• 12533 Citations
  • 55 h-Index
1976 …2021
If you made any changes in Pure, your changes will be visible here soon.

Publications 1976 2019

  • 12533 Citations
  • 55 h-Index
  • 139 Article
  • 4 Chapter
  • 1 Comment/debate
  • 1 Letter
2019
2 Citations (Scopus)

Loss-of-huntingtin in medial and lateral ganglionic lineages differentially disrupts regional interneuron and projection neuron subtypes and promotes huntington’s disease-associated behavioral, cellular, and pathological hallmarks

Mehler, M. F., Petronglo, J. R., Arteaga-Bracho, E. E., Gulinello, M. E., Winchester, M. L., Pichamoorthy, N., Young, S. K., Dejesus, C. D., Ishtiaq, H., Gokhan, S. & Molero, A. E., Mar 6 2019, In : Journal of Neuroscience. 39, 10, p. 1892-1909 18 p.

Research output: Contribution to journalArticle

Huntington Disease
Interneurons
Neurons
GABAergic Neurons
Parvalbumins
2018
5 Citations (Scopus)

Epigenetic mechanisms underlying nervous system diseases

Qureshi, I. A. & Mehler, M. F., Jan 1 2018, Handbook of Clinical Neurology. Elsevier B.V., p. 43-58 16 p. (Handbook of Clinical Neurology; vol. 147).

Research output: Chapter in Book/Report/Conference proceedingChapter

Nervous System Diseases
Epigenomics
Post Transcriptional RNA Processing
RNA Transport
Genetic Epigenesis
2017
7 Citations (Scopus)

A dedicated scholarly research program in an adult and pediatric neurology residency program

Robbins, M. S., Haut, S. R., Lipton, R. B., Milstein, M. J., Ocava, L. C., Ballaban-Gil, K. R., Moshe, S. L. & Mehler, M. F., Apr 4 2017, In : Neurology. 88, 14, p. 1366-1370 5 p.

Research output: Contribution to journalArticle

Mentors
Neurology
Internship and Residency
Pediatrics
Research

Author response: A dedicated scholarly research program in an adult and pediatric neurology residency program

Robbins, M. S. & Mehler, M. F., Sep 5 2017, In : Neurology. 89, 10, 1 p.

Research output: Contribution to journalLetter

23 Citations (Scopus)

Increased localization of APP-C99 in mitochondria-associated ER membranes causes mitochondrial dysfunction in Alzheimer disease

Pera, M., Larrea, D., Guardia-Laguarta, C., Montesinos, J., Velasco, K. R., Agrawal, R. R., Xu, Y., Chan, R. B., Di Paolo, G., Mehler, M. F., Perumal, G. S., Macaluso, F. P., Freyberg, Z. Z., Acin-Perez, R., Enriquez, J. A., Schon, E. A. & Area-Gomez, E., 2017, (Accepted/In press) In : EMBO Journal.

Research output: Contribution to journalArticle

Amyloid Precursor Protein Secretases
Mitochondria
Amyloid beta-Protein Precursor
Mitochondrial Membranes
Endoplasmic Reticulum
3 Citations (Scopus)
2016

Author Response

Beversdorf, D. Q., Lennon, V., Mehler, M. & Roos, R., Feb 9 2016, In : Neurology. 86, 6, p. 585-586 2 p.

Research output: Contribution to journalArticle

Animal Rights
Politics
Neurosciences
Violence
Biomedical Research
76 Citations (Scopus)

Emerging Roles for CSF-1 Receptor and its Ligands in the Nervous System

Chitu, V., Gokhan, S., Nandi, S., Mehler, M. F. & Stanley, E. R., 2016, (Accepted/In press) In : Trends in Neurosciences.

Research output: Contribution to journalArticle

Macrophage Colony-Stimulating Factor Receptors
Colony-Stimulating Factor Receptors
Macrophage Colony-Stimulating Factor
Nervous System
Ligands

Huntington’s disease

Molero, A. E. & Mehler, M. F., Jan 1 2016, Neuroscience in the 21st Century: From Basic to Clinical, Second Edition. Springer New York, p. 3863-3892 30 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Huntington Disease
neurodevelopment
pathogenesis
proteinases
neurotrophins
17 Citations (Scopus)

Postnatal and adult consequences of loss of huntingtin during development: Implications for Huntington's disease

Arteaga-Bracho, E. E., Gulinello, M. E., Winchester, M. L., Pichamoorthy, N., Petronglo, J. R., Zambrano, A. D., Inocencio, J., De Jesus, C. D., Louie, J. O., Gokhan, S., Mehler, M. F. & Molero, A. E., Dec 1 2016, In : Neurobiology of Disease. 96, p. 144-155 12 p.

Research output: Contribution to journalArticle

Huntington Disease
Corpus Striatum
Cell Death
Prosencephalon
Skeletal Muscle
40 Citations (Scopus)

Selective expression of mutant huntingtin during development recapitulates characteristic features of Huntington's disease

Molero, A. E., Arteaga-Bracho, E. E., Chen, C. H., Gulinello, M. E., Winchester, M. L., Pichamoorthy, N., Gokhan, S., Khodakhah, K. & Mehler, M. F., May 17 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 20, p. 5736-5741 6 p.

Research output: Contribution to journalArticle

Huntington Disease
Corpus Striatum
Disease Progression
Neurogenesis
N-Methylaspartate
2015
9 Citations (Scopus)
Cranial Irradiation
Brain
Radiation Injuries
Inbred C57BL Mouse
Hippocampus
2 Citations (Scopus)

Animal extremists' threats to neurologic research continue: Neuroreality II

Beversdorf, D. Q., Roos, R. P., Hauser, W. A., Lennon, V. A. & Mehler, M. F., Aug 25 2015, In : Neurology. 85, 8, p. 730-734 5 p.

Research output: Contribution to journalArticle

Animal Rights
Politics
Neurosciences
Violence
Nervous System
7 Citations (Scopus)

Epigenetics and therapeutic targets mediating neuroprotection

Qureshi, I. A. & Mehler, M. F., Dec 2 2015, In : Brain Research. 1628, p. 265-272 8 p.

Research output: Contribution to journalArticle

Epigenomics
Genetic Epigenesis
Therapeutics
Nervous System
Cell Death
4 Citations (Scopus)
Cranial Irradiation
Neurogenesis
Neural Stem Cells
Dentate Gyrus
Rodentia
26 Citations (Scopus)

Phenotypic characterization of a Csf1r haploinsufficient mouse model of adult-onset leukodystrophy with axonal spheroids and pigmented glia (ALSP)

Chitu, V., Gokhan, S., Gulinello, M. E., Branch, C. A., Patil, M., Basu, R., Stoddart, C., Mehler, M. F. & Richard Stanley, E., Feb 1 2015, In : Neurobiology of Disease. 74, p. 219-228 10 p.

Research output: Contribution to journalArticle

Neuroglia
Cell Count
Corpus Callosum
Microglia
Colony-Stimulating Factor Receptors
2014
16 Citations (Scopus)

An evolving view of epigenetic complexity in the brain

Qureshi, I. A. & Mehler, M. F., Sep 26 2014, In : Philosophical Transactions of the Royal Society B: Biological Sciences. 369, 1652

Research output: Contribution to journalArticle

Epigenomics
epigenetics
Chromatin
RNA
brain
13 Citations (Scopus)

Epigenetic Mechanisms Underlying the Pathogenesis of Neurogenetic Diseases

Qureshi, I. A. & Mehler, M. F., Oct 18 2014, In : Neurotherapeutics. 11, 4, p. 708-720 13 p.

Research output: Contribution to journalArticle

Epigenomics
Optogenetics
Synthetic Biology
Exome
Environmental Exposure
26 Citations (Scopus)

Epigenetics of sleep and chronobiology.

Qureshi, I. A. & Mehler, M. F., 2014, In : Current Neurology and Neuroscience Reports. 14, 3, p. 432 1 p.

Research output: Contribution to journalArticle

Epigenomics
Circadian Clocks
Sleep
Physiological Phenomena
Suprachiasmatic Nucleus
8 Citations (Scopus)

Sex, epilepsy, and epigenetics

Qureshi, I. A. & Mehler, M. F., Dec 1 2014, In : Neurobiology of Disease. 72, PB, p. 210-216 7 p.

Research output: Contribution to journalArticle

Epigenomics
Epilepsy
Sex Characteristics
Safe Sex
Sex Chromosomes
5 Citations (Scopus)
embryonic stem cells
Embryonic Stem Cells
Stem cells
histones
Histones
2013
17 Citations (Scopus)

Developing epigenetic diagnostics and therapeutics for brain disorders

Qureshi, I. A. & Mehler, M. F., Dec 2013, In : Trends in Molecular Medicine. 19, 12, p. 732-741 10 p.

Research output: Contribution to journalArticle

Brain Diseases
Epigenomics
Histone Code
Untranslated RNA
Molecular Pathology
24 Citations (Scopus)

Epigenetic mechanisms governing the process of neurodegeneration

Qureshi, I. A. & Mehler, M. F., Jul 2013, In : Molecular Aspects of Medicine. 34, 4, p. 875-882 8 p.

Research output: Contribution to journalArticle

Epigenomics
Molecular Pathology
14 Citations (Scopus)

Functions of Huntingtin in Germ Layer Specification and Organogenesis

Nguyen, G. D., Molero, A. E., Gokhan, S. & Mehler, M. F., Aug 13 2013, In : PLoS One. 8, 8, e72698.

Research output: Contribution to journalArticle

Germ Layers
Organogenesis
Huntington Disease
organogenesis
Specifications
15 Citations (Scopus)

Genetic and epigenetic studies of amyotrophic lateral sclerosis

Al-Chalabi, A., Kwak, S., Mehler, M. F., Rouleau, G., Siddique, T., Strong, M. & Leigh, P. N., May 2013, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 14, SUPPL1, p. 44-52 9 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Epigenomics
Axonal Transport
Proteasome Endopeptidase Complex
Age of Onset

Huntington's disease

Molero, A. E. & Mehler, M. F., Nov 1 2013, Neuroscience in the 21st Century: From Basic to Clinical. Springer New York, p. 2923-2951 29 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Huntington Disease
Peptide Hydrolases
Lipoylation
Sumoylation
Genes
67 Citations (Scopus)

Long Non-coding RNAs: Novel Targets for Nervous System Disease Diagnosis and Therapy

Qureshi, I. A. & Mehler, M. F., Oct 2013, In : Neurotherapeutics. 10, 4, p. 632-646 15 p.

Research output: Contribution to journalArticle

Long Noncoding RNA
Nervous System Diseases
Therapeutics
Genes
Genetic Epigenesis
69 Citations (Scopus)

Receptor-type protein-tyrosine phosphatase ζ is a functional receptor for interleukin-34

Nandi, S., Cioce, M., Yeung, Y. G., Nieves, E., Tesfa, L., Lin, H., Hsu, A. W., Halenbeck, R., Cheng, H. Y., Gokhan, S., Mehler, M. F. & Stanley, E. R., Jul 26 2013, In : Journal of Biological Chemistry. 288, 30, p. 21972-21986 15 p.

Research output: Contribution to journalArticle

Colony-Stimulating Factor Receptors
Interleukin Receptors
Protein Tyrosine Phosphatases
Glioblastoma
Brain
23 Citations (Scopus)

Selective Roles of Normal and Mutant Huntingtin in Neural Induction and Early Neurogenesis

Nguyen, G. D., Gokhan, S., Molero, A. E. & Mehler, M. F., May 14 2013, In : PLoS One. 8, 5, e64368.

Research output: Contribution to journalArticle

neurogenesis
Neurogenesis
Corpus Striatum
mutants
Huntington Disease
24 Citations (Scopus)

Towards a 'systems'-level understanding of the nervous system and its disorders

Qureshi, I. A. & Mehler, M. F., Nov 2013, In : Trends in Neurosciences. 36, 11, p. 674-684 11 p.

Research output: Contribution to journalArticle

Nervous System Diseases
Nervous System
Comorbidity
Energy Metabolism
Psychiatry
32 Citations (Scopus)

Understanding neurological disease mechanisms in the era of epigenetics

Qureshi, I. A. & Mehler, M. F., Jun 2013, In : JAMA Neurology. 70, 6, p. 703-710 8 p.

Research output: Contribution to journalArticle

Epigenomics
Genetic Epigenesis
Neurological Disease
Epigenetics
Genes
2012
6 Citations (Scopus)

Development and neurodegeneration: Turning HD pathogenesis on its head

Marder, K. & Mehler, M. F., Aug 14 2012, In : Neurology. 79, 7, p. 621-622 2 p.

Research output: Contribution to journalArticle

Head
338 Citations (Scopus)

Emerging roles of non-coding RNAs in brain evolution, development, plasticity and disease

Qureshi, I. A. & Mehler, M. F., Aug 2012, In : Nature Reviews Neuroscience. 13, 8, p. 528-541 14 p.

Research output: Contribution to journalArticle

Untranslated RNA
Genetic Epigenesis
Long Noncoding RNA
Small Untranslated RNA
Neuronal Plasticity
145 Citations (Scopus)

The CSF-1 receptor ligands IL-34 and CSF-1 exhibit distinct developmental brain expression patterns and regulate neural progenitor cell maintenance and maturation

Nandi, S., Gokhan, S., Dai, X. M., Wei, S., Enikolopov, G., Lin, H., Mehler, M. F. & Richard Stanley, E., Jul 15 2012, In : Developmental Biology. 367, 2, p. 100-113 14 p.

Research output: Contribution to journalArticle

Macrophage Colony-Stimulating Factor Receptors
Macrophage Colony-Stimulating Factor
Stem Cells
Maintenance
Ligands
2011
51 Citations (Scopus)

Advances in epigenetics and epigenomics for neurodegenerative diseases

Qureshi, I. A. & Mehler, M. F., Oct 2011, In : Current Neurology and Neuroscience Reports. 11, 5, p. 464-473 10 p.

Research output: Contribution to journalArticle

Epigenomics
Neurodegenerative Diseases
Histone Code
Genes
Untranslated RNA
1 Citation (Scopus)

Alu transcription: A rheostat for stem cell aging?

Qureshi, I. A. & Mehler, M. F., Nov 15 2011, In : Cell Cycle. 10, 22, p. 3820-3821 2 p.

Research output: Contribution to journalArticle

Cell Aging
Stem Cells
6 Citations (Scopus)

Chromatin-Modifying Agents for Epigenetic Reprogramming and Endogenous Neural Stem Cell-Mediated Repair in Stroke

Qureshi, I. A. & Mehler, M. F., Mar 2011, In : Translational Stroke Research. 2, 1, p. 7-16 10 p.

Research output: Contribution to journalArticle

Neural Stem Cells
Epigenomics
Chromatin
Transcriptional Silencer Elements
Stroke

Diagnosing and treating nervous system disorders by targeting novel classes of Non-coding RNAs

Qureshi, I. A. & Mehler, M. F., Jun 2011, In : International Drug Discovery. 2011, 4, p. 30-36 7 p.

Research output: Contribution to journalArticle

Untranslated RNA
Nervous System Diseases
4 Citations (Scopus)

Epigenetics, nervous system tumors, and cancer stem cells

Qureshi, I. A. & Mehler, M. F., Sep 2011, In : Cancers. 3, 3, p. 3525-3556 32 p.

Research output: Contribution to journalArticle

Nervous System Neoplasms
Neoplastic Stem Cells
Epigenomics
Histone Code
RNA Editing
46 Citations (Scopus)

Non-coding RNA networks underlying cognitive disorders across the lifespan

Qureshi, I. A. & Mehler, M. F., Jun 2011, In : Trends in Molecular Medicine. 17, 6, p. 337-346 10 p.

Research output: Contribution to journalArticle

Untranslated RNA
Long Noncoding RNA
Life Cycle Stages
Neurodegenerative Diseases
Brain
22 Citations (Scopus)

The emerging role of epigenetics in stroke: III. Neural stem cell biology and regenerative medicine

Qureshi, I. A. & Mehler, M. F., Mar 2011, In : Archives of Neurology. 68, 3, p. 294-302 9 p.

Research output: Contribution to journalArticle

Regenerative Medicine
Neural Stem Cells
Epigenomics
Cell Biology
Stem Cells
2010
43 Citations (Scopus)
Transcriptional Silencer Elements
Co-Repressor Proteins
Neural Stem Cells
Gene Regulatory Networks
Transcription Factors
3 Citations (Scopus)

Editorial: Emerging themes in epigenetics: Implications for understanding and treating nervous system disorders

Qureshi, I. A. & Mehler, M. F., Jun 2010, In : Epigenomics. 2, 3, p. 345-349 5 p.

Research output: Contribution to journalArticle

RNA Editing
Untranslated RNA
Nervous System Diseases
Epigenomics
Central Nervous System
71 Citations (Scopus)

Emerging role of epigenetics in stroke - Part 1: DNA methylation and chromatin modifications

Qureshi, I. A. & Mehler, M. F., Nov 2010, In : Archives of Neurology. 67, 11, p. 1316-1322 7 p.

Research output: Contribution to journalArticle

DNA Methylation
Epigenomics
Chromatin
Histone Code
Stroke
73 Citations (Scopus)

Epigenetic mechanisms underlying human epileptic disorders and the process of epileptogenesis

Qureshi, I. A. & Mehler, M. F., Jul 2010, In : Neurobiology of Disease. 39, 1, p. 53-60 8 p.

Research output: Contribution to journalArticle

Genetic Transcription
Immediate-Early Genes
Epigenomics
Histone Code
Epilepsy
3 Citations (Scopus)

Epigenetics and neuropsychiatric diseases: Introduction and meeting summary

Mehler, M. F., 2010, In : Annals of the New York Academy of Sciences. 1204, SUPPL.1, p. 1-7 7 p.

Research output: Contribution to journalArticle

Epigenomics
Medicine
Brain
Neural networks
Neurology
1976 Citations (Scopus)

Fate mapping analysis reveals that adult microglia derive from primitive macrophages

Ginhoux, F., Greter, M., Leboeuf, M., Nandi, S., See, P., Gokhan, S., Mehler, M. F., Conway, S. J., Ng, L. G., Stanley, E. R., Samokhvalov, I. M. & Merad, M., Nov 5 2010, In : Science. 330, 6005, p. 841-845 5 p.

Research output: Contribution to journalArticle

Microglia
Macrophages
Brain Diseases
Mononuclear Phagocyte System
Macrophage Colony-Stimulating Factor
48 Citations (Scopus)
Disease Susceptibility
Epigenomics
Sex Characteristics
Psychiatry
Brain
16 Citations (Scopus)
Neurology
Epigenomics
Central Nervous System
Post Transcriptional RNA Processing
RNA
1 Citation (Scopus)

Introduction: Epigenetics and neuropsychiatric diseases

Mehler, M. F., Jul 2010, In : Neurobiology of Disease. 39, 1, p. 1-2 2 p.

Research output: Contribution to journalArticle

Genetic Epigenesis
Genetic Predisposition to Disease
Nervous System Diseases
Epigenomics
Neurons