• 4268 Citations
  • 39 h-Index
1977 …2019
If you made any changes in Pure, your changes will be visible here soon.

Publications 1977 2019

  • 4268 Citations
  • 39 h-Index
  • 111 Article
  • 2 Review article
  • 1 Chapter
Filter
Article
2018
1 Citation (Scopus)

Phloretin cytoprotection and toxicity

Geohagen, B. C., Korsharskyy, B., Vydyanatha, A., Nordstroem, L. R. & LoPachin, R. M., Dec 25 2018, In : Chemico-Biological Interactions. 296, p. 117-123 7 p.

Research output: Contribution to journalArticle

Phloretin
Cytoprotection
Toxicity
Acetaminophen
Poisons
2016
3 Citations (Scopus)

Enolate-forming phloretin pharmacophores: Hepatoprotection in an experimental model of drug-induced toxicity

Geohagen, B. C., Vydyanathan, A., Kosharskyy, B., Shaparin, N., Gavin, T. & LoPachin, R. M., Jun 1 2016, In : Journal of Pharmacology and Experimental Therapeutics. 357, 3, p. 476-486 11 p.

Research output: Contribution to journalArticle

Phloretin
Acetaminophen
Drug-Related Side Effects and Adverse Reactions
Phloroglucinol
Theoretical Models
5 Citations (Scopus)

Joint toxic effects of the type-2 alkene electrophiles

Zhang, L., Geohagen, B. C., Gavin, T. & LoPachin, R. M., Jul 25 2016, In : Chemico-Biological Interactions. 254, p. 198-206 9 p.

Research output: Contribution to journalArticle

Poisons
Alkenes
Proteome
Toxicity
Acrolein
16 Citations (Scopus)

Reactions of electrophiles with nucleophilic thiolate sites: Relevance to pathophysiological mechanisms and remediation

LoPachin, R. M. & Gavin, T., Feb 1 2016, In : Free Radical Research. 50, 2, p. 195-205 11 p.

Research output: Contribution to journalArticle

Nucleophiles
Remediation
Acids
Electrons
Hardness
2015
6 Citations (Scopus)

2-Acetylcyclopentanone, an enolate-forming 1,3-dicarbonyl compound, is cytoprotective in warm ischemia-reperfusion injury of rat liver

Kosharskyy, B., Vydyanathan, A., Zhang, L., Shaparin, N., Geohagen, B. C., Bivin, W., Liu, Q., Gavin, T. & LoPachin, R. M., 2015, In : Journal of Pharmacology and Experimental Therapeutics. 353, 1, p. 150-158 9 p.

Research output: Contribution to journalArticle

Warm Ischemia
Reperfusion Injury
Liver
Reperfusion
Oxidative Stress

Letters to the editor: Protein adduct formation initiates acrolein - Induced endothelial cell toxicity

LoPachin, R. M. & Gavin, T., Mar 1 2015, In : Toxicological Sciences. 144, 1, p. 1-3 3 p.

Research output: Contribution to journalArticle

Acrolein
Endothelial cells
Toxicity
Endothelial Cells
Proteins
1 Citation (Scopus)
Acrolein
Vascular Endothelium
MicroRNAs
Cell Movement
Insulin Resistance
14 Citations (Scopus)

Toxic neuropathies: Mechanistic insights based on a chemical perspective

LoPachin, R. M. & Gavin, T., Jun 2 2015, In : Neuroscience Letters. 596, p. 78-83 6 p.

Research output: Contribution to journalArticle

Poisons
Methyl n-Butyl Ketone
Chemical Phenomena
Bromine
Methacrylates
2014
117 Citations (Scopus)

Molecular mechanisms of aldehyde toxicity: A chemical perspective

LoPachin, R. M. & Gavin, T., Jul 21 2014, In : Chemical Research in Toxicology. 27, 7, p. 1081-1091 11 p.

Research output: Contribution to journalArticle

Aldehydes
Toxicity
Alkenes
Derivatives
Nucleophiles
2013
13 Citations (Scopus)

Protective properties of 2-acetylcyclopentanone in a mouse model of acetaminophen hepatotoxicity

Zhang, L., Gavin, T., Geohagen, B. C., Liu, Q., Downey, K. J. & LoPachin, R. M., Aug 2013, In : Journal of Pharmacology and Experimental Therapeutics. 346, 2, p. 259-269 11 p.

Research output: Contribution to journalArticle

Acetaminophen
Acetylcysteine
Oxidative Stress
2-acetylcyclopentanone
Imines
16 Citations (Scopus)

Protein targets of acrylamide adduct formation in cultured rat dopaminergic cells

Martyniuk, C. J., Feswick, A., Fang, B., Koomen, J. M., Barber, D. S., Gavin, T. & LoPachin, R. M., 2013, In : Toxicology Letters. 219, 3, p. 279-287 9 p.

Research output: Contribution to journalArticle

Acrylamide
Rats
Proteins
Proteome
Peptides
2012
127 Citations (Scopus)

Application of the Hard and Soft, Acids and Bases (HSAB) theory to toxicant - Target interactions

LoPachin, R. M., Gavin, T., DeCaprio, A. & Barber, D. S., Feb 20 2012, In : Chemical Research in Toxicology. 25, 2, p. 239-251 13 p.

Research output: Contribution to journalArticle

Nucleophiles
Acids
Covalent bonds
Poisons
Hardness
76 Citations (Scopus)

Molecular mechanism of acrylamide neurotoxicity: Lessons learned from organic chemistry

LoPachin, R. M. & Gavin, T., 2012, In : Environmental Health Perspectives. 120, 12, p. 1650-1657 8 p.

Research output: Contribution to journalArticle

Organic Chemistry
Acrylamide
Alkenes
Oxidative Stress
Acrolein
2011
50 Citations (Scopus)

Molecular mechanism of glyceraldehyde-3-phosphate dehydrogenase inactivation by α,β-unsaturated carbonyl derivatives

Martyniuk, C. J., Fang, B., Koomen, J. M., Gavin, T., Zhang, L., Barber, D. S. & LoPachin, R. M., Dec 19 2011, In : Chemical Research in Toxicology. 24, 12, p. 2302-2311 10 p.

Research output: Contribution to journalArticle

Glyceraldehyde-3-Phosphate Dehydrogenases
Acrylamide
Cysteine
Derivatives
Acrolein
25 Citations (Scopus)

Role of the Nrf2-ARE pathway in acrylamide neurotoxicity

Zhang, L., Gavin, T., Barber, D. S. & LoPachin, R. M., Aug 10 2011, In : Toxicology Letters. 205, 1, p. 1-7 7 p.

Research output: Contribution to journalArticle

Acrylamide
Antioxidants
Proteins
Hepatocytes
Brain
29 Citations (Scopus)

β-Dicarbonyl enolates: A new class of neuroprotectants

LoPachin, R. M., Gavin, T., Geohagen, B. C., Zhang, L., Casper, D., Lekhraj, R. & Barber, D. S., Jan 2011, In : Journal of Neurochemistry. 116, 1, p. 132-143 12 p.

Research output: Contribution to journalArticle

Acrolein
Oxidative stress
Neuroprotective Agents
Aldehydes
Metal ions
2010
17 Citations (Scopus)

γ-diketone axonopathy: Analyses of cytoskeletal motors and highways in CNS myelinated axons

Zhang, L., Gavin, T., DeCaprio, A. P. & LoPachin, R. M., Jun 16 2010, In : Toxicological Sciences. 117, 1, p. 180-189 10 p.

Research output: Contribution to journalArticle

Axons
Microtubules
Dyneins
Proteins
Microtubule-Associated Proteins
2009
9 Citations (Scopus)

Comparative covalent protein binding of 2,5-Hexanedione and 3-Acetyl-2,5-Hexanedione in the rat

DeCaprio, A. P., Kinney, E. A. & LoPachin, R. M., 2009, In : Journal of Toxicology and Environmental Health - Part A: Current Issues. 72, 14, p. 861-869 9 p.

Research output: Contribution to journalArticle

Protein Binding
Rats
Pyrroles
Proteins
Intermediate Filaments
171 Citations (Scopus)

Molecular mechanisms of 4-hydroxy-2-nonenal and acrolein toxicity: Nucleophilic targets and adduct formation

LoPachin, R. M., Gavin, T., Petersen, D. R. & Barber, D. S., Sep 21 2009, In : Chemical Research in Toxicology. 22, 9, p. 1499-1508 10 p.

Research output: Contribution to journalArticle

Acrolein
Toxicity
Electrons
Nucleophiles
Oxidative stress
31 Citations (Scopus)

Synaptosomal toxicity and nucleophilic targets of 4-hydroxy-2-nonenal

LoPachin, R. M., Geohagen, B. C. & Gavin, T., 2009, In : Toxicological Sciences. 107, 1, p. 171-181 11 p.

Research output: Contribution to journalArticle

Toxicity
Corpus Striatum
Nucleophiles
Synaptosomes
Chemical potential
2008
57 Citations (Scopus)

Acrylamide-induced nerve terminal damage: Relevance to neurotoxic and neurodegenerative mechanisms

LoPachin, R. M. & Gavin, T., Aug 13 2008, In : Journal of Agricultural and Food Chemistry. 56, 15, p. 5994-6003 10 p.

Research output: Contribution to journalArticle

Acrylamide
acrylamides
nerve tissue
Synaptic Transmission
acrolein
100 Citations (Scopus)

Molecular mechanisms of the conjugated α,β-unsaturated carbonyl derivatives: Relevance to neurotoxicity and neurodegenerative diseases

LoPachin, R. M., Barber, D. S. & Gavin, T., Aug 2008, In : Toxicological Sciences. 104, 2, p. 235-249 15 p.

Research output: Contribution to journalArticle

Neurodegenerative diseases
Alkenes
Neurodegenerative Diseases
Derivatives
Toxicity
11 Citations (Scopus)

Response to "Paraquat: The Red Herring of Parkinson's Disease Research"

LoPachin, R. M. & Gavin, T., May 2008, In : Toxicological Sciences. 103, 1, p. 219-221 3 p.

Research output: Contribution to journalArticle

Paraquat
Parkinsonian Disorders
Herbicides
Parkinson Disease
Research
32 Citations (Scopus)

Type-2 alkenes mediate synaptotoxicity in neurodegenerative diseases

LoPachin, R. M., Gavin, T. & Barber, D. S., Sep 2008, In : NeuroToxicology. 29, 5, p. 871-882 12 p.

Research output: Contribution to journalArticle

Neurodegenerative diseases
Acrolein
Alkenes
Neurodegenerative Diseases
Derivatives
2007
61 Citations (Scopus)

Neurotoxic mechanisms of electrophilic type-2 Alkenes: Soft-soft interactions described by quantum mechanical parameters

LoPachin, R. M., Gavin, T., Geohagen, B. C. & Das, S., Aug 2007, In : Toxicological Sciences. 98, 2, p. 561-570 10 p.

Research output: Contribution to journalArticle

Alkenes
Acrylamide
Cysteine
Acetylcysteine
Rate constants
41 Citations (Scopus)

Proteomic analysis of rat striatal synaptosomes during acrylamide intoxication at a low dose rate

Barber, D. S., Stevens, S. & LoPachin, R. M., Nov 2007, In : Toxicological Sciences. 100, 1, p. 156-167 12 p.

Research output: Contribution to journalArticle

Corpus Striatum
Synaptosomes
Acrylamide
Proteomics
Isotope Labeling
49 Citations (Scopus)

Structure-toxicity analysis of Type-2 Alkenes: In vitro neurotoxicity

LoPachin, R. M., Barber, D. S., Geohagen, B. C., Gavin, T., He, D. & Das, S., Jan 2007, In : Toxicological Sciences. 95, 1, p. 136-146 11 p.

Research output: Contribution to journalArticle

Acrolein
Acrylamide
Alkenes
Sulfhydryl Compounds
Toxicity
2006
45 Citations (Scopus)

Acrylamide inhibits dopamine uptake in rat striatal synaptic vesicles

LoPachin, R. M., Barber, D. S., He, D. & Das, S., Jan 2006, In : Toxicological Sciences. 89, 1, p. 224-234 11 p.

Research output: Contribution to journalArticle

Corpus Striatum
Acrylamide
Synaptic Vesicles
Rats
Dopamine
85 Citations (Scopus)

Synaptic cysteine sulfhydryl groups as targets of electrophilic neurotoxicants

LoPachin, R. M. & Barber, D. S., Dec 2006, In : Toxicological Sciences. 94, 2, p. 240-255 16 p.

Research output: Contribution to journalArticle

Cysteine
Nitric Oxide
Research
Acrolein
Proteins
2005
30 Citations (Scopus)

2,5-Hexanedione-induced changes in the neurofilament subunit pools of rat peripheral nerve

LoPachin, R. M., He, D. & Reid, M. L., Mar 2005, In : NeuroToxicology. 26, 2, p. 229-240 12 p.

Research output: Contribution to journalArticle

Intermediate Filaments
Peripheral Nerves
Rats
Axons
Atrophy
60 Citations (Scopus)
Acrylamide
Animals
Animal Models
Chemical Industry
Muscle Weakness
110 Citations (Scopus)

Protein adduct formation as a molecular mechanism in neurotoxicity

LoPachin, R. M. & DeCaprio, A. P., Aug 2005, In : Toxicological Sciences. 86, 2, p. 214-225 12 p.

Research output: Contribution to journalArticle

Proteins
Nucleophiles
Covalent bonds
Acrylamide
Xenobiotics
10 Citations (Scopus)

γ-Diketone central neuropathy: Quantitative analyses of cytoskeletal components in myelinated axons of the rat rubrospinal tract

LoPachin, R. M., Jortner, B. S., Reid, M. L. & Monir, A., Dec 2005, In : NeuroToxicology. 26, 6, p. 1021-1030 10 p.

Research output: Contribution to journalArticle

Axons
Rats
Neurofilament Proteins
Intermediate Filaments
Microtubules
2004
25 Citations (Scopus)

2,5-Hexanedione-induced changes in the monomeric neurofilament protein content of rat spinal cord fractions

LoPachin, R. M., He, D., Reid, M. L. & Opanashuk, L. A., Jul 1 2004, In : Toxicology and Applied Pharmacology. 198, 1, p. 61-73 13 p.

Research output: Contribution to journalArticle

Neurofilament Proteins
Intermediate Filaments
Rats
Spinal Cord
Polymers
6 Citations (Scopus)

Acrylamide toxicities and food safety: Session IV summary and research needs

LoPachin, R. M. & Canady, R. A., Jun 2004, In : NeuroToxicology. 25, 4 SPEC. ISS., p. 507-509 3 p.

Research output: Contribution to journalArticle

Acrylamide
Food Safety
Research
63 Citations (Scopus)

In vivo and in vitro effects of acrylamide on synaptosomal neurotransmitter uptake and release

LoPachin, R. M., Schwarcz, A. I., Gaughan, C. L., Mansukhani, S. & Das, S., Mar 2004, In : NeuroToxicology. 25, 3, p. 349-363 15 p.

Research output: Contribution to journalArticle

Acrylamide
Neurotransmitter Agents
Iodoacetic Acid
Synaptosomes
Proteins
47 Citations (Scopus)

Proteomic analysis of acrylamide-protein adduct formation in rat brain synaptosomes

Barber, D. S. & LoPachin, R. M., Dec 1 2004, In : Toxicology and Applied Pharmacology. 201, 2, p. 120-136 17 p.

Research output: Contribution to journalArticle

Synaptosomes
Acrylamide
Proteomics
Rats
Brain
166 Citations (Scopus)

The changing view of acrylamide neurotoxicity

LoPachin, R. M., Jun 2004, In : NeuroToxicology. 25, 4 SPEC. ISS., p. 617-630 14 p.

Research output: Contribution to journalArticle

Acrylamide
Membrane Fusion
Laboratory Animals
Food
Animals
23 Citations (Scopus)

γ-Diketone neuropathy: Axon atrophy and the role of cytoskeletal protein adduction

LoPachin, R. M. & DeCaprio, A. P., Aug 15 2004, In : Toxicology and Applied Pharmacology. 199, 1, p. 20-34 15 p.

Research output: Contribution to journalArticle

Cytoskeletal Proteins
Atrophy
Axons
Swelling
Toxicity
2003
115 Citations (Scopus)

Acrylamide axonopathy revisited

LoPachin, R. M., Balaban, C. D. & Ross, J. F., May 1 2003, In : Toxicology and Applied Pharmacology. 188, 3, p. 135-153 19 p.

Research output: Contribution to journalArticle

Acrylamide
Axons
Purkinje Cells
Cerebellum
Brain
13 Citations (Scopus)

Acrylamide neuropathy. II. Spatiotemporal characteristics of nerve cell damage in brainstem and spinal cord.

Lehning, E. J., Balaban, C. D., Ross, J. F. & LoPachin, R. M., Jan 2003, In : NeuroToxicology. 24, 1, p. 109-123 15 p.

Research output: Contribution to journalArticle

Acrylamide
Brain Stem
Neurons
Spinal Cord
Axons
42 Citations (Scopus)

Acrylamide neuropathy. III. Spatiotemporal characteristics of nerve cell damage in forebrain.

Lehning, E. J., Balaban, C. D., Ross, J. F. & LoPachin, R. M., Jan 2003, In : NeuroToxicology. 24, 1, p. 125-136 12 p.

Research output: Contribution to journalArticle

Acrylamide
Prosencephalon
Neurons
Nerve Degeneration
Axons
25 Citations (Scopus)

Application of Proteomics to the Study of Molecular Mechanisms in Neurotoxicology

LoPachin, R. M., Jones, R. C., Patterson, T. A., Slikker, W. & Barber, D. S., Dec 2003, In : NeuroToxicology. 24, 6, p. 761-775 15 p.

Research output: Contribution to journalArticle

Proteomics
Proteome
Proteins
Post Translational Protein Processing
Multiprotein Complexes
Acrylamide
Toxicology
Brain Stem
Spinal Cord
Neurons
23 Citations (Scopus)

γ-Diketone central neuropathy: Quantitative morphometric analysis of axons in rat spinal cord white matter regions and nerve roots

LoPachin, R. M., Jortner, B. S., Reid, M. L. & Das, S., Nov 15 2003, In : Toxicology and Applied Pharmacology. 193, 1, p. 29-46 18 p.

Research output: Contribution to journalArticle

Axons
Rats
Spinal Cord
Chemical analysis
Spinal Nerve Roots
2002
52 Citations (Scopus)

Acrylamide neuropathy I. Spatiotemporal characteristics of nerve cell damage in rat cerebellum

Lehning, E. J., Balaban, C. D., Ross, J. F., Reid, M. A. & LoPachin, R. M., Sep 2002, In : NeuroToxicology. 23, 3, p. 397-414 18 p.

Research output: Contribution to journalArticle

Acrylamide
Purkinje Cells
Cerebellum
Neurons
Rats
23 Citations (Scopus)

Acrylamide neuropathy II. Spatiotemporal characteristics of nerve cell damage in brainstem and spinal cord

Lehning, E. J., Balaban, C. D., Ross, J. F. & LoPachin, R. M., Sep 2002, In : NeuroToxicology. 23, 3, p. 415-429 15 p.

Research output: Contribution to journalArticle

Acrylamide
Brain Stem
Neurons
Spinal Cord
Axons
76 Citations (Scopus)

Nerve terminals as the primary site of acrylamide action: A hypothesis

LoPachin, R. M., Ross, J. F. & Lehning, E. J., May 2002, In : NeuroToxicology. 23, 1, p. 43-59 17 p.

Research output: Contribution to journalArticle

Acrylamide
SNARE Proteins
Nerve Degeneration
Membranes
Axons
95 Citations (Scopus)

Neurological evaluation of toxic axonopathies in rats: Acrylamide and 2,5-hexanedione

LoPachin, R. M., Ross, J. F., Reid, M. L., Das, S., Mansukhani, S. & Lehning, E. J., May 2002, In : NeuroToxicology. 23, 1, p. 95-110 16 p.

Research output: Contribution to journalArticle

Acrylamide
Poisons
Hindlimb
Rats
Monomers
21 Citations (Scopus)
Acrylamide
Animals
Axons