• 2941 Citations
  • 31 h-Index
1993 …2019

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2019

Acute cerebellar knockdown of sgce reproduces salient features of myoclonus-dystonia (DYT11) in mice

Washburn, S. G., Fremont, R., Moreno, M. C., Angueyra, C. & Khodakhah, K., Dec 2019, In : eLife. 8, e52101.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Cerebellar modulation of the reward circuitry and social behavior

Carta, I., Chen, C. H., Schott, A. L., Dorizan, S. & Khodakhah, K., Jan 18 2019, In : Science. 363, 6424, eaav0581.

Research output: Contribution to journalArticle

62 Scopus citations
2018

Aberrant cerebellar Purkinje cell activity as the cause of motor attacks in a mouse model of episodic ataxia type 2

Tara, E., Vitenzon, A., Hess, E. & Khodakhah, K., Sep 2018, In : DMM Disease Models and Mechanisms. 11, 9, dmm034181.

Research output: Contribution to journalArticle

1 Scopus citations

Increased susceptibility to cortical spreading depression and epileptiform activity in a mouse model for FHM2

Kros, L., Lykke-Hartmann, K. & Khodakhah, K., Dec 1 2018, In : Scientific reports. 8, 1, 16959.

Research output: Contribution to journalArticle

5 Scopus citations
2017

A role for cerebellum in the hereditary dystonia DYT1

Fremont, R., Tewari, A., Angueyra, C. & Khodakhah, K., Feb 15 2017, In : eLife. 6, e22775.

Research output: Contribution to journalArticle

27 Scopus citations

Hypothermia-induced dystonia and abnormal cerebellar activity in a mouse model with a single disease-mutation in the sodium-potassium pump

Isaksen, T. J., Kros, L., Vedovato, N., Holm, T. H., Vitenzon, A., Gadsby, D. C., Khodakhah, K. & Lykke-Hartmann, K., May 2017, In : PLoS genetics. 13, 5, e1006763.

Research output: Contribution to journalArticle

14 Scopus citations
2016

Developmental change in the contribution of voltage-gated Ca2+ channels to the pacemaking of deep cerebellar nuclei neurons

Alviña, K., Tara, E. & Khodakhah, K., May 13 2016, In : Neuroscience. 322, p. 171-177 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

Selective expression of mutant huntingtin during development recapitulates characteristic features of Huntington's disease

Molero, A. E., Arteaga-Bracho, E. E., Chen, C. H., Gulinello, M., Winchester, M. L., Pichamoorthy, N., Gokhan, S., Khodakhah, K. & Mehler, M. F., May 17 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 20, p. 5736-5741 6 p.

Research output: Contribution to journalArticle

46 Scopus citations

The limited utility of multiunit data in differentiating neuronal population activity

Keller, C. J., Chen, C., Lado, F. A. & Khodakhah, K., Apr 1 2016, In : PLoS One. 11, 4, e0153154.

Research output: Contribution to journalArticle

3 Scopus citations
2015

Aberrant Purkinje cell activity is the cause of dystonia in a shRNA-based mouse model of Rapid Onset Dystonia-Parkinsonism

Fremont, R., Tewari, A. & Khodakhah, K., Oct 1 2015, In : Neurobiology of Disease. 82, p. 200-212 13 p.

Research output: Contribution to journalArticle

21 Scopus citations

A dystonia-like movement disorder with brain and spinal neuronal defects is caused by mutation of the mouse laminin β1 subunit, Lamb1

Liu, Y. B., Tewari, A., Salameh, J., Arystarkhova, E., Hampton, T. G., Brashear, A., Ozelius, L. J., Khodakhah, K. & Sweadner, K. J., Dec 24 2015, In : eLife. 4, DECEMBER2015, e11102.

Research output: Contribution to journalArticle

8 Scopus citations

Neuroscience: Decrypting a brain enigma

Khodakhah, K., Oct 14 2015, In : Nature. 526, 7573, p. 326-327 2 p.

Research output: Contribution to journalArticle

1 Scopus citations

Rescue of homeostatic regulation of striatal excitability and locomotor activity in a mouse model of huntington's disease

Cao, Y., Bartolomé-Martín, D., Rotem, N., Rozas, C., Dellal, S. S., Chacon, M. A., Kadriu, B., Gulinello, M., Khodakhah, K. & Faber, D. S., Feb 17 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 7, p. 2239-2244 6 p.

Research output: Contribution to journalArticle

12 Scopus citations
2014

Abnormal high-frequency burst firing of cerebellar neurons in rapid-onset dystonia-parkinsonism

Fremont, R., Paola Calderon, D., Maleki, S. & Khodakhah, K., Aug 27 2014, In : Journal of Neuroscience. 34, 35, p. 11723-11732 10 p.

Research output: Contribution to journalArticle

43 Scopus citations

Short latency cerebellar modulation of the basal ganglia

Chen, C. H., Fremont, R., Arteaga-Bracho, E. E. & Khodakhah, K., Jan 1 2014, In : Nature Neuroscience. 17, 12, p. 1767-1775 9 p.

Research output: Contribution to journalArticle

121 Scopus citations
2013

The neuronal code(s) of the cerebellum

Heck, D. H., De Zeeuw, C. I., Jaeger, D., Khodakhah, K. & Person, A. L., Nov 11 2013, In : Journal of Neuroscience. 33, 45, p. 17603-17609 7 p.

Research output: Contribution to journalArticle

30 Scopus citations
2012

Efficient generation of reciprocal signals by inhibition

Park, S. M., Tara, E. & Khodakhah, K., May 1 2012, In : Journal of neurophysiology. 107, 9, p. 2453-2462 10 p.

Research output: Contribution to journalArticle

11 Scopus citations
2011

The neural substrates of rapid-onset Dystonia-Parkinsonism

Calderon, D. P., Fremont, R., Kraenzlin, F. & Khodakhah, K., Mar 1 2011, In : Nature Neuroscience. 14, 3, p. 357-365 9 p.

Research output: Contribution to journalArticle

135 Scopus citations

The role of interneurons in shaping purkinje cell responses in the cerebellar cortex

Dizon, M. J. & Khodakhah, K., Jul 20 2011, In : Journal of Neuroscience. 31, 29, p. 10463-10473 11 p.

Research output: Contribution to journalArticle

52 Scopus citations
2010

KCa channels as therapeutic targets in episodic ataxia type-2

Alviña, K. & Khodakhah, K., May 26 2010, In : Journal of Neuroscience. 30, 21, p. 7249-7257 9 p.

Research output: Contribution to journalArticle

69 Scopus citations

The therapeutic mode of action of 4-aminopyridine in cerebellar ataxia

Alviña, K. & Khodakhah, K., May 26 2010, In : Journal of Neuroscience. 30, 21, p. 7258-7268 11 p.

Research output: Contribution to journalArticle

117 Scopus citations
2009

Large conductance calcium-activated potassium channels affect both spontaneous firing and intracellular calcium concentration in cerebellar Purkinje neurons

Womack, M. D., Hoang, C. & Khodakhah, K., Sep 15 2009, In : Neuroscience. 162, 4, p. 989-1000 12 p.

Research output: Contribution to journalArticle

32 Scopus citations

The advantages of linear information processing for cerebellar computation

Walter, J. T. & Khodakhah, K., Mar 17 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 11, p. 4471-4476 6 p.

Research output: Contribution to journalArticle

34 Scopus citations

The functional equivalence of ascending and parallel fiber inputs in cerebellar computation

Walter, J. T., Dizon, M. J. & Khodakhah, K., Jul 1 2009, In : Journal of Neuroscience. 29, 26, p. 8462-8473 12 p.

Research output: Contribution to journalArticle

34 Scopus citations

T-type calcium channels mediate rebound firing in intact deep cerebellar neurons

Alviña, K., Ellis-Davies, G. & Khodakhah, K., Jan 23 2009, In : Neuroscience. 158, 2, p. 635-641 7 p.

Research output: Contribution to journalArticle

41 Scopus citations
2008

Questioning the role of rebound firing in the cerebellum

Alvĩa, K., Walter, J. T., Kohn, A., Ellis-Davies, G. & Khodakhah, K., Nov 1 2008, In : Nature Neuroscience. 11, 11, p. 1256-1258 3 p.

Research output: Contribution to journalArticle

91 Scopus citations

Selective regulation of spontaneous activity of neurons of the deep cerebellar nuclei by N-type calcium channels in juvenile rats

Alviña, K. & Khodakhah, K., May 15 2008, In : Journal of Physiology. 586, 10, p. 2523-2538 16 p.

Research output: Contribution to journalArticle

40 Scopus citations
2006

Decreases in the precision of Purkinje cell pacemaking cause cerebellar dysfunction and ataxia

Walter, J. T., Alviña, K., Womack, M. D., Chevez, C. & Khodakhah, K., Mar 1 2006, In : Nature Neuroscience. 9, 3, p. 389-397 9 p.

Research output: Contribution to journalArticle

277 Scopus citations

The linear computational algorithm of cerebellar Purkinje cells

Walter, J. T. & Khodakhah, K., Dec 13 2006, In : Journal of Neuroscience. 26, 50, p. 12861-12872 12 p.

Research output: Contribution to journalArticle

57 Scopus citations
2005

Kv1 channels selectively prevent dendritic hyperexcitability in rat Purkinje cells

Khavandgar, S., Walter, J. T., Sageser, K. & Khodakhah, K., Dec 1 2005, In : Journal of Physiology. 569, 2, p. 545-557 13 p.

Research output: Contribution to journalArticle

28 Scopus citations
2004

Calcium-activated potassium channels are selectively coupled to P/Q-type calcium channels in cerebellar Purkinje neurons

Womack, M. D., Chevez, C. & Khodakhah, K., Oct 6 2004, In : Journal of Neuroscience. 24, 40, p. 8818-8822 5 p.

Research output: Contribution to journalArticle

122 Scopus citations

Dendritic Control of Spontaneous Bursting in Cerebellar Purkinje Cells

Womack, M. D. & Khodakhah, K., Apr 7 2004, In : Journal of Neuroscience. 24, 14, p. 3511-3521 11 p.

Research output: Contribution to journalArticle

108 Scopus citations
2003

Somatic and dendritic small-conductance calcium-activated potassium channels regulate the output of cerebellar Purkinje neurons

Womack, M. D. & Khodakhah, K., Apr 1 2003, In : Journal of Neuroscience. 23, 7, p. 2600-2607 8 p.

Research output: Contribution to journalArticle

Open Access
124 Scopus citations

Two intracellular pathways mediate metabotropic glutamate receptor-induced Ca2+ mobilization in dopamine neurons

Morikawa, H., Khodakhah, K. & Williams, J. T., Jan 1 2003, In : Journal of Neuroscience. 23, 1, p. 149-157 9 p.

Research output: Contribution to journalArticle

132 Scopus citations
2002

Active contribution of dendrites to the tonic and trimodal patterns of activity in cerebellar Purkinje neurons

Womack, M. & Khodakhah, K., Dec 15 2002, In : Journal of Neuroscience. 22, 24, p. 10603-10612 10 p.

Research output: Contribution to journalArticle

Open Access
133 Scopus citations

Characterization of large conductance Ca2+-activated K+ channels in cerebellar Purkinje neurons

Womack, M. D. & Khodakhah, K., Nov 26 2002, In : European Journal of Neuroscience. 16, 7, p. 1214-1222 9 p.

Research output: Contribution to journalArticle

85 Scopus citations
2000

Impaired calcium release in cerebellar Purkinje neurons maintained in culture

Womack, M. D., Walker, J. W. & Khodakhah, K., Sep 26 2000, In : Journal of General Physiology. 115, 3, p. 339-345 7 p.

Research output: Contribution to journalArticle

14 Scopus citations

Inositol 1,4,5-triphosphate-evoked responses in midbrain dopamine neurons.

Morikawa, H., Imani, F., Khodakhah, K. & Williams, J. T., Oct 15 2000, In : The Journal of neuroscience : the official journal of the Society for Neuroscience. 20, 20, p. RC103

Research output: Contribution to journalArticle

Open Access
67 Scopus citations
1998

Charge immobilization caused by modification of internal cysteines in squid Na channels

Khodakhah, K., Melishchuk, A. & Armstrong, C. M., Dec 1998, In : Biophysical journal. 75, 6, p. 2821-2829 9 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Presence and phosphorylation of transcription factors in developing dendrites

Crino, P., Khodakhah, K., Becker, K., Ginsberg, S., Hemby, S. & Eberwine, J., Mar 3 1998, In : Proceedings of the National Academy of Sciences of the United States of America. 95, 5, p. 2313-2318 6 p.

Research output: Contribution to journalArticle

120 Scopus citations
1997
77 Scopus citations

Inositol trisphosphate and ryanodine receptors share a common functional Ca2+ pool in cerebellar Purkinje neurons

Khodakhah, K. & Armstrong, C. M., Dec 1997, In : Biophysical journal. 73, 6, p. 3349-3357 9 p.

Research output: Contribution to journalArticle

Open Access
56 Scopus citations

Killing K channels with TEA+

Khodakhah, K., Melishchuk, A. & Armstrong, C. M., Nov 25 1997, In : Proceedings of the National Academy of Sciences of the United States of America. 94, 24, p. 13335-13338 4 p.

Research output: Contribution to journalArticle

31 Scopus citations
1996

Intracellular Ca2+ release by InsP3 in cerebellar Purkinje neurones

Ogden, D. & Khodakhah, K., Jan 1 1996, In : Acta Physiologica Scandinavica. 157, 3, p. 381-394 14 p.

Research output: Contribution to journalArticle

7 Scopus citations
1995
25 Scopus citations

Fast activation and inactivation of inositol trisphosphate‐evoked Ca2+ release in rat cerebellar Purkinje neurones.

Khodakhah, K. & Ogden, D., Sep 1 1995, In : The Journal of Physiology. 487, 2, p. 343-358 16 p.

Research output: Contribution to journalArticle

81 Scopus citations
1993
Open Access
134 Scopus citations

Postsynaptic activation at the squid giant synapse by photolytic release of L‐glutamate from a ‘caged’ L‐glutamate.

Corrie, J. E., DeSantis, A., Katayama, Y., Khodakhah, K., Messenger, J. B., Ogden, D. C. & Trentham, D. R., Jun 1 1993, In : The Journal of Physiology. 465, 1, p. 1-8 8 p.

Research output: Contribution to journalArticle

54 Scopus citations