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1977 …2020

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2019

A single discrete Rab5-binding site in phosphoinositide 3-kinase is required for tumor cell invasion

Heitz, S. D., Hamelin, D. J., Hoffmann, R. M., Greenberg, N., Salloum, G., Erami, Z., Khalil, B. D., Shymanets, A., Steidle, E. A., Gong, G. Q., Nürnberg, B., Burke, J. E., Flanagan, J. U., Bresnick, A. R. & Backer, J. M., Mar 22 2019, In : Journal of Biological Chemistry. 294, 12, p. 4621-4633 13 p.

Research output: Contribution to journalArticle

2 Scopus citations

PI3Kβ is selectively required for growth factor-stimulated macropinocytosis

Salloum, G., Jakubik, C. T., Erami, Z., Heitz, S. D., Bresnick, A. R. & Backer, J. M., Aug 16 2019, In : Journal of cell science. 132, 16

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

PI3Kβ links integrin activation and PI(3,4)P2 production during invadopodial maturation

Erami, Z., Heitz, S., Bresnick, A. R. & Backer, J. M., Aug 15 2019, In : Molecular biology of the cell. 30, 18, p. 2367-2376 10 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations
2018

Myosin-IIA heavy chain phosphorylation on S1943 regulates tumor metastasis

Norwood Toro, L. E., Wang, Y., Condeelis, J. S., Jones, J. G., Backer, J. M. & Bresnick, A. R., Sep 15 2018, In : Experimental Cell Research. 370, 2, p. 273-282 10 p.

Research output: Contribution to journalArticle

3 Scopus citations

S100A4 regulates macrophage invasion by distinct myosin-dependent and myosin-independent mechanisms

Dulyaninova, N. G., Ruiz, P. D., Gamble, M. J., Backer, J. M. & Bresnicka, A. R., Mar 1 2018, In : Molecular biology of the cell. 29, 5, p. 632-642 11 p.

Research output: Contribution to journalArticle

2 Scopus citations
2017

Rac1-stimulated macropinocytosis enhances Gβγ activation of PI3Kβ

Erami, Z., Khalil, B. D., Salloum, G., Yao, Y., LoPiccolo, J., Shymanets, A., Nürnberg, B., Bresnick, A. R. & Backer, J. M., Dec 1 2017, In : Biochemical Journal. 474, 23, p. 3903-3914 12 p.

Research output: Contribution to journalArticle

7 Scopus citations

Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism

Bilanges, B., Alliouachene, S., Pearce, W., Morelli, D., Szabadkai, G., Chung, Y. L., Chicanne, G., Valet, C., Hill, J. M., Voshol, P. J., Collinson, L., Peddie, C., Ali, K., Ghazaly, E., Rajeeve, V., Trichas, G., Srinivas, S., Chaussade, C., Salamon, R. S., Backer, J. M. & 8 others, Scudamore, C. L., Whitehead, M. A., Keaney, E. P., Murphy, L. O., Semple, R. K., Payrastre, B., Tooze, S. A. & Vanhaesebroeck, B., Dec 1 2017, In : Nature communications. 8, 1, 1804.

Research output: Contribution to journalArticle

20 Scopus citations
2016

Coincident signals from GPCRs and receptor tyrosine kinases are uniquely transduced by PI3Kβ in myeloid cells

Houslay, D. M., Anderson, K. E., Chessa, T., Kulkarni, S., Fritsch, R., Downward, J., Backer, J. M., Stephens, L. R. & Hawkins, P. T., Aug 16 2016, In : Science Signaling. 9, 441, ra82.

Research output: Contribution to journalArticle

18 Scopus citations

GPCR signaling mediates tumor metastasis via PI3Kβ

Khalil, B. D., Hsueh, C., Cao, Y., Saab, W. F. A., Wang, Y., Condeelis, J. S., Bresnick, A. R. & Backer, J. M., May 15 2016, In : Cancer Research. 76, 10, p. 2944-2953 10 p.

Research output: Contribution to journalArticle

23 Scopus citations
2015

Assembly and molecular architecture of the phosphoinositide 3-kinase p85α homodimer

LoPiccolo, J., Kim, S. J., Shi, Y., Wu, B., Wu, H., Chait, B. T., Singer, R. H., Sali, A., Brenowitz, M. D., Bresnick, A. R. & Backer, J. M., Dec 18 2015, In : Journal of Biological Chemistry. 290, 51, p. 30390-30405 16 p.

Research output: Contribution to journalArticle

10 Scopus citations

Identification of the rab5 binding site in p110β: Assays for pi3kβ binding to rab5

Salamon, R. S., Dbouk, H. A., Collado, D., Lopiccolo, J., Bresnick, A. R. & Backer, J. M., Jan 1 2015, In : Methods in Molecular Biology. 1298, p. 271-281 11 p.

Research output: Contribution to journalArticle

7 Scopus citations

Inactivation of the Class II PI3K-C2β Potentiates Insulin Signaling and Sensitivity

Alliouachene, S., Bilanges, B., Chicanne, G., Anderson, K. E., Pearce, W., Ali, K., Valet, C., Posor, Y., Low, P. C., Chaussade, C., Scudamore, C. L., Salamon, R. S., Backer, J. M., Stephens, L., Hawkins, P. T., Payrastre, B. & Vanhaesebroeck, B., Dec 1 2015, In : Cell Reports. 13, 9, p. 1881-1894 14 p.

Research output: Contribution to journalArticle

34 Scopus citations

Phosphatidylinositol 4-phosphate and phosphatidylinositol 3-phosphate regulate phagolysosome biogenesis

Jeschke, A., Zehethofer, N., Lindner, B., Krupp, J., Schwudke, D., Haneburger, I., Jovic, M., Backer, J. M., Balla, T., Hilbi, H. & Haas, A., Apr 14 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 15, p. 4636-4641 6 p.

Research output: Contribution to journalArticle

27 Scopus citations

PI3K-C2γ 3 is a Rab5 effector selectively controlling endosomal Akt2 activation downstream of insulin signalling

Braccini, L., Ciraolo, E., Campa, C. C., Perino, A., Longo, D. L., Tibolla, G., Pregnolato, M., Cao, Y., Tassone, B., Damilano, F., Laffargue, M., Calautti, E., Falasca, M., Norata, G. D., Backer, J. M. & Hirsch, E., Jun 23 2015, In : Nature communications. 6, 7400.

Research output: Contribution to journalArticle

63 Scopus citations
2014

NRBF2 regulates macroautophagy as a component of Vps34 complex I

Cao, Y., Wang, Y., Abi Saab, W. F., Yang, F., Pessin, J. E. & Backer, J. M., Jul 15 2014, In : Biochemical Journal. 461, 2, p. 315-322 8 p.

Research output: Contribution to journalArticle

34 Scopus citations

Suppression of mTORC1 activation in acid-α-glucosidase-deficient cells and mice is ameliorated by leucine supplementation

Shemesh, A., Wang, Y., Yang, Y., Yang, G. S., Johnson, D. E., Backer, J. M., Pessin, J. E. & Zong, H., Nov 15 2014, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 307, 10, p. R1251-R1259

Research output: Contribution to journalArticle

7 Scopus citations
2013

Characterization of a Tumor-Associated Activating Mutation of the p110β PI 3-Kinase

Dbouk, H. A., Khalil, B. D., Wu, H., Shymanets, A., Nürnberg, B. & Backer, J. M., May 29 2013, In : PloS one. 8, 5, e63833.

Research output: Contribution to journalArticle

25 Scopus citations

Class IA PI3K p110β Subunit Promotes Autophagy through Rab5 Small GTPase in Response to Growth Factor Limitation

Dou, Z., Pan, J. A., Dbouk, H. A., Ballou, L. M., DeLeon, J. L., Fan, Y., Chen, J. S., Liang, Z., Li, G., Backer, J. M., Lin, R. Z. & Zong, W. X., Apr 11 2013, In : Molecular Cell. 50, 1, p. 29-42 14 p.

Research output: Contribution to journalArticle

75 Scopus citations

Molecular determinants of PI3Kγ-mediated activation downstream of G-protein-coupled receptors (GPCRs)

Vadas, O., Dbouk, H. A., Shymanets, A., Perisic, O., Burke, J. E., Saab, W. F. A., Khalil, B. D., Harteneck, C., Bresnick, A. R., Nürnberg, B., Backer, J. M. & Williams, R. L., Nov 19 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 47, p. 18862-18867 6 p.

Research output: Contribution to journalArticle

60 Scopus citations

Phosphatidylinositol-3,4,5-trisphosphate: Tool of choice for class I PI 3-kinases

Salamon, R. S. & Backer, J. M., Jul 1 2013, In : BioEssays. 35, 7, p. 602-611 10 p.

Research output: Contribution to journalArticle

25 Scopus citations
2012

G protein-coupled receptor-mediated activation of p110b by Gβγ is required for cellular transformation and invasiveness

Dbouk, H. A., Vadas, O., Shymanets, A., Burke, J. E., Salamon, R. S., Khalil, B. D., Barrett, M. O., Waldo, G. L., Surve, C., Hsueh, C., Perisic, O., Harteneck, C., Shepherd, P. R., Harden, T. K., Smrcka, A. V., Taussig, R., Bresnick, A. R., Nürnberg, B., Williams, R. L. & Backer, J. M., Dec 4 2012, In : Science Signaling. 5, 253, ra89.

Research output: Contribution to journalArticle

84 Scopus citations

Phosphoinositide 3-kinase signaling is critical for ErbB3-driven breast cancer cell motility and metastasis

Smirnova, T., Zhou, Z. N., Flinn, R. J., Wyckoff, J., Boimel, P. J., Pozzuto, M., Coniglio, S. J., Backer, J. M., Bresnick, A. R., Condeelis, J. S., Hynes, N. E. & Segall, J. E., Feb 1 2012, In : Oncogene. 31, 6, p. 706-715 10 p.

Research output: Contribution to journalArticle

41 Scopus citations
2011

Class III PI-3-kinase activates phospholipase D in an amino acid-sensing mTORC1 pathway

Yoon, M. S., Du, G., Backer, J. M., Frohman, M. A. & Chen, J., Oct 31 2011, In : Journal of Cell Biology. 195, 3, p. 435-447 13 p.

Research output: Contribution to journalArticle

93 Scopus citations

Tripartite motif containing protein 27 negatively regulates CD4 T cells by ubiquitinating and inhibiting the class II PI3K-C2β

Cai, X., Srivastava, S., Sun, Y., Li, Z., Wu, H., Zuvela-Jelaska, L., Li, J., Salamon, R. S., Backer, J. M. & Skolnik, E. Y., Dec 13 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 50, p. 20072-20077 6 p.

Research output: Contribution to journalArticle

33 Scopus citations
2010
38 Scopus citations

Class I and class III phosphoinositide 3-kinases are required for actin polymerization that propels phagosomes

Bohdanowicz, M., Cosío, G., Backer, J. M. & Grinstein, S., Nov 29 2010, In : Journal of Cell Biology. 191, 5, p. 999-1012 14 p.

Research output: Contribution to journalArticle

51 Scopus citations

The late endosome is essential for mTORC1 signaling

Flinn, R. J., Yan, Y., Goswami, S., Parker, P. J. & Backer, J. M., Mar 1 2010, In : Molecular biology of the cell. 21, 5, p. 833-841 9 p.

Research output: Contribution to journalArticle

112 Scopus citations

The regulation of class IA PI 3-kinases by inter-subunit interactions

Backer, J. M., Dec 1 2010, In : Current Topics in Microbiology and Immunology. 346, 1, p. 87-114 28 p.

Research output: Contribution to journalArticle

53 Scopus citations

The structure of p85ni in class IA phosphoinositide 3-kinase exhibits interdomain disorder

Ilker Sen, K., Wu, H., Backer, J. M. & Gerfen, G. J., Mar 16 2010, In : Biochemistry. 49, 10, p. 2159-2166 8 p.

Research output: Contribution to journalArticle

7 Scopus citations
2009

Differential enhancement of breast cancer cell motility and metastasis by helical and kinase domain mutations of class IA phosphoinositide 3-kinase

Pang, H., Flinn, R., Patsialou, A., Wyckoff, J., Roussos, E. T., Wu, H., Pozzuto, M., Goswami, S., Condeelis, J. S., Bresnick, A. R., Segall, J. E. & Backer, J. M., Dec 1 2009, In : Cancer Research. 69, 23, p. 8868-8876 9 p.

Research output: Contribution to journalArticle

50 Scopus citations

Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex

Zhong, Y., Wang, Q. J., Li, X., Yan, Y., Backer, J. M., Chait, B. T., Heintz, N. & Yue, Z., Mar 9 2009, In : Nature Cell Biology. 11, 4, p. 468-476 9 p.

Research output: Contribution to journalArticle

576 Scopus citations

HVps15, but not Ca2+/CaM, is required for the activity and regulation of hVps34 in mammalian cells

Yan, Y., Flinn, R. J., Wu, H., Schnur, R. S. & Backer, J. M., Feb 1 2009, In : Biochemical Journal. 417, 3, p. 747-755 9 p.

Research output: Contribution to journalArticle

64 Scopus citations

Regulation of Class IA PI 3-kinases: C2 domain-iSH2 domain contacts inhibit p85/p110α and are disrupted in oncogenic p85 mutants

Wu, H., Chandra Shekar, S., Flinn, R. J., El-Sibai, M., Jaiswal, B. S., Sen, K. I., Janakiraman, V., Seshagiri, S., Gerfen, G. J., Girvin, M. E. & Backer, J. M., Dec 1 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 48, p. 20258-20263 6 p.

Research output: Contribution to journalArticle

54 Scopus citations

Somatic Mutations in p85α Promote Tumorigenesis through Class IA PI3K Activation

Jaiswal, B. S., Janakiraman, V., Kljavin, N. M., Chaudhuri, S., Stern, H. M., Wang, W., Kan, Z., Dbouk, H. A., Peters, B. A., Waring, P., Dela Vega, T., Kenski, D. M., Bowman, K. K., Lorenzo, M., Li, H., Wu, J., Modrusan, Z., Stinson, J., Eby, M., Yue, P. & 4 others, Kaminker, J. S., de Sauvage, F. J., Backer, J. M. & Seshagiri, S., Dec 8 2009, In : Cancer Cell. 16, 6, p. 463-474 12 p.

Research output: Contribution to journalArticle

214 Scopus citations

The class II phosphatidylinositol 3 kinase C2β is required for the activation of the K+ channel KCa3.1 and CD4 T-cells

Srivastava, S., Di, L., Zhdanova, O., Li, Z., Vardhana, S., Wan, Q., Yan, Y., Varma, R., Backer, J., Wulff, H., Dustin, M. L. & Skolnik, E. Y., Sep 1 2009, In : Molecular biology of the cell. 20, 17, p. 3783-3791 9 p.

Research output: Contribution to journalArticle

46 Scopus citations
2008

Activation of hypothalamic S6 kinase mediates diet-induced hepatic insulin resistance in rats

Ono, H., Pocai, A., Wang, Y., Sakoda, H., Asano, T., Backer, J. M., Schwartz, G. J. & Rossetti, L., Aug 1 2008, In : Journal of Clinical Investigation. 118, 8, p. 2959-2968 10 p.

Research output: Contribution to journalArticle

126 Scopus citations

Effectively doubling the magnetic field in spin-1/2-spin-1, HSQC, HDQC, coupled HSQC, and coupled HDQC in solution NMR

Shekar, S. C., Backer, J. M. & Girvin, M. E., May 26 2008, In : Journal of Chemical Physics. 128, 18, 184501.

Research output: Contribution to journalArticle

3 Scopus citations

In brain, Axl recruits Grb2 and the p85 regulatory subunit of PI3 kinase; in vitro mutagenesis defines the requisite binding sites for downstream Akt activation

Weinger, J. G., Gohari, P., Yan, Y., Backer, J. M., Varnum, B. & Shafit-Zagardo, B., Jul 1 2008, In : Journal of Neurochemistry. 106, 1, p. 134-146 13 p.

Research output: Contribution to journalArticle

29 Scopus citations

Phosphoinositide 3-kinase p110β activity: Key role in metabolism and mammary gland cancer but not development

Ciraolo, E., Iezzi, M., Marone, R., Marengo, S., Curcio, C., Costa, C., Azzolino, O., Gonella, C., Rubinetto, C., Wu, H., Dastrù, W., Martin, E. L., Silengo, L., Altruda, F., Turco, E., Lanzetti, L., Musiani, P., Rückle, T., Rommel, C., Backer, J. M. & 3 others, Forni, G., Wymann, M. P. & Hirsch, E., Sep 6 2008, In : Science Signaling. 1, 36, ra3.

Research output: Contribution to journalArticle

183 Scopus citations

Quantification of PtdIns(3,4,5)P3 dynamics in EGF-stimulated carcinoma cells: A comparison of PH-domain-mediated methods with immunological methods

Yip, S. C., Eddy, R. J., Branch, A. M., Pang, H., Wu, H., Yan, Y., Drees, B. E., Neilsen, P. O., Condeelis, J. & Backer, J. M., Apr 15 2008, In : Biochemical Journal. 411, 2, p. 441-448 8 p.

Research output: Contribution to journalArticle

24 Scopus citations

RhoA/ROCK-mediated switching between Cdc42- and Rac1-dependent protrusion in MTLn3 carcinoma cells

El-Sibai, M., Pertz, O., Pang, H., Yip, S. C., Lorenz, M., Symons, M., Condeelis, J. S., Hahn, K. M. & Backer, J. M., Apr 15 2008, In : Experimental Cell Research. 314, 7, p. 1540-1552 13 p.

Research output: Contribution to journalArticle

61 Scopus citations

Sequential actions of myotubularin lipid phosphatases regulate endosomal PI(3)P and growth factor receptor trafficking

Cao, C., Backer, J. M., Laporte, J., Bedrick, E. J. & Wandinger-Ness, A., Aug 1 2008, In : Molecular biology of the cell. 19, 8, p. 3334-3346 13 p.

Research output: Contribution to journalArticle

92 Scopus citations

The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in Drosophila

Juhász, G., Hill, J. H., Yan, Y., Sass, M., Baehrecke, E. H., Backer, J. M. & Neufeld, T. P., May 19 2008, In : Journal of Cell Biology. 181, 4, p. 655-666 12 p.

Research output: Contribution to journalArticle

243 Scopus citations

WASP family members and formin proteins coordinate regulation of cell protrusions in carcinoma cells

Sarmiento, C., Wang, W., Dovas, A., Yamaguchi, H., Sidani, M., El-Sibai, M., DesMarais, V., Holman, H. A., Kitchen, S., Backer, J. M., Alberts, A. & Condeelis, J., Mar 24 2008, In : Journal of Cell Biology. 180, 6, p. 1245-1260 16 p.

Research output: Contribution to journalArticle

103 Scopus citations
2007

Cdc42 is required for EGF-stimulated protrusion and motility in MTLn3 carcinoma cells

El-Sibai, M., Nalbant, P., Pang, H., Flinn, R. J., Sarmiento, C., Macaluso, F., Cammer, M., Condeelis, J. S., Hahn, K. M. & Backer, J. M., Oct 1 2007, In : Journal of cell science. 120, 19, p. 3465-3474 10 p.

Research output: Contribution to journalArticle

35 Scopus citations

Cofilin determines the migration behavior and turning frequency of metastatic cancer cells

Sidani, M., Wessels, D., Mouneimne, G., Ghosh, M., Goswami, S., Sarmiento, C., Wang, W., Kuhl, S., El-Sibai, M., Backer, J. M., Eddy, R., Soll, D. & Condeelis, J., Nov 19 2007, In : Journal of Cell Biology. 179, 4, p. 777-791 15 p.

Research output: Contribution to journalArticle

133 Scopus citations

EGF-induced PIP2 hydrolysis releases and activates cofilin locally in carcinoma cells

Van Rheenen, J., Song, X., Van Roosmalen, W., Cammer, M., Chen, X., DesMarais, V., Yip, S. C., Backer, J. M., Eddy, R. J. & Condeelis, J. S., Dec 17 2007, In : Journal of Cell Biology. 179, 6, p. 1247-1259 13 p.

Research output: Contribution to journalArticle

180 Scopus citations

Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit

Miled, N., Yan, Y., Hon, W. C., Perisic, O., Zvelebil, M., Inbar, Y., Schneidman-Duhovny, D., Wolfson, H. J., Backer, J. M. & Williams, R. L., Jul 13 2007, In : Science. 317, 5835, p. 239-242 4 p.

Research output: Contribution to journalArticle

274 Scopus citations

Myotubularin lipid phosphatase binds the hVPS15/hVPS34 lipid kinase complex on endosomes

Cao, C., Laporte, J., Backer, J. M., Wandinger-Ness, A. & Stein, M. P., Aug 1 2007, In : Traffic. 8, 8, p. 1052-1067 16 p.

Research output: Contribution to journalArticle

69 Scopus citations