• 13303 Citations
  • 57 h-Index
1974 …2019

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2019

Radiation-primed hepatocyte transplantation in murine monogeneic dyslipidemia normalizes cholesterol and prevents atherosclerosis

Barahman, M., Zhang, W., Harris, H. Y., Aiyer, A., Kabarriti, R., Kinkhabwala, M., Roy-Chowdhury, N., Beck, A. P., Scanlan, T. S., Roy-Chowdhury, J., Asp, P. & Guha, C., Jun 2019, In : Journal of Hepatology. 70, 6, p. 1170-1179 10 p.

Research output: Contribution to journalArticle

3 Scopus citations
2017

Drug- and Drug Abuse–Associated Hyperbilirubinemia: Experience With Atazanavir

Roy-Chowdhury, J., Roy-Chowdhury, N., Listowsky, I. & Wolkoff, A. W., Mar 1 2017, In : Clinical Pharmacology in Drug Development. 6, 2, p. 140-146 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

Host conditioning and rejection monitoring in hepatocyte transplantation in humans

Soltys, K. A., Setoyama, K., Tafaleng, E. N., Soto Gutiérrez, A., Fong, J., Fukumitsu, K., Nishikawa, T., Nagaya, M., Sada, R., Haberman, K., Gramignoli, R., Dorko, K., Tahan, V., Dreyzin, A., Baskin, K., Crowley, J. J., Quader, M. A., Deutsch, M., Ashokkumar, C., Shneider, B. L. & 15 others, Squires, R. H., Ranganathan, S., Reyes-Mugica, M., Dobrowolski, S. F., Mazariegos, G., Elango, R., Stolz, D. B., Strom, S. C., Vockley, G., Roy-Chowdhury, J., Cascalho, M., Guha, C., Sindhi, R., Platt, J. L. & Fox, I. J., May 2017, In : Journal of Hepatology. 66, 5, p. 987-1000 14 p.

Research output: Contribution to journalArticle

37 Scopus citations

Oxalobacter formigenes-derived bioactive factors stimulate oxalate transport by intestinal epithelial cells

Arvans, D., Jung, Y. C., Antonopoulos, D., Koval, J., Granja, I., Bashir, M., Karrar, E., Roy-Chowdhury, J., Musch, M., Asplin, J., Chang, E. & Hassan, H., Mar 2017, In : Journal of the American Society of Nephrology. 28, 3, p. 876-887 12 p.

Research output: Contribution to journalArticle

26 Scopus citations
2016

Gene therapy of Wilson disease: A "golden" opportunity using rAAV on the 50th anniversary of the discovery of the virus

Roy-Chowdhury, J. & Schilsky, M. L., Feb 1 2016, In : Journal of Hepatology. 64, 2, p. 265-267 3 p.

Research output: Contribution to journalArticle

6 Scopus citations

Hepatocyte-like cells derived from induced pluripotent stem cells

Roy-Chowdhury, N., Wang, X., Guha, C. & Roy-Chowdhury, J., Aug 17 2016, (Accepted/In press) In : Hepatology International. p. 1-16 16 p.

Research output: Contribution to journalArticle

21 Scopus citations

Human urinary epithelial cells as a source of engraftable hepatocyte-like cells using stem cell technology

Sauer, V., Tchaikovskaya, T., Wang, X., Li, Y., Zhang, W., Tar, K., Polgar, Z., Ding, J., Guha, C., Fox, I. J., Roy-Chowdhury, N. & Roy-Chowdhury, J., Jan 1 2016, In : Cell Transplantation. 25, 12, p. 2221-2243 23 p.

Research output: Contribution to journalArticle

11 Scopus citations
2015

Amelioration of Hyperbilirubinemia in Gunn Rats after Transplantation of Human Induced Pluripotent Stem Cell-Derived Hepatocytes

Chen, Y., Li, Y., Wang, X., Zhang, W., Sauer, V., Chang, C. J., Han, B., Tchaikovskaya, T., Avsar, Y., Tafaleng, E., Madhusudana Girija, S., Tar, K., Polgar, Z., Strom, S., Bouhassira, E. E., Guha, C., Fox, I. J., Roy-Chowdhury, J. & Roy-Chowdhury, N., Jul 14 2015, In : Stem Cell Reports. 5, 1, p. 22-30 9 p.

Research output: Contribution to journalArticle

39 Scopus citations

IndUced Pluripotent Stem Cells Model Personalized Variations in Liver Disease Resulting From α1-Antitrypsin Deficiency

Tafaleng, E. N., Chakraborty, S., Han, B., Hale, P., Wu, W., Soto-Gutierrez, A., Feghali-Bostwick, C. A., Wilson, A. A., Kotton, D. N., Nagaya, M., Strom, S. C., Roy-Chowdhury, J., Stolz, D. B., Perlmutter, D. H. & Fox, I. J., Jul 1 2015, In : Hepatology. 62, 1, p. 147-157 11 p.

Research output: Contribution to journalArticle

46 Scopus citations
2014
8 Scopus citations
10 Scopus citations

A nonhuman primate model of human radiation-induced venocclusive liver disease and hepatocyte injury

Yannam, G. R., Han, B., Setoyama, K., Yamamoto, T., Ito, R., Brooks, J. M., Guzman-Lepe, J., Galambos, C., Fong, J. V., Deutsch, M., Quader, M. A., Yamanouchi, K., Kabarriti, R., Mehta, K., Soto-Gutierrez, A., Roy-Chowdhury, J., Locker, J., Abe, M., Enke, C. A., Baranowska-Kortylewicz, J. & 3 others, Solberg, T. D., Guha, C. & Fox, I. J., Feb 1 2014, In : International Journal of Radiation Oncology Biology Physics. 88, 2, p. 404-411 8 p.

Research output: Contribution to journalArticle

18 Scopus citations

Small RNAs derived from lncRNA RNase MRP have gene-silencing activity relevant to human cartilage-hair hypoplasia

Rogler, L. E., Kosmyna, B., Moskowitz, D., Bebawee, R., Rahimzadeh, J., Kutchko, K., Laederach, A., Notarangelo, L. D., Giliani, S., Bouhassira, E., Frenette, P., Roy-Chowdhury, J. & Rogler, C. E., Jan 2014, In : Human molecular genetics. 23, 2, p. 368-382 15 p.

Research output: Contribution to journalArticle

57 Scopus citations
2012

Amelioration of murine Schistosoma mansoni induced liver fibrosis by mesenchymal stem cells

Abdel Aziz, M. T., Atta, H. M., Roshdy, N. K., Rashed, L. A., Sabry, D., Hassouna, A. A., Aboul Fotouh, G. I., Hasan, N. M., Younis, R. H. & Chowdhury, J. R., Jul 11 2012, In : Journal of Stem Cells and Regenerative Medicine. 8, 1, p. P28-P34

Research output: Contribution to journalArticle

17 Scopus citations

Single Liver Lobe Repopulation with Wildtype Hepatocytes Using Regional Hepatic Irradiation Cures Jaundice in Gunn Rats

Zhou, H., Dong, X., Kabarriti, R., Chen, Y., Avsar, Y., Wang, X., Ding, J., Liu, L., Fox, I. J., Roy-Chowdhury, J., Roy-Chowdhury, N. & Guha, C., Oct 16 2012, In : PloS one. 7, 10, e46775.

Research output: Contribution to journalArticle

25 Scopus citations
2011

Modeling and therapy of human liver diseases using induced pluripotent stem cells: How far have we come?

Soto-Gutierrez, A., Tafaleng, E., Kelly, V., Roy-Chowdhury, J. & Fox, I. J., Feb 1 2011, In : Hepatology. 53, 2, p. 708-711 4 p.

Research output: Contribution to journalArticle

12 Scopus citations

Spontaneous hepatic repopulation in transgenic mice expressing mutant human α1-antitrypsin by wild-type donor hepatocytes

Ding, J., Yannam, G. R., Roy-Chowdhury, N., Hidvegi, T., Basma, H., Rennard, S. I., Wong, R. J., Avsar, Y., Guha, C., Perlmutter, D. H., Fox, I. J. & Roy-Chowdhury, J., May 2 2011, In : Journal of Clinical Investigation. 121, 5, p. 1930-1934 5 p.

Research output: Contribution to journalArticle

47 Scopus citations
2010

Efficient CNS gene delivery by intravenous injection

Louboutin, J. P., Chekmasova, A. A., Marusich, E., Chowdhury, J. R. & Strayer, D. S., Nov 1 2010, In : Nature Methods. 7, 11, p. 905-907 3 p.

Research output: Contribution to journalArticle

44 Scopus citations

Hepatic differentiation of liver-derived progenitor cells and their characterization by microRNA analysis

Chen, Y., Zhou, H., Sarver, A. L., Zeng, Y., Roy-Chowdhury, J., Steer, C. J. & Sahin, M. B., Sep 1 2010, In : Liver Transplantation. 16, 9, p. 1086-1097 12 p.

Research output: Contribution to journalArticle

19 Scopus citations
2009

Differentiation and Transplantation of Human Embryonic Stem Cell-Derived Hepatocytes

Basma, H., Soto-Gutiérrez, A., Yannam, G. R., Liu, L., Ito, R., Yamamoto, T., Ellis, E., Carson, S. D., Sato, S., Chen, Y., Muirhead, D., Navarro-Álvarez, N., Wong, R. J., Roy-Chowdhury, J., Platt, J. L., Mercer, D. F., Miller, J. D., Strom, S. C., Kobayashi, N. & Fox, I. J., Mar 2009, In : Gastroenterology. 136, 3, p. 990-999.e4

Research output: Contribution to journalArticle

385 Scopus citations

Ex vivo gene transfer into hepatocytes.

Wang, X., Mani, P., Sarkar, D. P., Roy-Chowdhury, N. & Roy-Chowdhury, J., 2009, In : Methods in molecular biology (Clifton, N.J.). 481, p. 117-140 24 p.

Research output: Contribution to journalArticle

Hepatic irradiation augments engraftment of donor cells following hepatocyte transplantation

Yamanouchi, K., Zhou, H., Roy-Chowdhury, N., Macaluso, F., Liu, L., Yamamoto, T., Yannam, G. R., Enke, C., Solberg, T. D., Adelson, A. B., Platt, J. L., Fox, I. J., Roy-Chowdhury, J. & Guha, C., Mar 9 2009, In : Hepatology. 49, 1, p. 258-267 10 p.

Research output: Contribution to journalArticle

83 Scopus citations

Long-term reduction of jaundice in Gunn rats by nonviral liver-targeted delivery of Sleeping Beauty transposon

Wang, X., Sarkar, D. P., Mani, P., Steer, C. J., Chen, Y., Guha, C., Chandrasekhar, V., Chaudhuri, A., Roy-Chowdhury, N., Kren, B. T. & Roy-Chowdhury, J., Nov 27 2009, In : Hepatology. 50, 3, p. 815-824 10 p.

Research output: Contribution to journalArticle

32 Scopus citations

Protective role of R-spondin1, an intestinal stem cell growth factor, against radiation-induced gastrointestinal syndrome in mice

Bhanja, P., Saha, S., Kabarriti, R., Liu, L., Roy-Chowdhury, N., Roy-Chowdhury, J., Sellers, R. S., Alfieri, A. A. & Guha, C., Nov 24 2009, In : PloS one. 4, 11, e8014.

Research output: Contribution to journalArticle

77 Scopus citations
2008

Correction of hyperoxaluria by liver repopulation with hepatocytes in a mouse model of primary hyperoxaluria type-1

Jiang, J., Salido, E. C., Guha, C., Wang, X., Moitra, R., Liu, L., Roy-Chowdhury, J. & Roy-Chowdhury, N., May 1 2008, In : Transplantation. 85, 9, p. 1253-1260 8 p.

Research output: Contribution to journalArticle

33 Scopus citations

Hepatic repopulation with stably transduced conditionally immortalized hepatocytes in the Gunn rat

Kawashita, Y., Guha, C., Moitra, R., Wang, X., Fox, I. J., Roy-Chowdhury, J. & Roy-Chowdhury, N., Jul 1 2008, In : Journal of Hepatology. 49, 1, p. 99-106 8 p.

Research output: Contribution to journalArticle

18 Scopus citations
2007

Prevention of hepatocyte allograft rejection in rats by transferring adenoviral early region 3 genes into donor cells

Mashalova, E. V., Guha, C., Roy-Chowdhury, N., Liu, L., Fox, I. J., Roy-Chowdhury, J. & Horwitz, M. S., Mar 1 2007, In : Hepatology. 45, 3, p. 755-766 12 p.

Research output: Contribution to journalArticle

12 Scopus citations
2006

Alanine-glyoxylate aminotransferase-deficient mice, a model for primary hyperoxaluria that responds to adenoviral gene transfer

Salido, E. C., Li, X. M., Lu, Y., Wang, X., Santana, A., Roy-Chowdhury, N., Torres, A., Shapiro, L. J. & Roy-Chowdhury, J., Nov 28 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 48, p. 18249-18254 6 p.

Research output: Contribution to journalArticle

70 Scopus citations

Bilirubin metabolism: Applied physiology

Wang, X., Chowdhury, J. R. & Chowdhury, N. R., Feb 2006, In : Current Paediatrics. 16, 1, p. 70-74 5 p.

Research output: Contribution to journalArticle

56 Scopus citations

Noninvasive evaluation of liver repopulation by transplanted hepatocytes using 31P MRS imaging in mice

Landis, C. S., Yamanouchi, K., Zhou, H., Mohan, S., Roy-Chowdhury, N., Shafritz, D. A., Koretsky, A., Roy-Chowdhury, J., Hetherington, H. P. & Guha, C., Nov 1 2006, In : Hepatology. 44, 5, p. 1250-1258 9 p.

Research output: Contribution to journalArticle

29 Scopus citations
2005

Feasibility of hepatocyte transplantation-based therapies for primary hyperoxalurias

Guha, C., Yamanouchi, K., Jiang, J., Wang, X., Chowdhury, N. R., Santana, A., Shapiro, L. J., Salido, E. & Roy-Chowdhury, J., Mar 1 2005, In : American Journal of Nephrology. 25, 2, p. 161-170 10 p.

Research output: Contribution to journalArticle

41 Scopus citations

Role of cysteine residues in the function of human UDP glucuronosyltransferase isoform 1A1 (UGT1A1)

Ghosh, S. S., Lu, Y., Lee, S. W., Wang, X., Guha, C., Roy-Chowdhury, J. & Roy-Chowdhury, N., Dec 15 2005, In : Biochemical Journal. 392, 3, p. 685-692 8 p.

Research output: Contribution to journalArticle

13 Scopus citations
2004

Glucuronidation and the UDP-glucuronosyltransferases in health and disease

Wells, P. G., Mackenzie, P. I., Chowdhury, J. R., Guillemette, C., Gregory, P. A., Ishii, Y., Hansen, A. J., Kessler, F. K., Kim, P. M., Chowdhury, N. R. & Ritter, J. K., Mar 1 2004, In : Drug Metabolism and Disposition. 32, 3, p. 281-290 10 p.

Research output: Contribution to journalArticle

191 Scopus citations

Hepatocyte transplantation

Fox, I. J. & Chowdhury, J. R., 2004, In : American Journal of Transplantation. 4, SUPPL. 6, p. 7-13 7 p.

Research output: Contribution to journalArticle

110 Scopus citations
2003

Expression of Unmodified Hepatitis C Virus Envelope Glycoprotein-Coding Sequences Leads to Cryptic Intron Excision and Cell Surface Expression of E1/E2 Heterodimers Comprising Full-Length and Partially Deleted E1

Dumonceaux, J., Cormier, E. G., Kajumo, F., Donovan, G. P., Roy-Chowdhury, J., Fox, I. J., Gardner, J. P. & Dragic, T., Dec 2003, In : Journal of virology. 77, 24, p. 13418-13424 7 p.

Research output: Contribution to journalArticle

12 Scopus citations

The human organic anion transport protein SLC21A6 is not sufficient for bilirubin transport

Wang, P., Kim, R. B., Chowdhury, J. R. & Wolkoff, A. W., Jun 6 2003, In : Journal of Biological Chemistry. 278, 23, p. 20695-20699 5 p.

Research output: Contribution to journalArticle

73 Scopus citations

Using new gene delivery systems to advance HIV gene therapy

Strayer, D. S., Goldstein, H., Cordelier, P., Ghosh, S., Strayer, M. S., Pettoello-Mantovani, M. & Chowdhury, J. R., Jan 1 2003, In : Clinical and Applied Immunology Reviews. 3, 4-5, p. 247-259 13 p.

Research output: Contribution to journalArticle

1 Scopus citations
2002

A long-awaited small animal model for hepatitis C

Guha, C. & Chowdhury, J. R., Jan 1 2002, In : Journal of Hepatology. 36, 3, p. 447-449 3 p.

Research output: Contribution to journalArticle

A non-immunogenic adenoviral vector, coexpressing CTLA4lg and bilirubin-uridine-diphosphoglucuronateglucuronosyltransferase permits long-term, repeatable transgene expression in the Gunn rat model of Crigler-Najjar syndrome

Thummala, N. R., Ghosh, S. S., Lee, S. W., Reddy, B., Davidson, A., Horwitz, M. S., Chowdhury, J. R. & Chowdury, N. R., Aug 27 2002, In : Gene Therapy. 9, 15, p. 981-990 10 p.

Research output: Contribution to journalArticle

49 Scopus citations

A novel intronic mutation results in the use of a cryptic splice acceptor site within the coding region of UGT1A1, causing Crigler-Najjar syndrome type 1

Sappal, B. S., Ghosh, S. S., Shneider, B., Kadakol, A., Chowdhury, J. R. & Chowdhury, N. R., Jan 1 2002, In : Molecular Genetics and Metabolism. 75, 2, p. 134-142 9 p.

Research output: Contribution to journalArticle

14 Scopus citations

Evolution of adenoviruses as gene therapy vectors

Roy-Chowdhury, J. & Horwitz, M. S., Jan 1 2002, In : Molecular Therapy. 5, 4, p. 340-344 5 p.

Research output: Contribution to journalArticle

23 Scopus citations

Gene therapy as an alternative to liver transplantation

Kren, B. T., Chowdhury, N. R., Chowdhury, J. R. & Steer, C. J., Dec 1 2002, In : Liver Transplantation. 8, 12, p. 1089-1108 20 p.

Research output: Contribution to journalArticle

31 Scopus citations

Normal hepatocytes correct serum bilirubin after repopulation of Gunn rat liver subjected to irradiation/partial resection

Guha, C., Parashar, B., Deb, N. J., Garg, M., Gorla, G. R., Singh, A., Roy-Chowdhury, N., Vikram, B. & Roy-Chowdhury, J., Jan 1 2002, In : Hepatology. 36, 2, p. 354-362 9 p.

Research output: Contribution to journalArticle

89 Scopus citations

Oligonucleotide-mediated site-directed gene repair

Kren, B. T., Bandyopadhyay, P., Chowdhury, N. R., Chowdhury, J. R. & Steer, C. J., Jan 1 2002, In : Methods in enzymology. 346, p. 14-35 22 p., 2.

Research output: Contribution to journalArticle

7 Scopus citations

Treatment of liver failure in rats with end-stage cirrhosis by transplantation of immortalized hepatocytes

Cai, J., Ito, M., Nagata, H., Westerman, K. A., LaFleur, D., Chowdhury, J. R., Leboulch, P. & Fox, I. J., 2002, In : Hepatology. 36, 2, p. 386-394 9 p.

Research output: Contribution to journalArticle

68 Scopus citations
2001

Amplification of engrafted hepatocytes by preparative manipulation of the host liver

Guha, C., Deb, N. J., Sappal, B. S., Ghosh, S. S., Roy-Chowdhury, N. & Roy-Chowdhury, J., Jan 1 2001, In : Artificial Organs. 25, 7, p. 522-528 7 p.

Research output: Contribution to journalArticle

35 Scopus citations

Gene therapy for inherited hyperbilirubinemias

Roy-Chowdhury, N., Kadakol, A., Sappal, B. S., Thummala, N. R., Ghosh, S. S., Lee, S. W. & Roy-Chowdhury, J., Dec 1 2001, In : Journal of Perinatology. 21, p. S114-S118

Research output: Contribution to journalArticle

Open Access
14 Scopus citations

Hepatocyte-based gene therapy

Guha, C., Roy-Chowdhury, N., Jauregui, H. & Roy-Chowdhury, J., Dec 1 2001, In : Journal of Hepato-Biliary-Pancreatic Surgery. 8, 1, p. 51-57 7 p.

Research output: Contribution to journalArticle

17 Scopus citations

Homodimerization of Human Bilirubin-Uridine-diphosphoglucuronate Glucuronosyltransferase-1 (UGT1A1) and Its Functional Implications

Ghosh, S. S., Sappal, B. S., Kalpana, G. V., Leet, S. W., Roy Chowdhury, J. & Roy Chowdhury, N., Nov 9 2001, In : Journal of Biological Chemistry. 276, 45, p. 42108-42115 8 p.

Research output: Contribution to journalArticle

80 Scopus citations

Liver irradiation: A potential preparative regimen for hepatocyte transplantation

Guha, C., Parashar, B., Deb, N. J., Sharma, A., Gorla, G. R., Alfieri, A., Roy-Chowdhury, N., Roy-Chowdhury, J. & Vikram, B., Feb 1 2001, In : International Journal of Radiation Oncology Biology Physics. 49, 2, p. 451-457 7 p.

Research output: Contribution to journalArticle

31 Scopus citations