• 9430 Citations
  • 53 h-Index
1980 …2019
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Fingerprint Dive into the research topics where John S. Blanchard is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 2 Similar Profiles
Mycobacterium tuberculosis Medicine & Life Sciences
Enzymes Medicine & Life Sciences
Kinetics Chemical Compounds
Isotopes Chemical Compounds
NAD Medicine & Life Sciences
Substrates Chemical Compounds
Acetyltransferases Chemical Compounds
NADP Chemical Compounds

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Grants 1984 2019

Aminoglycosides
Anti-Bacterial Agents
Biological Products
Gram-Negative Bacterial Infections
Genes
Acetyltransferases
Proteins
Acetylation
Mycobacterium tuberculosis
Aminoglycosides
coenzymes
biochemical pathways
enzymology
enzymes
canes
Tuberculosis
Enzymes
Biosynthetic Pathways
Mycobacterium tuberculosis
Anti-Bacterial Agents
Flavoproteins
Oxidoreductases
NAD+ peroxidase
Glutathione Reductase
Enzymes

Publications 1980 2019

  • 9430 Citations
  • 53 h-Index
  • 216 Article
  • 2 Chapter
  • 1 Review article

The active site of the Mycobacterium tuberculosis branched-chain amino acid biosynthesis enzyme dihydroxyacid dehydratase contains a 2Fe-2S cluster

Bashiri, G., Grove, T. L., Hegde, S., Lagautriere, T., Gerfen, G. J., Almo, S. C., Squire, C. J., Blanchard, J. S. & Baker, E. N., Jan 1 2019, In : Journal of Biological Chemistry. 294, 35, p. 13158-13170 13 p.

Research output: Contribution to journalArticle

dihydroxyacid dehydratase
Branched Chain Amino Acids
Biosynthesis
Mycobacterium tuberculosis
Catalytic Domain

Biochemical Characterization of the Mycobacterium smegmatis Threonine Deaminase

Favrot, L., Amorim Franco, T. M. & Blanchard, J. S., Oct 16 2018, In : Biochemistry. 57, 41, p. 6003-6012 10 p.

Research output: Contribution to journalArticle

Threonine Dehydratase
Mycobacterium smegmatis
Isoleucine
Biosynthesis
Valine
13 Citations (Scopus)

Bacterial Branched-Chain Amino Acid Biosynthesis: Structures, Mechanisms, and Drugability

Amorim Franco, T. M. & Blanchard, J. S., Nov 7 2017, In : Biochemistry. 56, 44, p. 5849-5865 17 p.

Research output: Contribution to journalReview article

Branched Chain Amino Acids
Biosynthesis
Bacterial Drug Resistance
Isoleucine
Valine
7 Citations (Scopus)

Identification of mycobacterial RplJ/L10 and RpsA/S1 proteins as novel targets for CD4+ T cells

Johnson, A. J., Kennedy, S. C., Arlehamn, C. S. L., Goldberg, M. F., Saini, N. K., Xu, J., Paul, S., Hegde, S., Blanchard, J. S., Chan, J., Jacobs, W. R., Sette, A. & Porcelli, S. A., Apr 1 2017, In : Infection and Immunity. 85, 4, e01023-16.

Research output: Contribution to journalArticle

T-Lymphocytes
Ribosomes
Mycobacterium tuberculosis
Tuberculosis Vaccines
Proteins
8 Citations (Scopus)

Mechanism-Based Inhibition of the Mycobacterium tuberculosis Branched-Chain Aminotransferase by d - And l -Cycloserine

Amorim Franco, T. M., Favrot, L., Vergnolle, O. M. & Blanchard, J. S., May 19 2017, In : ACS Chemical Biology. 12, 5, p. 1235-1244 10 p.

Research output: Contribution to journalArticle

Cycloserine
Mycobacterium tuberculosis
Multidrug-Resistant Tuberculosis
branched-chain-amino-acid transaminase
Pyridoxal Phosphate