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2020

Accelerated viral dynamics in bat cell lines, with implications for zoonotic emergence

Brook, C. E., Boots, M., Chandran, K., Dobson, A. P., Drosten, C., Graham, A. L., Grenfell, B. T., Müller, M. A., Ng, M., Wang, L. F. & Leeuwen, A. V., Feb 2020, In : eLife. 9, e48401.

Research output: Contribution to journalArticle

Open Access
16 Scopus citations

A Replication-Competent Vesicular Stomatitis Virus for Studies of SARS-CoV-2 Spike-Mediated Cell Entry and Its Inhibition

Dieterle, M. E., Haslwanter, D., Bortz, R. H., Wirchnianski, A. S., Lasso, G., Vergnolle, O., Abbasi, S. A., Fels, J. M., Laudermilch, E., Florez, C., Mengotto, A., Kimmel, D., Malonis, R. J., Georgiev, G., Quiroz, J., Barnhill, J., Pirofski, L. A., Daily, J. P., Dye, J. M., Lai, J. R. & 3 others, Herbert, A. S., Chandran, K. & Jangra, R. K., Sep 9 2020, In : Cell Host and Microbe. 28, 3, p. 486-496.e6

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Conformational changes in the Ebola virus membrane fusion machine induced by pH, Ca2+, and receptor binding

Das, D. K., Bulow, U., Diehl, W. E., Durham, N. D., Senjobe, F., Chandran, K., Luban, J. & Munro, J. B., 2020, In : PLoS biology. 18, 2, e3000626.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Development of an antibody cocktail for treatment of Sudan virus infection

Herbert, A. S., Froude, J. W., Ortiz, R. A., Kuehne, A. I., Dorosky, D. E., Bakken, R. R., Zak, S. E., Josleyn, N. M., Musiychuk, K., Mark Jones, R., Green, B., Streatfield, S. J., Wec, A. Z., Bohorova, N., Bohorov, O., Kim, D. H., Pauly, M. H., Velasco, J., Whaley, K. J., Stonier, S. W. & 6 others, Bornholdt, Z. A., Chandran, K., Zeitlin, L., Sampey, D., Yusibov, V. & Dye, J. M., Feb 18 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 7, p. 3768-3778 11 p.

Research output: Contribution to journalArticle

Exploiting pre-existing CD4+T cell help from bacille Calmette-Guérin vaccination to improve antiviral antibody responses

Ng, T. W., Wirchnianski, A. S., Wec, A. Z., Fels, J. M., Johndrow, C. T., Saunders, K. O., Liao, H. X., Chan, J., Jacobs, W. R., Chandran, K. & Porcelli, S. A., Jul 15 2020, In : Journal of Immunology. 205, 2, p. 425-437 13 p.

Research output: Contribution to journalArticle

Longitudinal dynamics of the human B cell response to the yellow fever 17D vaccine

Wec, A. Z., Haslwanter, D., Abdiche, Y. N., Shehata, L., Pedreño-Lopez, N., Moyer, C. L., Bornholdt, Z. A., Lilov, A., Nett, J. H., Jangra, R. K., Brown, M., Watkins, D. I., Ahlm, C., Forsell, M. N., Rey, F. A., Barba-Spaeth, G., Chandran, K. & Walker, L. M., Mar 24 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 12, p. 6675-6685 11 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Oral Vaccination With Recombinant Vesicular Stomatitis Virus Expressing Sin Nombre Virus Glycoprotein Prevents Sin Nombre Virus Transmission in Deer Mice

Warner, B. M., Jangra, R., Griffin, B. D., Stein, D. R., Kobasa, D., Chandran, K., Kobinger, G. P. & Safronetz, D., Jul 8 2020, In : Frontiers in Cellular and Infection Microbiology. 10, 333.

Research output: Contribution to journalArticle

Open Access

Real‐time analysis of individual Ebola virus glycoproteins reveals pre‐fusion, entry‐relevant conformational dynamics

Durham, N. D., Howard, A. R., Govindan, R., Senjobe, F., Fels, J. M., Diehl, W. E., Luban, J., Chandran, K. & Munro, J. B., 2020, In : Viruses. 12, 1, 103.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Site-Specific Photo-Crosslinking Proteomics Reveal Regulation of IFITM3 Trafficking and Turnover by VCP/p97 ATPase

Wu, X., Spence, J. S., Das, T., Yuan, X., Chen, C., Zhang, Y., Li, Y., Sun, Y., Chandran, K., Hang, H. C. & Peng, T., May 21 2020, In : Cell Chemical Biology. 27, 5, p. 571-585.e6

Research output: Contribution to journalArticle

Open Access

Structure and characterization of crimean-congo hemorrhagic fever virus GP38

Mishra, A. K., Moyer, C. L., Abelson, D. M., Deer, D. J., El Omari, K., Duman, R., Lobel, L., Lutwama, J. J., Dye, J. M., Wagner, A., Chandran, K., Cross, R. W., Geisbert, T. W., Zeitlin, L., Bornholdt, Z. A. & McLellan, J. S., Mar 1 2020, In : Journal of virology. 94, 8, e02005-19.

Research output: Contribution to journalArticle

Open Access

VSV-Displayed HIV-1 Envelope Identifies Broadly Neutralizing Antibodies Class-Switched to IgG and IgA

Jia, M., Liberatore, R. A., Guo, Y., Chan, K. W., Pan, R., Lu, H., Waltari, E., Mittler, E., Chandran, K., Finzi, A., Kaufmann, D. E., Seaman, M. S., Ho, D. D., Shapiro, L., Sheng, Z., Kong, X. P., Bieniasz, P. D. & Wu, X., Jun 10 2020, In : Cell Host and Microbe. 27, 6, p. 963-975.e5

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
2019

A hyperstabilizing mutation in the base of the Ebola virus glycoprotein acts at multiple steps to abrogate viral entry

Maximilian Fels, J., Spence, J. S., Bortz, R. H., Bornholdt, Z. A. & Chandran, K., Jul 1 2019, In : mBio. 10, 4, e01408-19.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

A Two-Antibody Pan-Ebolavirus Cocktail Confers Broad Therapeutic Protection in Ferrets and Nonhuman Primates

Bornholdt, Z. A., Herbert, A. S., Mire, C. E., He, S., Cross, R. W., Wec, A. Z., Abelson, D. M., Geisbert, J. B., James, R. M., Rahim, M. N., Zhu, W., Borisevich, V., Banadyga, L., Gunn, B. M., Agans, K. N., Wirchnianski, A. S., Goodwin, E., Tierney, K., Shestowsky, W. S., Bohorov, O. & 13 others, Bohorova, N., Velasco, J., Ailor, E., Kim, D., Pauly, M. H., Whaley, K. J., Alter, G., Walker, L. M., Chandran, K., Zeitlin, L., Qiu, X., Geisbert, T. W. & Dye, J. M., Jan 9 2019, In : Cell Host and Microbe. 25, 1, p. 49-58.e5

Research output: Contribution to journalArticle

20 Scopus citations

Development of a Human Antibody Cocktail that Deploys Multiple Functions to Confer Pan-Ebolavirus Protection

Wec, A. Z., Bornholdt, Z. A., He, S., Herbert, A. S., Goodwin, E., Wirchnianski, A. S., Gunn, B. M., Zhang, Z., Zhu, W., Liu, G., Abelson, D. M., Moyer, C. L., Jangra, R. K., James, R. M., Bakken, R. R., Bohorova, N., Bohorov, O., Kim, D. H., Pauly, M. H., Velasco, J. & 10 others, Bortz, R. H., Whaley, K. J., Goldstein, T., Anthony, S. J., Alter, G., Walker, L. M., Dye, J. M., Zeitlin, L., Qiu, X. & Chandran, K., Jan 9 2019, In : Cell Host and Microbe. 25, 1, p. 39-48.e5

Research output: Contribution to journalArticle

18 Scopus citations

Human, nonhuman primate, and bat cells are broadly susceptible to tibrovirus particle cell entry

Caì, Y., Yú, S., Jangra, R. K., Postnikova, E. N., Wada, J., Tesh, R. B., Whelan, S. P. J., Lauck, M., Wiley, M. R., Finch, C. L., Radoshitzky, S. R., O'Connor, D. H., Palacios, G., Chandran, K., Chiu, C. Y. & Kuhn, J. H., 2019, In : Frontiers in Microbiology. 10, APR, 856.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Human monoclonal antibodies against chikungunya virus target multiple distinct epitopes in the E1 and E2 glycoproteins

Quiroz, J. A., Malonis, R. J., Thackray, L. B., Cohen, C. A., Pallesen, J., Jangra, R. K., Brown, R. S., Hofmann, D., Holtsberg, F. W., Shulenin, S., Nyakatura, E. K., Durnell, L. A., Rayannavar, V., Daily, J. P., Ward, A. B., Javad Aman, M., Dye, J. M., Chandran, K., Diamond, M. S., Kielian, M. & 1 others, Lai, J. R., 2019, In : PLoS pathogens. 15, 11, e1008061.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

ICTV virus taxonomy profile: Filoviridae

ICTV Report Consortium, Jun 2019, In : Journal of General Virology. 100, 6, p. 911-912 2 p.

Research output: Contribution to journalArticle

7 Scopus citations

IFITM3 directly engages and shuttles incoming virus particles to lysosomes

Spence, J. S., He, R., Hoffmann, H. H., Das, T., Thinon, E., Rice, C. M., Peng, T., Chandran, K. & Hang, H. C., Mar 1 2019, In : Nature Chemical Biology. 15, 3, p. 259-268 10 p.

Research output: Contribution to journalArticle

26 Scopus citations

Single dose of a rVSV-based vaccine elicits complete protection against severe fever with thrombocytopenia syndrome virus

Dong, F., Li, D., Wen, D., Li, S., Zhao, C., Qi, Y., Jangra, R. K., Wu, C., Xia, D., Zhang, X., Deng, F., Chandran, K., Zou, Z., Yuan, F. & Zheng, A., Dec 1 2019, In : npj Vaccines. 4, 1, 5.

Research output: Contribution to journalArticle

13 Scopus citations

Structural basis of broad ebolavirus neutralization by a human survivor antibody

West, B. R., Wec, A. Z., Moyer, C. L., Fusco, M. L., Ilinykh, P. A., Huang, K., Wirchnianski, A. S., James, R. M., Herbert, A. S., Hui, S., Goodwin, E., Howell, K. A., Kailasan, S., Aman, M. J., Walker, L. M., Dye, J. M., Bukreyev, A., Chandran, K. & Saphire, E. O., Mar 1 2019, In : Nature Structural and Molecular Biology. 26, 3, p. 204-212 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Taxonomy of the order Mononegavirales: update 2019

Amarasinghe, G. K., Ayllón, M. A., Bào, Y., Basler, C. F., Bavari, S., Blasdell, K. R., Briese, T., Brown, P. A., Bukreyev, A., Balkema-Buschmann, A., Buchholz, U. J., Chabi-Jesus, C., Chandran, K., Chiapponi, C., Crozier, I., de Swart, R. L., Dietzgen, R. G., Dolnik, O., Drexler, J. F., Dürrwald, R. & 64 others, Dundon, W. G., Duprex, W. P., Dye, J. M., Easton, A. J., Fooks, A. R., Formenty, P. B. H., Fouchier, R. A. M., Freitas-Astúa, J., Griffiths, A., Hewson, R., Horie, M., Hyndman, T. H., Jiāng, D., Kitajima, E. W., Kobinger, G. P., Kondō, H., Kurath, G., Kuzmin, I. V., Lamb, R. A., Lavazza, A., Lee, B., Lelli, D., Leroy, E. M., Lǐ, J., Maes, P., Marzano, S. Y. L., Moreno, A., Mühlberger, E., Netesov, S. V., Nowotny, N., Nylund, A., Økland, A. L., Palacios, G., Pályi, B., Pawęska, J. T., Payne, S. L., Prosperi, A., Ramos-González, P. L., Rima, B. K., Rota, P., Rubbenstroth, D., Shī, M., Simmonds, P., Smither, S. J., Sozzi, E., Spann, K., Stenglein, M. D., Stone, D. M., Takada, A., Tesh, R. B., Tomonaga, K., Tordo, N., Towner, J. S., van den Hoogen, B., Vasilakis, N., Wahl, V., Walker, P. J., Wang, L. F., Whitfield, A. E., Williams, J. V., Zerbini, F. M., Zhāng, T., Zhang, Y. Z. & Kuhn, J. H., Jul 1 2019, In : Archives of Virology. 164, 7, p. 1967-1980 14 p.

Research output: Contribution to journalArticle

Open Access
50 Scopus citations

Taxonomy of the order Mononegavirales: second update 2018

Maes, P., Amarasinghe, G. K., Ayllón, M. A., Basler, C. F., Bavari, S., Blasdell, K. R., Briese, T., Brown, P. A., Bukreyev, A., Balkema-Buschmann, A., Buchholz, U. J., Chandran, K., Crozier, I., de Swart, R. L., Dietzgen, R. G., Dolnik, O., Domier, L. L., Drexler, J. F., Dürrwald, R., Dundon, W. G. & 57 others, Duprex, W. P., Dye, J. M., Easton, A. J., Fooks, A. R., Formenty, P. B. H., Fouchier, R. A. M., Freitas-Astúa, J., Ghedin, E., Griffiths, A., Hewson, R., Horie, M., Hurwitz, J. L., Hyndman, T. H., Jiāng, D., Kobinger, G. P., Kondō, H., Kurath, G., Kuzmin, I. V., Lamb, R. A., Lee, B., Leroy, E. M., Lǐ, J., Marzano, S. Y. L., Mühlberger, E., Netesov, S. V., Nowotny, N., Palacios, G., Pályi, B., Pawęska, J. T., Payne, S. L., Rima, B. K., Rota, P., Rubbenstroth, D., Simmonds, P., Smither, S. J., Song, Q., Song, T., Spann, K., Stenglein, M. D., Stone, D. M., Takada, A., Tesh, R. B., Tomonaga, K., Tordo, N., Towner, J. S., van den Hoogen, B., Vasilakis, N., Wahl, V., Walker, P. J., Wang, D., Wang, L. F., Whitfield, A. E., Williams, J. V., Yè, G., Zerbini, F. M., Zhang, Y. Z. & Kuhn, J. H., Apr 3 2019, In : Archives of Virology. 164, 4, p. 1233-1244 12 p.

Research output: Contribution to journalArticle

Open Access
32 Scopus citations
3 Scopus citations

Vesicular stomatitis virus-based vaccines provide cross-protection against andes and sin nombre viruses

Warner, B. M., Stein, D. R., Jangra, R. K., Slough, M. M., Sroga, P., Sloan, A., Frost, K. L., Booth, S., Chandran, K. & Safronetz, D., Jul 2019, In : Viruses. 11, 7, 645.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
2018

A naturally occurring antiviral ribonucleotide encoded by the human genome

Gizzi, A. S., Grove, T. L., Arnold, J. J., Jose, J., Jangra, R. K., Garforth, S. J., Du, Q., Cahill, S. M., Dulyaninova, N. G., Love, J. D., Chandran, K., Bresnick, A. R., Cameron, C. E. & Almo, S. C., Jun 28 2018, In : Nature. 558, 7711, p. 610-614 5 p.

Research output: Contribution to journalArticle

52 Scopus citations

A Role for Fc Function in Therapeutic Monoclonal Antibody-Mediated Protection against Ebola Virus

Gunn, B. M., Yu, W. H., Karim, M. M., Brannan, J. M., Herbert, A. S., Wec, A. Z., Halfmann, P. J., Fusco, M. L., Schendel, S. L., Gangavarapu, K., Krause, T., Qiu, X., He, S., Das, J., Suscovich, T. J., Lai, J., Chandran, K., Zeitlin, L., Crowe, J. E., Lauffenburger, D. & 6 others, Kawaoka, Y., Kobinger, G. P., Andersen, K. G., Dye, J. M., Saphire, E. O. & Alter, G., Aug 8 2018, In : Cell Host and Microbe. 24, 2, p. 221-233.e5

Research output: Contribution to journalArticle

45 Scopus citations

Design and evaluation of bi- and trispecific antibodies targeting multiple filovirus glycoproteins

Nyakatura, E. K., Zak, S. E., Wec, A. Z., Hofmann, D., Shulenin, S., Bakken, R. R., Javad Aman, M., Chandran, K., Dye, J. M. & Lai, J. R., Apr 20 2018, In : Journal of Biological Chemistry. 293, 16, p. 6201-6211 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Protocadherin-1 is essential for cell entry by New World hantaviruses

Jangra, R. K., Herbert, A. S., Li, R., Jae, L. T., Kleinfelter, L. M., Slough, M. M., Barker, S. L., Guardado-Calvo, P., Román-Sosa, G., Dieterle, M. E., Kuehne, A. I., Muena, N. A., Wirchnianski, A. S., Nyakatura, E. K., Fels, J. M., Ng, M., Mittler, E., Pan, J., Bharrhan, S., Wec, A. Z. & 9 others, Lai, J. R., Sidhu, S. S., Tischler, N. D., Rey, F. A., Moffat, J., Brummelkamp, T. R., Wang, Z., Dye, J. M. & Chandran, K., Nov 22 2018, In : Nature. 563, 7732, p. 559-563 5 p.

Research output: Contribution to journalArticle

17 Scopus citations

Systematic Analysis of Monoclonal Antibodies against Ebola Virus GP Defines Features that Contribute to Protection

the Viral Hemorrhagic Fever Immunotherapeutic Consortium, Aug 9 2018, In : Cell. 174, 4, p. 938-952.e13

Research output: Contribution to journalArticle

60 Scopus citations

Taxonomy of the order Mononegavirales: update 2018

Amarasinghe, G. K., Aréchiga Ceballos, N. G., Banyard, A. C., Basler, C. F., Bavari, S., Bennett, A. J., Blasdell, K. R., Briese, T., Bukreyev, A., Caì, Y., Calisher, C. H., Campos Lawson, C., Chandran, K., Chapman, C. A., Chiu, C. Y., Choi, K. S., Collins, P. L., Dietzgen, R. G., Dolja, V. V., Dolnik, O. & 71 others, Domier, L. L., Dürrwald, R., Dye, J. M., Easton, A. J., Ebihara, H., Echevarría, J. E., Fooks, A. R., Formenty, P. B. H., Fouchier, R. A. M., Freuling, C. M., Ghedin, E., Goldberg, T. L., Hewson, R., Horie, M., Hyndman, T. H., Jiāng, D., Kityo, R., Kobinger, G. P., Kondō, H., Koonin, E. V., Krupovic, M., Kurath, G., Lamb, R. A., Lee, B., Leroy, E. M., Maes, P., Maisner, A., Marston, D. A., Mor, S. K., Müller, T., Mühlberger, E., Ramírez, V. M. N., Netesov, S. V., Ng, T. F. F., Nowotny, N., Palacios, G., Patterson, J. L., Pawęska, J. T., Payne, S. L., Prieto, K., Rima, B. K., Rota, P., Rubbenstroth, D., Schwemmle, M., Siddell, S., Smither, S. J., Song, Q., Song, T., Stenglein, M. D., Stone, D. M., Takada, A., Tesh, R. B., Thomazelli, L. M., Tomonaga, K., Tordo, N., Towner, J. S., Vasilakis, N., Vázquez-Morón, S., Verdugo, C., Volchkov, V. E., Wahl, V., Walker, P. J., Wang, D., Wang, L. F., Wellehan, J. F. X., Wiley, M. R., Whitfield, A. E., Wolf, Y. I., Yè, G., Zhāng, Y. Z. & Kuhn, J. H., Aug 1 2018, In : Archives of Virology. 163, 8, p. 2283-2294 12 p.

Research output: Contribution to journalArticle

81 Scopus citations

The discovery of Bombali virus adds further support for bats as hosts of ebolaviruses

Goldstein, T., Anthony, S. J., Gbakima, A., Bird, B. H., Bangura, J., Tremeau-Bravard, A., Belaganahalli, M. N., Wells, H. L., Dhanota, J. K., Liang, E., Grodus, M., Jangra, R. K., DeJesus, V. A., Lasso, G., Smith, B. R., Jambai, A., Kamara, B. O., Kamara, S., Bangura, W., Monagin, C. & 7 others, Shapira, S., Johnson, C. K., Saylors, K., Rubin, E. M., Chandran, K., Lipkin, W. I. & Mazet, J. A. K., Oct 1 2018, In : Nature Microbiology. 3, 10, p. 1084-1089 6 p.

Research output: Contribution to journalArticle

90 Scopus citations
2017

Antibodies from a Human Survivor Define Sites of Vulnerability for Broad Protection against Ebolaviruses

Wec, A. Z., Herbert, A. S., Murin, C. D., Nyakatura, E. K., Abelson, D. M., Fels, J. M., He, S., James, R. M., de La Vega, M. A., Zhu, W., Bakken, R. R., Goodwin, E., Turner, H. L., Jangra, R. K., Zeitlin, L., Qiu, X., Lai, J. R., Walker, L. M., Ward, A. B., Dye, J. M. & 2 others, Chandran, K. & Bornholdt, Z. A., May 18 2017, In : Cell. 169, 5, p. 878-890.e15

Research output: Contribution to journalArticle

65 Scopus citations

Generation and characterization of protective antibodies to Marburg virus

Froude, J. W., Pelat, T., Miethe, S., Zak, S. E., Wec, A. Z., Chandran, K., Brannan, J. M., Bakken, R. R., Hust, M., Thullier, P. & Dye, J. M., May 19 2017, In : mAbs. 9, 4, p. 696-703 8 p.

Research output: Contribution to journalArticle

16 Scopus citations

Immunization-Elicited Broadly Protective Antibody Reveals Ebolavirus Fusion Loop as a Site of Vulnerability

Zhao, X., Howell, K. A., He, S., Brannan, J. M., Wec, A. Z., Davidson, E., Turner, H. L., Chiang, C. I., Lei, L., Fels, J. M., Vu, H., Shulenin, S., Turonis, A. N., Kuehne, A. I., Liu, G., Ta, M., Wang, Y., Sundling, C., Xiao, Y., Spence, J. S. & 8 others, Doranz, B. J., Holtsberg, F. W., Ward, A. B., Chandran, K., Dye, J. M., Qiu, X., Li, Y. & Aman, M. J., May 18 2017, In : Cell. 169, 5, p. 891-904.e15

Research output: Contribution to journalArticle

46 Scopus citations

Mechanistic and Fc requirements for inhibition of Sudan virus entry and in vivo protection by a synthetic antibody

Hofmann, D., Zak, S. E., Nyakatura, E. K., Mittler, E., Bakken, R. R., Chandran, K., Dye, J. M. & Lai, J. R., Oct 2017, In : Immunology Letters. 190, p. 289-295 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

Possibility and challenges of conversion of current virus species names to Linnaean binomials

Postler, T. S., Clawson, A. N., Amarasinghe, G. K., Basler, C. F., Bavari, S., Benko, M., Blasdell, K. R., Briese, T., Buchmeier, M. J., Bukreyev, A., Calisher, C. H., Chandran, K., Charrel, R., Clegg, C. S., Collins, P. L., De La Torre, J. C., DeRisi, J. L., Dietzgen, R. G., Dolnik, O., Dürrwald, R. & 52 others, Dye, J. M., Easton, A. J., Emonet, S., Formenty, P., Fouchier, R. A. M., Ghedin, E., Gonzalez, J. P., Harrach, B., Hewson, R., Horie, M., Jiāng, D., Kobinger, G., Kondo, H., Kropinski, A. M., Krupovic, M., Kurath, G., Lamb, R. A., Leroy, E. M., Lukashevich, I. S., Maisner, A., Mushegian, A. R., Netesov, S. V., Nowotny, N., Patterson, J. L., Payne, S. L., Paweska, J. T., Peters, C. J., Radoshitzky, S. R., Rima, B. K., Romanowski, V., Rubbenstroth, D., Sabanadzovic, S., Sanfaçon, H., Salvato, M. S., Schwemmle, M., Smither, S. J., Stenglein, M. D., Stone, D. M., Takada, A., Tesh, R. B., Tomonaga, K., Tordo, N., Towner, J. S., Vasilakis, N., Volchkov, V. E., Wahl-Jensen, V., Walker, P. J., Wang, L. F., Varsani, A., Whitfield, A. E., Murilo Zerbini, F. & Kuhn, J. H., May 1 2017, In : Systematic Biology. 66, 3, p. 463-473 11 p.

Research output: Contribution to journalArticle

10 Scopus citations

Structural basis for antibody-mediated neutralization of Lassa virus

Hastie, K. M., Zandonatti, M. A., Kleinfelter, L. M., Heinrich, M. L., Rowland, M. M., Chandran, K., Branco, L. M., Robinson, J. E., Garry, R. F. & Saphire, E. O., Jun 2 2017, In : Science. 356, 6341, p. 923-928 6 p.

Research output: Contribution to journalArticle

65 Scopus citations

Taxonomy of the order Mononegavirales: update 2017

Amarasinghe, G. K., Bào, Y., Basler, C. F., Bavari, S., Beer, M., Bejerman, N., Blasdell, K. R., Bochnowski, A., Briese, T., Bukreyev, A., Calisher, C. H., Chandran, K., Collins, P. L., Dietzgen, R. G., Dolnik, O., Dürrwald, R., Dye, J. M., Easton, A. J., Ebihara, H., Fang, Q. & 53 others, Formenty, P., Fouchier, R. A. M., Ghedin, E., Harding, R. M., Hewson, R., Higgins, C. M., Hong, J., Horie, M., James, A. P., Jiāng, D., Kobinger, G. P., Kondo, H., Kurath, G., Lamb, R. A., Lee, B., Leroy, E. M., Li, M., Maisner, A., Mühlberger, E., Netesov, S. V., Nowotny, N., Patterson, J. L., Payne, S. L., Paweska, J. T., Pearson, M. N., Randall, R. E., Revill, P. A., Rima, B. K., Rota, P., Rubbenstroth, D., Schwemmle, M., Smither, S. J., Song, Q., Stone, D. M., Takada, A., Terregino, C., Tesh, R. B., Tomonaga, K., Tordo, N., Towner, J. S., Vasilakis, N., Volchkov, V. E., Wahl-Jensen, V., Walker, P. J., Wang, B., Wang, D., Wang, F., Wang, L. F., Werren, J. H., Whitfield, A. E., Yan, Z., Ye, G. & Kuhn, J. H., Aug 1 2017, In : Archives of Virology. 162, 8, p. 2493-2504 12 p.

Research output: Contribution to journalArticle

126 Scopus citations
2016

A New Transferrin Receptor Aptamer Inhibits New World Hemorrhagic Fever Mammarenavirus Entry

Maier, K. E., Jangra, R. K., Shieh, K. R., Cureton, D. K., Xiao, H., Snapp, E. L., Whelan, S. P., Chandran, K. & Levy, M., 2016, In : Molecular Therapy - Nucleic Acids. 5, p. e321

Research output: Contribution to journalArticle

24 Scopus citations

Antibody Treatment of Ebola and Sudan Virus Infection via a Uniquely Exposed Epitope within the Glycoprotein Receptor-Binding Site

Howell, K. A., Qiu, X., Brannan, J. M., Bryan, C., Davidson, E., Holtsberg, F. W., Wec, A. Z., Shulenin, S., Biggins, J. E., Douglas, R., Enterlein, S. G., Turner, H. L., Pallesen, J., Murin, C. D., He, S., Kroeker, A., Vu, H., Herbert, A. S., Fusco, M. L., Nyakatura, E. K. & 11 others, Lai, J. R., Keck, Z. Y., Foung, S. K. H., Saphire, E. O., Zeitlin, L., Ward, A. B., Chandran, K., Doranz, B. J., Kobinger, G. P., Dye, J. M. & Aman, M. J., May 17 2016, In : Cell Reports. 15, 7, p. 1514-1526 13 p.

Research output: Contribution to journalArticle

46 Scopus citations

A single residue in Ebola virus receptor NPC1 influences cellular host range in reptiles

Ndungo, E., Herbert, A. S., Raaben, M., Obernosterer, G., Biswas, R., Miller, E. H., Wirchnianski, A. S., Carette, J. E., Brummelkamp, T. R., Whelan, S. P., Dye, J. M. & Chandran, K., Mar 1 2016, In : mSphere. 1, 2, e00007-16.

Research output: Contribution to journalArticle

12 Scopus citations

A "Trojan horse" bispecific-antibody strategy for broad protection against ebolaviruses

Wec, A. Z., Nyakatura, E. K., Herbert, A. S., Howell, K. A., Holtsberg, F. W., Bakken, R. R., Mittler, E., Christin, J. R., Shulenin, S., Jangra, R. K., Bharrhan, S., Kuehne, A. I., Bornholdt, Z. A., Flyak, A. I., Saphire, E. O., Crowe, J. E., Aman, M. J., Dye, J. M., Lai, J. R. & Chandran, K., Oct 21 2016, In : Science. 354, 6310, p. 350-354 5 p.

Research output: Contribution to journalArticle

57 Scopus citations

Bispecific antibody affords complete post-exposure protection of mice from both Ebola (Zaire) and Sudan viruses

Frei, J. C., Nyakatura, E. K., Zak, S. E., Bakken, R. R., Chandran, K., Dye, J. M. & Lai, J. R., Jan 13 2016, In : Scientific Reports. 6, 19193.

Research output: Contribution to journalArticle

15 Scopus citations

Cysteine Cathepsin Inhibitors as Anti-Ebola Agents

Van Der Linden, W. A., Schulze, C. J., Herbert, A. S., Krause, T. B., Wirchnianski, A. A., Dye, J. M., Chandran, K. & Bogyo, M., Mar 11 2016, In : ACS Infectious Diseases. 2, 3, p. 173-179 7 p.

Research output: Contribution to journalArticle

20 Scopus citations

Direct visualization of Ebola virus fusion triggering in the endocytic pathway

Spence, J. S., Krause, T. B., Mittler, E., Jangra, R. K. & Chandran, K., Feb 9 2016, In : mBio. 7, 1, e01857-15.

Research output: Contribution to journalArticle

42 Scopus citations

Host-primed Ebola virus GP exposes a hydrophobic NPC1 receptor-binding pocket, revealing a target for broadly neutralizing antibodies

Bornholdt, Z. A., Ndungo, E., Fusco, M. L., Bale, S., Flyak, A. I., Crowe, J. E., Chandran, K. & Saphire, E. O., Feb 23 2016, In : mBio. 7, 1, e02154-15.

Research output: Contribution to journalArticle

51 Scopus citations

Taxonomy of the order Mononegavirales: update 2016

Afonso, C. L., Amarasinghe, G. K., Bányai, K., Bào, Y., Basler, C. F., Bavari, S., Bejerman, N., Blasdell, K. R., Briand, F. X., Briese, T., Bukreyev, A., Calisher, C. H., Chandran, K., Chéng, J., Clawson, A. N., Collins, P. L., Dietzgen, R. G., Dolnik, O., Domier, L. L., Dürrwald, R. & 63 others, Dye, J. M., Easton, A. J., Ebihara, H., Farkas, S. L., Freitas-Astúa, J., Formenty, P., Fouchier, R. A. M., Fù, Y., Ghedin, E., Goodin, M. M., Hewson, R., Horie, M., Hyndman, T. H., Jiāng, D., Kitajima, E. W., Kobinger, G. P., Kondo, H., Kurath, G., Lamb, R. A., Lenardon, S., Leroy, E. M., Li, C. X., Lin, X. D., Liú, L., Longdon, B., Marton, S., Maisner, A., Mühlberger, E., Netesov, S. V., Nowotny, N., Patterson, J. L., Payne, S. L., Paweska, J. T., Randall, R. E., Rima, B. K., Rota, P., Rubbenstroth, D., Schwemmle, M., Shi, M., Smither, S. J., Stenglein, M. D., Stone, D. M., Takada, A., Terregino, C., Tesh, R. B., Tian, J. H., Tomonaga, K., Tordo, N., Towner, J. S., Vasilakis, N., Verbeek, M., Volchkov, V. E., Wahl-Jensen, V., Walsh, J. A., Walker, P. J., Wang, D., Wang, L. F., Wetzel, T., Whitfield, A. E., Xiè, J., Yuen, K. Y., Zhang, Y. Z. & Kuhn, J. H., Aug 1 2016, In : Archives of Virology. 161, 8, p. 2351-2360 10 p.

Research output: Contribution to journalArticle

253 Scopus citations
2015

Distinct cathepsins control necrotic cell death mediated by pyroptosis inducers and lysosome-destabilizing agents

Brojatsch, J., Lima, H., Palliser, D., Jacobson, L. S., Muehlbauer, S. M., Furtado, R., Goldman, D. L., Lisanti, M. P. & Chandran, K., Apr 1 2015, In : Cell Cycle. 14, 7, p. 964-972 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

Filovirus receptor NPC1 contributes to species-specific patterns of ebolavirus susceptibility in bats

Ng, M., Ndungo, E., Kaczmarek, M. E., Herbert, A. S., Binger, T., Kuehne, A. I., Jangra, R. K., Hawkins, J. A., Gifford, R. J., Biswas, R., Demogines, A., James, R. M., Yu, M., Brummelkamp, T. R., Drosten, C., Wang, L. F., Kuhn, J. H., Müller, M. A., Dye, J. M., Sawyer, S. L. & 1 others, Chandran, K., Dec 23 2015, In : eLife. 4, DECEMBER2015, e11785.

Research output: Contribution to journalArticle

57 Scopus citations