• 13008 Citations
  • 55 h-Index
1976 …2020

Research output per year

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Publications

2020

EEG findings in acutely ill patients investigated for SARS-CoV-2/COVID-19: A small case series preliminary report

Galanopoulou, A. S., Ferastraoaru, V., Correa, D. J., Cherian, K., Duberstein, S., Gursky, J., Hanumanthu, R., Hung, C., Molinero, I., Khodakivska, O., Legatt, A. D., Patel, P., Rosengard, J., Rubens, E., Sugrue, W., Yozawitz, E., Mehler, M. F., Ballaban-Gil, K., Haut, S. R., Moshé, S. L. & 1 others, Boro, A., Jun 1 2020, In : Epilepsia Open. 5, 2, p. 314-324 11 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Microglial Homeostasis Requires Balanced CSF-1/CSF-2 Receptor Signaling

Chitu, V., Biundo, F., Shlager, G. G. L., Park, E. S., Wang, P., Gulinello, M. E., Gokhan, Ş., Ketchum, H. C., Saha, K., DeTure, M. A., Dickson, D. W., Wszolek, Z. K., Zheng, D., Croxford, A. L., Becher, B., Sun, D., Mehler, M. F. & Stanley, E. R., Mar 3 2020, In : Cell Reports. 30, 9, p. 3004-3019.e5

Research output: Contribution to journalArticle

Open Access
2019

Loss-of-huntingtin in medial and lateral ganglionic lineages differentially disrupts regional interneuron and projection neuron subtypes and promotes huntington’s disease-associated behavioral, cellular, and pathological hallmarks

Mehler, M. F., Petronglo, J. R., Arteaga-Bracho, E. E., Gulinello, M. E., Winchester, M. L., Pichamoorthy, N., Young, S. K., Dejesus, C. D., Ishtiaq, H., Gokhan, S. & Molero, A. E., Mar 6 2019, In : Journal of Neuroscience. 39, 10, p. 1892-1909 18 p.

Research output: Contribution to journalArticle

6 Scopus citations
2018

Epigenetic mechanisms underlying nervous system diseases

Qureshi, I. A. & Mehler, M. F., Jan 1 2018, Handbook of Clinical Neurology. Elsevier B.V., p. 43-58 16 p. (Handbook of Clinical Neurology; vol. 147).

Research output: Chapter in Book/Report/Conference proceedingChapter

7 Scopus citations
2017

A dedicated scholarly research program in an adult and pediatric neurology residency program

Robbins, M. S., Haut, S. R., Lipton, R. B., Milstein, M. J., Ocava, L. C., Ballaban-Gil, K. R., Moshe, S. L. & Mehler, M. F., Apr 4 2017, In : Neurology. 88, 14, p. 1366-1370 5 p.

Research output: Contribution to journalArticle

9 Scopus citations

Author response: A dedicated scholarly research program in an adult and pediatric neurology residency program

Robbins, M. S. & Mehler, M. F., Sep 5 2017, In : Neurology. 89, 10, 1 p.

Research output: Contribution to journalLetter

Increased localization of APP-C99 in mitochondria-associated ER membranes causes mitochondrial dysfunction in Alzheimer disease

Pera, M., Larrea, D., Guardia-Laguarta, C., Montesinos, J., Velasco, K. R., Agrawal, R. R., Xu, Y., Chan, R. B., Di Paolo, G., Mehler, M. F., Perumal, G. S., Macaluso, F. P., Freyberg, Z. Z., Acin-Perez, R., Enriquez, J. A., Schon, E. A. & Area-Gomez, E., Nov 15 2017, In : EMBO Journal. 36, 22, p. 3356-3371 16 p.

Research output: Contribution to journalArticle

30 Scopus citations
3 Scopus citations
2016

Author Response

Beversdorf, D. Q., Lennon, V., Mehler, M. & Roos, R., Feb 9 2016, In : Neurology. 86, 6, p. 585-586 2 p.

Research output: Contribution to journalArticle

Emerging Roles for CSF-1 Receptor and its Ligands in the Nervous System

Chitu, V., Gokhan, Ş., Nandi, S., Mehler, M. F. & Stanley, E. R., 2016, (Accepted/In press) In : Trends in Neurosciences.

Research output: Contribution to journalArticle

95 Scopus citations

Huntington’s disease

Molero, A. E. & Mehler, M. F., Jan 1 2016, Neuroscience in the 21st Century: From Basic to Clinical, Second Edition. Springer New York, p. 3863-3892 30 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Postnatal and adult consequences of loss of huntingtin during development: Implications for Huntington's disease

Arteaga-Bracho, E. E., Gulinello, M., Winchester, M. L., Pichamoorthy, N., Petronglo, J. R., Zambrano, A. D., Inocencio, J., De Jesus, C. D., Louie, J. O., Gokhan, S., Mehler, M. F. & Molero, A. E., Dec 1 2016, In : Neurobiology of Disease. 96, p. 144-155 12 p.

Research output: Contribution to journalArticle

20 Scopus citations

Selective expression of mutant huntingtin during development recapitulates characteristic features of Huntington's disease

Molero, A. E., Arteaga-Bracho, E. E., Chen, C. H., Gulinello, M., Winchester, M. L., Pichamoorthy, N., Gokhan, S., Khodakhah, K. & Mehler, M. F., May 17 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 20, p. 5736-5741 6 p.

Research output: Contribution to journalArticle

46 Scopus citations
2015
10 Scopus citations

Animal extremists' threats to neurologic research continue: Neuroreality II

Beversdorf, D. Q., Roos, R. P., Hauser, W. A., Lennon, V. A. & Mehler, M. F., Aug 25 2015, In : Neurology. 85, 8, p. 730-734 5 p.

Research output: Contribution to journalReview article

2 Scopus citations

Epigenetics and therapeutic targets mediating neuroprotection

Qureshi, I. A. & Mehler, M. F., Dec 2 2015, In : Brain Research. 1628, p. 265-272 8 p.

Research output: Contribution to journalArticle

7 Scopus citations
5 Scopus citations

Phenotypic characterization of a Csf1r haploinsufficient mouse model of adult-onset leukodystrophy with axonal spheroids and pigmented glia (ALSP)

Chitu, V., Gokhan, S., Gulinello, M., Branch, C. A., Patil, M., Basu, R., Stoddart, C., Mehler, M. F. & Richard Stanley, E., Feb 1 2015, In : Neurobiology of Disease. 74, p. 219-228 10 p.

Research output: Contribution to journalArticle

30 Scopus citations
2014

An evolving view of epigenetic complexity in the brain

Qureshi, I. A. & Mehler, M. F., 2014, In : Philosophical Transactions of the Royal Society B: Biological Sciences. 369, 1652, 20130506.

Research output: Contribution to journalReview article

16 Scopus citations

Epigenetic Mechanisms Underlying the Pathogenesis of Neurogenetic Diseases

Qureshi, I. A. & Mehler, M. F., Oct 18 2014, In : Neurotherapeutics. 11, 4, p. 708-720 13 p.

Research output: Contribution to journalReview article

13 Scopus citations

Epigenetics of sleep and chronobiology

Qureshi, I. A. & Mehler, M. F., Mar 2014, In : Current neurology and neuroscience reports. 14, 3, 432.

Research output: Contribution to journalReview article

30 Scopus citations

Sex, epilepsy, and epigenetics

Qureshi, I. A. & Mehler, M. F., Dec 1 2014, In : Neurobiology of Disease. 72, PB, p. 210-216 7 p.

Research output: Contribution to journalReview article

8 Scopus citations
5 Scopus citations
2013

Developing epigenetic diagnostics and therapeutics for brain disorders

Qureshi, I. A. & Mehler, M. F., Dec 1 2013, In : Trends in Molecular Medicine. 19, 12, p. 732-741 10 p.

Research output: Contribution to journalReview article

17 Scopus citations

Epigenetic mechanisms governing the process of neurodegeneration

Qureshi, I. A. & Mehler, M. F., Jul 1 2013, In : Molecular aspects of medicine. 34, 4, p. 875-882 8 p.

Research output: Contribution to journalReview article

24 Scopus citations

Functions of Huntingtin in Germ Layer Specification and Organogenesis

Nguyen, G. D., Molero, A. E., Gokhan, S. & Mehler, M. F., Aug 13 2013, In : PloS one. 8, 8, e72698.

Research output: Contribution to journalArticle

16 Scopus citations

Genetic and epigenetic studies of amyotrophic lateral sclerosis

Al-Chalabi, A., Kwak, S., Mehler, M., Rouleau, G., Siddique, T., Strong, M. & Leigh, P. N., May 1 2013, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 14, SUPPL1, p. 44-52 9 p.

Research output: Contribution to journalArticle

18 Scopus citations

Huntington's disease

Molero, A. & Mehler, M. F., Nov 1 2013, Neuroscience in the 21st Century: From Basic to Clinical. Springer New York, p. 2923-2951 29 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Long Non-coding RNAs: Novel Targets for Nervous System Disease Diagnosis and Therapy

Qureshi, I. A. & Mehler, M. F., Oct 1 2013, In : Neurotherapeutics. 10, 4, p. 632-646 15 p.

Research output: Contribution to journalReview article

72 Scopus citations

Receptor-type protein-tyrosine phosphatase ζ is a functional receptor for interleukin-34

Nandi, S., Cioce, M., Yeung, Y. G., Nieves, E., Tesfa, L., Lin, H., Hsu, A. W., Halenbeck, R., Cheng, H. Y., Gokhan, S., Mehler, M. F. & Stanley, E. R., Jul 26 2013, In : Journal of Biological Chemistry. 288, 30, p. 21972-21986 15 p.

Research output: Contribution to journalArticle

77 Scopus citations

Selective Roles of Normal and Mutant Huntingtin in Neural Induction and Early Neurogenesis

Nguyen, G. D., Gokhan, S., Molero, A. E. & Mehler, M. F., May 14 2013, In : PloS one. 8, 5, e64368.

Research output: Contribution to journalArticle

23 Scopus citations

Towards a 'systems'-level understanding of the nervous system and its disorders

Qureshi, I. A. & Mehler, M. F., Nov 1 2013, In : Trends in Neurosciences. 36, 11, p. 674-684 11 p.

Research output: Contribution to journalReview article

25 Scopus citations

Understanding neurological disease mechanisms in the era of epigenetics

Qureshi, I. A. & Mehler, M. F., Jun 2013, In : JAMA Neurology. 70, 6, p. 703-710 8 p.

Research output: Contribution to journalReview article

36 Scopus citations
2012

Development and neurodegeneration: Turning HD pathogenesis on its head

Marder, K. & Mehler, M. F., Aug 14 2012, In : Neurology. 79, 7, p. 621-622 2 p.

Research output: Contribution to journalEditorial

7 Scopus citations

Emerging roles of non-coding RNAs in brain evolution, development, plasticity and disease

Qureshi, I. A. & Mehler, M. F., Aug 1 2012, In : Nature Reviews Neuroscience. 13, 8, p. 528-541 14 p.

Research output: Contribution to journalReview article

353 Scopus citations

The CSF-1 receptor ligands IL-34 and CSF-1 exhibit distinct developmental brain expression patterns and regulate neural progenitor cell maintenance and maturation

Nandi, S., Gokhan, S., Dai, X. M., Wei, S., Enikolopov, G., Lin, H., Mehler, M. F. & Richard Stanley, E., Jul 15 2012, In : Developmental Biology. 367, 2, p. 100-113 14 p.

Research output: Contribution to journalArticle

160 Scopus citations
2011

Advances in epigenetics and epigenomics for neurodegenerative diseases

Qureshi, I. A. & Mehler, M. F., Oct 1 2011, In : Current neurology and neuroscience reports. 11, 5, p. 464-473 10 p.

Research output: Contribution to journalArticle

52 Scopus citations

Alu transcription: A rheostat for stem cell aging?

Qureshi, I. A. & Mehler, M. F., Nov 15 2011, In : Cell Cycle. 10, 22, 1 p.

Research output: Contribution to journalShort survey

1 Scopus citations

Chromatin-Modifying Agents for Epigenetic Reprogramming and Endogenous Neural Stem Cell-Mediated Repair in Stroke

Qureshi, I. A. & Mehler, M. F., Mar 1 2011, In : Translational Stroke Research. 2, 1, p. 7-16 10 p.

Research output: Contribution to journalReview article

7 Scopus citations

Diagnosing and treating nervous system disorders by targeting novel classes of Non-coding RNAs

Qureshi, I. A. & Mehler, M. F., Jun 1 2011, In : International Drug Discovery. 2011, 4, p. 30-36 7 p.

Research output: Contribution to journalArticle

Epigenetics, nervous system tumors, and cancer stem cells

Qureshi, I. A. & Mehler, M. F., Sep 1 2011, In : Cancers. 3, 3, p. 3525-3556 32 p.

Research output: Contribution to journalReview article

4 Scopus citations

Non-coding RNA networks underlying cognitive disorders across the lifespan

Qureshi, I. A. & Mehler, M. F., Jun 1 2011, In : Trends in Molecular Medicine. 17, 6, p. 337-346 10 p.

Research output: Contribution to journalReview article

46 Scopus citations

The emerging role of epigenetics in stroke: III. Neural stem cell biology and regenerative medicine

Qureshi, I. A. & Mehler, M. F., Mar 1 2011, In : Archives of Neurology. 68, 3, p. 294-302 9 p.

Research output: Contribution to journalReview article

22 Scopus citations
2010
44 Scopus citations

Editorial: Emerging themes in epigenetics: Implications for understanding and treating nervous system disorders

Qureshi, I. A. & Mehler, M. F., Jun 1 2010, In : Epigenomics. 2, 3, p. 345-349 5 p.

Research output: Contribution to journalEditorial

3 Scopus citations

Emerging role of epigenetics in stroke - Part 1: DNA methylation and chromatin modifications

Qureshi, I. A. & Mehler, M. F., Nov 1 2010, In : Archives of Neurology. 67, 11, p. 1316-1322 7 p.

Research output: Contribution to journalReview article

76 Scopus citations

Epigenetic mechanisms underlying human epileptic disorders and the process of epileptogenesis

Qureshi, I. A. & Mehler, M. F., Jul 1 2010, In : Neurobiology of Disease. 39, 1, p. 53-60 8 p.

Research output: Contribution to journalReview article

74 Scopus citations

Epigenetics and neuropsychiatric diseases: Introduction and meeting summary

Mehler, M. F., Jan 1 2010, In : Annals of the New York Academy of Sciences. 1204, SUPPL.1, p. 1-7 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

Fate mapping analysis reveals that adult microglia derive from primitive macrophages

Ginhoux, F., Greter, M., Leboeuf, M., Nandi, S., See, P., Gokhan, S., Mehler, M. F., Conway, S. J., Ng, L. G., Stanley, E. R., Samokhvalov, I. M. & Merad, M., Nov 5 2010, In : Science. 330, 6005, p. 841-845 5 p.

Research output: Contribution to journalArticle

2144 Scopus citations

Genetic and epigenetic underpinnings of sex differences in the brain and in neurological and psychiatric disease susceptibility

Qureshi, I. A. & Mehler, M. F., Jan 1 2010, Progress in Brain Research. C ed. Elsevier B.V., p. 77-95 19 p. (Progress in Brain Research; vol. 186, no. C).

Research output: Chapter in Book/Report/Conference proceedingChapter

49 Scopus citations