• 16965 Citations
  • 71 h-Index
19952020

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Article
2020

The role of Smad2 and Smad3 in regulating homeostatic functions of fibroblasts in vitro and in adult mice

Huang, S., Chen, B., Humeres, C., Alex, L., Hanna, A. & Frangogiannis, N. G., Jul 2020, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1867, 7, 118703.

Research output: Contribution to journalArticle

2019

Distinct roles of myofibroblast-specific Smad2 and Smad3 signaling in repair and remodeling of the infarcted heart

Huang, S., Chen, B., Su, Y., Alex, L., Humeres, C., Shinde, A. V., Conway, S. J. & Frangogiannis, N. G., Jul 2019, In : Journal of Molecular and Cellular Cardiology. 132, p. 84-97 14 p.

Research output: Contribution to journalArticle

9 Scopus citations

Macrophage Smad3 protects the infarcted heart, stimulating phagocytosis and regulating inflammation

Chen, B., Huang, S., Su, Y., Wu, Y. J., Hanna, A., Brickshawana, A., Graff, J. & Frangogiannis, N. G., 2019, In : Circulation research. 125, 1, p. 55-70 16 p.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations

Protective Effects of Activated Myofibroblasts in the Pressure-Overloaded Myocardium Are Mediated Through Smad-Dependent Activation of a Matrix-Preserving Program

Russo, I., Cavalera, M., Huang, S., Su, Y., Hanna, A., Chen, B., Shinde, A. V., Conway, S. J., Graff, J. & Frangogiannis, N. G., Apr 12 2019, In : Circulation research. 124, 8, p. 1214-1227 14 p.

Research output: Contribution to journalArticle

18 Scopus citations
2018
18 Scopus citations

Opposing actions of fibroblast and cardiomyocyte smad3 signaling in the infarcted myocardium

Kong, P., Shinde, A. V., Su, Y., Russo, I., Chen, B., Saxena, A., Conway, S. J., Graff, J. M. & Frangogiannis, N. G., Feb 13 2018, In : Circulation. 137, 7, p. 707-724 18 p.

Research output: Contribution to journalArticle

38 Scopus citations
10 Scopus citations
2017

Left atrial remodeling, hypertrophy, and fibrosis in mouse models of heart failure

Hanif, W., Alex, L., Su, Y., Shinde, A. V., Russo, I., Li, N. & Frangogiannis, N. G., Sep 2017, In : Cardiovascular Pathology. 30, p. 27-37 11 p.

Research output: Contribution to journalArticle

15 Scopus citations
79 Scopus citations

Tissue transglutaminase induction in the pressure-overloaded myocardium regulates matrix remodelling

Shinde, A. V., Dobaczewski, M., De Haan, J. J., Saxena, A., Lee, K. K., Xia, Y., Chen, W., Su, Y., Hanif, W., Kaur Madahar, I., Paulino, V. M., Melino, G. & Frangogiannis, N. G., Jul 1 2017, In : Cardiovascular research. 113, 8, p. 892-905 14 p.

Research output: Contribution to journalArticle

13 Scopus citations

Uncontrolled angiogenic precursor expansion causes coronary artery anomalies in mice lacking Pofut1

Wang, Y., Wu, B., Lu, P., Zhang, D., Wu, B., Varshney, S., Del Monte-Nieto, G., Zhuang, Z., Charafeddine, R., Kramer, A. H., Sibinga, N. E., Frangogiannis, N. G., Kitsis, R. N., Adams, R. H., Alitalo, K., Sharp, D. J., Harvey, R. P., Stanley, P. & Zhou, B., Dec 1 2017, In : Nature communications. 8, 1, 578.

Research output: Contribution to journalArticle

12 Scopus citations
2016
137 Scopus citations

Inflammation as a therapeutic target in myocardial infarction: Learning from past failures to meet future challenges

Saxena, A., Russo, I. & Frangogiannis, N. G., Jan 1 2016, In : Translational Research. 167, 1, p. 152-166 15 p.

Research output: Contribution to journalArticle

56 Scopus citations

Myocardial Galectin-3 Expression Is Associated with Remodeling of the Pressure-Overloaded Heart and May Delay the Hypertrophic Response without Affecting Survival, Dysfunction, and Cardiac Fibrosis

Frunza, O., Russo, I., Saxena, A., Shinde, A. V., Humeres, C., Hanif, W., Rai, V., Su, Y. & Frangogiannis, N. G., May 1 2016, In : American Journal of Pathology. 186, 5, p. 1114-1127 14 p.

Research output: Contribution to journalArticle

34 Scopus citations
2015

Pathophysiology of myocardial infarction

Frangogiannis, N. G., Oct 1 2015, In : Comprehensive Physiology. 5, 4, p. 1841-1875 35 p.

Research output: Contribution to journalArticle

114 Scopus citations

Smad3 signaling promotes fibrosis while preserving cardiac and aortic geometry in obese diabetic mice

Biernacka, A., Cavalera, M., Wang, J., Russo, I., Shinde, A., Kong, P., Gonzalez-Quesada, C., Rai, V., Dobaczewski, M., Lee, D. W., Wang, X. F. & Frangogiannis, N. G., May 1 2015, In : Circulation: Heart Failure. 8, 4, p. 788-798 11 p.

Research output: Contribution to journalArticle

50 Scopus citations
9 Scopus citations
2014

CXCR3-independent actions of theCXCchemokine CXCL10in the infarctedmyocardium and in isolated cardiac fibroblasts are mediated through proteoglycans

Saxena, A., Bujak, M., Frunza, O., Dobaczewski, M., Gonzalez-Quesada, C., Lu, B., Gerard, C. & Frangogiannis, N. G., Jul 15 2014, In : Cardiovascular research. 103, 2, p. 217-227 11 p.

Research output: Contribution to journalArticle

37 Scopus citations

Regulatory T cells are recruited in the infarcted mouse myocardium and may modulate fibroblast phenotype and function

Saxena, A., Dobaczewski, M., Rai, V., Haque, Z., Chen, W., Li, N. & Frangogiannis, N. G., Oct 15 2014, In : American Journal of Physiology - Heart and Circulatory Physiology. 307, 8, p. H1233-H1242

Research output: Contribution to journalArticle

75 Scopus citations

Targeting the chemokines in cardiac repair

Cavalera, M. & Frangogiannis, N. G., 2014, In : Current pharmaceutical design. 20, 12, p. 1971-1979 9 p.

Research output: Contribution to journalArticle

29 Scopus citations
2013

IL-1 induces proinflammatory leukocyte infiltration and regulates fibroblast phenotype in the infarcted myocardium

Saxena, A., Chen, W., Su, Y., Rai, V., Uche, O. U., Li, N. & Frangogiannis, N. G., Nov 1 2013, In : Journal of Immunology. 191, 9, p. 4838-4848 11 p.

Research output: Contribution to journalArticle

107 Scopus citations

Lack of specificity of fibroblast-specific protein 1 in cardiac remodeling and fibrosis

Kong, P., Christia, P., Saxena, A., Su, Y. & Frangogiannis, N. G., Nov 1 2013, In : American Journal of Physiology - Heart and Circulatory Physiology. 305, 9, p. H1363-H1372

Research output: Contribution to journalArticle

101 Scopus citations

Systematic Characterization of Myocardial Inflammation, Repair, and Remodeling in a Mouse Model of Reperfused Myocardial Infarction

Christia, P., Bujak, M., Gonzalez-Quesada, C., Chen, W., Dobaczewski, M., Reddy, A. & Frangogiannis, N. G., May 1 2013, In : Journal of Histochemistry and Cytochemistry. 61, 8, p. 555-570 16 p.

Research output: Contribution to journalArticle

53 Scopus citations

Thrombospondin-1 induction in the diabetic myocardium stabilizes the cardiac matrix in addition to promoting vascular rarefaction through angiopoietin-2 upregulation

Gonzalez-Quesada, C., Cavalera, M., Biernacka, A., Kong, P., Lee, D. W., Saxena, A., Frunza, O., Dobaczewski, M., Shinde, A. & Frangogiannis, N. G., Dec 6 2013, In : Circulation research. 113, 12, p. 1331-1344 14 p.

Research output: Contribution to journalArticle

58 Scopus citations
37 Scopus citations
2012

Endogenous IRAK-M attenuates postinfarction remodeling through effects on macrophages and fibroblasts

Chen, W., Saxena, A., Li, N., Sun, J., Gupta, A., Lee, D. W., Tian, Q., Dobaczewski, M. & Frangogiannis, N. G., Nov 1 2012, In : Arteriosclerosis, thrombosis, and vascular biology. 32, 11, p. 2598-2608 11 p.

Research output: Contribution to journalArticle

54 Scopus citations

The extracellular matrix modulates fibroblast phenotype and function in the infarcted myocardium

Dobaczewski, M., De Haan, J. J. & Frangogiannis, N. G., Dec 2012, In : Journal of Cardiovascular Translational Research. 5, 6, p. 837-847 11 p.

Research output: Contribution to journalArticle

64 Scopus citations
2011

Endogenous thrombospondin 1 protects the pressure-overloaded myocardium by modulating fibroblast phenotype and matrix metabolism

Xia, Y., Dobaczewski, M., Gonzalez-Quesada, C., Chen, W., Biernacka, A., Li, N., Lee, D. W. & Frangogiannis, N. G., Nov 1 2011, In : Hypertension. 58, 5, p. 902-911 10 p.

Research output: Contribution to journalArticle

82 Scopus citations

TGF-β signaling in fibrosis

Biernacka, A., Dobaczewski, M. & Frangogiannis, N. G., Oct 1 2011, In : Growth Factors. 29, 5, p. 196-202 7 p.

Research output: Contribution to journalArticle

491 Scopus citations
2010

CCR5 signaling suppresses inflammation and reduces adverse remodeling of the infarcted heart, mediating recruitment of regulatory T cells

Dobaczewski, M., Xia, Y., Bujak, M., Gonzalez-Quesada, C. & Frangogiannis, N. G., May 2010, In : American Journal of Pathology. 176, 5, p. 2177-2187 11 p.

Research output: Contribution to journalArticle

181 Scopus citations

Short communication: Ischemia/reperfusion tolerance is time-of-day- dependent: Mediation by the cardiomyocyte circadian clock

Durgan, D. J., Pulinilkunnil, T., Villegas-Montoya, C., Garvey, M. E., Frangogiannis, N. G., Michael, L. H., Chow, C-W., Dyck, J. R. B. & Young, M. E., Feb 1 2010, In : Circulation research. 106, 3, p. 546-550 5 p.

Research output: Contribution to journalArticle

139 Scopus citations

Smad3 signaling critically regulates fibroblast phenotype and function in healing myocardial infarction

Dobaczewski, M., Bujak, M., Li, N., Gonzalez-Quesada, C., Mendoza, L. H., Wang, X. F. & Frangogiannis, N. G., Aug 6 2010, In : Circulation research. 107, 3, p. 418-428 11 p.

Research output: Contribution to journalArticle

209 Scopus citations
2009

Characterization of the inflammatory and fibrotic response in a mouse model of cardiac pressure overload

Xia, Y., Lee, K., Li, N., Corbett, D., Mendoza, L. & Frangogiannis, N. G., Apr 1 2009, In : Histochemistry and Cell Biology. 131, 4, p. 471-481 11 p.

Research output: Contribution to journalArticle

150 Scopus citations

Chemokines and cardiac fibrosis

Dobaczewski, M. & Frangogiannis, N. G., Jan 6 2009, In : Frontiers in Bioscience - Scholar. 1 S, 2, p. 391-405 15 p.

Research output: Contribution to journalArticle

64 Scopus citations

Induction of the CXC chemokine interferon-γ-inducible protein 10 regulates the reparative response following myocardial infarction

Bujak, M., Dobaczewski, M., Gonzalez-Quesada, C., Xia, Y., Leucker, T., Zymek, P., Veeranna, V., Tager, A. M., Luster, A. D. & Frangogiannis, N. G., Nov 1 2009, In : Circulation research. 105, 10, p. 973-983 11 p.

Research output: Contribution to journalArticle

92 Scopus citations

Monocyte chemoattractant protein-1/CCL2 as a biomarker in acute coronary syndromes

Gonzalez-Quesada, C. & Frangogiannis, N. G., Mar 2 2009, In : Current atherosclerosis reports. 11, 2, p. 131-138 8 p.

Research output: Contribution to journalArticle

48 Scopus citations
2008

Aging-Related Defects Are Associated With Adverse Cardiac Remodeling in a Mouse Model of Reperfused Myocardial Infarction

Bujak, M., Kweon, H. J., Chatila, K., Li, N., Taffet, G. & Frangogiannis, N. G., Apr 8 2008, In : Journal of the American College of Cardiology. 51, 14, p. 1384-1392 9 p.

Research output: Contribution to journalArticle

122 Scopus citations

CD44 is critically involved in infarct healing by regulating the inflammatory and fibrotic response

Huebener, P., Abou-Khamis, T., Zymek, P., Bujak, M., Ying, X., Chatila, K., Haudek, S., Thakker, G. & Frangogiannis, N. G., Feb 15 2008, In : Journal of Immunology. 180, 4, p. 2625-2633 9 p.

Research output: Contribution to journalArticle

Open Access
120 Scopus citations

Increased myocardial susceptibility to repetitive ischemia with high-fat diet-induced obesity

Thakker, G. D., Frangogiannis, N. G., Zymek, P. T., Sharma, S., Raya, J. L., Barger, P. M., Taegtmeyer, H., Entman, M. L. & Ballantyne, C. M., Dec 1 2008, In : Obesity. 16, 12, p. 2593-2600 8 p.

Research output: Contribution to journalArticle

28 Scopus citations

Integrated multimodal-catheter imaging unveils principal relationships among ventricular electrical activity, anatomy, and function

Rao, L., Ling, Y., He, R., Gilbert, A. L., Frangogiannis, N. G., Wang, J., Nagueh, S. F. & Khoury, D. S., Feb 1 2008, In : American Journal of Physiology - Heart and Circulatory Physiology. 294, 2, p. H1002-H1009

Research output: Contribution to journalArticle

5 Scopus citations

Interleukin-1 receptor type I signaling critically regulates infarct healing and cardiac remodeling

Bujak, M., Dobaczewski, M., Chatila, K., Mendoza, L. H., Li, N., Reddy, A. & Frangogiannis, N. G., Jul 2008, In : American Journal of Pathology. 173, 1, p. 57-67 11 p.

Research output: Contribution to journalArticle

192 Scopus citations

The immune system and cardiac repair

Frangogiannis, N. G., Aug 1 2008, In : Pharmacological Research. 58, 2, p. 88-111 24 p.

Research output: Contribution to journalArticle

440 Scopus citations
2007

Critical role of monocyte chemoattractant protein-1/CC chemokine ligand 2 in the pathogenesis of ischemic cardiomyopathy

Frangogiannis, N. G., Dewald, O., Xia, Y., Ren, G., Haudek, S., Leucker, T., Kraemer, D., Taffet, G., Rollins, B. J. & Entman, M. L., Feb 1 2007, In : Circulation. 115, 5, p. 584-592 9 p.

Research output: Contribution to journalArticle

174 Scopus citations

Essential role of Smad3 in infarct healing and in the pathogenesis of cardiac remodeling

Bujak, M., Ren, G., Kweon, H. J., Dobaczewski, M., Reddy, A., Taffet, G., Wang, X. F. & Frangogiannis, N. G., Nov 1 2007, In : Circulation. 116, 19, p. 2127-2138 12 p.

Research output: Contribution to journalArticle

237 Scopus citations

Interleukin-10 is not a critical regulator of infarct healing and left ventricular remodeling

Zymek, P., Nah, D. Y., Bujak, M., Ren, G., Koerting, A., Leucker, T., Huebener, P., Taffet, G., Entman, M. & Frangogiannis, N. G., May 1 2007, In : Cardiovascular research. 74, 2, p. 313-322 10 p.

Research output: Contribution to journalArticle

56 Scopus citations
2006

Bone marrow-derived fibroblast precursors mediate ischemic cardiomyopathy in mice

Haudek, S. B., Xia, Y., Huebener, P., Lee, J. M., Carlson, S., Crawford, J. R., Pilling, D., Gomer, R. H., Trial, J. A., Frangogiannis, N. G. & Entman, M. L., Nov 28 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 48, p. 18284-18289 6 p.

Research output: Contribution to journalArticle

258 Scopus citations

Effects of diet-induced obesity on inflammation and remodeling after myocardial infarction

Thakker, G. D., Frangogiannis, N. G., Bujak, M., Zymek, P., Gaubatz, J. W., Reddy, A. K., Taffet, G., Michael, L. H., Entman, M. L. & Ballantyne, C. M., Nov 24 2006, In : American Journal of Physiology - Heart and Circulatory Physiology. 291, 5, p. H2504-H2514

Research output: Contribution to journalArticle

81 Scopus citations

Extracellular matrix remodeling in canine and mouse myocardial infarcts

Dobaczewski, M., Bujak, M., Zymek, P., Ren, G., Entman, M. L. & Frangogiannis, N. G., Jun 1 2006, In : Cell and Tissue Research. 324, 3, p. 475-488 14 p.

Research output: Contribution to journalArticle

116 Scopus citations

Identification of mast cells in the cellular response to myocardial infarction.

Frangogiannis, N. G. & Entman, M. L., 2006, In : Methods in molecular biology (Clifton, N.J.). 315, p. 91-101 11 p.

Research output: Contribution to journalArticle

7 Scopus citations

Impact of myocardial structure and function postinfarction on diastolic strain measurements: Implications for assessment of myocardial viability

Park, T. H., Nagueh, S. F., Khoury, D. S., Kopelen, H. A., Akrivakis, S., Nasser, K., Ren, G. & Frangogiannis, N. G., Feb 1 2006, In : American Journal of Physiology - Heart and Circulatory Physiology. 290, 2, p. H724-H731

Research output: Contribution to journalArticle

83 Scopus citations