• 10286 Citations
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1990 …2020

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A Combined Optogenetic-Knockdown Strategy Reveals a Major Role of Tomosyn in Mossy Fiber Synaptic Plasticity

Ben-Simon, Y., Rodenas-Ruano, A., Alviña, K., Lam, A. D., Stuenkel, E. L., Castillo, P. E. & Ashery, U., Jul 21 2015, In : Cell Reports. 12, 3, p. 396-404 9 p.

Research output: Contribution to journalArticle

11 Scopus citations

Actinin-4 governs dendritic spine dynamics and promotes their remodeling by metabotropic glutamate receptors

Kalinowska, M., Chávez, A. E., Lutzu, S., Castillo, P. E., Bukauskas, F. F. & Francesconi, A., Jun 26 2015, In : Journal of Biological Chemistry. 290, 26, p. 15909-15920 12 p.

Research output: Contribution to journalArticle

13 Scopus citations

Age-dependent impairment of cognitive and synaptic function in the htau mouse model of Tau pathology

Polydoro, M., Acker, C. M., Duff, K., Castillo, P. E. & Davies, P., Aug 26 2009, In : Journal of Neuroscience. 29, 34, p. 10741-10749 9 p.

Research output: Contribution to journalArticle

199 Scopus citations

Altered synaptic physiology and reduced susceptibility to kainate- induced secures in GluR6-deficient mice

Mulle, C., Sailer, A., Pérez-Otaño, I., Dickinson-Anson, H., Castillo, P. E., Bureau, I., Maron, C., Gage, F. H., Mann, J. R., Bettler, B. & Heinemann, S. F., Apr 9 1998, In : Nature. 392, 6676, p. 601-605 5 p.

Research output: Contribution to journalArticle

362 Scopus citations

A medullary inhibitory region for trigeminal motoneurons in the cat

Castillo, P., Pedroarena, C., Chase, M. H. & Morales, F. R., May 24 1991, In : Brain Research. 549, 2, p. 346-349 4 p.

Research output: Contribution to journalArticle

13 Scopus citations

ANKS1B gene product AIDA-1 controls hippocampal synaptic transmission by regulating GluN2B subunit localization

Tindi, J. O., Chávez, A. E., Cvejic, S., Calvo-Ochoa, E., Castillo, P. E. & Jordan, B. A., Jun 17 2015, In : Journal of Neuroscience. 35, 24, p. 8986-8996 11 p.

Research output: Contribution to journalArticle

13 Scopus citations

APP and APLP2 interact with the synaptic release machinery and facilitate transmitter release at hippocampal synapses

Fanutza, T., del Prete, D., Ford, M. J., Castillo, P. E. & D’Adamio, L., Nov 9 2015, In : eLife. 4, NOVEMBER2015, e09743.

Research output: Contribution to journalArticle

31 Scopus citations

A single in-vivo exposure to Δ9THC blocks endocannabinoid-mediated synaptic plasticity

Mato, S., Chevaleyre, V., Robbe, D., Pazos, A., Castillo, P. E. & Manzoni, O. J., Jun 1 2004, In : Nature Neuroscience. 7, 6, p. 585-586 2 p.

Research output: Contribution to journalArticle

166 Scopus citations
154 Scopus citations

Bidirectional NMDA receptor plasticity controls CA3 output and heterosynaptic metaplasticity

Hunt, D. L., Puente, N., Grandes, P. & Castillo, P. E., Aug 1 2013, In : Nature Neuroscience. 16, 8, p. 1049-1059 11 p.

Research output: Contribution to journalArticle

29 Scopus citations
165 Scopus citations

CA1 pyramidal cell theta-burst firing triggers endocannabinoid-mediated long-term depression at both somatic and dendritic inhibitory synapses

Younts, T. J., Chevaleyre, V. & Castillo, P. E., 2013, In : Journal of Neuroscience. 33, 34, p. 13743-13757 15 p.

Research output: Contribution to journalArticle

35 Scopus citations

CaMKII Phosphorylation of TARPγ-8 Is a Mediator of LTP and Learning and Memory

Park, J., Chávez, A. E., Mineur, Y. S., Morimoto-Tomita, M., Lutzu, S., Kim, K. S., Picciotto, M. R., Castillo, P. E. & Tomita, S., Oct 5 2016, In : Neuron. 92, 1, p. 75-83 9 p.

Research output: Contribution to journalArticle

36 Scopus citations

Characterizing the site and mode of action of dynorphin at hippocampal mossy fiber synapses in the guinea pig

Castillo, P. E., Salin, P. A., Weisskopf, M. G. & Nicoll, R. A., Oct 1 1996, In : Journal of Neuroscience. 16, 19, p. 5942-5950 9 p.

Research output: Contribution to journalArticle

Open Access
33 Scopus citations

Compartment-specific modulation of GABAergic synaptic transmission by TRPV1 channels in the dentate gyrus

Chávez, A. E., Hernández, V. M., Rodenas-Ruano, A., Savio Chan, C. & Castillo, P. E., Dec 10 2014, In : Journal of Neuroscience. 34, 50, p. 16621-16629 9 p.

Research output: Contribution to journalArticle

30 Scopus citations

Coordination between translation and degradation regulates inducibility of mGluR-LTD

Klein, M. E., Castillo, P. E. & Jordan, B. A., Mar 10 2015, In : Cell Reports. 10, 9, p. 1459-1466 8 p.

Research output: Contribution to journalArticle

22 Scopus citations

De novo synaptogenesis induced by GABA in the developing mouse cortex

Oh, W. C., Lutzu, S., Castillo, P. E. & Kwon, H. B., Sep 2 2016, In : Science. 353, 6303, p. 1037-1040 4 p.

Research output: Contribution to journalArticle

58 Scopus citations

Distinct functions of kainate receptors in the brain are determined by the auxiliary subunit Neto1

Straub, C., Hunt, D. L., Yamasaki, M., Kim, K. S., Watanabe, M., Castillo, P. E. & Tomita, S., Jul 2011, In : Nature Neuroscience. 14, 7, p. 866-873 8 p.

Research output: Contribution to journalArticle

79 Scopus citations

Dopaminergic modulation of endocannabinoid-mediated plasticity at GABAergic synapses in the prefrontal cortex

Chiu, C. Q., Puente, N., Grandes, P. & Castillo, P. E., May 26 2010, In : Journal of Neuroscience. 30, 21, p. 7236-7248 13 p.

Research output: Contribution to journalArticle

92 Scopus citations

Double-knockout mice for α- and β-synucleins: Effect on synaptic functions

Chandra, S., Fornai, F., Kwon, H. B., Yazdani, U., Atasoy, D., Liu, X., Hammer, R. E., Battaglia, G., German, D. C., Castillo, P. E. & Südhof, T. C., Oct 12 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 41, p. 14966-14971 6 p.

Research output: Contribution to journalArticle

291 Scopus citations

ELKS2α/CAST Deletion Selectively Increases Neurotransmitter Release at Inhibitory Synapses

Kaeser, P. S., Deng, L., Chávez, A. E., Liu, X., Castillo, P. E. & Südhof, T. C., Oct 29 2009, In : Neuron. 64, 2, p. 227-239 13 p.

Research output: Contribution to journalArticle

70 Scopus citations

Endocannabinoid-Mediated Long-Term Plasticity Requires cAMP/PKA Signaling and RIM1α

Chevaleyre, V., Heifets, B. D., Kaeser, P. S., Südhof, T. C., Purpura, D. P. & Castillo, P. E., Jun 7 2007, In : Neuron. 54, 5, p. 801-812 12 p.

Research output: Contribution to journalArticle

183 Scopus citations

Endocannabinoid-mediated metaplasticity in the hippocampus

Chevaleyre, V. & Castillo, P. E., Sep 16 2004, In : Neuron. 43, 6, p. 871-881 11 p.

Research output: Contribution to journalArticle

219 Scopus citations

Estradiol attenuates ischemia-induced death of hippocampal neurons and enhances synaptic transmission in aged, long-term hormone-deprived female rats

Inagaki, T., Kaneko, N., Zukin, R. S., Castillo, P. E. & Etgen, A. M., Jun 4 2012, In : PloS one. 7, 6, e38018.

Research output: Contribution to journalArticle

18 Scopus citations

Evidence against a role for metabotropic glutamate receptors in mossy fiber LTP: the use of mutant mice and pharmacological antagonists

Hsia, A. Y., Salin, P. A., Castillo, P. E., Aiba, A., Abeliovich, A., Tonegawa, S. & Nicoll, R. A., Nov 1995, In : Neuropharmacology. 34, 11, p. 1567-1572 6 p.

Research output: Contribution to journalArticle

41 Scopus citations

Experimental analysis of the method of 'peeling' exponentials for measuring passive electrical properties of mammalian motoneurons

Engelhardt, J. K., Morales, F. R., Castillo, P. E., Pedroarena, C., Pose, I. & Chase, M. H., Mar 27 1995, In : Brain research. 675, 1-2, p. 241-248 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

Heterosynaptic LTD of hippocampal GABAergic synapses: A novel role of endocannabinoids in regulating excitability

Chevaleyre, V. & Castillo, P. E., May 8 2003, In : Neuron. 38, 3, p. 461-472 12 p.

Research output: Contribution to journalArticle

487 Scopus citations

Input-specific plasticity at excitatory synapses mediated by endocannabinoids in the dentate gyrus

Chiu, C. Q. & Castillo, P. E., Jan 1 2008, In : Neuropharmacology. 54, 1, p. 68-78 11 p.

Research output: Contribution to journalArticle

33 Scopus citations

Interneuron activity controls endocannabinoid-mediated presynaptic plasticity through calcineurin

Heifets, B. D., Chevaleyre, V. & Castillo, P. E., Jul 22 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 29, p. 10250-10255 6 p.

Research output: Contribution to journalArticle

82 Scopus citations

Kainate receptors mediate a slow postsynaptic current in hippocampal CA3 neurons

Castillo, P. E., Malenka, R. C. & Nicoll, R. A., Jul 28 1997, In : Nature. 388, 6638, p. 182-186 5 p.

Research output: Contribution to journalArticle

399 Scopus citations

Long-Term Potentiation Selectively Expressed by NMDA Receptors at Hippocampal Mossy Fiber Synapses

Kwon, H. B. & Castillo, P. E., Jan 10 2008, In : Neuron. 57, 1, p. 108-120 13 p.

Research output: Contribution to journalArticle

99 Scopus citations

LTP at Hilar Mossy Cell-Dentate Granule Cell Synapses Modulates Dentate Gyrus Output by Increasing Excitation/Inhibition Balance

Hashimotodani, Y., Nasrallah, K., Jensen, K. R., Chávez, A. E., Carrera, D. & Castillo, P. E., Aug 16 2017, In : Neuron. 95, 4, p. 928-943.e3

Research output: Contribution to journalArticle

19 Scopus citations

Mediation of hippocampal mossy fiber long-term potentiation by cyclic AMP

Weisskopf, M. G., Castillo, P. E., Zalutsky, R. A. & Nicoll, R. A., Sep 23 1994, In : Science. 265, 5180, p. 1878-1882 5 p.

Research output: Contribution to journalArticle

455 Scopus citations

Mice lacking α-synuclein display functional deficits in the nigrostriatal dopamine system

Abeliovich, A., Schmitz, Y., Fariñas, I., Choi-Lundberg, D., Ho, W. H., Castillo, P. E., Shinsky, N., Garcia Verdugo, J. M., Armanini, M., Ryan, A., Hynes, M., Phillips, H., Sulzer, D. & Rosenthal, A., Jan 2000, In : Neuron. 25, 1, p. 239-252 14 p.

Research output: Contribution to journalArticle

Open Access
1231 Scopus citations

Multiple and opposing roles of cholinergic transmission in the main olfactory bulb

Castillo, P. E., Carleton, A., Vincent, J. D. & Lledo, P. M., Nov 1 1999, In : Journal of Neuroscience. 19, 21, p. 9180-9191 12 p.

Research output: Contribution to journalArticle

Open Access
109 Scopus citations

Neuroligin1 drives synaptic and behavioral maturation through intracellular interactions

Hoy, J. L., Haeger, P. A., Constable, J. R. L., Arias, R. J., McCallum, R., Kyweriga, M., Davis, L., Schnell, E., Wehr, M., Castillo, P. E. & Washbourne, P., May 29 2013, In : Journal of Neuroscience. 33, 22, p. 9364-9384 21 p.

Research output: Contribution to journalArticle

14 Scopus citations

Neurotrophin and FGF Signaling Adapter Proteins, FRS2 and FRS3, Regulate Dentate Granule Cell Maturation and Excitatory Synaptogenesis

Nandi, S., Alviña, K., Lituma, P. J., Castillo, P. E. & Hébert, J. M., Jan 15 2018, In : Neuroscience. 369, p. 192-201 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

Non-reciprocal postsynaptic inhibition of digastric motoneurons

Pedroarena, C., Castillo, P., Chase, M. H. & Morales, F. R., Dec 10 1990, In : Brain research. 535, 2, p. 339-342 4 p.

Research output: Contribution to journalArticle

10 Scopus citations

Npas4 Is a Critical Regulator of Learning-Induced Plasticity at Mossy Fiber-CA3 Synapses during Contextual Memory Formation

Weng, F. J., Garcia, R. I., Lutzu, S., Alviña, K., Zhang, Y., Dushko, M., Ku, T., Zemoura, K., Rich, D., Garcia-Dominguez, D., Hung, M., Yelhekar, T. D., Sørensen, A. T., Xu, W., Chung, K., Castillo, P. E. & Lin, Y., Mar 7 2018, In : Neuron. 97, 5, p. 1137-1152.e5

Research output: Contribution to journalArticle

16 Scopus citations

Oxytocin improves behavioral and electrophysiological deficits in a novel Shank3-deficient rat

Harony-Nicolas, H., Kay, M., du Hoffmann, J., Klein, M. E., Bozdagi-Gunal, O., Riad, M., Daskalakis, N. P., Sonar, S., Castillo, P. E., Hof, P. R., Shapiro, M. L., Baxter, M. G., Wagner, S. & Buxbaum, J. D., Jan 31 2017, In : eLife. 6, e18904.

Research output: Contribution to journalArticle

46 Scopus citations

Pharmacology of metabotropic glutamate receptors at the mossy fiber synapses of the guinea pig hippocampus

Manzoni, O. J., Castillo, P. E. & Nicoll, R. A., Aug 1995, In : Neuropharmacology. 34, 8, p. 965-971 7 p.

Research output: Contribution to journalArticle

91 Scopus citations

Piccolo and bassoon maintain synaptic vesicle clustering without directly participating in vesicle exocytosis

Mukherjee, K., Yang, X., Gerber, S. H., Kwon, H. B., Ho, A., Castillo, P. E., Liu, X. & Südhof, T. C., Apr 6 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 14, p. 6504-6509 6 p.

Research output: Contribution to journalArticle

107 Scopus citations
62 Scopus citations

Presynaptic Protein Synthesis Is Required for Long-Term Plasticity of GABA Release

Younts, T. J., Monday, H. R., Dudok, B., Klein, M. E., Jordan, B. A., Katona, I. & Castillo, P. E., Oct 19 2016, In : Neuron. 92, 2, p. 479-492 14 p.

Research output: Contribution to journalArticle

70 Scopus citations

Protein kinase A regulates calcium permeability of NMDA receptors

Skeberdis, V. A., Chevaleyre, V., Lau, C. G., Goldberg, J. H., Pettit, D. L., Suadicani, S. O., Lin, Y., Bennett, M. V. L., Yuste, R., Castillo, P. E. & Zukin, R. S., Apr 1 2006, In : Nature Neuroscience. 9, 4, p. 501-510 10 p.

Research output: Contribution to journalArticle

219 Scopus citations

Rab3A is essential for mossy fibre long-term potentiation in the hippocampus

Castillo, P. E., Janz, R., Südhof, T. C., Tzounopoulos, T., Malenka, R. C. & Nicoll, R. A., Aug 25 1997, In : Nature. 388, 6642, p. 590-593 4 p.

Research output: Contribution to journalArticle

280 Scopus citations

Rab3B protein is required for long-term depression of hippocampal inhibitory synapses and for normal reversal learning

Tsetsenis, T., Younts, T. J., Chiu, C. Q., Kaeser, P. S., Castillo, P. E. & Südhof, T. C., Aug 23 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 34, p. 14300-14305 6 p.

Research output: Contribution to journalArticle

44 Scopus citations

Redundant functions of RIM1α and RIM2α in Ca 2+-triggered neurotransmitter release

Schoch, S., Mittelstaedt, T., Kaeser, P. S., Padgett, D., Feldmann, N., Chevaleyre, V., Castillo, P. E., Hammer, R. E., Han, W., Schmitz, F., Lin, W. & Südhof, T. C., Dec 13 2006, In : EMBO Journal. 25, 24, p. 5852-5863 12 p.

Research output: Contribution to journalArticle

94 Scopus citations

REST-dependent epigenetic remodeling promotes the developmental switch in synaptic NMDA receptors

Rodenas-Ruano, A., Chávez, A. E., Cossio, M. J., Castillo, P. E. & Zukin, R. S., Oct 1 2012, In : Nature Neuroscience. 15, 10, p. 1382-1390 9 p.

Research output: Contribution to journalArticle

119 Scopus citations

RIM1α and RIM1β are synthesized from distinct promoters of the RIM1 gene to mediate differential but overlapping synaptic functions

Kaeser, P. S., Kwon, H. B., Chiu, C. Q., Deng, L., Castillo, P. E. & Südhof, T. C., Dec 10 2008, In : Journal of Neuroscience. 28, 50, p. 13435-13447 13 p.

Research output: Contribution to journalArticle

61 Scopus citations