• 10134 Citations
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1990 …2020

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2019

Sam68 Enables Metabotropic Glutamate Receptor-Dependent LTD in Distal Dendritic Regions of CA1 Hippocampal Neurons

Klein, M. E., Younts, T. J., Cobo, C. F., Buxbaum, A. R., Aow, J., Erdjument-Bromage, H., Richard, S., Malinow, R., Neubert, T. A., Singer, R. H., Castillo, P. E. & Jordan, B. A., Nov 12 2019, In : Cell Reports. 29, 7, p. 1789-1799.e6

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2018

Neurotrophin and FGF Signaling Adapter Proteins, FRS2 and FRS3, Regulate Dentate Granule Cell Maturation and Excitatory Synaptogenesis

Nandi, S., Alviña, K., Lituma, P. J., Castillo, P. E. & Hébert, J. M., Jan 15 2018, In : Neuroscience. 369, p. 192-201 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

Npas4 Is a Critical Regulator of Learning-Induced Plasticity at Mossy Fiber-CA3 Synapses during Contextual Memory Formation

Weng, F. J., Garcia, R. I., Lutzu, S., Alviña, K., Zhang, Y., Dushko, M., Ku, T., Zemoura, K., Rich, D., Garcia-Dominguez, D., Hung, M., Yelhekar, T. D., Sørensen, A. T., Xu, W., Chung, K., Castillo, P. E. & Lin, Y., Mar 7 2018, In : Neuron. 97, 5, p. 1137-1152.e5

Research output: Contribution to journalArticle

16 Scopus citations
2017

LTP at Hilar Mossy Cell-Dentate Granule Cell Synapses Modulates Dentate Gyrus Output by Increasing Excitation/Inhibition Balance

Hashimotodani, Y., Nasrallah, K., Jensen, K. R., Chávez, A. E., Carrera, D. & Castillo, P. E., Aug 16 2017, In : Neuron. 95, 4, p. 928-943.e3

Research output: Contribution to journalArticle

19 Scopus citations

Oxytocin improves behavioral and electrophysiological deficits in a novel Shank3-deficient rat

Harony-Nicolas, H., Kay, M., du Hoffmann, J., Klein, M. E., Bozdagi-Gunal, O., Riad, M., Daskalakis, N. P., Sonar, S., Castillo, P. E., Hof, P. R., Shapiro, M. L., Baxter, M. G., Wagner, S. & Buxbaum, J. D., Jan 31 2017, In : eLife. 6, e18904.

Research output: Contribution to journalArticle

41 Scopus citations

Unconventional NMDA receptor signaling

Dore, K., Stein, I. S., Brock, J. A., Castillo, P. E., Zito, K. & Sjöström, P. J., Nov 8 2017, In : Journal of Neuroscience. 37, 45, p. 10800-10807 8 p.

Research output: Contribution to journalArticle

35 Scopus citations
2016

CaMKII Phosphorylation of TARPγ-8 Is a Mediator of LTP and Learning and Memory

Park, J., Chávez, A. E., Mineur, Y. S., Morimoto-Tomita, M., Lutzu, S., Kim, K. S., Picciotto, M. R., Castillo, P. E. & Tomita, S., Oct 5 2016, In : Neuron. 92, 1, p. 75-83 9 p.

Research output: Contribution to journalArticle

31 Scopus citations

De novo synaptogenesis induced by GABA in the developing mouse cortex

Oh, W. C., Lutzu, S., Castillo, P. E. & Kwon, H. B., Sep 2 2016, In : Science. 353, 6303, p. 1037-1040 4 p.

Research output: Contribution to journalArticle

54 Scopus citations

Presynaptic Protein Synthesis Is Required for Long-Term Plasticity of GABA Release

Younts, T. J., Monday, H. R., Dudok, B., Klein, M. E., Jordan, B. A., Katona, I. & Castillo, P. E., Oct 19 2016, In : Neuron. 92, 2, p. 479-492 14 p.

Research output: Contribution to journalArticle

67 Scopus citations

Targeted deletion of AKAP7 in dentate granule cells impairs spatial discrimination

Jones, B. W., Deem, J., Younts, T. J., Weisenhaus, M., Sanford, C. A., Slack, M. C., Chin, J., Nachmanson, D., McKennon, A., Castillo, P. E. & McKnight, G. S., Dec 2 2016, In : eLife. 5, DECEMBER2016, e20695.

Research output: Contribution to journalArticle

9 Scopus citations
2015

A Combined Optogenetic-Knockdown Strategy Reveals a Major Role of Tomosyn in Mossy Fiber Synaptic Plasticity

Ben-Simon, Y., Rodenas-Ruano, A., Alviña, K., Lam, A. D., Stuenkel, E. L., Castillo, P. E. & Ashery, U., Jul 21 2015, In : Cell Reports. 12, 3, p. 396-404 9 p.

Research output: Contribution to journalArticle

11 Scopus citations

Actinin-4 governs dendritic spine dynamics and promotes their remodeling by metabotropic glutamate receptors

Kalinowska, M., Chávez, A. E., Lutzu, S., Castillo, P. E., Bukauskas, F. F. & Francesconi, A., Jun 26 2015, In : Journal of Biological Chemistry. 290, 26, p. 15909-15920 12 p.

Research output: Contribution to journalArticle

13 Scopus citations

ANKS1B gene product AIDA-1 controls hippocampal synaptic transmission by regulating GluN2B subunit localization

Tindi, J. O., Chávez, A. E., Cvejic, S., Calvo-Ochoa, E., Castillo, P. E. & Jordan, B. A., Jun 17 2015, In : Journal of Neuroscience. 35, 24, p. 8986-8996 11 p.

Research output: Contribution to journalArticle

12 Scopus citations

APP and APLP2 interact with the synaptic release machinery and facilitate transmitter release at hippocampal synapses

Fanutza, T., del Prete, D., Ford, M. J., Castillo, P. E. & D’Adamio, L., Nov 9 2015, In : eLife. 4, NOVEMBER2015, e09743.

Research output: Contribution to journalArticle

31 Scopus citations

Coordination between translation and degradation regulates inducibility of mGluR-LTD

Klein, M. E., Castillo, P. E. & Jordan, B. A., Mar 10 2015, In : Cell Reports. 10, 9, p. 1459-1466 8 p.

Research output: Contribution to journalArticle

22 Scopus citations

Selective dysregulation of hippocampal inhibition in the mouse lacking autism candidate gene CNTNAP2

Jurgensen, S. & Castillo, P. E., Oct 28 2015, In : Journal of Neuroscience. 35, 43, p. 14681-14687 7 p.

Research output: Contribution to journalArticle

32 Scopus citations
2014

Compartment-specific modulation of GABAergic synaptic transmission by TRPV1 channels in the dentate gyrus

Chávez, A. E., Hernández, V. M., Rodenas-Ruano, A., Savio Chan, C. & Castillo, P. E., Dec 10 2014, In : Journal of Neuroscience. 34, 50, p. 16621-16629 9 p.

Research output: Contribution to journalArticle

30 Scopus citations

Synucleins regulate the kinetics of synaptic vesicle endocytosis

Vargas, K. J., Makani, S., Davis, T., Westphal, C. H., Castillo, P. E. & Chandra, S. S., Jan 1 2014, In : Journal of Neuroscience. 34, 28, p. 9364-9376 13 p.

Research output: Contribution to journalArticle

130 Scopus citations

The Rac1 inhibitor NSC23766 suppresses CREB signaling by targeting NMDA receptor function

Hou, H., Chavez, A. E., Wang, C. C., Yang, H., Gu, H., Siddoway, B. A., Hall, B. J., Castillo, P. E. & Xia, H., Oct 15 2014, In : Journal of Neuroscience. 34, 42, p. 14006-14012 7 p.

Research output: Contribution to journalArticle

10 Scopus citations
2013

Bidirectional NMDA receptor plasticity controls CA3 output and heterosynaptic metaplasticity

Hunt, D. L., Puente, N., Grandes, P. & Castillo, P. E., Aug 1 2013, In : Nature Neuroscience. 16, 8, p. 1049-1059 11 p.

Research output: Contribution to journalArticle

29 Scopus citations

CA1 pyramidal cell theta-burst firing triggers endocannabinoid-mediated long-term depression at both somatic and dendritic inhibitory synapses

Younts, T. J., Chevaleyre, V. & Castillo, P. E., 2013, In : Journal of Neuroscience. 33, 34, p. 13743-13757 15 p.

Research output: Contribution to journalArticle

32 Scopus citations

Neuroligin1 drives synaptic and behavioral maturation through intracellular interactions

Hoy, J. L., Haeger, P. A., Constable, J. R. L., Arias, R. J., McCallum, R., Kyweriga, M., Davis, L., Schnell, E., Wehr, M., Castillo, P. E. & Washbourne, P., May 29 2013, In : Journal of Neuroscience. 33, 22, p. 9364-9384 21 p.

Research output: Contribution to journalArticle

14 Scopus citations
40 Scopus citations

Synaptotagmin-12 phosphorylation by cAMP-dependent protein kinase is essential for hippocampal mossy fiber LTP

Kaeser-Woo, Y. J., Younts, T. J., Yang, X., Zhou, P., Wu, D., Castillo, P. E. & Südhof, T. C., 2013, In : Journal of Neuroscience. 33, 23, p. 9769-9780 12 p.

Research output: Contribution to journalArticle

19 Scopus citations
2012

Estradiol attenuates ischemia-induced death of hippocampal neurons and enhances synaptic transmission in aged, long-term hormone-deprived female rats

Inagaki, T., Kaneko, N., Zukin, R. S., Castillo, P. E. & Etgen, A. M., Jun 4 2012, In : PloS one. 7, 6, e38018.

Research output: Contribution to journalArticle

18 Scopus citations
59 Scopus citations

REST-dependent epigenetic remodeling promotes the developmental switch in synaptic NMDA receptors

Rodenas-Ruano, A., Chávez, A. E., Cossio, M. J., Castillo, P. E. & Zukin, R. S., Oct 1 2012, In : Nature Neuroscience. 15, 10, p. 1382-1390 9 p.

Research output: Contribution to journalArticle

114 Scopus citations
2011

Distinct functions of kainate receptors in the brain are determined by the auxiliary subunit Neto1

Straub, C., Hunt, D. L., Yamasaki, M., Kim, K. S., Watanabe, M., Castillo, P. E. & Tomita, S., Jul 2011, In : Nature Neuroscience. 14, 7, p. 866-873 8 p.

Research output: Contribution to journalArticle

79 Scopus citations

Rab3B protein is required for long-term depression of hippocampal inhibitory synapses and for normal reversal learning

Tsetsenis, T., Younts, T. J., Chiu, C. Q., Kaeser, P. S., Castillo, P. E. & Südhof, T. C., Aug 23 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 34, p. 14300-14305 6 p.

Research output: Contribution to journalArticle

42 Scopus citations

The extent and strength of electrical coupling between inferior olivary neurons is heterogeneous

Hoge, G. J., Davidson, K. G. V., Yasumura, T., Castillo, P. E., Rash, J. E. & Pereda, A. E., Mar 1 2011, In : Journal of neurophysiology. 105, 3, p. 1089-1101 13 p.

Research output: Contribution to journalArticle

56 Scopus citations
2010

Dopaminergic modulation of endocannabinoid-mediated plasticity at GABAergic synapses in the prefrontal cortex

Chiu, C. Q., Puente, N., Grandes, P. & Castillo, P. E., May 26 2010, In : Journal of Neuroscience. 30, 21, p. 7236-7248 13 p.

Research output: Contribution to journalArticle

90 Scopus citations

Piccolo and bassoon maintain synaptic vesicle clustering without directly participating in vesicle exocytosis

Mukherjee, K., Yang, X., Gerber, S. H., Kwon, H. B., Ho, A., Castillo, P. E., Liu, X. & Südhof, T. C., Apr 6 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 14, p. 6504-6509 6 p.

Research output: Contribution to journalArticle

107 Scopus citations

TRPV1 activation by endogenous anandamide triggers postsynaptic long-term depression in dentate gyrus

Chávez, A. E., Chiu, C. Q. & Castillo, P. E., Dec 1 2010, In : Nature Neuroscience. 13, 12, p. 1511-1519 9 p.

Research output: Contribution to journalArticle

210 Scopus citations

αβγ-Synuclein triple knockout mice revealage-dependent neuronal dysfunction

Greten-Harrison, B., Polydoro, M., Morimoto-Tomita, M., Diao, L., Williams, A. M., Nie, E. H., Makani, S., Tian, N., Castillo, P. E., Buchman, V. L. & Chandra, S. S., Nov 9 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 45, p. 19573-19578 6 p.

Research output: Contribution to journalArticle

160 Scopus citations
2009

Age-dependent impairment of cognitive and synaptic function in the htau mouse model of Tau pathology

Polydoro, M., Acker, C. M., Duff, K., Castillo, P. E. & Davies, P., Aug 26 2009, In : Journal of Neuroscience. 29, 34, p. 10741-10749 9 p.

Research output: Contribution to journalArticle

193 Scopus citations

ELKS2α/CAST Deletion Selectively Increases Neurotransmitter Release at Inhibitory Synapses

Kaeser, P. S., Deng, L., Chávez, A. E., Liu, X., Castillo, P. E. & Südhof, T. C., Oct 29 2009, In : Neuron. 64, 2, p. 227-239 13 p.

Research output: Contribution to journalArticle

67 Scopus citations
2008

Input-specific plasticity at excitatory synapses mediated by endocannabinoids in the dentate gyrus

Chiu, C. Q. & Castillo, P. E., Jan 1 2008, In : Neuropharmacology. 54, 1, p. 68-78 11 p.

Research output: Contribution to journalArticle

33 Scopus citations

Interneuron activity controls endocannabinoid-mediated presynaptic plasticity through calcineurin

Heifets, B. D., Chevaleyre, V. & Castillo, P. E., Jul 22 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 29, p. 10250-10255 6 p.

Research output: Contribution to journalArticle

81 Scopus citations

Long-Term Potentiation Selectively Expressed by NMDA Receptors at Hippocampal Mossy Fiber Synapses

Kwon, H. B. & Castillo, P. E., Jan 10 2008, In : Neuron. 57, 1, p. 108-120 13 p.

Research output: Contribution to journalArticle

98 Scopus citations

RIM1α and RIM1β are synthesized from distinct promoters of the RIM1 gene to mediate differential but overlapping synaptic functions

Kaeser, P. S., Kwon, H. B., Chiu, C. Q., Deng, L., Castillo, P. E. & Südhof, T. C., Dec 10 2008, In : Journal of Neuroscience. 28, 50, p. 13435-13447 13 p.

Research output: Contribution to journalArticle

60 Scopus citations

RIM1α phosphorylation at serine-413 by protein kinase A is not required for presynaptic long-term plasticity or learning

Kaeser, P. S., Kwon, H. B., Blundell, J., Chevaleyre, V., Morishita, W., Malenka, R. C., Powell, C. M., Castillo, P. E. & Südhof, T. C., Sep 23 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 38, p. 14680-14685 6 p.

Research output: Contribution to journalArticle

50 Scopus citations

Role of Glutamate Autoreceptors at Hippocampal Mossy Fiber Synapses

Kwon, H. B. & Castillo, P. E., Dec 26 2008, In : Neuron. 60, 6, p. 1082-1094 13 p.

Research output: Contribution to journalArticle

47 Scopus citations
2007

Endocannabinoid-Mediated Long-Term Plasticity Requires cAMP/PKA Signaling and RIM1α

Chevaleyre, V., Heifets, B. D., Kaeser, P. S., Südhof, T. C., Purpura, D. P. & Castillo, P. E., Jun 7 2007, In : Neuron. 54, 5, p. 801-812 12 p.

Research output: Contribution to journalArticle

180 Scopus citations
2006

Protein kinase A regulates calcium permeability of NMDA receptors

Skeberdis, V. A., Chevaleyre, V., Lau, C. G., Goldberg, J. H., Pettit, D. L., Suadicani, S. O., Lin, Y., Bennett, M. V. L., Yuste, R., Castillo, P. E. & Zukin, R. S., Apr 1 2006, In : Nature Neuroscience. 9, 4, p. 501-510 10 p.

Research output: Contribution to journalArticle

216 Scopus citations

Redundant functions of RIM1α and RIM2α in Ca 2+-triggered neurotransmitter release

Schoch, S., Mittelstaedt, T., Kaeser, P. S., Padgett, D., Feldmann, N., Chevaleyre, V., Castillo, P. E., Hammer, R. E., Han, W., Schmitz, F., Lin, W. & Südhof, T. C., Dec 13 2006, In : EMBO Journal. 25, 24, p. 5852-5863 12 p.

Research output: Contribution to journalArticle

94 Scopus citations

The CB1 cannabinoid receptor mediates glutamatergic synaptic suppression in the hippocampus

Takahashi, K. A. & Castillo, P. E., Sep 6 2006, In : Neuroscience. 139, 3, p. 795-802 8 p.

Research output: Contribution to journalArticle

108 Scopus citations
2005
163 Scopus citations
2004

A single in-vivo exposure to Δ9THC blocks endocannabinoid-mediated synaptic plasticity

Mato, S., Chevaleyre, V., Robbe, D., Pazos, A., Castillo, P. E. & Manzoni, O. J., Jun 1 2004, In : Nature Neuroscience. 7, 6, p. 585-586 2 p.

Research output: Contribution to journalArticle

164 Scopus citations

Double-knockout mice for α- and β-synucleins: Effect on synaptic functions

Chandra, S., Fornai, F., Kwon, H. B., Yazdani, U., Atasoy, D., Liu, X., Hammer, R. E., Battaglia, G., German, D. C., Castillo, P. E. & Südhof, T. C., Oct 12 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 41, p. 14966-14971 6 p.

Research output: Contribution to journalArticle

287 Scopus citations

Endocannabinoid-mediated metaplasticity in the hippocampus

Chevaleyre, V. & Castillo, P. E., Sep 16 2004, In : Neuron. 43, 6, p. 871-881 11 p.

Research output: Contribution to journalArticle

213 Scopus citations