• 9484 Citations
  • 50 h-Index
1986 …2020

Research output per year

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Publications

2020

Antioxidant effects of n-acetylcysteine prevent programmed metabolic disease in mice

Charron, M. J., Williams, L., Seki, Y., Du, X. Q., Chaurasia, B., Saghatelian, A., Summers, S. A., Katz, E. B., Vuguin, P. M. & Reznik, S. E., Aug 2020, In : Diabetes. 69, 8, p. 1650-1661 12 p.

Research output: Contribution to journalArticle

1 Scopus citations

Dietary Advanced Glycation End Products (AGEs) could alter ovarian function in mice

Thornton, K. A., Merhi, Z., Jindal, S., Goldsammler, M., Charron, M. J. & Buyuk, E., Jun 15 2020, In : Molecular and Cellular Endocrinology. 510, 110826.

Research output: Contribution to journalArticle

Monocyte chemotactic protein-1 plays a role in ovarian dysfunction related to high-fat diet-induced obesity

Asemota, O., Thornton, K., Merhi, Z., Berger, D. S., Williams, L., Seki, Y., Du, X. Q., Jindal, S., Charron, M. J. & Buyuk, E., Jul 3 2020, In : Systems Biology in Reproductive Medicine. 66, 4, p. 236-243 8 p.

Research output: Contribution to journalArticle

Perinatal exposure to high dietary advanced glycation end products affects the reproductive system in female offspring in mice

Merhi, Z., Du, X. Q. & Charron, M. J., Aug 1 2020, In : Molecular Human Reproduction. 26, 8, p. 615-623 9 p.

Research output: Contribution to journalArticle

2019

Glucagon: The Name Says It All, or Not!

Dean, E. D., Vuguin, P. M. & Charron, M. J., Jan 1 2019, In : Endocrinology. 160, 5, p. 1359-1361 3 p.

Research output: Contribution to journalComment/debate

Open Access
1 Scopus citations

Loss of glucagon signaling alters white adipose tissue browning

Townsend, L. K., Medak, K. D., Knuth, C. M., Peppler, W. T., Charron, J. & Wright, D. C., Jan 1 2019, In : FASEB Journal. 33, 4, p. 4824-4835 12 p.

Research output: Contribution to journalArticle

10 Scopus citations

N-Acetylcysteine Resolves Placental Inflammatory-Vasculopathic Changes in Mice Consuming a High-Fat Diet

Williams, L., Burgos, E. S., Vuguin, P. M., Manuel, C. R., Pekson, R., Munnangi, S., Reznik, S. E. & Charron, M. J., Nov 2019, In : American Journal of Pathology. 189, 11, p. 2246-2257 12 p.

Research output: Contribution to journalArticle

1 Scopus citations

Regulation of Hepatic Follistatin Expression at Rest and during Exercise in Mice

Peppler, W. T., Castellani, L. N., Root-Mccaig, J., Townsend, L. K., Sutton, C. D., Frendo-Cumbo, S., Medak, K. D., Macpherson, R. E. K., Charron, M. J. & Wright, D. C., Jun 1 2019, In : Medicine and Science in Sports and Exercise. 51, 6, p. 1116-1125 10 p.

Research output: Contribution to journalArticle

1 Scopus citations
2018

Disruption of glucagon receptor signaling causes hyperaminoacidemia exposing a possible liver-alpha-cell axis

Galsgaard, K. D., Winther-Sørensen, M., Ørskov, C., Kissow, H., Poulsen, S. S., Vilstrup, H., Prehn, C., Adamski, J., Jepsen, S. L., Hartmann, B., Hunt, J., Charron, M. J., Pedersen, J., Wewer Albrechtsen, N. J. & Holst, J. J., Jan 2018, In : American Journal of Physiology - Endocrinology and Metabolism. 314, 1, p. E93-E103

Research output: Contribution to journalArticle

26 Scopus citations

GLP-2 receptor signaling controls circulating bile acid levels but not glucose homeostasis in Gcgr−/− mice and is dispensable for the metabolic benefits ensuing after vertical sleeve gastrectomy

Patel, A., Yusta, B., Matthews, D., Charron, M. J., Seeley, R. J. & Drucker, D. J., Oct 2018, In : Molecular Metabolism. 16, p. 45-54 10 p.

Research output: Contribution to journalArticle

9 Scopus citations
5 Scopus citations
2017

A High Fat Diet during Pregnancy and Lactation Induces Cardiac and Renal Abnormalities in GLUT4 +/- Male Mice

Kruse, M., Fiallo, A., Katz, E. B. & Charron, M. J., 2017, In : Kidney and Blood Pressure Research. 42, 3, p. 468-482 15 p.

Research output: Contribution to journalArticle

1 Scopus citations

Glucagon receptor knockout mice are protected against acute olanzapine-induced hyperglycemia

Castellani, L. N., Peppler, W. T., Sutton, C. D., Whitfield, J., Charron, M. J. & Wright, D. C., Aug 1 2017, In : Psychoneuroendocrinology. 82, p. 38-45 8 p.

Research output: Contribution to journalArticle

10 Scopus citations
6 Scopus citations

Hypoglycemic effect of combined ghrelin and glucagon receptor blockade

Mani, B. K., Uchida, A., Lee, Y., Osborne-Lawrence, S., Charron, M. J., Unger, R. H., Berglund, E. D. & Zigman, J. M., Jul 1 2017, In : Diabetes. 66, 7, p. 1847-1857 11 p.

Research output: Contribution to journalArticle

10 Scopus citations

In utero exposure to a high-fat diet programs hepatic hypermethylation and gene dysregulation and development of metabolic syndrome in male mice

Seki, Y., Suzuki, M., Guo, X., Glenn, A. S., Vuguin, P. M., Fiallo, A., Du, Q., Ko, Y. A., Yu, Y., Susztak, K., Zheng, D., Greally, J. M., Katz, E. B. & Charron, M. J., Sep 1 2017, In : Endocrinology. 158, 9, p. 2860-2872 13 p.

Research output: Contribution to journalArticle

16 Scopus citations
2016

Berry intake changes hepatic gene expression and DNA methylation patterns associated with high-fat diet

Heyman-Lindén, L., Seki, Y., Storm, P., Jones, H. A., Charron, M. J., Berger, K. & Holm, C., Jan 1 2016, In : Journal of Nutritional Biochemistry. 27, p. 79-95 17 p.

Research output: Contribution to journalArticle

14 Scopus citations

Blockade of glucagon signaling prevents or reverses diabetes onset only if residual β-cells persist

Damond, N., Thorel, F., Moyers, J. S., Charron, M. J., Vuguin, P. M., Powers, A. C. & Herrera, P. L., Apr 19 2016, In : eLife. 5, APRIL2016, e13828.

Research output: Contribution to journalArticle

36 Scopus citations

DNA hypermethylation of CD3+ T cells from cord blood of infants exposed to intrauterine growth restriction

Williams, L., Seki, Y., Delahaye, F., Cheng, A., Fuloria, M., Hughes Einstein, F. & Charron, M. J., May 17 2016, (Accepted/In press) In : Diabetologia. p. 1-10 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

Glucagon receptor gene deletion in insulin knockout mice modestly reduces blood glucose and ketones but does not promote survival

Neumann, U. H., Ho, J. S. S., Mojibian, M., Covey, S. D., Charron, M. J. & Kieffer, T. J., Aug 1 2016, In : Molecular Metabolism. 5, 8, p. 731-736 6 p.

Research output: Contribution to journalArticle

17 Scopus citations

Ovarian kisspeptin expression is related to age and to monocyte chemoattractant protein-1

Merhi, Z., Thornton, K., Bonney, E., Cipolla, M. J., Charron, M. J. & Buyuk, E., Feb 15 2016, (Accepted/In press) In : Journal of Assisted Reproduction and Genetics. p. 1-9 9 p.

Research output: Contribution to journalArticle

8 Scopus citations
8 Scopus citations
2015

Cardiomyocyte glucagon receptor signaling modulates outcomes in mice with experimental myocardial infarction

Ali, S., Ussher, J. R., Baggio, L. L., Kabir, M. G., Charron, M. J., Ilkayeva, O., Newgard, C. B. & Drucker, D. J., Feb 1 2015, In : Molecular Metabolism. 4, 2, p. 132-143 12 p.

Research output: Contribution to journalArticle

36 Scopus citations

Inhibition of the prostaglandin transporter PGT lowers blood pressure in hypertensive rats and mice

Chi, Y., Jasmin, J. F., Seki, Y., Lisanti, M. P., Charron, M. J., Lefer, D. J. & Schuster, V. L., Jun 29 2015, In : PloS one. 10, 6, e0131735.

Research output: Contribution to journalArticle

6 Scopus citations

Lack of glucagon receptor signaling and its implications beyond glucose homeostasis

Charron, M. J. & Vuguin, P. M., Jan 1 2015, In : Journal of Endocrinology. 224, 3, p. R123-R130

Research output: Contribution to journalReview article

34 Scopus citations

Maintenance of GLUT4 expression in smooth muscle prevents hypertension-induced changes in vascular reactivity

Atkins, K. B., Seki, Y., Saha, J., Eichinger, F., Charron, M. J. & Brosius, F. C., 2015, In : Physiological Reports. 3, 2, e12299.

Research output: Contribution to journalArticle

2 Scopus citations
2014

Animal models of in utero exposure to a high fat diet: A review

Williams, L., Seki, Y., Vuguin, P. M. & Charron, M. J., Mar 1 2014, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1842, 3, p. 507-519 13 p.

Research output: Contribution to journalReview article

112 Scopus citations

Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones

Maianti, J. P., McFedries, A., Foda, Z. H., Kleiner, R. E., Du, X. Q., Leissring, M. A., Tang, W. J., Charron, M. J., Seeliger, M. A., Saghatelian, A. & Liu, D. R., Jan 1 2014, In : Nature. 511, 7507, p. 94-98 5 p.

Research output: Contribution to journalArticle

117 Scopus citations

Critical periods of increased fetal vulnerability to a maternal high fat diet

Plata, M. D. M., Williams, L., Seki, Y., Hartil, K., Kaur, H., Lin, C. L., Fiallo, A., Glenn, A. S., Katz, E. B., Fuloria, M., Charron, M. J. & Vuguin, P. M., Aug 18 2014, In : Reproductive Biology and Endocrinology. 12, 1, 80.

Research output: Contribution to journalArticle

14 Scopus citations

Effects of genetics and In utero diet on murine pancreatic development

Lin, C. L., Williams, L., Seki, Y., Kaur, H., Hartil, K., Fiallo, A., Glenn, A. S., Katz, E. B., Charron, M. J. & Vuguin, P. M., 2014, In : Journal of Endocrinology. 222, 2, p. 217-227 11 p.

Research output: Contribution to journalArticle

1 Scopus citations

Evidence for a regulatory role of Cullin-RING E3 ubiquitin ligase 7 in insulin signaling

Scheufele, F., Wolf, B., Kruse, M., Hartmann, T., Lempart, J., Muehlich, S., Pfeiffer, A. F. H., Field, L. J., Charron, M. J., Pan, Z. Q., Engelhardt, S. & Sarikas, A., Feb 1 2014, In : Cellular Signalling. 26, 2, p. 233-239 7 p.

Research output: Contribution to journalArticle

18 Scopus citations

Hyperglycemia in rodent models of type 2 diabetes requires insulin-resistant alpha cells

Lee, Y., Berglund, E. D., Yu, X., Wang, M. Y., Evans, M. R., Scherer, P. E., Holland, W. L., Charron, M. J., Roth, M. G. & Unger, R. H., 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 36, p. 13217-13222 6 p.

Research output: Contribution to journalArticle

49 Scopus citations

In utero exposure to a maternal high-fat diet alters the epigenetic histone code in a murine model

Suter, M. A., Ma, J., Vuguin, P. M., Hartil, K., Fiallo, A., Harris, R. A., Charron, M. J. & Aagaard, K. M., May 2014, In : American journal of obstetrics and gynecology. 210, 5, p. 463.e1-463.e11

Research output: Contribution to journalArticle

39 Scopus citations
2013

High-fat intake during pregnancy and lactation exacerbates high-fat diet-induced complications in male offspring in mice

Kruse, M., Seki, Y., Vuguin, P. M., Du, X. Q., Fiallo, A., Glenn, A. S., Singer, S., Breuhahn, K., Katz, E. B. & Charron, M. J., Oct 1 2013, In : Endocrinology. 154, 10, p. 3565-3576 12 p.

Research output: Contribution to journalArticle

35 Scopus citations

Hypothalamic glucagon signaling inhibits hepatic glucose production

Mighiu, P. I., Yue, J. T. Y., Filippi, B. M., Abraham, M. A., Chari, M., Lam, C. K. L., Yang, C. S., Christian, N. R., Charron, M. J. & Lam, T. K. T., Jun 1 2013, In : Nature Medicine. 19, 6, p. 766-772 7 p.

Research output: Contribution to journalArticle

73 Scopus citations

Liver-specific disruption of the murine glucagon receptor produces α-cell hyperplasia evidence for a circulating α-Cell Growth Factor

Longuet, C., Robledo, A. M., Dean, E. D., Dai, C., Ali, S., McGuinness, I., De Chavez, V., Vuguin, P. M., Charron, M. J., Powers, A. C. & Drucker, D. J., Apr 2013, In : Diabetes. 62, 4, p. 1196-1205 10 p.

Research output: Contribution to journalArticle

100 Scopus citations

Oxyntomodulin increases intrinsic heart rate through the glucagon receptor

Mukharji, A., Drucker, D. J., Charron, M. J. & Swoap, S. J., 2013, In : Physiological Reports. 1, 5, e00112.

Research output: Contribution to journalArticle

9 Scopus citations

Shared Effects of Genetic and Intrauterine and Perinatal Environment on the Development of Metabolic Syndrome

Vuguin, P. M., Hartil, K., Kruse, M., Kaur, H., Lin, C. L. V., Fiallo, A., Glenn, A. S., Patel, A., Williams, L., Seki, Y., Katz, E. B. & Charron, M. J., May 17 2013, In : PloS one. 8, 5, e63021.

Research output: Contribution to journalArticle

24 Scopus citations
2012

Hypoglycemia, hyperglucagonemia, and fetoplacental defects in glucagon receptor knockout mice: A role for glucagon action in pregnancy maintenance

Ouhilal, S., Vuguin, P., Cui, L., Du, X. Q., Gelling, R. W., Reznik, S. E., Russell, R., Parlow, A. F., Karpovsky, C., Santoro, N. & Charron, M. J., Mar 2012, In : American Journal of Physiology - Endocrinology and Metabolism. 302, 5, p. E522-E531

Research output: Contribution to journalArticle

18 Scopus citations

Major Facilitator Superfamily Domain-Containing Protein 2a (MFSD2A) Has Roles in Body Growth, Motor Function, and Lipid Metabolism

Berger, J. H., Charron, M. J. & Silver, D. L., Nov 29 2012, In : PloS one. 7, 11, e50629.

Research output: Contribution to journalArticle

44 Scopus citations

Metabolic manifestations of insulin deficiency do not occur without glucagon action

Lee, Y., Berglund, E. D., Wang, M. Y., Fu, X., Yu, X., Charron, M. J., Burgess, S. C. & Unger, R. H., Sep 11 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 37, p. 14972-14976 5 p.

Research output: Contribution to journalArticle

89 Scopus citations

Minireview: Epigenetic programming of diabetes and obesity: Animal models

Seki, Y., Williams, L., Vuguin, P. M. & Charron, M. J., Mar 2012, In : Endocrinology. 153, 3, p. 1031-1038 8 p.

Research output: Contribution to journalShort survey

124 Scopus citations

Regulation of mouse intestinal L cell progenitors proliferation by the glucagon family of peptides

Grigoryan, M., Kedees, M. H., Charron, M. J., Guz, Y. & Teitelman, G., Jul 1 2012, In : Endocrinology. 153, 7, p. 3076-3088 13 p.

Research output: Contribution to journalArticle

20 Scopus citations
2011

Dual elimination of the glucagon and GLP-1 receptors in mice reveals plasticity in the incretin axis

Ali, S., Lamont, B. J., Charron, M. J. & Drucker, D. J., May 2 2011, In : Journal of Clinical Investigation. 121, 5, p. 1917-1929 13 p.

Research output: Contribution to journalArticle

71 Scopus citations

Glucagon receptor knockout prevents insulin-deficient type 1 diabetes in mice

Lee, Y., Wang, M. Y., Du, X. Q., Charron, M. J. & Unger, R. H., Feb 2011, In : Diabetes. 60, 2, p. 391-397 7 p.

Research output: Contribution to journalArticle

221 Scopus citations

Hepatic glucagon action is essential for exercise-induced reversal of mouse fatty liver

Berglund, E. D., Lustig, D. G., Baheza, R. A., Hasenour, C. M., Lee-Young, R. S., Donahue, E. P., Lynes, S. E., Swift, L. L., Charron, M. J., Damon, B. M. & Wasserman, D. H., Nov 2011, In : Diabetes. 60, 11, p. 2720-2729 10 p.

Research output: Contribution to journalArticle

28 Scopus citations

Novel insight into glucagon receptor action: Lessons from knockout and transgenic mouse models

Vuguin, P. M. & Charron, M. J., Oct 2011, In : Diabetes, Obesity and Metabolism. 13, SUPPL. 1, p. 144-150 7 p.

Research output: Contribution to journalReview article

28 Scopus citations

Reduced neurotrophin receptor tropomyosin-related kinase A expression in human granulosa cells: A novel marker of diminishing ovarian reserve

Buyuk, E., Santoro, N., Cohen, H. W., Charron, M. J. & Jindal, S., Aug 2011, In : Fertility and Sterility. 96, 2, p. 474-478.e4

Research output: Contribution to journalArticle

5 Scopus citations
2010

Glucagon and lipid interactions in the regulation of hepatic AMPK signaling and expression of PPARα and FGF21 transcripts in vivo

Berglund, E. D., Kang, L., Lee-Young, R. S., Hasenour, C. M., Lustig, D. G., Lynes, S. E., Donahue, E. P., Swift, L. L., Charron, M. J. & Wasserman, D. H., Oct 2010, In : American Journal of Physiology - Endocrinology and Metabolism. 299, 4, p. E607-E614

Research output: Contribution to journalArticle

78 Scopus citations

Leptin therapy in insulin-deficient type I diabetes

Wang, M. Y., Chen, L., Clark, G. O., Lee, Y., Stevens, R. D., Ilkayeva, O. R., Wenner, B. R., Bain, J. R., Charron, M. J., Newgard, C. B. & Unger, R. H., Mar 16 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 11, p. 4813-4819 7 p.

Research output: Contribution to journalArticle

224 Scopus citations