• 13303 Citations
  • 57 h-Index
1974 …2019

Research output per year

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Publications

2019

Bile pigment metabolism and its disorders

Roy-Chowdhury, N., Wang, X. & Roy-Chowdhury, J., Jan 1 2019, Emery and Rimoin's Principles and Practice of Medical Genetics and Genomics: Cardiovascular, Respiratory, and Gastrointestinal Disorders. Elsevier, p. 507-553 47 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Hepatocyte Transplantation: Quo Vadis?

Barahman, M., Asp, P., Roy-Chowdhury, N., Kinkhabwala, M., Roy-Chowdhury, J., Kabarriti, R. & Guha, C., Mar 15 2019, In : International Journal of Radiation Oncology Biology Physics. 103, 4, p. 922-934 13 p.

Research output: Contribution to journalReview article

1 Scopus citations

Radiation-primed hepatocyte transplantation in murine monogeneic dyslipidemia normalizes cholesterol and prevents atherosclerosis

Barahman, M., Zhang, W., Harris, H. Y., Aiyer, A., Kabarriti, R., Kinkhabwala, M., Roy-Chowdhury, N., Beck, A. P., Scanlan, T. S., Roy-Chowdhury, J., Asp, P. & Guha, C., Jun 2019, In : Journal of Hepatology. 70, 6, p. 1170-1179 10 p.

Research output: Contribution to journalArticle

3 Scopus citations
2017

Drug- and Drug Abuse–Associated Hyperbilirubinemia: Experience With Atazanavir

Roy-Chowdhury, J., Roy-Chowdhury, N., Listowsky, I. & Wolkoff, A. W., Mar 1 2017, In : Clinical Pharmacology in Drug Development. 6, 2, p. 140-146 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

Gunn rats as a surrogate model for evaluation of hepatocyte transplantation-based therapies of crigler-najjar syndrome type 1

Polgar, Z., Li, Y., Li Wang, X., Guha, C., Roy-Chowdhury, N. & Roy-Chowdhury, J., 2017, Methods in Molecular Biology. Humana Press Inc., Vol. 1506. p. 131-147 17 p. (Methods in Molecular Biology; vol. 1506).

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations

Host conditioning and rejection monitoring in hepatocyte transplantation in humans

Soltys, K. A., Setoyama, K., Tafaleng, E. N., Soto Gutiérrez, A., Fong, J., Fukumitsu, K., Nishikawa, T., Nagaya, M., Sada, R., Haberman, K., Gramignoli, R., Dorko, K., Tahan, V., Dreyzin, A., Baskin, K., Crowley, J. J., Quader, M. A., Deutsch, M., Ashokkumar, C., Shneider, B. L. & 15 others, Squires, R. H., Ranganathan, S., Reyes-Mugica, M., Dobrowolski, S. F., Mazariegos, G., Elango, R., Stolz, D. B., Strom, S. C., Vockley, G., Roy-Chowdhury, J., Cascalho, M., Guha, C., Sindhi, R., Platt, J. L. & Fox, I. J., May 2017, In : Journal of Hepatology. 66, 5, p. 987-1000 14 p.

Research output: Contribution to journalArticle

37 Scopus citations

Oxalobacter formigenes-derived bioactive factors stimulate oxalate transport by intestinal epithelial cells

Arvans, D., Jung, Y. C., Antonopoulos, D., Koval, J., Granja, I., Bashir, M., Karrar, E., Roy-Chowdhury, J., Musch, M., Asplin, J., Chang, E. & Hassan, H., Mar 2017, In : Journal of the American Society of Nephrology. 28, 3, p. 876-887 12 p.

Research output: Contribution to journalArticle

26 Scopus citations
2016

Gene therapy of Wilson disease: A "golden" opportunity using rAAV on the 50th anniversary of the discovery of the virus

Roy-Chowdhury, J. & Schilsky, M. L., Feb 1 2016, In : Journal of Hepatology. 64, 2, p. 265-267 3 p.

Research output: Contribution to journalArticle

6 Scopus citations

Hepatocyte-like cells derived from induced pluripotent stem cells

Roy-Chowdhury, N., Wang, X., Guha, C. & Roy-Chowdhury, J., Aug 17 2016, (Accepted/In press) In : Hepatology International. p. 1-16 16 p.

Research output: Contribution to journalArticle

21 Scopus citations

Human urinary epithelial cells as a source of engraftable hepatocyte-like cells using stem cell technology

Sauer, V., Tchaikovskaya, T., Wang, X., Li, Y., Zhang, W., Tar, K., Polgar, Z., Ding, J., Guha, C., Fox, I. J., Roy-Chowdhury, N. & Roy-Chowdhury, J., Jan 1 2016, In : Cell Transplantation. 25, 12, p. 2221-2243 23 p.

Research output: Contribution to journalArticle

11 Scopus citations
2015

Amelioration of Hyperbilirubinemia in Gunn Rats after Transplantation of Human Induced Pluripotent Stem Cell-Derived Hepatocytes

Chen, Y., Li, Y., Wang, X., Zhang, W., Sauer, V., Chang, C. J., Han, B., Tchaikovskaya, T., Avsar, Y., Tafaleng, E., Madhusudana Girija, S., Tar, K., Polgar, Z., Strom, S., Bouhassira, E. E., Guha, C., Fox, I. J., Roy-Chowdhury, J. & Roy-Chowdhury, N., Jul 14 2015, In : Stem Cell Reports. 5, 1, p. 22-30 9 p.

Research output: Contribution to journalArticle

39 Scopus citations

Hepatocyte-Like Cells Derived from Pluripotent Stem Cells

Li, Y., Polgar, Z., Roy-Chowdhury, N. & Roy-Chowdhury, J., Jan 1 2015, Liver Regeneration: Basic Mechanisms, Relevant Models and Clinical Applications. Elsevier Inc., p. 267-278 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

IndUced Pluripotent Stem Cells Model Personalized Variations in Liver Disease Resulting From α1-Antitrypsin Deficiency

Tafaleng, E. N., Chakraborty, S., Han, B., Hale, P., Wu, W., Soto-Gutierrez, A., Feghali-Bostwick, C. A., Wilson, A. A., Kotton, D. N., Nagaya, M., Strom, S. C., Roy-Chowdhury, J., Stolz, D. B., Perlmutter, D. H. & Fox, I. J., Jul 1 2015, In : Hepatology. 62, 1, p. 147-157 11 p.

Research output: Contribution to journalArticle

46 Scopus citations
2014
8 Scopus citations
10 Scopus citations

A nonhuman primate model of human radiation-induced venocclusive liver disease and hepatocyte injury

Yannam, G. R., Han, B., Setoyama, K., Yamamoto, T., Ito, R., Brooks, J. M., Guzman-Lepe, J., Galambos, C., Fong, J. V., Deutsch, M., Quader, M. A., Yamanouchi, K., Kabarriti, R., Mehta, K., Soto-Gutierrez, A., Roy-Chowdhury, J., Locker, J., Abe, M., Enke, C. A., Baranowska-Kortylewicz, J. & 3 others, Solberg, T. D., Guha, C. & Fox, I. J., Feb 1 2014, In : International Journal of Radiation Oncology Biology Physics. 88, 2, p. 404-411 8 p.

Research output: Contribution to journalArticle

18 Scopus citations
20 Scopus citations

Induced Pluripotent Stem Cells as a Source of Hepatocytes

Sauer, V., Roy-Chowdhury, N., Guha, C. & Roy-Chowdhury, J., Mar 1 2014, In : Current Pathobiology Reports. 2, 1, p. 11-20 10 p.

Research output: Contribution to journalReview article

Open Access
19 Scopus citations

Monogenic Liver Diseases

Sauer, V., Roy-Chowdhury, N. & Roy-Chowdhury, J., Jan 1 2014, Pathobiology of Human Disease: A Dynamic Encyclopedia of Disease Mechanisms. Elsevier Inc., p. 1857-1865 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Small RNAs derived from lncRNA RNase MRP have gene-silencing activity relevant to human cartilage-hair hypoplasia

Rogler, L. E., Kosmyna, B., Moskowitz, D., Bebawee, R., Rahimzadeh, J., Kutchko, K., Laederach, A., Notarangelo, L. D., Giliani, S., Bouhassira, E., Frenette, P., Roy-Chowdhury, J. & Rogler, C. E., Jan 2014, In : Human molecular genetics. 23, 2, p. 368-382 15 p.

Research output: Contribution to journalArticle

57 Scopus citations
2013

Bile Pigment Metabolism and Its Disorders

Chowdhury, N. R., Chowdhury, J. R. & Avsar, Y., Aug 29 2013, Emery and Rimoin's Principles and Practice of Medical Genetics. Elsevier Ltd., p. 1-34 34 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations
2012

Amelioration of murine Schistosoma mansoni induced liver fibrosis by mesenchymal stem cells

Abdel Aziz, M. T., Atta, H. M., Roshdy, N. K., Rashed, L. A., Sabry, D., Hassouna, A. A., Aboul Fotouh, G. I., Hasan, N. M., Younis, R. H. & Chowdhury, J. R., Jul 11 2012, In : Journal of Stem Cells and Regenerative Medicine. 8, 1, p. P28-P34

Research output: Contribution to journalArticle

17 Scopus citations

Bilirubin Metabolism and its Disorders

Roy-Chowdhury, J. & Roy-Chowdhury, N., Dec 1 2012, Zakim and Boyer's Hepatology. Elsevier Inc., p. 1079-1109 31 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Improving the techniques for human hepatocyte transplantation: Report from a consensus meeting in London

Puppi, J., Strom, S. C., Hughes, R. D., Bansal, S., Castell, J. V., Dagher, I., Ellis, E. C. S., Nowak, G., Ericzon, B. G., Fox, I. J., Gómez-Lechón, J. M., Guha, C., Gupta, S., Mitry, R. R., Ohashi, K., Ott, M., Reid, L. M., Roy-Chowdhury, J., Sokal, E., Weber, A. & 1 others, Dhawan, A., 2012, In : Cell Transplantation. 21, 1, p. 1-10 10 p.

Research output: Contribution to journalReview article

126 Scopus citations

Single Liver Lobe Repopulation with Wildtype Hepatocytes Using Regional Hepatic Irradiation Cures Jaundice in Gunn Rats

Zhou, H., Dong, X., Kabarriti, R., Chen, Y., Avsar, Y., Wang, X., Ding, J., Liu, L., Fox, I. J., Roy-Chowdhury, J., Roy-Chowdhury, N. & Guha, C., Oct 16 2012, In : PloS one. 7, 10, e46775.

Research output: Contribution to journalArticle

25 Scopus citations
2011

Modeling and therapy of human liver diseases using induced pluripotent stem cells: How far have we come?

Soto-Gutierrez, A., Tafaleng, E., Kelly, V., Roy-Chowdhury, J. & Fox, I. J., Feb 1 2011, In : Hepatology. 53, 2, p. 708-711 4 p.

Research output: Contribution to journalArticle

12 Scopus citations

Spontaneous hepatic repopulation in transgenic mice expressing mutant human α1-antitrypsin by wild-type donor hepatocytes

Ding, J., Yannam, G. R., Roy-Chowdhury, N., Hidvegi, T., Basma, H., Rennard, S. I., Wong, R. J., Avsar, Y., Guha, C., Perlmutter, D. H., Fox, I. J. & Roy-Chowdhury, J., May 2 2011, In : Journal of Clinical Investigation. 121, 5, p. 1930-1934 5 p.

Research output: Contribution to journalArticle

47 Scopus citations
2010

Barriers to the successful treatment of liver disease by hepatocyte transplantation

Soltys, K. A., Soto-Gutiérrez, A., Nagaya, M., Baskin, K. M., Deutsch, M., Ito, R., Shneider, B. L., Squires, R., Vockley, J., Guha, C., Roy-Chowdhury, J., Strom, S. C., Platt, J. L. & Fox, I. J., Oct 2010, In : Journal of Hepatology. 53, 4, p. 769-774 6 p.

Research output: Contribution to journalComment/debate

108 Scopus citations

Efficient CNS gene delivery by intravenous injection

Louboutin, J. P., Chekmasova, A. A., Marusich, E., Chowdhury, J. R. & Strayer, D. S., Nov 1 2010, In : Nature Methods. 7, 11, p. 905-907 3 p.

Research output: Contribution to journalArticle

44 Scopus citations

Hepatic differentiation of liver-derived progenitor cells and their characterization by microRNA analysis

Chen, Y., Zhou, H., Sarver, A. L., Zeng, Y., Roy-Chowdhury, J., Steer, C. J. & Sahin, M. B., Sep 1 2010, In : Liver Transplantation. 16, 9, p. 1086-1097 12 p.

Research output: Contribution to journalArticle

19 Scopus citations
2009

Differentiation and Transplantation of Human Embryonic Stem Cell-Derived Hepatocytes

Basma, H., Soto-Gutiérrez, A., Yannam, G. R., Liu, L., Ito, R., Yamamoto, T., Ellis, E., Carson, S. D., Sato, S., Chen, Y., Muirhead, D., Navarro-Álvarez, N., Wong, R. J., Roy-Chowdhury, J., Platt, J. L., Mercer, D. F., Miller, J. D., Strom, S. C., Kobayashi, N. & Fox, I. J., Mar 2009, In : Gastroenterology. 136, 3, p. 990-999.e4

Research output: Contribution to journalArticle

385 Scopus citations

Disorders of Bilirubin Metabolism

Chowdhury, N. R. & Chowdhury, J. R., Oct 6 2009, The Liver: Biology and Pathobiology: Fifth Edition. John Wiley & Sons, Ltd., p. 251-256 6 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

7 Scopus citations

Experimental Therapies: Hepatocyte Transplantation, Gene Therapy, and Liver Assist Devices

Roy-Chowdhury, J., Roy-Chowdhury, N., Horslen, S. P. & Fox, I. J., Feb 17 2009, Textbook of Gastroenterology, Fifth Edition. Blackwell Publishing Ltd, Vol. 2. p. 2432-2448 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Ex vivo gene transfer into hepatocytes

Wang, X., Mani, P., Sarkar, D. P., Roy-Chowdhury, N. & Roy-Chowdhury, J., Jan 1 2009, Hepatocyte Transplantation: Methods and Protocols. Humana Press, p. 117-139 23 p. (Methods in Molecular Biology; vol. 481).

Research output: Chapter in Book/Report/Conference proceedingChapter

23 Scopus citations

Ex vivo gene transfer into hepatocytes.

Wang, X., Mani, P., Sarkar, D. P., Roy-Chowdhury, N. & Roy-Chowdhury, J., 2009, In : Methods in molecular biology (Clifton, N.J.). 481, p. 117-140 24 p.

Research output: Contribution to journalArticle

Hepatic irradiation augments engraftment of donor cells following hepatocyte transplantation

Yamanouchi, K., Zhou, H., Roy-Chowdhury, N., Macaluso, F., Liu, L., Yamamoto, T., Yannam, G. R., Enke, C., Solberg, T. D., Adelson, A. B., Platt, J. L., Fox, I. J., Roy-Chowdhury, J. & Guha, C., Mar 9 2009, In : Hepatology. 49, 1, p. 258-267 10 p.

Research output: Contribution to journalArticle

83 Scopus citations

Liver-Directed Gene Therapy

Kren, B. T., Steer, C. J., Roy Chowdhury, N. & Roy Chowdhury, J., Oct 6 2009, The Liver: Biology and Pathobiology: Fifth Edition. John Wiley & Sons, Ltd., p. 965-990 26 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Long-term reduction of jaundice in Gunn rats by nonviral liver-targeted delivery of Sleeping Beauty transposon

Wang, X., Sarkar, D. P., Mani, P., Steer, C. J., Chen, Y., Guha, C., Chandrasekhar, V., Chaudhuri, A., Roy-Chowdhury, N., Kren, B. T. & Roy-Chowdhury, J., Nov 27 2009, In : Hepatology. 50, 3, p. 815-824 10 p.

Research output: Contribution to journalArticle

32 Scopus citations

Protective role of R-spondin1, an intestinal stem cell growth factor, against radiation-induced gastrointestinal syndrome in mice

Bhanja, P., Saha, S., Kabarriti, R., Liu, L., Roy-Chowdhury, N., Roy-Chowdhury, J., Sellers, R. S., Alfieri, A. A. & Guha, C., Nov 24 2009, In : PloS one. 4, 11, e8014.

Research output: Contribution to journalArticle

77 Scopus citations
2008

Correction of hyperoxaluria by liver repopulation with hepatocytes in a mouse model of primary hyperoxaluria type-1

Jiang, J., Salido, E. C., Guha, C., Wang, X., Moitra, R., Liu, L., Roy-Chowdhury, J. & Roy-Chowdhury, N., May 1 2008, In : Transplantation. 85, 9, p. 1253-1260 8 p.

Research output: Contribution to journalArticle

33 Scopus citations

Emerging Therapies

Yannam, G. R., Roy-Chowdhury, J., Fox, I. J., Stadlbauer, V. & Jalan, R., Apr 15 2008, Textbook of Hepatology: From Basic Science to Clinical Practice, Third Edition. Blackwell Publishing Ltd, p. 2032-2052 21 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Hepatic repopulation with stably transduced conditionally immortalized hepatocytes in the Gunn rat

Kawashita, Y., Guha, C., Moitra, R., Wang, X., Fox, I. J., Roy-Chowdhury, J. & Roy-Chowdhury, N., Jul 1 2008, In : Journal of Hepatology. 49, 1, p. 99-106 8 p.

Research output: Contribution to journalArticle

18 Scopus citations

Metabolism

Boden, G., Scapa, E. F., Kanno, K., Cohen, D. E., Brosnan, M. E., Brosnan, J. T., Pessayre, D., Roy-Chowdhury, N., Lu, Y., Roy-Chowdhury, J., Jansen, P. L. M., Faber, K. N., Häussinger, D., Lingappa, V. R., Fernández-Checa, J. C., García-Ruiz, C., Puy, H., Deybach, J. C., Okuno, M., Matsushima-Nishiwaki, R. & 8 others, Kojima, S., Brown, K. E., Brewer, G. J., Harris, E. D., Askari, F. K., Neuschwander-Tetri, B. A., Liddle, C. & Stedman, C. A. M., Apr 15 2008, Textbook of Hepatology: From Basic Science to Clinical Practice, Third Edition. Blackwell Publishing Ltd, p. 129-249 121 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations
2007

Prevention of hepatocyte allograft rejection in rats by transferring adenoviral early region 3 genes into donor cells

Mashalova, E. V., Guha, C., Roy-Chowdhury, N., Liu, L., Fox, I. J., Roy-Chowdhury, J. & Horwitz, M. S., Mar 1 2007, In : Hepatology. 45, 3, p. 755-766 12 p.

Research output: Contribution to journalArticle

12 Scopus citations
2006

Alanine-glyoxylate aminotransferase-deficient mice, a model for primary hyperoxaluria that responds to adenoviral gene transfer

Salido, E. C., Li, X. M., Lu, Y., Wang, X., Santana, A., Roy-Chowdhury, N., Torres, A., Shapiro, L. J. & Roy-Chowdhury, J., Nov 28 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 48, p. 18249-18254 6 p.

Research output: Contribution to journalArticle

70 Scopus citations

Bilirubin metabolism: Applied physiology

Wang, X., Chowdhury, J. R. & Chowdhury, N. R., Feb 2006, In : Current Paediatrics. 16, 1, p. 70-74 5 p.

Research output: Contribution to journalArticle

56 Scopus citations

Bilirubin Metabolism and its Disorders

Roy-Chowdhury, J., Roy-Chowdhury, N. & Jansen, P. L. M., Dec 1 2006, Zakim and Boyer's Hepatology. Elsevier Inc., p. 1449-1485 37 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Noninvasive evaluation of liver repopulation by transplanted hepatocytes using 31P MRS imaging in mice

Landis, C. S., Yamanouchi, K., Zhou, H., Mohan, S., Roy-Chowdhury, N., Shafritz, D. A., Koretsky, A., Roy-Chowdhury, J., Hetherington, H. P. & Guha, C., Nov 1 2006, In : Hepatology. 44, 5, p. 1250-1258 9 p.

Research output: Contribution to journalArticle

29 Scopus citations
2005

Cell culture models and animal models of viral hepatitis. Part II: Hepatitis C

Guha, C., Lee, S. W., Chowdhury, N. R. & Chowdhury, J. R., Jan 1 2005, In : Lab Animal. 34, 2, p. 39-47 9 p.

Research output: Contribution to journalReview article

19 Scopus citations

Feasibility of hepatocyte transplantation-based therapies for primary hyperoxalurias

Guha, C., Yamanouchi, K., Jiang, J., Wang, X., Chowdhury, N. R., Santana, A., Shapiro, L. J., Salido, E. & Roy-Chowdhury, J., Mar 1 2005, In : American Journal of Nephrology. 25, 2, p. 161-170 10 p.

Research output: Contribution to journalArticle

41 Scopus citations