ICORS 2010. p. 281-282 2 p. (AIP Conference Proceedings; vol. 1267).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2009

Loop-tryptophan human purine nucleoside phosphorylase reveals submillisecond protein dynamics

Ghanem, M., Zhadin, N., Callender, R. & Schramm, V. L., Apr 28 2009, In : Biochemistry. 48, 16, p. 3658-3668 11 p.

Research output: Contribution to journalArticle

13 Scopus citations
2008

On the pathway of forming enzymatically productive ligand-protein complexes in lactate dehydrogenase

Deng, H., Brewer, S., Vu, D. M., Clinch, K., Callender, R. & Dyery, R. B., Jul 15 2008, In : Biophysical journal. 95, 2, p. 804-813 10 p.

Research output: Contribution to journalArticle

26 Scopus citations

Probing the role of dynamics in hydride transfer catalyzed by lactate dehydrogenase

Zhadin, N., Gulotta, M. & Callender, R., Aug 15 2008, In : Biophysical journal. 95, 4, p. 1974-1984 11 p.

Research output: Contribution to journalArticle

24 Scopus citations

Tryptophan-free human PNP reveals catalytic site interactions

Ghanem, M., Saen-oon, S., Zhadin, N., Wing, C., Cahill, S. M., Schwartz, S. D., Callender, R. & Schramm, V. L., Mar 11 2008, In : Biochemistry. 47, 10, p. 3202-3215 14 p.

Research output: Contribution to journalArticle

24 Scopus citations
2007

Effects of cell volume regulating osmolytes on glycerol 3-phosphate binding to triosephosphate isomerase

Gulotta, M., Qiu, L., Desamero, R., Rösgen, J., Bolen, D. W. & Callender, R., Sep 4 2007, In : Biochemistry. 46, 35, p. 10055-10062 8 p.

Research output: Contribution to journalArticle

18 Scopus citations

Lactate dehydrogenase undergoes a substantial structural change to bind its substrate

Qiu, L., Gulotta, M. & Callender, R., Sep 2007, In : Biophysical journal. 93, 5, p. 1677-1686 10 p.

Research output: Contribution to journalArticle

33 Scopus citations

Ligand binding and protein dynamics in lactate dehydrogenase

Pineda, J. R. E. T., Callender, R. & Schwartz, S. D., Sep 2007, In : Biophysical Journal. 93, 5, p. 1474-1483 10 p.

Research output: Contribution to journalArticle

48 Scopus citations

Loop dynamics and ligand binding kinetics in the reaction catalyzed by the Yersinia protein tyrosine phosphatase

Khajehpour, M., Wu, L., Liu, S., Zhadin, N., Zhang, Z. Y. & Callender, R., Apr 10 2007, In : Biochemistry. 46, 14, p. 4370-4378 9 p.

Research output: Contribution to journalArticle

32 Scopus citations

Spectroscopic Probes of Hydride Transfer Activation by Enzymes

Callender, R. & Deng, H., Jul 17 2007, Hydrogen-Transfer Reactions. John Wiley and Sons, Vol. 4. p. 1393-1415 23 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations
2006

Advances in time-resolved approaches to characterize the dynamical nature of enzymatic catalysis

Callender, R. & Dyer, R. B., Aug 1 2006, In : Chemical Reviews. 106, 8, p. 3031-3042 12 p.

Research output: Contribution to journalReview article

68 Scopus citations
2005

Structural transformations in the dynamics of Michaelis complex formation in lactate dehydrogenase

McClendon, S., Vu, D. M., Clinch, K., Callender, R. & Dyer, R. B., Jul 2005, In : Biophysical journal. 89, 1, p. L07-L09

Research output: Contribution to journalArticle

24 Scopus citations

The approach to the Michaelis complex in lactate dehydrogenase: The substrate binding pathway

McClendon, S., Zhadin, N. & Callender, R., Sep 2005, In : Biophysical journal. 89, 3, p. 2024-2032 9 p.

Research output: Contribution to journalArticle

44 Scopus citations
2004
37 Scopus citations

Active site contacts in the purine nucleoside phosphorylase-hypoxanthine complex by NMR and ab initio calculations

Deng, H., Cahill, S. M., Abad, J. L., Lewandowicz, A., Callender, R. H., Schramm, V. L. & Jones, R. A., Dec 21 2004, In : Biochemistry. 43, 50, p. 15966-15974 9 p.

Research output: Contribution to journalArticle

18 Scopus citations

Assignment of Downfield Proton Resonances in Purine Nucleoside Phosphorylase·Immucillin-H Complex by Saturation-Transferred NOEs

Deng, H., Lewandowicz, A., Cahill, S. M., Furneaux, R. H., Tyler, P. C., Girvin, M. E., Callender, R. H. & Schramm, V. L., Feb 24 2004, In : Biochemistry. 43, 7, p. 1980-1987 8 p.

Research output: Contribution to journalArticle

11 Scopus citations
5 Scopus citations
2003

Active site loop motion in triosephosphate isomerase: T-jump relaxation spectroscopy of thermal activation

Desamero, R., Rozovsky, S., Zhadin, N., McDermott, A. & Callender, R., Mar 18 2003, In : Biochemistry. 42, 10, p. 2941-2951 11 p.

Research output: Contribution to journalArticle

79 Scopus citations

Primary folding dynamics of sperm whale apomyoglobin: Core formation

Gulotta, M., Rogatsky, E., Callender, R. H. & Dyer, R. B., Mar 1 2003, In : Biophysical journal. 84, 3, p. 1909-1918 10 p.

Research output: Contribution to journalArticle

Open Access
26 Scopus citations
2002

Determination of the ionization state and catalytic function of Glu-133 in peptide deformylase by difference FTIR spectroscopy

Deng, H., Callender, R., Zhu, J., Nguyen, K. T. & Pei, D., Aug 20 2002, In : Biochemistry. 41, 33, p. 10563-10569 7 p.

Research output: Contribution to journalArticle

14 Scopus citations

Environmental effects on phosphoryl group bonding probed by vibrational spectroscopy: Implications for understanding phosphoryl transfer and enzymatic catalysis

Cheng, H., Nikolic-Hughes, I., Wang, J. H., Deng, H., O'Brien, P. J., Wu, L., Zhang, Z. Y., Herschlag, D. & Callender, R., Sep 25 2002, In : Journal of the American Chemical Society. 124, 38, p. 11295-11306 12 p.

Research output: Contribution to journalArticle

44 Scopus citations

Interactions of amidated acids with heparin

Desamero, R. Z. B., Cheng, H., Cahill, S., Girvin, M., Deng, H., Callender, R., Rath, P., Variano, B. & Smart, J. E., 2002, In : Biopolymers - Biospectroscopy Section. 67, 1, p. 41-48 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Is the PTPase - Vanadate complex a true transition state analogue?

Deng, H., Callender, R., Huang, Z. & Zhang, Z. Y., May 7 2002, In : Biochemistry. 41, 18, p. 5865-5872 8 p.

Research output: Contribution to journalArticle

24 Scopus citations

Physical properties of compounds promoting oral delivery of macromolecular drugs

Desamero, R. Z. B., Cheng, H., Cahill, S., Girvin, M., Deng, H., Callender, R., Rath, P., Variano, B. & Smart, J. E., 2002, In : Biopolymers - Biospectroscopy Section. 67, 1, p. 26-40 15 p.

Research output: Contribution to journalArticle

4 Scopus citations

Probing protein dynamics using temperature jump relaxation spectroscopy

Callender, R. & Dyer, R. B., Oct 1 2002, In : Current Opinion in Structural Biology. 12, 5, p. 628-633 6 p.

Research output: Contribution to journalReview article

74 Scopus citations

Toward an understanding of the role of dynamics on enzymatic catalysis in lactate dehydrogenase

Gulotta, M., Deng, H., Deng, H., Dyer, R. B. & Callender, R. H., Mar 12 2002, In : Biochemistry. 41, 10, p. 3353-3363 11 p.

Research output: Contribution to journalArticle

48 Scopus citations

Vibrational analysis of NADH cofactors bound to glycerol-3-phosphate dehydrogenase and dogfish lactate dehydrogenase

Van Beek, J., Deng, H., Callender, R. & Burgner, J., Jul 2 2002, In : Journal of Raman Spectroscopy. 33, 5, p. 397-403 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

Vibrational structure of NAD(P) cofactors bound to three NAD(P) dependent enzymes: An investigation of ground state activation

Chen, Y. Q., Van Beek, J., Deng, H., Burgner, J. & Callender, R., Oct 17 2002, In : Journal of Physical Chemistry B. 106, 41, p. 10733-10740 8 p.

Research output: Contribution to journalArticle

12 Scopus citations
2001

Core formation in apomyoglobin: Probing the upper reaches of the folding energy landscape

Gulotta, M., Gilmanshin, R., Buscher, T. C., Callender, R. H. & Dyer, R. B., May 1 2001, In : Biochemistry. 40, 17, p. 5137-5143 7 p.

Research output: Contribution to journalArticle

39 Scopus citations

Dynamics of protein ligand binding on multiple time scales: NADH binding to lactate dehydrogenase

Deng, H., Zhadin, N. & Callender, R., Apr 3 2001, In : Biochemistry. 40, 13, p. 3767-3773 7 p.

Research output: Contribution to journalArticle

42 Scopus citations

Femtosecond dynamics of rhodopsin photochemistry probed by a double pump spectroscopic approach

Yan, M., Rothberg, L. & Callender, R., Feb 1 2001, In : Journal of Physical Chemistry B. 105, 4, p. 856-859 4 p.

Research output: Contribution to journalArticle

27 Scopus citations