• 9714 Citations
  • 44 h-Index
1990 …2023
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Publications 1990 2019

  • 9714 Citations
  • 44 h-Index
  • 85 Article
  • 2 Chapter
  • 2 Review article
2019

Sam68 Enables Metabotropic Glutamate Receptor-Dependent LTD in Distal Dendritic Regions of CA1 Hippocampal Neurons

Klein, M. E., Younts, T. J., Cobo, C. F., Buxbaum, A. R., Aow, J., Erdjument-Bromage, H., Richard, S., Malinow, R., Neubert, T. A., Singer, R. H., Castillo, P. E. & Jordan, B. A., Nov 12 2019, In : Cell Reports. 29, 7, p. 1789-1799.e6

Research output: Contribution to journalArticle

Open Access
Hippocampal CA1 Region
Metabotropic Glutamate Receptors
Dendrites
Neurons
Plasticity
2018
10 Citations (Scopus)

Long-term plasticity of neurotransmitter release: Emerging mechanisms and contributions to brain function and disease

Monday, H. R., Younts, T. J. & Castillo, P. E., Jul 8 2018, In : Annual Review of Neuroscience. 41, p. 299-322 24 p.

Research output: Contribution to journalReview article

Brain Diseases
Neurotransmitter Agents
Neuronal Plasticity
Long-Term Potentiation
Autistic Disorder

Neurotrophin and FGF Signaling Adapter Proteins, FRS2 and FRS3, Regulate Dentate Granule Cell Maturation and Excitatory Synaptogenesis

Nandi, S., Alviña, K., Lituma, P. J., Castillo, P. E. & Hebert, J. M., Jan 15 2018, In : Neuroscience. 369, p. 192-201 10 p.

Research output: Contribution to journalArticle

Nerve Growth Factors
Fibroblast Growth Factor Receptors
Proteins
Dendritic Spines
Neurogenesis
11 Citations (Scopus)

Npas4 Is a Critical Regulator of Learning-Induced Plasticity at Mossy Fiber-CA3 Synapses during Contextual Memory Formation

Weng, F. J., Garcia, R. I., Lutzu, S., Alviña, K., Zhang, Y., Dushko, M., Ku, T., Zemoura, K., Rich, D., Garcia-Dominguez, D., Hung, M., Yelhekar, T. D., Sørensen, A. T., Xu, W., Chung, K., Castillo, P. E. & Lin, Y., Jan 1 2018, (Accepted/In press) In : Neuron.

Research output: Contribution to journalArticle

Synapses
Pyramidal Cells
Learning
Transcription Factors
Hippocampal Mossy Fibers
2017
14 Citations (Scopus)

Closing the gap: long-term presynaptic plasticity in brain function and disease

Monday, H. R. & Castillo, P. E., Aug 1 2017, In : Current Opinion in Neurobiology. 45, p. 106-112 7 p.

Research output: Contribution to journalReview article

Brain Diseases
Social Adjustment
Neuronal Plasticity
Research
Neurotransmitter Agents
15 Citations (Scopus)

LTP at Hilar Mossy Cell-Dentate Granule Cell Synapses Modulates Dentate Gyrus Output by Increasing Excitation/Inhibition Balance

Hashimotodani, Y., Nasrallah, K., Jensen, K. R., Chávez, A. E., Carrera, D. & Castillo, P. E., Aug 16 2017, In : Neuron. 95, 4, p. 928-943.e3

Research output: Contribution to journalArticle

Long-Term Potentiation
Dentate Gyrus
Synapses
Inhibition (Psychology)
Presynaptic Receptors
34 Citations (Scopus)

Oxytocin improves behavioral and electrophysiological deficits in a novel Shank3-deficient rat

Harony-Nicolas, H., Kay, M., du Hoffmann, J., Klein, M. E., Bozdagi-Gunal, O., Riad, M., Daskalakis, N. P., Sonar, S., Castillo, P. E., Hof, P. R., Shapiro, M. L., Baxter, M. G., Wagner, S. & Buxbaum, J. D., Jan 31 2017, In : eLife. 6, e18904.

Research output: Contribution to journalArticle

Oxytocin
Rats
Plasticity
Genes
Intellectual Disability
43 Citations (Scopus)

Synaptic functions of endocannabinoid signaling in health and disease

Araque, A., Castillo, P. E., Manzoni, O. J. & Tonini, R., Apr 30 2017, (Accepted/In press) In : Neuropharmacology.

Research output: Contribution to journalArticle

Endocannabinoids
Neuronal Plasticity
Health
Cannabinoid Receptor CB1
Long-Term Potentiation
31 Citations (Scopus)

Unconventional NMDA receptor signaling

Dore, K., Stein, I. S., Brock, J. A., Castillo, P. E., Zito, K. & Sjöström, P. J., Nov 8 2017, In : Journal of Neuroscience. 37, 45, p. 10800-10807 8 p.

Research output: Contribution to journalArticle

N-Methyl-D-Aspartate Receptors
Membranes
2016
27 Citations (Scopus)

CaMKII Phosphorylation of TARPγ-8 Is a Mediator of LTP and Learning and Memory

Park, J., Chávez, A. E., Mineur, Y. S., Morimoto-Tomita, M., Lutzu, S., Kim, K. S., Picciotto, M. R., Castillo, P. E. & Tomita, S., Oct 5 2016, In : Neuron. 92, 1, p. 75-83 9 p.

Research output: Contribution to journalArticle

Calcium-Calmodulin-Dependent Protein Kinase Type 2
Long-Term Memory
Long-Term Potentiation
Phosphorylation
Learning
50 Citations (Scopus)

De novo synaptogenesis induced by GABA in the developing mouse cortex

Oh, W. C., Lutzu, S., Castillo, P. E. & Kwon, H. B., Sep 2 2016, In : Science. 353, 6303, p. 1037-1040 4 p.

Research output: Contribution to journalArticle

gamma-Aminobutyric Acid
Dendritic Spines
Pyramidal Cells
Dendrites
Synapses
58 Citations (Scopus)

Presynaptic Protein Synthesis Is Required for Long-Term Plasticity of GABA Release

Younts, T. J., Monday, H. R., Dudok, B., Klein, M. E., Jordan, B. A., Katona, I. & Castillo, P. E., Oct 19 2016, In : Neuron. 92, 2, p. 479-492 14 p.

Research output: Contribution to journalArticle

gamma-Aminobutyric Acid
Proteins
Neurotransmitter Agents
Axons
Brain
7 Citations (Scopus)

Targeted deletion of AKAP7 in dentate granule cells impairs spatial discrimination

Jones, B. W., Deem, J., Younts, T. J., Weisenhaus, M., Sanford, C. A., Slack, M. C., Chin, J., Nachmanson, D., McKennon, A., Castillo, P. E. & McKnight, G. S., Dec 2 2016, In : eLife. 5, DECEMBER2016, e20695.

Research output: Contribution to journalArticle

Cyclic AMP-Dependent Protein Kinases
Plasticity
Neuronal Plasticity
Fibers
Data storage equipment
2015
8 Citations (Scopus)

A Combined Optogenetic-Knockdown Strategy Reveals a Major Role of Tomosyn in Mossy Fiber Synaptic Plasticity

Ben-Simon, Y., Rodenas-Ruano, A., Alviña, K., Lam, A. D., Stuenkel, E. L., Castillo, P. E. & Ashery, U., Jul 21 2015, In : Cell Reports. 12, 3, p. 396-404 9 p.

Research output: Contribution to journalArticle

Optogenetics
Neuronal Plasticity
Synapses
Plasticity
Long-Term Potentiation
12 Citations (Scopus)

Actinin-4 governs dendritic spine dynamics and promotes their remodeling by metabotropic glutamate receptors

Kalinowska, M., Chávez, A. E., Lutzu, S., Castillo, P. E., Bukauskas, F. F. & Francesconi, A., Jun 26 2015, In : Journal of Biological Chemistry. 290, 26, p. 15909-15920 12 p.

Research output: Contribution to journalArticle

Actinin
Dendritic Spines
Metabotropic Glutamate Receptors
Spine
Neurons
12 Citations (Scopus)

ANKS1B gene product AIDA-1 controls hippocampal synaptic transmission by regulating GluN2B subunit localization

Tindi, J. O., Chávez, A. E., Cvejic, S., Calvo-Ochoa, E., Castillo, P. E. & Jordan, B. A., Jun 17 2015, In : Journal of Neuroscience. 35, 24, p. 8986-8996 11 p.

Research output: Contribution to journalArticle

Amyloid
Synaptic Transmission
N-Methyl-D-Aspartate Receptors
Genes
Proteins
23 Citations (Scopus)

APP and APLP2 interact with the synaptic release machinery and facilitate transmitter release at hippocampal synapses

Fanutza, T., del Prete, D., Ford, M. J., Castillo, P. E. & D’Adamio, L., Nov 9 2015, In : eLife. 4, NOVEMBER2015, e09743.

Research output: Contribution to journalArticle

Amyloid beta-Protein Precursor
Synapses
Machinery
Transmitters
Proteins
21 Citations (Scopus)

Coordination between translation and degradation regulates inducibility of mGluR-LTD

Klein, M. E., Castillo, P. E. & Jordan, B. A., Mar 10 2015, In : Cell Reports. 10, 9, p. 1459-1466 8 p.

Research output: Contribution to journalArticle

Metabotropic Glutamate Receptors
Degradation
Proteasome Endopeptidase Complex
Proteins
Neuronal Plasticity
29 Citations (Scopus)

Selective dysregulation of hippocampal inhibition in the mouse lacking autism candidate gene CNTNAP2

Jurgensen, S. & Castillo, P. E., Oct 28 2015, In : Journal of Neuroscience. 35, 43, p. 14681-14687 7 p.

Research output: Contribution to journalArticle

Contactins
Autistic Disorder
Genes
Proteins
Phenotype
2014
27 Citations (Scopus)

Compartment-specific modulation of GABAergic synaptic transmission by TRPV1 channels in the dentate gyrus

Chávez, A. E., Hernández, V. M., Rodenas-Ruano, A., Savio Chan, C. & Castillo, P. E., Dec 10 2014, In : Journal of Neuroscience. 34, 50, p. 16621-16629 9 p.

Research output: Contribution to journalArticle

Dentate Gyrus
Synaptic Transmission
Brain
Ligand-Gated Ion Channels
TRPV Cation Channels
23 Citations (Scopus)

Endogenous cannabinoid signaling at inhibitory interneurons

Younts, T. J. & Castillo, P. E., Jun 2014, In : Current Opinion in Neurobiology. 26, p. 42-50 9 p.

Research output: Contribution to journalArticle

Cannabinoids
Interneurons
Synapses
Signal Transduction
Central Nervous System
118 Citations (Scopus)

Synucleins regulate the kinetics of synaptic vesicle endocytosis

Vargas, K. J., Makani, S., Davis, T., Westphal, C. H., Castillo, P. E. & Chandra, S. S., 2014, In : Journal of Neuroscience. 34, 28, p. 9364-9376 13 p.

Research output: Contribution to journalArticle

Synucleins
Synaptic Vesicles
Endocytosis
Parkinson Disease
Dynamins
7 Citations (Scopus)

The Rac1 inhibitor NSC23766 suppresses CREB signaling by targeting NMDA receptor function

Hou, H., Chavez, A. E., Wang, C. C., Yang, H., Gu, H., Siddoway, B. A., Hall, B. J., Castillo, P. E. & Xia, H., Oct 15 2014, In : Journal of Neuroscience. 34, 42, p. 14006-14012 7 p.

Research output: Contribution to journalArticle

N-Methyl-D-Aspartate Receptors
Neurons
GTP Phosphohydrolases
N-Methylaspartate
Baths
2013
28 Citations (Scopus)

Bidirectional NMDA receptor plasticity controls CA3 output and heterosynaptic metaplasticity

Hunt, D. L., Puente, N., Grandes, P. & Castillo, P. E., Aug 2013, In : Nature Neuroscience. 16, 8, p. 1049-1059 11 p.

Research output: Contribution to journalArticle

N-Methyl-D-Aspartate Receptors
Synapses
Neuronal Plasticity
Pyramidal Cells
30 Citations (Scopus)

CA1 pyramidal cell theta-burst firing triggers endocannabinoid-mediated long-term depression at both somatic and dendritic inhibitory synapses

Younts, T. J., Chevaleyre, V. & Castillo, P. E., 2013, In : Journal of Neuroscience. 33, 34, p. 13743-13757 15 p.

Research output: Contribution to journalArticle

Endocannabinoids
Pyramidal Cells
Synapses
Interneurons
Long-Term Synaptic Depression
13 Citations (Scopus)

Neuroligin1 drives synaptic and behavioral maturation through intracellular interactions

Hoy, J. L., Haeger, P. A., Constable, J. R. L., Arias, R. J., McCallum, R., Kyweriga, M., Davis, L., Schnell, E., Wehr, M., Castillo, P. E. & Washbourne, P., May 29 2013, In : Journal of Neuroscience. 33, 22, p. 9364-9384 21 p.

Research output: Contribution to journalArticle

Synapses
Learning
Aptitude
Social Behavior
Drive
6 Citations (Scopus)

Presenilin-ryanodine receptor connection

D'Adamioa, L. & Castillo, P. E., Sep 10 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 37, p. 14825-14826 2 p.

Research output: Contribution to journalArticle

Presenilin-2
Presenilins
Presenilin-1
Ryanodine Receptor Calcium Release Channel
Hippocampus
38 Citations (Scopus)
RNA-Binding Proteins
Dendrites
Synapses
Actins
Messenger RNA
15 Citations (Scopus)

Synaptotagmin-12 phosphorylation by cAMP-dependent protein kinase is essential for hippocampal mossy fiber LTP

Kaeser-Woo, Y. J., Younts, T. J., Yang, X., Zhou, P., Wu, D., Castillo, P. E. & Südhof, T. C., 2013, In : Journal of Neuroscience. 33, 23, p. 9769-9780 12 p.

Research output: Contribution to journalArticle

Hippocampal Mossy Fibers
Synaptotagmins
Long-Term Potentiation
Cyclic AMP-Dependent Protein Kinases
Phosphorylation
2012
372 Citations (Scopus)

Endocannabinoid Signaling and Synaptic Function

Castillo, P. E., Younts, T. J., Chávez, A. E. & Hashimotodani, Y., Oct 4 2012, In : Neuron. 76, 1, p. 70-81 12 p.

Research output: Contribution to journalArticle

Endocannabinoids
Synapses
Cannabinoid Receptors
Neuronal Plasticity
Central Nervous System
18 Citations (Scopus)

Estradiol attenuates ischemia-induced death of hippocampal neurons and enhances synaptic transmission in aged, long-term hormone-deprived female rats

Inagaki, T., Kaneko, N., Zukin, R. S., Castillo, P. E. & Etgen, A. M., Jun 4 2012, In : PLoS One. 7, 6, e38018.

Research output: Contribution to journalArticle

synaptic transmission
ischemia
Synaptic Transmission
Neurons
estradiol
34 Citations (Scopus)

Neto1 and Neto2: Auxiliary subunits that determine key properties of native kainate receptors

Tomita, S. & Castillo, P. E., May 2012, In : Journal of Physiology. 590, 10, p. 2217-2223 7 p.

Research output: Contribution to journalArticle

Kainic Acid Receptors
Ionotropic Glutamate Receptors
Brain
Neurotransmitter Receptor
Synaptic Transmission
52 Citations (Scopus)
Long-Term Potentiation
Synapses
Plasticity
Presynaptic Terminals
Depression
Long-Term Potentiation
Synapses
Plasticity
Presynaptic Terminals
Depression
108 Citations (Scopus)

REST-dependent epigenetic remodeling promotes the developmental switch in synaptic NMDA receptors

Rodenas-Ruano, A., Chávez, A. E., Cossio, M. J., Castillo, P. E. & Zukin, R. S., Oct 2012, In : Nature Neuroscience. 15, 10, p. 1382-1390 9 p.

Research output: Contribution to journalArticle

Neurotransmitter Receptor
N-Methyl-D-Aspartate Receptors
Epigenomics
Maternal Deprivation
Phenotype
130 Citations (Scopus)

Synaptic plasticity of NMDA receptors: Mechanisms and functional implications

Hunt, D. L. & Castillo, P. E., Jun 2012, In : Current Opinion in Neurobiology. 22, 3, p. 496-508 13 p.

Research output: Contribution to journalArticle

Neuronal Plasticity
N-Methyl-D-Aspartate Receptors
AMPA Receptors
Information Storage and Retrieval
Synaptic Transmission
2011
75 Citations (Scopus)

Distinct functions of kainate receptors in the brain are determined by the auxiliary subunit Neto1

Straub, C., Hunt, D. L., Yamasaki, M., Kim, K. S., Watanabe, M., Castillo, P. E. & Tomita, S., Jul 2011, In : Nature Neuroscience. 14, 7, p. 866-873 8 p.

Research output: Contribution to journalArticle

Kainic Acid Receptors
Brain
Ionotropic Glutamate Receptors
Neurotransmitter Receptor
Excitatory Postsynaptic Potentials

Endocannabinoid mediated long-term depression at inhibitory synapses

Chiu, C. Q. & Castillo, P. E., 2011, Inhibitory Synaptic Plasticity. Springer New York, p. 149-166 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Endocannabinoids
Synapses
Depression
Neuronal Plasticity
Neurons
116 Citations (Scopus)

Long-term plasticity at inhibitory synapses

Castillo, P. E., Chiu, C. Q. & Carroll, R. C., Apr 2011, In : Current Opinion in Neurobiology. 21, 2, p. 328-338 11 p.

Research output: Contribution to journalArticle

Neuronal Plasticity
Synapses
Learning
39 Citations (Scopus)

Rab3B protein is required for long-term depression of hippocampal inhibitory synapses and for normal reversal learning

Tsetsenis, T., Younts, T. J., Chiu, C. Q., Kaeser, P. S., Castillo, P. E. & Südhof, T. C., Aug 23 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 34, p. 14300-14305 6 p.

Research output: Contribution to journalArticle

Reversal Learning
Synapses
Protein Isoforms
Learning
Proteins

The battle over inhibitory synaptic plasticity in satiety brain circuits

Younts, T. J. & Castillo, P. E., Aug 11 2011, In : Neuron. 71, 3, p. 385-387 3 p.

Research output: Contribution to journalArticle

Endocannabinoids
Neuronal Plasticity
Hypothalamus
Nitric Oxide
Eating
53 Citations (Scopus)

The extent and strength of electrical coupling between inferior olivary neurons is heterogeneous

Hoge, G. J., Davidson, K. G. V., Yasumura, T., Castillo, P. E., Rash, J. E. & Pereda, A. E., Mar 2011, In : Journal of Neurophysiology. 105, 3, p. 1089-1101 13 p.

Research output: Contribution to journalArticle

Neurons
Gap Junctions
Goldfish
Synapses
Post-Synaptic Density
2010
85 Citations (Scopus)

Dopaminergic modulation of endocannabinoid-mediated plasticity at GABAergic synapses in the prefrontal cortex

Chiu, C. Q., Puente, N., Grandes, P. & Castillo, P. E., May 26 2010, In : Journal of Neuroscience. 30, 21, p. 7236-7248 13 p.

Research output: Contribution to journalArticle

Endocannabinoids
Prefrontal Cortex
Synapses
Cannabinoid Receptors
Dopamine Receptors
100 Citations (Scopus)

Piccolo and bassoon maintain synaptic vesicle clustering without directly participating in vesicle exocytosis

Mukherjee, K., Yang, X., Gerber, S. H., Kwon, H. B., Ho, A., Castillo, P. E., Liu, X. & Südhof, T. C., Apr 6 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 14, p. 6504-6509 6 p.

Research output: Contribution to journalArticle

Synaptic Vesicles
Exocytosis
Cluster Analysis
Neurons
Knockout Mice
206 Citations (Scopus)

TRPV1 activation by endogenous anandamide triggers postsynaptic long-term depression in dentate gyrus

Chávez, A. E., Chiu, C. Q. & Castillo, P. E., Dec 2010, In : Nature Neuroscience. 13, 12, p. 1511-1519 9 p.

Research output: Contribution to journalArticle

Endocannabinoids
Dentate Gyrus
Synapses
Depression
Cannabinoid Receptors
152 Citations (Scopus)

αβγ-Synuclein triple knockout mice revealage-dependent neuronal dysfunction

Greten-Harrison, B., Polydoro, M., Morimoto-Tomita, M., Diao, L., Williams, A. M., Nie, E. H., Makani, S., Tian, N., Castillo, P. E., Buchman, V. L. & Chandra, S. S., Nov 9 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 45, p. 19573-19578 6 p.

Research output: Contribution to journalArticle

Synucleins
Knockout Mice
Synapses
Parkinson Disease
Proteins
2009
181 Citations (Scopus)

Age-dependent impairment of cognitive and synaptic function in the htau mouse model of Tau pathology

Polydoro, M., Acker, C. M., Duff, K., Castillo, P. E. & Davies, P., Aug 26 2009, In : Journal of Neuroscience. 29, 34, p. 10741-10749 9 p.

Research output: Contribution to journalArticle

Cognition
Neurofibrillary Tangles
Pathology
Memory Disorders
Synaptic Transmission
61 Citations (Scopus)

ELKS2α/CAST Deletion Selectively Increases Neurotransmitter Release at Inhibitory Synapses

Kaeser, P. S., Deng, L., Chávez, A. E., Liu, X., Castillo, P. E. & Südhof, T. C., Oct 29 2009, In : Neuron. 64, 2, p. 227-239 13 p.

Research output: Contribution to journalArticle

Synapses
Neurotransmitter Agents
Synaptic Vesicles
Exploratory Behavior
Electron Microscopy
284 Citations (Scopus)

Endocannabinoid signaling and long-term synaptic plasticity

Heifets, B. D. & Castillo, P. E., Mar 2009, In : Annual Review of Physiology. 71, p. 283-306 24 p.

Research output: Contribution to journalArticle

Endocannabinoids
Neuronal Plasticity
Depression
Synapses
Cannabinoids
2008
33 Citations (Scopus)

Input-specific plasticity at excitatory synapses mediated by endocannabinoids in the dentate gyrus

Chiu, C. Q. & Castillo, P. E., Jan 2008, In : Neuropharmacology. 54, 1, p. 68-78 11 p.

Research output: Contribution to journalArticle

Endocannabinoids
Dentate Gyrus
Synapses
Lipase
Perforant Pathway