• 5354 Citations
  • 43 h-Index
1977 …2023

Research output per year

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Publications

  • 5354 Citations
  • 43 h-Index
  • 96 Article
  • 10 Review article
  • 4 Short survey
  • 1 Foreword/postscript
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Article
2019

Human monoclonal antibodies against chikungunya virus target multiple distinct epitopes in the E1 and E2 glycoproteins

Quiroz, J. A., Malonis, R. J., Thackray, L. B., Cohen, C. A., Pallesen, J., Jangra, R. K., Brown, R. S., Hofmann, D., Holtsberg, F. W., Shulenin, S., Nyakatura, E. K., Durnell, L. A., Rayannavar, V., Daily, J. P., Ward, A. B., Javad Aman, M., Dye, J. M., Chandran, K., Diamond, M. S., Kielian, M. & 1 others, Lai, J. R., Jan 1 2019, In : PLoS pathogens. 15, 11, e1008061.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Mechanism of tetherin inhibition of alphavirus release

Wan, J. J., Ooi, Y. S. & Kielian, M., Jan 1 2019, In : Journal of virology. 93, 7, e02165.

Research output: Contribution to journalArticle

Surface (S) Layer Proteins of Lactobacillus acidophilus Block Virus Infection via DC-SIGN Interaction

Acosta, M. P., Geoghegan, E. M., Lepenies, B., Ruzal, S., Kielian, M. & Martinez, M. G., Jan 1 2019, In : Frontiers in Microbiology. 10, MAR, 810.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

The alphavirus E2 membrane-proximal domain impacts capsid interaction and glycoprotein lattice formation

Byrd, E. A. & Kielian, M., Feb 1 2019, In : Journal of virology. 93, 4, e0188118.

Research output: Contribution to journalArticle

2018

Engineered dengue virus domain III proteins elicit cross-neutralizing antibody responses in mice

Frei, J. C., Wirchnianski, A. S., Govero, J., Vergnolle, O., Dowd, K. A., Pierson, T. C., Kielian, M., Girvin, M. E., Diamond, M. S. & Lai, J. R., Sep 1 2018, In : Journal of virology. 92, 18, e01023.

Research output: Contribution to journalArticle

8 Scopus citations

Insertion of Dengue E into lipid bilayers studied by neutron reflectivity and molecular dynamics simulations

Vanegas, J. M., Heinrich, F., Rogers, D. M., Carson, B. D., La Bauve, S., Vernon, B. C., Akgun, B., Satija, S., Zheng, A., Kielian, M., Rempe, S. B. & Kent, M. S., May 2018, In : Biochimica et Biophysica Acta - Biomembranes. 1860, 5, p. 1216-1230 15 p.

Research output: Contribution to journalArticle

3 Scopus citations
2017

An alphavirus E2 membrane-proximal domain promotes envelope protein lateral interactions and virus budding

Byrd, E. A. & Kielian, M., Nov 1 2017, In : mBio. 8, 6, e01564-17.

Research output: Contribution to journalArticle

10 Scopus citations
2016

Calcium-Dependent Rubella Virus Fusion Occurs in Early Endosomes

Dubé, M., Etienne, L., Fels, M. & Kielian, M., 2016, In : Journal of Virology. 90, 14, p. 6303-6313 11 p.

Research output: Contribution to journalArticle

7 Scopus citations

Intercellular Extensions Are Induced by the Alphavirus Structural Proteins and Mediate Virus Transmission

Martinez, M. G. & Kielian, M., Dec 15 2016, In : PLoS Pathogens. 12, 12, e1006061.

Research output: Contribution to journalArticle

10 Scopus citations

Method for measuring the unbinding energy of strongly-bound membrane-associated proteins

La Bauve, E., Vernon, B. C., Ye, D., Rogers, D. M., Siegrist, C. M., Carson, B. D., Rempe, S. B., Zheng, A., Kielian, M., Shreve, A. P. & Kent, M. S., Nov 1 2016, In : Biochimica et Biophysica Acta - Biomembranes. 1858, 11, p. 2753-2762 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

Role of TSPAN9 in alphavirus entry and early endosomes

Stiles, K. M. & Kielian, M., May 1 2016, In : Journal of Virology. 90, 9, p. 4289-4297 9 p.

Research output: Contribution to journalArticle

8 Scopus citations
2015

An alphavirus temperature-sensitive capsid mutant reveals stages of nucleocapsid assembly

Zheng, Y. & Kielian, M., Oct 1 2015, In : Virology. 484, p. 412-420 9 p.

Research output: Contribution to journalArticle

5 Scopus citations

BST2/Tetherin inhibition of alphavirus exit

Ooi, Y. S., Dubé, M. & Kielian, M., Apr 22 2015, In : Viruses. 7, 4, p. 2147-2167 21 p.

Research output: Contribution to journalArticle

17 Scopus citations
11 Scopus citations

Haploid genetic screen reveals a profound and direct dependence on cholesterol for hantavirus membrane fusion

Kleinfelter, L. M., Jangra, R. K., Jae, L. T., Herbert, A. S., Mittler, E., Stiles, K. M., Wirchnianski, A. S., Kielian, M., Brummelkamp, T. R., Dye, J. M. & Chandran, K., Jun 30 2015, In : mBio. 6, 4, e00801-15.

Research output: Contribution to journalArticle

42 Scopus citations

Interactions involved in pH protection of the alphavirus fusion protein

Fields, W. & Kielian, M., Dec 1 2015, In : Virology. 486, p. 173-179 7 p.

Research output: Contribution to journalArticle

2014

A toggle switch controls the low pH-triggered rearrangement and maturation of the dengue virus envelope proteins

Zheng, A., Yuan, F., Kleinfelter, L. M. & Kielian, M., May 20 2014, In : Nature communications. 5, 3877.

Research output: Contribution to journalArticle

24 Scopus citations

Imaging the alphavirus exit pathway

Martinez, M. G., Snapp, E. L., Perumal, G. S., Macaluso, F. P. & Kielian, M., Jun 2014, In : Journal of virology. 88, 12, p. 6922-6933 12 p.

Research output: Contribution to journalArticle

27 Scopus citations

Mechanisms of virus membrane fusion proteins

Kielian, M., Sep 29 2014, In : Annual Review of Virology. 1, 1, p. 171-189 19 p.

Research output: Contribution to journalArticle

51 Scopus citations

Rubella Virus: First Calcium-Requiring Viral Fusion Protein

Dubé, M., Rey, F. A. & Kielian, M., Dec 1 2014, In : PLoS pathogens. 10, 12

Research output: Contribution to journalArticle

21 Scopus citations
2013

A key interaction between the alphavirus envelope proteins responsible for initial dimer dissociation during fusion

Fields, W. & Kielian, M., Apr 1 2013, In : Journal of virology. 87, 7, p. 3774-3781 8 p.

Research output: Contribution to journalArticle

14 Scopus citations

A Mechanistic Paradigm for Broad-Spectrum Antivirals that Target Virus-Cell Fusion

Vigant, F., Lee, J., Hollmann, A., Tanner, L. B., Akyol Ataman, Z., Yun, T., Shui, G., Aguilar, H. C., Zhang, D., Meriwether, D., Roman-Sosa, G., Robinson, L. R., Juelich, T. L., Buczkowski, H., Chou, S., Castanho, M. A. R. B., Wolf, M. C., Smith, J. K., Banyard, A., Kielian, M. & 7 others, Reddy, S., Wenk, M. R., Selke, M., Santos, N. C., Freiberg, A. N., Jung, M. E. & Lee, B., Apr 1 2013, In : PLoS pathogens. 9, 4, e1003297.

Research output: Contribution to journalArticle

43 Scopus citations

Cross-inhibition of chikungunya virus fusion and infection by alphavirus E1 domain III proteins

Martín, C. S. S., Nanda, S., Zheng, Y., Fields, W. & Kielian, M., Jul 2013, In : Journal of virology. 87, 13, p. 7680-7687 8 p.

Research output: Contribution to journalArticle

10 Scopus citations

Genome-Wide RNAi Screen Identifies Novel Host Proteins Required for Alphavirus Entry

Ooi, Y. S., Stiles, K. M., Liu, C. Y., Taylor, G. M. & Kielian, M., Jan 1 2013, In : PLoS pathogens. 9, 12, p. 1-10 10 p., e1003835.

Research output: Contribution to journalArticle

47 Scopus citations

Imaging of the alphavirus capsid protein during virus replication

Zheng, Y. & Kielian, M., Sep 5 2013, In : Journal of virology. 87, 17, p. 9579-9589 11 p.

Research output: Contribution to journalArticle

15 Scopus citations

The role of E3 in pH protection during alphavirus assembly and exit

Uchime, O., Fields, W. & Kielian, M., Sep 5 2013, In : Journal of virology. 87, 18, p. 10255-10262 8 p.

Research output: Contribution to journalArticle

23 Scopus citations
2012

Identification of a specific region in the E1 fusion protein involved in zinc inhibition of semliki forest virus fusion

Liu, C. Y. & Kielian, M., Apr 1 2012, In : Journal of virology. 86, 7, p. 3588-3594 7 p.

Research output: Contribution to journalArticle

3 Scopus citations
2011

The domain I-domain III linker plays an important role in the fusogenic conformational change of the alphavirus membrane fusion protein

Zheng, Y., Martín, C. S. S., Qin, Z. L. & Kielian, M., Jul 2011, In : Journal of virology. 85, 13, p. 6334-6342 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

The interaction of alphavirus E1 protein with exogenous domain III defines stages in virus-membrane fusion

Roman-Sosa, G. & Kielian, M., Dec 1 2011, In : Journal of virology. 85, 23, p. 12271-12279 9 p.

Research output: Contribution to journalArticle

9 Scopus citations
2010

In Vitro and In vivo studies identify important features of dengue virus pr-E protein interactions

Zheng, A., Umashankar, M. & Kielian, M., Oct 1 2010, In : PLoS pathogens. 6, 10, e1001157.

Research output: Contribution to journalArticle

48 Scopus citations

In Vitro reconstitution reveals key intermediate states of trimer formation by the dengue virus membrane fusion protein

Liao, M., Sánchez-San Martín, C., Zheng, A. & Kielian, M., Jun 1 2010, In : Journal of virology. 84, 11, p. 5730-5740 11 p.

Research output: Contribution to journalArticle

34 Scopus citations

Pseudorevertants of a semliki forest virus fusion-blocking mutation reveal a critical interchain interaction in the core trimer

Liu, C. Y., Besanceney, C., Song, Y. & Kielian, M., Nov 1 2010, In : Journal of virology. 84, 22, p. 11624-11633 10 p.

Research output: Contribution to journalArticle

8 Scopus citations
2009

E1 mutants identify a critical region in the trimer interface of the Semliki Forest virus fusion protein

Liu, C. Y. & Kielian, M., Nov 1 2009, In : Journal of virology. 83, 21, p. 11298-11306 9 p.

Research output: Contribution to journalArticle

20 Scopus citations

Role of conserved histidine residues in the low-pH dependence of the Semliki Forest virus fusion protein

Qin, Z. L., Zheng, Y. & Kielian, M., May 1 2009, In : Journal of virology. 83, 9, p. 4670-4677 8 p.

Research output: Contribution to journalArticle

52 Scopus citations
2008

A Stable Prefusion Intermediate of the Alphavirus Fusion Protein Reveals Critical Features of Class II Membrane Fusion

Sánchez-San Martín, C., Sosa, H. & Kielian, M., Dec 11 2008, In : Cell Host and Microbe. 4, 6, p. 600-608 9 p.

Research output: Contribution to journalArticle

33 Scopus citations

Differential cholesterol binding by class II fusion proteins determines membrane fusion properties

Umashankar, M., Sánchez-San Martín, C., Liao, M., Reilly, B., Guo, A., Taylor, G. & Kielian, M., Sep 1 2008, In : Journal of virology. 82, 18, p. 9245-9253 9 p.

Research output: Contribution to journalArticle

64 Scopus citations
2007

Fusion induced by a class II viral fusion protein, Semliki Forest virus E1, is dependent on the voltage of the target cell

Markosyan, R. M., Kielian, M. & Cohen, F. S., Oct 1 2007, In : Journal of virology. 81, 20, p. 11218-11225 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Ubiquitin depletion and dominant-negative VPS4 inhibit rhabdovirus budding without affecting alphavirus budding

Taylor, G. M., Hanson, P. I. & Kielian, M., Dec 1 2007, In : Journal of virology. 81, 24, p. 13631-13639 9 p.

Research output: Contribution to journalArticle

59 Scopus citations
2006

Functions of the stem region of the Semliki Forest virus fusion protein during virus fusion and assembly

Liao, M. & Kielian, M., Nov 1 2006, In : Journal of virology. 80, 22, p. 11362-11369 8 p.

Research output: Contribution to journalArticle

22 Scopus citations

Second-site revertants of a Semliki Forest Virus fusion-block mutation reveal the dynamics of a class II membrane fusion protein

Chanel-Vos, C. & Kielian, M., Jun 1 2006, In : Journal of virology. 80, 12, p. 6115-6122 8 p.

Research output: Contribution to journalArticle

22 Scopus citations
10 Scopus citations
2005

An interaction site of the envelope proteins of Semliki Forest virus that is preserved after proteolytic activation

Zhang, X. & Kielian, M., Jul 5 2005, In : Virology. 337, 2, p. 344-352 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

Domain III from class II fusion proteins functions as a dominant-negative inhibitor of virus membrane fusion

Liao, M. & Kielian, M., Oct 1 2005, In : Journal of Cell Biology. 171, 1, p. 111-120 10 p.

Research output: Contribution to journalArticle

102 Scopus citations
8 Scopus citations
2004

A conserved histidine in the ij loop of the Semliki Forest virus E1 protein plays an important role in membrane fusion

Chanel-Vos, C. & Kielian, M., Dec 1 2004, In : Journal of virology. 78, 24, p. 13543-13552 10 p.

Research output: Contribution to journalArticle

53 Scopus citations

Conformational change and protein-protein interactions of the fusion protein of Semliki Forest virus

Gibbons, D. L., Vaney, M. C., Roussel, A., Vigouroux, A., Reilly, B., Lepault, J., Kielian, M. & Rey, F. A., Jan 22 2004, In : Nature. 427, 6972, p. 320-325 6 p.

Research output: Contribution to journalArticle

276 Scopus citations

Multistep Regulation of Membrane Insertion of the Fusion Peptide of Semliki Forest Virus

Gibbons, D. L., Ahn, A., Liao, M., Hammar, L., Cheng, R. H. & Kielian, M., Apr 1 2004, In : Journal of virology. 78, 7, p. 3312-3318 7 p.

Research output: Contribution to journalArticle

41 Scopus citations

Mutations that promote furin-independent growth of Semliki Forest virus affect p62-E1 interactions and membrane fusion

Zhang, X. & Kielian, M., Oct 1 2004, In : Virology. 327, 2, p. 287-296 10 p.

Research output: Contribution to journalArticle

14 Scopus citations

Purification and Crystallization Reveal Two Types of Interactions of the Fusion Protein Homotrimer of Semliki Forest Virus

Gibbons, D. L., Reilly, B., Ahn, A., Vaney, M. C., Vigouroux, A., Rey, F. A. & Kielian, M., Apr 1 2004, In : Journal of virology. 78, 7, p. 3514-3523 10 p.

Research output: Contribution to journalArticle

22 Scopus citations
2003

Furin processing and proteolytic activation of Semliki Forest virus

Zhang, X., Fugère, M., Day, R. & Kielian, M., Mar 1 2003, In : Journal of virology. 77, 5, p. 2981-2989 9 p.

Research output: Contribution to journalArticle

64 Scopus citations