• 17274 Citations
  • 75 h-Index
1973 …2022

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2019

GADD45B acts as neuroprotective effector in global ischemia-induced neuronal death

Cho, C. H., Byun, H. R., Jover-Mengual, T., Pontarelli, F., Dejesus, C., Cho, A. R., Zukin, R. S. & Hwang, J. Y., Jan 1 2019, In : International Neurourology Journal. 23, p. S11-S21

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
2018

Activation of autophagy rescues synaptic and cognitive deficits in fragile X mice

Yan, J., Porch, M. W., Court-Vazquez, B., Bennett, M. V. L. & Zukin, R. S., Oct 9 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 41, p. E9707-E9716

Research output: Contribution to journalArticle

23 Scopus citations

Early uneven ear input induces long-lasting differences in left–right motor function

Antoine, M. W., Zhu, X., Dieterich, M., Brandt, T., Vijayakumar, S., McKeehan, N., Arezzo, J. C., Zukin, R. S., Borkholder, D. A., Jones, S. M., Frisina, R. D. & Hébert, J. M., Mar 13 2018, In : PLoS biology. 16, 3, e2002988.

Research output: Contribution to journalArticle

2 Scopus citations
2017

Aberrant Rac1-cofilin signaling mediates defects in dendritic spines, synaptic function, and sensory perception in fragile X syndrome

Pyronneau, A., He, Q., Hwang, J. Y., Porch, M., Contractor, A. & Zukin, R. S., Nov 7 2017, In : Science Signaling. 10, 504, eaan0852.

Research output: Contribution to journalArticle

28 Scopus citations

Global ischemia induces lysosomal-mediated degradation of mTOR and activation of autophagy in hippocampal neurons destined to die

Hwang, J. Y., Gertner, M., Pontarelli, F., Court-Vazquez, B., Bennett, M. V. L., Ofengeim, D. & Zukin, R. S., Feb 1 2017, In : Cell Death and Differentiation. 24, 2, p. 317-329 13 p.

Research output: Contribution to journalArticle

31 Scopus citations
2016
31 Scopus citations

HERG 1a LQT2 C-terminus truncation mutants display hERG 1b-dependent dominant negative mechanisms

Puckerin, A., Aromolaran, K. A., Chang, D. D., Zukin, R. S., Colecraft, H. M., Boutjdir, M. & Aromolaran, A. S., 2016, (Accepted/In press) In : Heart Rhythm.

Research output: Contribution to journalArticle

12 Scopus citations

Multiple drug treatments thatincrease cAMP signaling restorelong-term memory and aberrantsignaling in fragile X syndromemodels

Choi, C. H., Schoenfeld, B. P., Bell, A. J., Hinchey, J., Rosenfelt, C., Gertner, M. J., Campbell, S. R., Emerson, D., Hinchey, P., Kollaros, M., Ferrick, N. J., Chambers, D. B., Langer, S., Sust, S., Malik, A., Terlizzi, A. M., Liebelt, D. A., Ferreiro, D., Sharma, A., Koenigsberg, E. & 10 others, Choi, R. J., Louneva, N., Arnold, S. E., Featherstone, R. E., Siegel, S. J., Suzanne Zukin, R., McDonald, T. V., Bolduc, F. V., Jongens, T. A. & McBride, S. M. J., Jun 30 2016, In : Frontiers in Behavioral Neuroscience. 10, Jun, 136.

Research output: Contribution to journalArticle

17 Scopus citations
2015

Dysregulation of mammalian target of rapamycin signaling in mouse models of autism

Huber, K. M., Klann, E., Costa-Mattioli, M. & Zukin, R. S., Oct 14 2015, In : Journal of Neuroscience. 35, 41, p. 13836 1 p.

Research output: Contribution to journalArticle

72 Scopus citations

Estradiol pretreatment ameliorates impaired synaptic plasticity at synapses of insulted CA1 neurons after transient global ischemia

Takeuchi, K., Yang, Y., Takayasu, Y., Gertner, M., Hwang, J. Y., Aromolaran, K., Bennett, M. V. L. & Zukin, R. S., Sep 24 2015, In : Brain Research. 1621, p. 222-230 9 p.

Research output: Contribution to journalArticle

11 Scopus citations

Pde-4 inhibition rescues aberrant synaptic plasticity in drosophila and mouse models of fragile x syndrome

Choi, C. H., Schoenfeld, B. P., Weisz, E. D., Bell, A. J., Chambers, D. B., Hinchey, J., Choi, R. J., Hinchey, P., Kollaros, M., Gertner, M. J., Ferrick, N. J., Terlizzi, A. M., Yohn, N., Koenigsberg, E., Liebelt, D. A., Zukin, R. S., Woo, N. H., Tranfaglia, M. R., Louneva, N., Arnold, S. E. & 5 others, Siegel, S. J., Bolduc, F. V., McDonald, T. V., Jongens, T. A. & McBride, S. M. J., Jan 7 2015, In : Journal of Neuroscience. 35, 1, p. 396-408 13 p.

Research output: Contribution to journalArticle

26 Scopus citations
2014

Casein Kinase 1 suppresses activation of REST in insulted hippocampal neurons and halts ischemia-induced neuronal death

Kaneko, N., Hwang, J. Y., Gertner, M., Pontarelli, F. & Suzanne Zukin, R., Jan 1 2014, In : Journal of Neuroscience. 34, 17, p. 6030-6039 10 p.

Research output: Contribution to journalArticle

33 Scopus citations

Phosphorylation of Ser1166 on GluN2B by PKA is critical to synaptic NMDA receptor function and Ca2+ signaling in spines

Murphy, J. A., Stein, I. S., Geoffrey Lau, C., Peixoto, R. T., Aman, T. K., Kaneko, N., Aromolaran, K., Saulnier, J. L., Popescu, G. K., Sabatini, B. L., Hell, J. W. & Zukin, R. S., Jan 20 2014, In : Journal of Neuroscience. 34, 3, p. 869-879 11 p.

Research output: Contribution to journalArticle

58 Scopus citations

The gene silencing transcription factor rest represses miR-132 expression in hippocampal neurons destined to die

Hwang, J. Y., Kaneko, N., Noh, K. M., Pontarelli, F. & Zukin, R. S., Oct 9 2014, In : Journal of Molecular Biology. 426, 20, p. 3454-3466 13 p.

Research output: Contribution to journalArticle

44 Scopus citations
2013
65 Scopus citations

Survivin is a transcriptional target of STAT3 critical to estradiol neuroprotection in global ischemia

Sehara, Y., Sawicka, K., Hwang, J. Y., Latuszek-Barrantes, A., Etgen, A. M. & Zukin, R. S., Jul 30 2013, In : Journal of Neuroscience. 33, 30, p. 12364-12374 11 p.

Research output: Contribution to journalArticle

38 Scopus citations
2012

Altered mTOR signaling and enhanced CYFIP2 expression levels in subjects with fragile X syndrome

Hoeffer, C. A., Sanchez, E., Hagerman, R. J., Mu, Y., Nguyen, D. V., Wong, H., Whelan, A. M., Zukin, R. S., Klann, E. & Tassone, F., Apr 1 2012, In : Genes, Brain and Behavior. 11, 3, p. 332-341 10 p.

Research output: Contribution to journalArticle

102 Scopus citations

Bidirectional Control of mRNA Translation and Synaptic Plasticity by the Cytoplasmic Polyadenylation Complex

Udagawa, T., Swanger, S. A., Takeuchi, K., Kim, J. H., Nalavadi, V., Shin, J., Lorenz, L. J., Zukin, R. S., Bassell, G. J. & Richter, J. D., Jul 27 2012, In : Molecular Cell. 47, 2, p. 253-266 14 p.

Research output: Contribution to journalArticle

74 Scopus citations

Effects of global ischemia and estradiol pretreatment on phosphorylation of Akt, CREB and STAT3 in hippocampal CA1 of young and middle-aged female rats

De Butte-Smith, M., Zukin, R. S. & Etgen, A. M., Aug 30 2012, In : Brain Research. 1471, p. 118-128 11 p.

Research output: Contribution to journalArticle

12 Scopus citations

Effects of protopanaxatriol-ginsenoside metabolites on rat N-methyl-D-aspartic acid receptor-mediated ion currents

Shin, T. J., Hwang, S. H., Choi, S. H., Lee, B. H., Kang, J., Kim, H. J., Zukin, R. S., Rhim, H. & Nah, S. Y., Apr 1 2012, In : Korean Journal of Physiology and Pharmacology. 16, 2, p. 113-118 6 p.

Research output: Contribution to journalArticle

8 Scopus citations

Estradiol attenuates ischemia-induced death of hippocampal neurons and enhances synaptic transmission in aged, long-term hormone-deprived female rats

Inagaki, T., Kaneko, N., Zukin, R. S., Castillo, P. E. & Etgen, A. M., Jun 4 2012, In : PloS one. 7, 6, e38018.

Research output: Contribution to journalArticle

18 Scopus citations

Gintonin, a ginseng-derived novel ingredient, evokes long-term potentiation through N-methyl-D-aspartic acid receptor activation: involvement of LPA receptors.

Shin, T. J., Kim, H. J., Kwon, B. J., Choi, S. H., Kim, H. B., Hwang, S. H., Lee, B. H., Lee, S. M., Zukin, R. S., Park, J. H., Kim, H. C., Rhim, H., Lee, J. H. & Nah, S. Y., 2012, In : Molecules and Cells. 34, 6, p. 563-572 10 p.

Research output: Contribution to journalArticle

32 Scopus citations

N-terminally cleaved Bcl-x L mediates ischemia-induced neuronal death

Ofengeim, D., Chen, Y. B., Miyawaki, T., Li, H., Sacchetti, S., Flannery, R. J., Alavian, K. N., Pontarelli, F., Roelofs, B. A., Hickman, J. A., Hardwick, J. M., Zukin, R. S. & Jonas, E. A., Apr 1 2012, In : Nature Neuroscience. 15, 4, p. 574-580 7 p.

Research output: Contribution to journalArticle

45 Scopus citations
104 Scopus citations

REST-dependent epigenetic remodeling promotes the developmental switch in synaptic NMDA receptors

Rodenas-Ruano, A., Chávez, A. E., Cossio, M. J., Castillo, P. E. & Zukin, R. S., Oct 1 2012, In : Nature Neuroscience. 15, 10, p. 1382-1390 9 p.

Research output: Contribution to journalArticle

112 Scopus citations
2011

A silent synapse-based mechanism for cocaine-induced locomotor sensitization

Brown, T. E., Lee, B. R., Mu, P., Ferguson, D., Dietz, D., Ohnishi, Y. N., Lin, Y., Suska, A., Ishikawa, M., Huang, Y. H., Shen, H., Kalivas, P. W., Sorg, B. A., Suzanne Zukin, R., Nestler, E. J., Dong, Y. & Schlüüter, O. M., Jun 1 2011, In : Journal of Neuroscience. 31, 22, p. 8163-8174 12 p.

Research output: Contribution to journalArticle

111 Scopus citations

Differences in NMDA receptor expression during human development determine the response of neurons to HIV-Tat-mediated neurotoxicity

Eugenin, E. A., King, J. E., Hazleton, J. E., Major, E. O., Bennett, M. V. L., Zukin, R. S. & Berman, J. W., Jan 1 2011, In : Neurotoxicity Research. 19, 1, p. 138-148 11 p.

Research output: Contribution to journalArticle

17 Scopus citations

EphB controls NMDA receptor function and synaptic targeting in a subunit-specific manner

Nolt, M. J., Lin, Y., Hruska, M., Murphy, J., Sheffler-Colins, S. I., Kayser, M. S., Passer, J., Bennett, M. V. L., Zukin, R. S. & Dalva, M. B., Apr 6 2011, In : Journal of Neuroscience. 31, 14, p. 5353-5364 12 p.

Research output: Contribution to journalArticle

82 Scopus citations

Pharmacological reversal of synaptic plasticity deficits in the mouse model of Fragile X syndrome by group II mGluR antagonist or lithium treatment

Choi, C. H., Schoenfeld, B. P., Bell, A. J., Hinchey, P., Kollaros, M., Gertner, M. J., Woo, N. H., Tranfaglia, M. R., Bear, M. F., Zukin, R. S., McDonald, T. V., Jongens, T. A. & McBride, S. M. J., Mar 22 2011, In : Brain Research. 1380, p. 106-119 14 p.

Research output: Contribution to journalArticle

75 Scopus citations

Serotonin Mediates Cross-Modal Reorganization of Cortical Circuits

Jitsuki, S., Takemoto, K., Kawasaki, T., Tada, H., Takahashi, A., Becamel, C., Sano, A., Yuzaki, M., Zukin, R. S., Ziff, E. B., Kessels, H. W. & Takahashi, T., Feb 24 2011, In : Neuron. 69, 4, p. 780-792 13 p.

Research output: Contribution to journalArticle

86 Scopus citations

β-catenin-dependent FGF signaling sustains cell survival in the anterior embryonic head by countering Smad4

Paek, H., Hwang, J. Y., Zukin, R. S. & Hébert, J. M., May 17 2011, In : Developmental cell. 20, 5, p. 689-699 11 p.

Research output: Contribution to journalArticle

23 Scopus citations
2010

Acute administration of non-classical estrogen receptor agonists attenuates ischemia-induced hippocampal neuron loss in middle-aged female rats

Lebesgue, D., Traub, M., De Butte-Smith, M., Chen, C., Zukin, R. S., Kelly, M. J. & Etgen, A. M., Jan 8 2010, In : PloS one. 5, 1, e8642.

Research output: Contribution to journalArticle

107 Scopus citations

Acute estradiol protects CA1 neurons from ischemia-induced apoptotic cell death via the PI3K/Akt pathway

Jover-Mengual, T., Miyawaki, T., Latuszek, A., Alborch, E., Zukin, R. S. & Etgen, A. M., Mar 19 2010, In : Brain Research. 1321, p. 1-12 12 p.

Research output: Contribution to journalArticle

58 Scopus citations

Apurinic/apyrimidinic endonuclease APE1 is required for PACAP-induced neuroprotection against global cerebral ischemia

Stetler, R. A., Gao, Y., Zukin, R. S., Vosler, P. S., Zhang, L., Zhang, F., Cao, G., Bennett, M. V. L. & Chen, J., Feb 16 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 7, p. 3204-3209 6 p.

Research output: Contribution to journalArticle

58 Scopus citations

A single fear-inducing stimulus induces a transcription-dependent switch in synaptic AMPAR phenotype

Liu, Y., Formisano, L., Savtchouk, I., Takayasu, Y., Szabó, G., Zukin, R. S. & Liu, S. J., Feb 18 2010, In : Nature Neuroscience. 13, 2, p. 223-231 9 p.

Research output: Contribution to journalArticle

53 Scopus citations
24 Scopus citations

Dysregulation of mTOR signaling in fragile X syndrome

Sharma, A., Hoeffer, C. A., Takayasu, Y., Miyawaki, T., McBride, S. M., Klann, E. & Suzanne Zukin, R., Jan 13 2010, In : Journal of Neuroscience. 30, 2, p. 694-702 9 p.

Research output: Contribution to journalArticle

350 Scopus citations

SNAP-25 is a target of protein kinase C phosphorylation critical to NMDA receptor trafficking

Lau, C. G., Takayasu, Y., Rodenas-Ruano, A., Paternain, A. V., Lerma, J., Bennett, M. V. L. & Suzanne Zukin, R., Jan 6 2010, In : Journal of Neuroscience. 30, 1, p. 242-254 13 p.

Research output: Contribution to journalArticle

80 Scopus citations
2009
16 Scopus citations

Developmental switch in requirement for PKA RIIβ in NMDA-receptor-dependent synaptic plasticity at Schaffer collateral to CA1 pyramidal cell synapses

Yang, Y., Takeuchi, K., Rodenas-Ruano, A., Takayasu, Y., Bennett, M. V. L. & Zukin, R. S., Jan 1 2009, In : Neuropharmacology. 56, 1, p. 56-65 10 p.

Research output: Contribution to journalArticle

19 Scopus citations

Estradiol rescues neurons from global ischemia-induced cell death: Multiple cellular pathways of neuroprotection

Lebesgue, D., Chevaleyre, V., Zukin, R. S. & Etgen, A. M., Jul 1 2009, In : Steroids. 74, 7, p. 555-561 7 p.

Research output: Contribution to journalArticle

177 Scopus citations

In vivo cocaine experience generates silent synapses.

Huang, Y. H., Lin, Y., Mu, P., Lee, B. R., Brown, T. E., Wayman, G., Marie, H., Liu, W., Yan, Z., Sorg, B. A., Schlüter, O. M., Zukin, R. S. & Dong, Y., Jul 16 2009, In : Neuron. 63, 1, p. 40-47 8 p.

Research output: Contribution to journalArticle

161 Scopus citations

Oestradiol and insulin-like growth factor-1 reduce cell loss after global ischaemia in middle-aged female rats

Traub, M. L., De Butte-Smith, M., Zukin, R. S. & Etgen, A. M., Dec 1 2009, In : Journal of Neuroendocrinology. 21, 12, p. 1038-1044 7 p.

Research output: Contribution to journalArticle

22 Scopus citations

Proteomic analysis reveals novel binding partners of metabotropic glutamate receptor 1

Francesconi, A., Kumari, R. & Suzanne Zukin, R., Mar 1 2009, In : Journal of Neurochemistry. 108, 6, p. 1515-1525 11 p.

Research output: Contribution to journalArticle

14 Scopus citations

Regulation of group i metabotropic glutamate receptor trafficking and signaling by the caveolar/lipid raft pathway

Francesconi, A., Kumari, R. & Zukin, R. S., Mar 18 2009, In : Journal of Neuroscience. 29, 11, p. 3590-3602 13 p.

Research output: Contribution to journalArticle

68 Scopus citations

Regulation of NMDA receptor Ca2+ signalling and synaptic plasticity

Lau, C. G., Takeuchi, K., Rodenas-Ruano, A., Takayasu, Y., Murphy, J., Bennett, M. V. I. & Zukin, R. S., Nov 27 2009, In : Biochemical Society transactions. 37, 6, p. 1369-1374 6 p.

Research output: Contribution to journalArticle

50 Scopus citations

The endogenous inhibitor of Akt, CTMP, is critical to ischemia-induced neuronal death

Miyawaki, T., Ofengeim, D., Noh, K. M., Latuszek-Barrantes, A., Hemmings, B. A., Follenzi, A. & Zukin, R. S., May 1 2009, In : Nature Neuroscience. 12, 5, p. 618-626 9 p.

Research output: Contribution to journalArticle

77 Scopus citations
2008

CREB modulates the functional output of nucleus accumbens neurons: A critical role of N-methyl-D-aspartate glutamate receptor (NMDAR) receptors

Huang, Y. H., Lin, Y., Brown, T. E., Han, M. H., Saal, D. B., Neve, R. L., Zukin, R. S., Sorg, B. A., Nestler, E. J., Malenka, R. C. & Dong, Y., Feb 1 2008, In : Journal of Biological Chemistry. 283, 5, p. 2751-2760 10 p.

Research output: Contribution to journalArticle

49 Scopus citations

Ischemic preconditioning blocks BAD translocation, Bcl-xL cleavage, and large channel activity in mitochondria of postischemic hippocampal neurons

Miyawaki, T., Mashiko, T., Ofengeim, D., Flannery, R. J., Noh, K. M., Fujisawa, S., Bonanni, L., Bennett, M. V. L., Zukin, R. S. & Jonas, E. A., Mar 25 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 12, p. 4892-4897 6 p.

Research output: Contribution to journalArticle

70 Scopus citations