• 10286 Citations
  • 46 h-Index
1990 …2020

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1990

Non-reciprocal postsynaptic inhibition of digastric motoneurons

Pedroarena, C., Castillo, P., Chase, M. H. & Morales, F. R., Dec 10 1990, In : Brain research. 535, 2, p. 339-342 4 p.

Research output: Contribution to journalArticle

10 Scopus citations
1991

A medullary inhibitory region for trigeminal motoneurons in the cat

Castillo, P., Pedroarena, C., Chase, M. H. & Morales, F. R., May 24 1991, In : Brain Research. 549, 2, p. 346-349 4 p.

Research output: Contribution to journalArticle

13 Scopus citations

Strychnine blockade of the non-reciprocal inhibition of trigeminal motoneurons induced by stimulation of the parvocellular reticular formation

Castillo, P., Pedroarena, C., Chase, M. H. & Morales, F. R., Dec 20 1991, In : Brain Research. 567, 2, p. 346-349 4 p.

Research output: Contribution to journalArticle

25 Scopus citations
1994

Mediation of hippocampal mossy fiber long-term potentiation by cyclic AMP

Weisskopf, M. G., Castillo, P. E., Zalutsky, R. A. & Nicoll, R. A., Sep 23 1994, In : Science. 265, 5180, p. 1878-1882 5 p.

Research output: Contribution to journalArticle

455 Scopus citations

The control of jaw-opener motoneurons during active sleep

Pedroarena, C., Castillo, P., Chase, M. H. & Morales, F. R., Aug 8 1994, In : Brain Research. 653, 1-2, p. 31-38 8 p.

Research output: Contribution to journalArticle

56 Scopus citations

The role of Ca2+ channels in hippocampal mossy fiber synaptic transmission and long-term potentiation

Castillo, P. E., Weisskopf, M. G. & Nicoll, R. A., Feb 1994, In : Neuron. 12, 2, p. 261-269 9 p.

Research output: Contribution to journalArticle

245 Scopus citations

The role of Ca2+ in transmitter release and long-term potentiation at hippocampal mossy fiber synapses

Nicoll, R. A., Castillo, P. E. & Weisskopf, M. G., Jan 1 1994, In : Advances in Second Messenger and Phosphoprotein Research. 29, C, p. 497-505 9 p.

Research output: Contribution to journalArticle

6 Scopus citations
1995

Evidence against a role for metabotropic glutamate receptors in mossy fiber LTP: the use of mutant mice and pharmacological antagonists

Hsia, A. Y., Salin, P. A., Castillo, P. E., Aiba, A., Abeliovich, A., Tonegawa, S. & Nicoll, R. A., Nov 1995, In : Neuropharmacology. 34, 11, p. 1567-1572 6 p.

Research output: Contribution to journalArticle

41 Scopus citations

Experimental analysis of the method of 'peeling' exponentials for measuring passive electrical properties of mammalian motoneurons

Engelhardt, J. K., Morales, F. R., Castillo, P. E., Pedroarena, C., Pose, I. & Chase, M. H., Mar 27 1995, In : Brain research. 675, 1-2, p. 241-248 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

Pharmacology of metabotropic glutamate receptors at the mossy fiber synapses of the guinea pig hippocampus

Manzoni, O. J., Castillo, P. E. & Nicoll, R. A., Aug 1995, In : Neuropharmacology. 34, 8, p. 965-971 7 p.

Research output: Contribution to journalArticle

91 Scopus citations
1996

Characterizing the site and mode of action of dynorphin at hippocampal mossy fiber synapses in the guinea pig

Castillo, P. E., Salin, P. A., Weisskopf, M. G. & Nicoll, R. A., Oct 1 1996, In : Journal of Neuroscience. 16, 19, p. 5942-5950 9 p.

Research output: Contribution to journalArticle

Open Access
33 Scopus citations
1997

Kainate receptors mediate a slow postsynaptic current in hippocampal CA3 neurons

Castillo, P. E., Malenka, R. C. & Nicoll, R. A., Jul 28 1997, In : Nature. 388, 6638, p. 182-186 5 p.

Research output: Contribution to journalArticle

399 Scopus citations

Rab3A is essential for mossy fibre long-term potentiation in the hippocampus

Castillo, P. E., Janz, R., Südhof, T. C., Tzounopoulos, T., Malenka, R. C. & Nicoll, R. A., Aug 25 1997, In : Nature. 388, 6642, p. 590-593 4 p.

Research output: Contribution to journalArticle

280 Scopus citations
1998

Altered synaptic physiology and reduced susceptibility to kainate- induced secures in GluR6-deficient mice

Mulle, C., Sailer, A., Pérez-Otaño, I., Dickinson-Anson, H., Castillo, P. E., Bureau, I., Maron, C., Gage, F. H., Mann, J. R., Bettler, B. & Heinemann, S. F., Apr 9 1998, In : Nature. 392, 6676, p. 601-605 5 p.

Research output: Contribution to journalArticle

362 Scopus citations
1999

Multiple and opposing roles of cholinergic transmission in the main olfactory bulb

Castillo, P. E., Carleton, A., Vincent, J. D. & Lledo, P. M., Nov 1 1999, In : Journal of Neuroscience. 19, 21, p. 9180-9191 12 p.

Research output: Contribution to journalArticle

Open Access
109 Scopus citations
2000

Mice lacking α-synuclein display functional deficits in the nigrostriatal dopamine system

Abeliovich, A., Schmitz, Y., Fariñas, I., Choi-Lundberg, D., Ho, W. H., Castillo, P. E., Shinsky, N., Garcia Verdugo, J. M., Armanini, M., Ryan, A., Hynes, M., Phillips, H., Sulzer, D. & Rosenthal, A., Jan 2000, In : Neuron. 25, 1, p. 239-252 14 p.

Research output: Contribution to journalArticle

Open Access
1231 Scopus citations
2002
154 Scopus citations

RIM1α forms a protein scaffold for regulating neurotransmitter release at the active zone

Schoch, S., Castillo, P. E., Jo, T., Mukherjee, K., Geppert, M., Wang, Y., Schmitz, F., Malenka, R. C. & Südhof, T. C., Jan 17 2002, In : Nature. 415, 6869, p. 321-326 6 p.

Research output: Contribution to journalArticle

441 Scopus citations

RIM1α is required for presynaptic long-term potentiation

Castillo, P. E., Schoch, S., Schmitz, F., Südhof, T. C. & Malenka, R. C., Jan 17 2002, In : Nature. 415, 6869, p. 327-330 4 p.

Research output: Contribution to journalArticle

302 Scopus citations
2003

Heterosynaptic LTD of hippocampal GABAergic synapses: A novel role of endocannabinoids in regulating excitability

Chevaleyre, V. & Castillo, P. E., May 8 2003, In : Neuron. 38, 3, p. 461-472 12 p.

Research output: Contribution to journalArticle

487 Scopus citations
2004

A single in-vivo exposure to Δ9THC blocks endocannabinoid-mediated synaptic plasticity

Mato, S., Chevaleyre, V., Robbe, D., Pazos, A., Castillo, P. E. & Manzoni, O. J., Jun 1 2004, In : Nature Neuroscience. 7, 6, p. 585-586 2 p.

Research output: Contribution to journalArticle

166 Scopus citations

Double-knockout mice for α- and β-synucleins: Effect on synaptic functions

Chandra, S., Fornai, F., Kwon, H. B., Yazdani, U., Atasoy, D., Liu, X., Hammer, R. E., Battaglia, G., German, D. C., Castillo, P. E. & Südhof, T. C., Oct 12 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 41, p. 14966-14971 6 p.

Research output: Contribution to journalArticle

291 Scopus citations

Endocannabinoid-mediated metaplasticity in the hippocampus

Chevaleyre, V. & Castillo, P. E., Sep 16 2004, In : Neuron. 43, 6, p. 871-881 11 p.

Research output: Contribution to journalArticle

219 Scopus citations
2005
165 Scopus citations
2006

Protein kinase A regulates calcium permeability of NMDA receptors

Skeberdis, V. A., Chevaleyre, V., Lau, C. G., Goldberg, J. H., Pettit, D. L., Suadicani, S. O., Lin, Y., Bennett, M. V. L., Yuste, R., Castillo, P. E. & Zukin, R. S., Apr 1 2006, In : Nature Neuroscience. 9, 4, p. 501-510 10 p.

Research output: Contribution to journalArticle

219 Scopus citations

Redundant functions of RIM1α and RIM2α in Ca 2+-triggered neurotransmitter release

Schoch, S., Mittelstaedt, T., Kaeser, P. S., Padgett, D., Feldmann, N., Chevaleyre, V., Castillo, P. E., Hammer, R. E., Han, W., Schmitz, F., Lin, W. & Südhof, T. C., Dec 13 2006, In : EMBO Journal. 25, 24, p. 5852-5863 12 p.

Research output: Contribution to journalArticle

94 Scopus citations

The CB1 cannabinoid receptor mediates glutamatergic synaptic suppression in the hippocampus

Takahashi, K. A. & Castillo, P. E., Sep 6 2006, In : Neuroscience. 139, 3, p. 795-802 8 p.

Research output: Contribution to journalArticle

108 Scopus citations
2007

Endocannabinoid-Mediated Long-Term Plasticity Requires cAMP/PKA Signaling and RIM1α

Chevaleyre, V., Heifets, B. D., Kaeser, P. S., Südhof, T. C., Purpura, D. P. & Castillo, P. E., Jun 7 2007, In : Neuron. 54, 5, p. 801-812 12 p.

Research output: Contribution to journalArticle

183 Scopus citations
2008

Input-specific plasticity at excitatory synapses mediated by endocannabinoids in the dentate gyrus

Chiu, C. Q. & Castillo, P. E., Jan 1 2008, In : Neuropharmacology. 54, 1, p. 68-78 11 p.

Research output: Contribution to journalArticle

33 Scopus citations

Interneuron activity controls endocannabinoid-mediated presynaptic plasticity through calcineurin

Heifets, B. D., Chevaleyre, V. & Castillo, P. E., Jul 22 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 29, p. 10250-10255 6 p.

Research output: Contribution to journalArticle

82 Scopus citations

Long-Term Potentiation Selectively Expressed by NMDA Receptors at Hippocampal Mossy Fiber Synapses

Kwon, H. B. & Castillo, P. E., Jan 10 2008, In : Neuron. 57, 1, p. 108-120 13 p.

Research output: Contribution to journalArticle

99 Scopus citations

RIM1α and RIM1β are synthesized from distinct promoters of the RIM1 gene to mediate differential but overlapping synaptic functions

Kaeser, P. S., Kwon, H. B., Chiu, C. Q., Deng, L., Castillo, P. E. & Südhof, T. C., Dec 10 2008, In : Journal of Neuroscience. 28, 50, p. 13435-13447 13 p.

Research output: Contribution to journalArticle

61 Scopus citations

RIM1α phosphorylation at serine-413 by protein kinase A is not required for presynaptic long-term plasticity or learning

Kaeser, P. S., Kwon, H. B., Blundell, J., Chevaleyre, V., Morishita, W., Malenka, R. C., Powell, C. M., Castillo, P. E. & Südhof, T. C., Sep 23 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 38, p. 14680-14685 6 p.

Research output: Contribution to journalArticle

50 Scopus citations

Role of Glutamate Autoreceptors at Hippocampal Mossy Fiber Synapses

Kwon, H. B. & Castillo, P. E., Dec 26 2008, In : Neuron. 60, 6, p. 1082-1094 13 p.

Research output: Contribution to journalArticle

47 Scopus citations
2009

Age-dependent impairment of cognitive and synaptic function in the htau mouse model of Tau pathology

Polydoro, M., Acker, C. M., Duff, K., Castillo, P. E. & Davies, P., Aug 26 2009, In : Journal of Neuroscience. 29, 34, p. 10741-10749 9 p.

Research output: Contribution to journalArticle

199 Scopus citations

ELKS2α/CAST Deletion Selectively Increases Neurotransmitter Release at Inhibitory Synapses

Kaeser, P. S., Deng, L., Chávez, A. E., Liu, X., Castillo, P. E. & Südhof, T. C., Oct 29 2009, In : Neuron. 64, 2, p. 227-239 13 p.

Research output: Contribution to journalArticle

70 Scopus citations
2010

Dopaminergic modulation of endocannabinoid-mediated plasticity at GABAergic synapses in the prefrontal cortex

Chiu, C. Q., Puente, N., Grandes, P. & Castillo, P. E., May 26 2010, In : Journal of Neuroscience. 30, 21, p. 7236-7248 13 p.

Research output: Contribution to journalArticle

92 Scopus citations

Piccolo and bassoon maintain synaptic vesicle clustering without directly participating in vesicle exocytosis

Mukherjee, K., Yang, X., Gerber, S. H., Kwon, H. B., Ho, A., Castillo, P. E., Liu, X. & Südhof, T. C., Apr 6 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 14, p. 6504-6509 6 p.

Research output: Contribution to journalArticle

107 Scopus citations

TRPV1 activation by endogenous anandamide triggers postsynaptic long-term depression in dentate gyrus

Chávez, A. E., Chiu, C. Q. & Castillo, P. E., Dec 2010, In : Nature Neuroscience. 13, 12, p. 1511-1519 9 p.

Research output: Contribution to journalArticle

212 Scopus citations

αβγ-Synuclein triple knockout mice revealage-dependent neuronal dysfunction

Greten-Harrison, B., Polydoro, M., Morimoto-Tomita, M., Diao, L., Williams, A. M., Nie, E. H., Makani, S., Tian, N., Castillo, P. E., Buchman, V. L. & Chandra, S. S., Nov 9 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 45, p. 19573-19578 6 p.

Research output: Contribution to journalArticle

164 Scopus citations
2011

Distinct functions of kainate receptors in the brain are determined by the auxiliary subunit Neto1

Straub, C., Hunt, D. L., Yamasaki, M., Kim, K. S., Watanabe, M., Castillo, P. E. & Tomita, S., Jul 2011, In : Nature Neuroscience. 14, 7, p. 866-873 8 p.

Research output: Contribution to journalArticle

79 Scopus citations

Rab3B protein is required for long-term depression of hippocampal inhibitory synapses and for normal reversal learning

Tsetsenis, T., Younts, T. J., Chiu, C. Q., Kaeser, P. S., Castillo, P. E. & Südhof, T. C., Aug 23 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 34, p. 14300-14305 6 p.

Research output: Contribution to journalArticle

44 Scopus citations

The extent and strength of electrical coupling between inferior olivary neurons is heterogeneous

Hoge, G. J., Davidson, K. G. V., Yasumura, T., Castillo, P. E., Rash, J. E. & Pereda, A. E., Mar 2011, In : Journal of neurophysiology. 105, 3, p. 1089-1101 13 p.

Research output: Contribution to journalArticle

60 Scopus citations
2012

Estradiol attenuates ischemia-induced death of hippocampal neurons and enhances synaptic transmission in aged, long-term hormone-deprived female rats

Inagaki, T., Kaneko, N., Zukin, R. S., Castillo, P. E. & Etgen, A. M., Jun 4 2012, In : PloS one. 7, 6, e38018.

Research output: Contribution to journalArticle

18 Scopus citations
62 Scopus citations

REST-dependent epigenetic remodeling promotes the developmental switch in synaptic NMDA receptors

Rodenas-Ruano, A., Chávez, A. E., Cossio, M. J., Castillo, P. E. & Zukin, R. S., Oct 1 2012, In : Nature Neuroscience. 15, 10, p. 1382-1390 9 p.

Research output: Contribution to journalArticle

119 Scopus citations
2013

Bidirectional NMDA receptor plasticity controls CA3 output and heterosynaptic metaplasticity

Hunt, D. L., Puente, N., Grandes, P. & Castillo, P. E., Aug 1 2013, In : Nature Neuroscience. 16, 8, p. 1049-1059 11 p.

Research output: Contribution to journalArticle

29 Scopus citations

CA1 pyramidal cell theta-burst firing triggers endocannabinoid-mediated long-term depression at both somatic and dendritic inhibitory synapses

Younts, T. J., Chevaleyre, V. & Castillo, P. E., 2013, In : Journal of Neuroscience. 33, 34, p. 13743-13757 15 p.

Research output: Contribution to journalArticle

35 Scopus citations

Neuroligin1 drives synaptic and behavioral maturation through intracellular interactions

Hoy, J. L., Haeger, P. A., Constable, J. R. L., Arias, R. J., McCallum, R., Kyweriga, M., Davis, L., Schnell, E., Wehr, M., Castillo, P. E. & Washbourne, P., May 29 2013, In : Journal of Neuroscience. 33, 22, p. 9364-9384 21 p.

Research output: Contribution to journalArticle

14 Scopus citations
41 Scopus citations