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Richard Seither, Ph.D., M.B.A., M.S.

  • 339 Citations
  • 11 h-Index
19821997
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  • 3 Similar Profiles
Leukemia L1210 Medicine & Life Sciences
Folic Acid Antagonists Chemical Compounds
Trimetrexate Medicine & Life Sciences
Biosynthesis Chemical Compounds
Folic Acid Chemical Compounds
Thymidylate Synthase Chemical Compounds
Paraquat Chemical Compounds
Methotrexate Medicine & Life Sciences

Publications 1982 1997

  • 339 Citations
  • 11 h-Index
  • 21 Article
  • 1 Conference contribution
54 Citations (Scopus)

Impact of overexpression of the reduced folate carrier (RFC1), an anion exchanger, on concentrative transport in murine L1210 leukemia cells

Zhao, R., Seither, R., Brigle, K. E., Sharina, I. G., Wang, P. J. & Goldman, I. D., Aug 22 1997, In : Journal of Biological Chemistry. 272, 34, p. 21207-21212 6 p.

Research output: Contribution to journal › Article

Reduced Folate Carrier Protein
Leukemia L1210
Methotrexate
Anions
Folic Acid

Increased expression and genomic organization of a folate-binding protein homologous to the human placental isoform in L1210 murine leukemia cell lines with a defective reduced folate carrier

Brigle, K. E., Seither, R., Westin, E. H. & Goldman, I. D., Feb 11 1994, In : Journal of Biological Chemistry. 269, 6, p. 4267-4272 6 p.

Research output: Contribution to journal › Article

Reduced Folate Carrier Protein
Leukemia L1210
Folic Acid
Carrier Proteins
Protein Isoforms
1 Citation (Scopus)

Interconversion of tetrahydrofolate cofactors to dihydrofolate induced by trimetrexate after suppression of thymidylate synthase by fluorodeoxyuridine in L1210 leukemia cells

Seither, R., Rape, T. J. & Goldman, I. D., Jun 23 1992, In : Biochemical Pharmacology. 43, 12, p. 2647-2654 8 p.

Research output: Contribution to journal › Article

Trimetrexate
Floxuridine
Leukemia L1210
Thymidylate Synthase
Folic Acid Antagonists
21 Citations (Scopus)

Compartmentation of intracellular folates. Failure to interconvert tetrahydrofolate cofactors to dihydrofolate in mitochondria of L1210 leukemia cells treated with trimetrexate

Trent, D. F., Seither, R. & Goldman, I. D., Aug 8 1991, In : Biochemical Pharmacology. 42, 5, p. 1015-1019 5 p.

Research output: Contribution to journal › Article

Trimetrexate
Leukemia L1210
Mitochondria
Folic Acid
Folic Acid Antagonists

Effect of direct suppression of thymidylate synthase at the 5,10-methylenetetrahydrofolate binding site on the interconversion of tetrahydrofolate cofactors to dihydrofolate by antifolates: Influence of degree of dihydrofolate reductase inhibition

Seither, R., Trent, D. F., Mikulecky, D. C., Rape, T. J. & Goldman, I. D., Mar 5 1991, In : Journal of Biological Chemistry. 266, 7, p. 4112-4118 7 p.

Research output: Contribution to journal › Article

Folic Acid Antagonists
Thymidylate Synthase
Tetrahydrofolate Dehydrogenase
Binding Sites
Trimetrexate