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Paul S. Frenette, M.D.

  • 20041 Citations
  • 72 h-Index
1987 …2021
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  • 8 Similar Profiles
Hematopoietic Stem Cells Medicine & Life Sciences
Bone Marrow Medicine & Life Sciences
E-Selectin Medicine & Life Sciences
Selectins Medicine & Life Sciences
P-Selectin Medicine & Life Sciences
Stem Cell Niche Medicine & Life Sciences
Bone Chemical Compounds
Stem cells Chemical Compounds

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Grants 2000 2021

Mechanisms regulating the aging of HSC niches

Frenette, P. S.

National Institutes of Health

1/15/18 → 12/31/21

Project: Research project

Stem Cell Niche
Sympathetic Nervous System
Hematopoietic Stem Cells
Nestin
Cell Aging

Evaluating neural circuitry of the bone marrow

Frenette, P. S.

National Institutes of Health

9/20/17 → 8/31/20

Project: Research project

Bone Marrow
Sympathetic Nervous System
Hematopoietic Stem Cells
Regeneration
Hematopoiesis

In Vivo Sickle Cell Vasoocclusion: Adhesion Mechanisms

Frenette, P. S.

National Institutes of Health

9/30/01 → 5/31/21

Project: Research project

Leukocytes
Sickle Cell Anemia
Neutrophils
Venules
Cell Adhesion

In vivo function of macrophage in healthy and diseased erythropoiesis

Frenette, P. S.

National Institutes of Health

9/26/12 → 6/30/17

Project: Research project

Erythropoiesis
Bone Marrow
Macrophages
Genetic Models
Polycythemia Vera

Inhibition of platelet-leukocyte interactions to treat TRALI

Frenette, P. S.

National Institutes of Health

9/30/09 → 8/31/11

Project: Research project

Acute Lung Injury
Leukocytes
Blood Platelets
Neutrophil Activation
Neutrophils

Publications 1987 2019

Author Correction: Adrenergic nerve degeneration in bone marrow drives aging of the hematopoietic stem cell niche (Nature Medicine, (2018), 24, 6, (782-791), 10.1038/s41591-018-0030-x)

Maryanovich, M., Zahalka, A. H., Pierce, H., Pinho, S. I., Nakahara, F., Asada, N., Wei, Q., Wang, X., Ciero, P., Xu, J., Leftin, A. & Frenette, P. S., Jan 1 2019, In : Nature Medicine.

Research output: Contribution to journal › Comment/debate

Open Access
Stem Cell Niche
Nerve Degeneration
HTML
Manuscripts
Hematopoietic Stem Cells

Cross talk between neutrophils and the microbiota

Zhang, D. & Frenette, P. S., May 16 2019, In : Blood. 133, 20, p. 2168-2177 10 p.

Research output: Contribution to journal › Review article

Immune system
Microbiota
Metabolites
Neutrophils
Modulation
3 Citations (Scopus)

Engineering a haematopoietic stem cell niche by revitalizing mesenchymal stromal cells

Nakahara, F., Borger, D. K., Wei, Q., Pinho, S. I., Maryanovich, M., Zahalka, A. H., Suzuki, M., Cruz, C. D., Wang, Z., Xu, C., Boulais, P. E., Ma’ayan, A., Greally, J. M. & Frenette, P. S., May 1 2019, In : Nature Cell Biology. 21, 5, p. 560-567 8 p.

Research output: Contribution to journal › Letter

Stem Cell Niche
Hematopoietic Stem Cells
Mesenchymal Stromal Cells
Bone Marrow
MEF2 Transcription Factors
9 Citations (Scopus)

Haematopoietic stem cell activity and interactions with the niche

Pinho, S. I. & Frenette, P. S., Jan 1 2019, In : Nature Reviews Molecular Cell Biology.

Research output: Contribution to journal › Review article

Hematopoietic Stem Cells
Stem Cell Niche
Bone Marrow
Homeostasis
Megakaryocytes
1 Citation (Scopus)

Maea expressed by macrophages, but not erythroblasts, maintains postnatal murine bone marrow erythroblastic islands

Wei, Q., Boulais, P. E., Zhang, D., Pinho, S. I., Tanaka, M. & Frenette, P. S., Mar 14 2019, In : Blood. 133, 11, p. 1222-1232 11 p.

Research output: Contribution to journal › Article

Erythroblasts
Macrophages
Bone
Bone Marrow
Erythropoiesis