• 10649 Citations
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1973 …2020

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2019

Distinct cellular roles for PDCD10 define a gut-brain axis in cerebral cavernous malformation

Tang, A. T., Sullivan, K. R., Hong, C. C., Goddard, L. M., Mahadevan, A., Ren, A., Pardo, H., Peiper, A., Griffin, E., Tanes, C., Mattei, L. M., Yang, J., Li, L., Mericko-Ishizuka, P., Shen, L., Hobson, N., Girard, R., Lightle, R., Moore, T., Shenkar, R. & 19 others, Polster, S. P., Roedel, C. J., Li, N., Zhu, Q., Whitehead, K. J., Zheng, X., Akers, A., Morrison, L., Kim, H., Bittinger, K., Lengner, C. J., Schwaninger, M., Velcich, A., Augenlicht, L., Abdelilah-Seyfried, S., Min, W., Marchuk, D. A., Awad, I. A. & Kahn, M. L., Nov 27 2019, In : Science translational medicine. 11, 520, eaaw3521.

Research output: Contribution to journalArticle

6 Scopus citations

The nutritional environment determines which and how intestinal stem cells contribute to homeostasis and tumorigenesis

Li, W., Zimmerman, S. E., Peregrina, K., Houston, M., Mayoral, J., Zhang, J., Maqbool, S., Zhang, Z., Cai, Y., Ye, K. & Augenlicht, L. H., Aug 22 2019, In : Carcinogenesis. 40, 8, p. 937-946 10 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations
2017
7 Scopus citations
2016

Calcium and 1,25-dihydroxyvitamin D3 modulate genes of immune and inflammatory pathways in the human colon: A human crossover trial

Protiva, P., Pendyala, S., Nelson, C., Augenlicht, L. H., Lipkin, M. & Holt, P. R., May 1 2016, In : American Journal of Clinical Nutrition. 103, 5, p. 1224-1231 8 p.

Research output: Contribution to journalArticle

16 Scopus citations

NOTCH signaling regulates asymmetric cell fate of fast- and slow-cycling colon cancer-initiating cells

Srinivasan, T., Walters, J., Bu, P., Than, E. B., Tung, K. L., Chen, K. Y., Panarelli, N. C., Milsom, J., Augenlicht, L. H., Lipkin, S. M. & Shen, X., Jun 1 2016, In : Cancer Research. 76, 11, p. 3411-3421 11 p.

Research output: Contribution to journalArticle

21 Scopus citations

Notch signalling regulates asymmetric division and inter-conversion between lgr5 and bmi1 expressing intestinal stem cells

Srinivasan, T., Than, E. B., Bu, P., Tung, K. L., Chen, K. Y., Augenlicht, L., Lipkin, S. M. & Shen, X., May 16 2016, In : Scientific reports. 6, 26069.

Research output: Contribution to journalArticle

14 Scopus citations
2015

Vitamin D is a determinant of mouse intestinal Lgr5 stem cell functions

Peregrina, K., Houston, M., Daroqui, C., Dhima, E., Sellers, R. S. & Augenlicht, L. H., Jan 1 2015, In : Carcinogenesis. 36, 1, p. 25-31 7 p.

Research output: Contribution to journalArticle

18 Scopus citations
2014

Circulating soluble cytokine receptors and colorectal cancer risk

Ho, G. Y. F., Wang, T., Zheng, S. L., Tinker, L., Xu, J., Rohan, T. E., Wassertheil-Smoller, S., Xue, X., Augenlicht, L. H., Peters, U., Phipps, A. I., Strickler, H. D., Gunter, M. J. & Cushman, M., Jan 2014, In : Cancer Epidemiology Biomarkers and Prevention. 23, 1, p. 179-188 10 p.

Research output: Contribution to journalArticle

11 Scopus citations
12 Scopus citations

The intestinal epithelial cell differentiation marker intestinal alkaline phosphatase (ALPi) is selectively induced by histone deacetylase inhibitors (HDACi) in colon cancer cells in a Kruppel-like Factor 5 (KLF5)-defendent manner

Shin, J., Carr, A., Corner, G. A., Tögel, L., Dávaos-Salas, M., Tran, H., Chueh, A. C., Al-Obaidi, S., Chionh, F., Ahmed, N., Buchanan, D. D., Young, J. P., Malo, M. S., Hodin, R. A., Arango, D., Sieber, O. M., Augenlicht, L. H., Dhillon, A. S., Weber, T. K. & Mariadason, J. M., 2014, In : Journal of Biological Chemistry. 289, 36, p. 25306-25316 11 p.

Research output: Contribution to journalArticle

28 Scopus citations

The role of STAT1 for crosstalk between fibroblasts and colon cancer cells

Kaler, P., Owusu, B. Y., Augenlicht, L. & Klampfer, L., Jan 1 2014, In : Frontiers in Oncology. 4 APR, Article 88.

Research output: Contribution to journalArticle

15 Scopus citations
2013

Abdominal obesity, independent from caloric intake, accounts for the development of intestinal tumors in Apc1638N/+ female mice

Huffman, D. M., Augenlicht, L. H., Zhang, X., Lofrese, J. J., Atzmon, G., Chamberland, J. P. & Mantzoros, C. S., Mar 2013, In : Cancer Prevention Research. 6, 3, p. 177-187 11 p.

Research output: Contribution to journalArticle

25 Scopus citations

Mucus enhances gut homeostasis and oral tolerance by delivering immunoregulatory signals

Shan, M., Gentile, M., Yeiser, J. R., Walland, A. C., Bornstein, V. U., Chen, K., He, B., Cassis, L., Bigas, A., Cols, M., Comerma, L., Huang, B., Blander, J. M., Xiong, H., Mayer, L., Berin, C., Augenlicht, L. H., Velcich, A. & Cerutti, A., 2013, In : Science. 342, 6157, p. 447-453 7 p.

Research output: Contribution to journalArticle

287 Scopus citations

STAT3 in epithelial cells regulates inflammation and tumor progression to malignant state in colon

Nguyen, A. V., Wu, Y. Y., Liu, Q., Wang, D., Nguyen, S., Loh, R., Pang, J., Friedman, K., Orlofsky, A., Augenlicht, L., Pollard, J. W. & Lin, E. Y., Sep 2013, In : Neoplasia (United States). 15, 9, p. 998-1008 11 p.

Research output: Contribution to journalArticle

43 Scopus citations

The Effect of Lung Cancer on Cytokine Expression in Peripheral Blood Mononuclear Cells

Chang, D. H., Rutledge, J. R., Patel, A. A., Heerdt, B. G., Augenlicht, L. H. & Korst, R. J., Jun 6 2013, In : PloS one. 8, 6, e64456.

Research output: Contribution to journalArticle

14 Scopus citations
2012

Activating Mutations in β-Catenin in Colon Cancer Cells Alter Their Interaction with Macrophages; the Role of Snail

Kaler, P., Augenlicht, L. & Klampfer, L., Sep 21 2012, In : PloS one. 7, 9, e45462.

Research output: Contribution to journalArticle

26 Scopus citations

Dietary cholecalciferol and calcium levels in a western-style defined rodent diet alter energy metabolism and inflammatory responses in mice

Bastie, C. C., Gaffney-Stomberg, E., Lee, T. W. A., Dhima, E., Pessin, J. E. & Augenlicht, L. H., May 1 2012, In : Journal of Nutrition. 142, 5, p. 859-865 7 p.

Research output: Contribution to journalArticle

20 Scopus citations
2011

Intestinal epithelial-specific PTEN inactivation results in tumor formation

Byun, D. S., Ahmed, N., Nasser, S., Shin, J., Al-Obaidi, S., Goel, S., Corner, G. A., Wilson, A. J., Flanagan, D. J., Williams, D. S., Augenlicht, L. H., Vincan, E. & Mariadason, J. M., Nov 2011, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 301, 5, p. G856-G864

Research output: Contribution to journalArticle

17 Scopus citations

Intrinsic mitochondrial membrane potential and associated tumor phenotype are independent of MUC1 over-expression

Houston, M. A., Augenlicht, L. H. & Heerdt, B. G., Sep 23 2011, In : PloS one. 6, 9, e25207.

Research output: Contribution to journalArticle

9 Scopus citations

MYBL2, a link between proliferation and differentiation in maturing colon epithelial cells

Papetti, M. & Augenlicht, L. H., Mar 1 2011, In : Journal of Cellular Physiology. 226, 3, p. 785-791 7 p.

Research output: Contribution to journalArticle

15 Scopus citations
16 Scopus citations

Paneth cell marker expression in intestinal villi and colon crypts characterizes dietary induced risk for mouse sporadic intestinal cancer

Wang, D., Peregrina, K., Dhima, E., Lin, E. Y., Mariadason, J. M. & Augenlicht, L. H., Jun 21 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 25, p. 10272-10277 6 p.

Research output: Contribution to journalArticle

31 Scopus citations
28 Scopus citations
2010

Altered dynamics of intestinal cell maturation in APC1638N/+ mice

Wang, D., Pezo, R. C., Corner, G., Sison, C., Lesser, M. L., Shenoy, S. M., Mariadason, J. M., Singer, R. H. & Augenlicht, L. H., Jul 1 2010, In : Cancer research. 70, 13, p. 5348-5357 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

A novel mouse model of inflammatory bowel disease links mammalian target of rapamycin-dependent hyperproliferation of colonic epithelium to inflammation-associated tumorigenesis

Deng, L., Zhou, J. F., Sellers, R. S., Li, J. F., Nguyen, A. V., Wang, Y., Orlofsky, A., Liu, Q., Hume, D. A., Pollard, J. W., Augenlicht, L. & Lin, E. Y., Feb 2010, In : American Journal of Pathology. 176, 2, p. 952-967 16 p.

Research output: Contribution to journalArticle

127 Scopus citations

Apoptotic sensitivity of colon cancer cells to histone deacetylase inhibitors is mediated by an Sp1/Sp3-activated transcriptional program involving immediate-early gene induction

Wilson, A. J., Chueh, A. C., Tögel, L., Corner, G. A., Ahmed, N., Goel, S., Byun, D. S., Nasser, S., Houston, M. A., Jhawer, M., Smartt, H. J. M., Murray, L. B., Nicholas, C., Heerdt, B. G., Arango, D., Augenlicht, L. H. & Mariadason, J. M., Jan 15 2010, In : Cancer research. 70, 2, p. 609-620 12 p.

Research output: Contribution to journalArticle

73 Scopus citations

Gene expression profiling of primary and metastatic colon cancers identifies a reduced proliferative rate in metastatic tumors

Ganepola, G. A. P., Mazziotta, R. M., Weeresinghe, D., Corner, G. A., Parish, C. J., Chang, D. H., Tebbutt, N. C., Murone, C., Ahmed, N., Augenlicht, L. H. & Mariadason, J. M., Jan 1 2010, In : Clinical and Experimental Metastasis. 27, 1, p. 1-9 9 p.

Research output: Contribution to journalArticle

18 Scopus citations

Heterogeneity of Jagged1 expression in human and mouse intestinal tumors: Implications for targeting Notch signaling

Guilmeau, S., Flandez, M., Mariadason, J. M. & Augenlicht, L. H., Feb 1 2010, In : Oncogene. 29, 7, p. 992-1002 11 p.

Research output: Contribution to journalArticle

35 Scopus citations

Oxaliplatin resistance induced by ERCC1 up-regulation is abrogated by siRNA-mediated gene silencing in human colorectal cancer cells

Seetharam, R. N., Sood, A., Basu-Mallick, A., Augenlicht, L. H., Mariadason, J. M. & Goel, S., Jul 1 2010, In : Anticancer Research. 30, 7, p. 2531-2538 8 p.

Research output: Contribution to journalArticle

19 Scopus citations

Prediction and testing of biological networks underlying intestinal cancer

Patel, V. N., Bebek, G., Mariadason, J. M., Wang, D., Augenlicht, L. H. & Chance, M. R., 2010, In : PloS one. 5, 9, p. 1-12 12 p., e12497.

Research output: Contribution to journalArticle

10 Scopus citations

Transcriptional attenuation in colon carcinoma cells in response to butyrate

Daroqui, M. C. & Augenlicht, L. H., Oct 1 2010, In : Cancer Prevention Research. 3, 10, p. 1292-1302 11 p.

Research output: Contribution to journalArticle

20 Scopus citations

Tumor associated macrophages protect colon cancer cells from TRAIL-induced apoptosis through IL-1β- dependent stabilization of snail in tumor cells

Kaler, P., Galea, V., Augenlicht, L. & Klampfer, L., 2010, In : PloS one. 5, 7, e11700.

Research output: Contribution to journalArticle

52 Scopus citations
2009

An A13 repeat within the 3′-untranslated region of epidermal growth factor receptor (EGFR) is frequently mutated in microsatellite instability colon cancers and is associated with increased EGFR expression

Ziqiang, Y., Joongho, S., Wilson, A., Goel, S., Ling, Y. H., Ahmed, N., Dopeso, H., Jhawer, M., Nasser, S., Montagna, C., Fordyce, K., Augenlicht, L. H., Aaltonen, L. A., Arango, D., Weber, T. K. & Mariadason, J. M., Oct 1 2009, In : Cancer research. 69, 19, p. 7811-7818 8 p.

Research output: Contribution to journalArticle

29 Scopus citations

Butyrate and vitamin D3 induce transcriptional attenuation at the cyclin D1 locus in colonic carcinoma cells

Maier, S., Daroqui, M. C., Scherer, S., Roepcke, S., Velcich, A., Shenoy, S. M., Singer, R. H. & Augenlicht, L. H., Mar 2009, In : Journal of Cellular Physiology. 218, 3, p. 638-642 5 p.

Research output: Contribution to journalArticle

15 Scopus citations

Chemoprevention of colorectal neoplasia by estrogen: Potential role of vitamin D activity

Protiva, P., Cross, H. S., Hopkins, M. E., Kállay, E., Bises, G., Dreyhaupt, E., Augenlicht, L., Lipkin, M., Lesser, M., Livote, E. & Holt, P. R., Jan 2009, In : Cancer Prevention Research. 2, 1, p. 43-51 9 p.

Research output: Contribution to journalArticle

46 Scopus citations

Macrophage-derived IL-1Β stimulates Wnt signaling and growth of colon cancer cells: A crosstalk interrupted by vitamin D"3

Kaler, P., Augenlicht, L. & Klampfer, L., Nov 2009, In : Oncogene. 28, 44, p. 3892-3902 11 p.

Research output: Contribution to journalArticle

159 Scopus citations

PKCα tumor suppression in the intestine is associated with transcriptional and translational inhibition of cyclin D1

Pysz, M. A., Leontieva, O. V., Bateman, N. W., Uronis, J. M., Curry, K. J., Threadgill, D. W., Janssen, K. P., Robine, S., Velcich, A., Augenlicht, L. H., Black, A. R. & Black, J. D., May 1 2009, In : Experimental Cell Research. 315, 8, p. 1415-1428 14 p.

Research output: Contribution to journalArticle

27 Scopus citations

Sulindac effects on inflammation and tumorigenesis in the intestine of mice with Apc and Mlh1 mutations

Itano, O., Yang, K., Fan, K., Kurihara, N., Shinozaki, H., Abe, S., Jin, B., Gravaghi, C., Edelmann, W., Augenlicht, L., Kopelovich, L., Kucherlapati, R., Lamprecht, S. & Lipkin, M., 2009, In : Carcinogenesis. 30, 11, p. 1923-1926 4 p.

Research output: Contribution to journalArticle

9 Scopus citations

The NF-κB/AKT-dependent induction of Wnt signaling in colon cancer cells by macrophages and IL-1β

Kaler, P., Godasi, B. N., Augenlicht, L. & Klampfer, L., Jan 2009, In : Cancer Microenvironment. 2, 1, p. 69-80 12 p.

Research output: Contribution to journalArticle

75 Scopus citations

Western-style diet-induced colonic tumors and their modulation by calcium and vitamin D in C57Bl/6 mice: A preclinical model for human sporadic colon cancer

Newmark, H. L., Yang, K., Kurihara, N., Fan, K., Augenlicht, L. H. & Lipkin, M., Feb 3 2009, In : Carcinogenesis. 30, 1, p. 88-92 5 p.

Research output: Contribution to journalArticle

139 Scopus citations
2008

Activated kRas protects colon cancer cells from cucurbitacin-induced apoptosis: The role of p53 and p21

Escandell, J. M., Kaler, P., Recio, M. C., Sasazuki, T., Shirasawa, S., Augenlicht, L., Ríos, J. L. & Klampfer, L., Jul 15 2008, In : Biochemical Pharmacology. 76, 2, p. 198-207 10 p.

Research output: Contribution to journalArticle

40 Scopus citations

Dietary calcium and cholecalciferol modulate cyclin D1 expression, apoptosis, and tumorigenesis in intestine of adenomatous polyposis coli 1638N/1 mice

Yang, K., Lamprecht, S. A., Shinozaki, H., Fan, K., Yang, W. C., Newmark, H. L., Kopelovich, L., Edelmann, W., Jin, B., Gravaghi, C., Augenlicht, L., Kucherlapati, R. & Lipkin, M., Sep 2008, In : Journal of Nutrition. 138, 9, p. 1658-1663 6 p.

Research output: Contribution to journalArticle

Open Access
40 Scopus citations

Dietary induction of colonic tumors in a mouse model of sporadic colon cancer

Yang, K., Kurihara, N., Fan, K., Newmark, H., Rigas, B., Bancroft, L., Corner, G., Livote, E., Lesser, M., Edelmann, W., Velcich, A., Lipkin, M. & Augenlicht, L., Oct 1 2008, In : Cancer Research. 68, 19, p. 7803-7810 8 p.

Research output: Contribution to journalArticle

79 Scopus citations

DR5 receptor mediates anoikis in human colorectal carcinoma cell lines

Laguinge, L. M., Samara, R. N., Wang, W., El-Deiry, W. S., Corner, G., Augenlicht, L., Mishra, L. & Jessup, J. M., Feb 1 2008, In : Cancer research. 68, 3, p. 909-917 9 p.

Research output: Contribution to journalArticle

35 Scopus citations

Expression of selenium-binding protein 1 characterizes intestinal cell maturation and predicts survival for patients with colorectal cancer

Li, T., Yang, W., Li, M., Byun, D. S., Tong, C., Nasser, S., Zhuang, M., Arango, D., Mariadason, J. M. & Augenlicht, L. H., Nov 1 2008, In : Molecular Nutrition and Food Research. 52, 11, p. 1289-1299 11 p.

Research output: Contribution to journalArticle

60 Scopus citations

Genetic deficiency of decorin causes intestinal tumor formation through disruption of intestinal cell maturation

Bi, X., Tong, C., Dockendorff, A., Bancroft, L., Gallagher, L., Guzman, G., Iozzo, R. V., Augenlicht, L. H. & Yang, W., Aug 19 2008, In : Carcinogenesis. 29, 7, p. 1435-1440 6 p.

Research output: Contribution to journalArticle

96 Scopus citations

HDAC2 deficiency sensitizes colon cancer cells to TNFα-induced apoptosis through inhibition of NF-κB activity

Kaler, P., Sasazuki, T., Shirasawa, S., Augenlicht, L. & Klampfer, L., Apr 15 2008, In : Experimental Cell Research. 314, 7, p. 1507-1518 12 p.

Research output: Contribution to journalArticle

26 Scopus citations

HDAC4 promotes growth of colon cancer cells via repression of p21

Wilson, A. J., Byun, D. S., Nasser, S., Murray, L. B., Ayyanar, K., Arango, D., Figueroa, M., Melnick, A., Kao, G. D., Augenlicht, L. H. & Mariadason, J. M., Oct 2008, In : Molecular biology of the cell. 19, 10, p. 4062-4075 14 p.

Research output: Contribution to journalArticle

138 Scopus citations

Interaction of Muc2 and Apc on Wnt signaling and in intestinal tumorigenesis: Potential role of chronic inflammation

Yang, K., Popova, N. V., Wan, C. Y., Lozonschi, I., Tadesse, S., Kent, S., Bancroft, L., Matise, I., Cormier, R. T., Scherer, S. J., Edelmann, W., Lipkin, M., Augenlicht, L. & Velcich, A., Sep 15 2008, In : Cancer research. 68, 18, p. 7313-7322 10 p.

Research output: Contribution to journalArticle

74 Scopus citations

Intestinal Deletion of Pofut1 in the Mouse Inactivates Notch Signaling and Causes Enterocolitis

Guilmeau, S., Flandez, M., Bancroft, L., Sellers, R. S., Tear, B., Stanley, P. & Augenlicht, L. H., Sep 2008, In : Gastroenterology. 135, 3, p. 849-860.e6

Research output: Contribution to journalArticle

54 Scopus citations