• 13684 Citations
  • 60 h-Index
1983 …2020

Research output per year

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Publications

2020

FOXO3a acts to suppress DNA double-strand break-induced mutations

White, R. R., Maslov, A. Y., Lee, M., Wilner, S. E., Levy, M. & Vijg, J., Sep 1 2020, In : Aging cell. 19, 9, e13184.

Research output: Contribution to journalArticle

Open Access

Genetics of extreme human longevity to guide drug discovery for healthy ageing

Zhang, Z. D., Milman, S., Lin, J. R., Wierbowski, S., Yu, H., Barzilai, N., Gorbunova, V., Ladiges, W. C., Niedernhofer, L. J., Suh, Y., Robbins, P. D. & Vijg, J., Aug 1 2020, In : Nature Metabolism. 2, 8, p. 663-672 10 p.

Research output: Contribution to journalReview article

Inducible aging in Hydra oligactis implicates sexual reproduction, loss of stem cells, and genome maintenance as major pathways

Sun, S., White, R. R., Fischer, K. E., Zhang, Z., Austad, S. N. & Vijg, J., Aug 1 2020, In : GeroScience. 42, 4, p. 1119-1132 14 p.

Research output: Contribution to journalArticle

Pathogenic Mechanisms of Somatic Mutation and Genome Mosaicism in Aging

Vijg, J. & Dong, X., Jul 9 2020, In : Cell. 182, 1, p. 12-23 12 p.

Research output: Contribution to journalReview article

Open Access
Open Access
3 Scopus citations
2019

A direct comparison of interphase FISH versus low-coverage single cell sequencing to detect aneuploidy reveals respective strengths and weaknesses

Andriani, G. A., Maggi, E., Piqué, D., Zimmerman, S. E., Lee, M., Quispe-Tintaya, W., Maslov, A., Campisi, J., Vijg, J., Mar, J. C. & Montagna, C., Dec 1 2019, In : Scientific reports. 9, 1, 10508.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Age is in the nucleus

Schumacher, B. & Vijg, J., Oct 1 2019, In : Nature Metabolism. 1, 10, p. 931-932 2 p.

Research output: Contribution to journalComment/debate

1 Scopus citations

New Insights into Bioactive Compounds of Traditional Chinese Medicines for Insulin Resistance Based on Signaling Pathways

He, J., Wang, H. & Vijg, J., Sep 1 2019, In : Chemistry and Biodiversity. 16, 9, e1900176.

Research output: Contribution to journalReview article

1 Scopus citations
Open Access
35 Scopus citations

SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species

Tian, X., Firsanov, D., Zhang, Z., Cheng, Y., Luo, L., Tombline, G., Tan, R., Simon, M., Henderson, S., Steffan, J., Goldfarb, A., Tam, J., Zheng, K., Cornwell, A., Johnson, A., Yang, J. N., Mao, Z., Manta, B., Dang, W., Zhang, Z. & 8 others, Vijg, J., Wolfe, A., Moody, K., Kennedy, B. K., Bohmann, D., Gladyshev, V. N., Seluanov, A. & Gorbunova, V., Apr 18 2019, In : Cell. 177, 3, p. 622-638.e22

Research output: Contribution to journalArticle

34 Scopus citations
2018

Bleomycin-induced genome structural variations in normal, non-tumor cells

Quispe-Tintaya, W., Lee, M., Dong, X., Weiser, D. A., Vijg, J. & Maslov, A. Y., Dec 1 2018, In : Scientific reports. 8, 1, 16523.

Research output: Contribution to journalArticle

3 Scopus citations

Cell Replacement to Reverse Brain Aging: Challenges, Pitfalls, and Opportunities

Hébert, J. M. & Vijg, J., May 2018, In : Trends in Neurosciences. 41, 5, p. 267-279 13 p.

Research output: Contribution to journalReview article

4 Scopus citations

Development of a method to implement whole-genome bisulfite sequencing of cfDNA from cancer patients and a mouse tumor model

Maggi, E. C., Gravina, S., Cheng, H., Piperdi, B., Yuan, Z., Dong, X., Libutti, S. K., Vijg, J. & Montagna, C., Jan 23 2018, In : Frontiers in Genetics. 9, JAN, 6.

Research output: Contribution to journalArticle

10 Scopus citations

Global, integrated analysis of methylomes and transcriptomes from laser capture microdissected bronchial and alveolar cells in human lung

Dong, X., Shi, M., Lee, M., Toro, R., Gravina, S., Han, W., Yasuda, S., Wang, T., Zhang, Z., Vijg, J., Suh, Y. & Spivack, S. D., Mar 4 2018, In : Epigenetics. 13, 3, p. 264-274 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

Mechanisms of cancer resistance in long-lived mammals

Seluanov, A., Gladyshev, V. N., Vijg, J. & Gorbunova, V., Jul 1 2018, In : Nature Reviews Cancer. 18, 7, p. 433-441 9 p.

Research output: Contribution to journalReview article

40 Scopus citations

Nuclear Genomic Instability and Aging

Niedernhofer, L. J., Gurkar, A. U., Wang, Y., Vijg, J., Hoeijmakers, J. H. J. & Robbins, P. D., Jun 20 2018, In : Annual Review of Biochemistry. 87, p. 295-322 28 p.

Research output: Contribution to journalReview article

26 Scopus citations

Somatic mutagenesis in mammals and its implications for human disease and aging

Zhang, L. & Vijg, J., Nov 23 2018, In : Annual review of genetics. 52, p. 397-419 23 p.

Research output: Contribution to journalReview article

26 Scopus citations
2017

Accurate identification of single-nucleotide variants in whole-genome-amplified single cells

Dong, X., Zhang, L., Milholland, B., Lee, M., Maslov, A. Y., Wang, T. & Vijg, J., Apr 27 2017, In : Nature Methods. 14, 5, p. 491-493 3 p.

Research output: Contribution to journalArticle

58 Scopus citations

Ageing: Biomarkers get physical

Dong, X. & Vijg, J., Jun 30 2017, In : Nature Biomedical Engineering. 1, 7, 0102.

Research output: Contribution to journalComment/debate

Aging and the Inevitable Limit to Human Life Span

Vijg, J. & Le Bourg, E., Aug 1 2017, In : Gerontology. 63, 5, p. 432-434 3 p.

Research output: Contribution to journalArticle

16 Scopus citations
2 Scopus citations

Analysis of individual cells identifies cell-to-cell variability following induction of cellular senescence

Wiley, C. D., Flynn, J. M., Morrissey, C., Lebofsky, R., Shuga, J., Dong, X., Unger, M. A., Vijg, J., Melov, S. & Campisi, J., Oct 2017, In : Aging cell. 16, 5, p. 1043-1050 8 p.

Research output: Contribution to journalArticle

48 Scopus citations

A review of the biomedical innovations for healthy longevity

Moskalev, A., Anisimov, V., Aliper, A., Artemov, A., Asadullah, K., Belsky, D., Baranova, A., de Grey, A., Dixit, V. D., Debonneuil, E., Dobrovolskaya, E., Fedichev, P., Fedintsev, A., Fraifeld, V., Franceschi, C., Freer, R., Fülöp, T., Feige, J., Gems, D., Gladyshev, V. & 50 others, Gorbunova, V., Irincheeva, I., Jager, S., Jazwinski, S. M., Kaeberlein, M., Kennedy, B., Khaltourina, D., Kovalchuk, I., Kovalchuk, O., Kozin, S., Kulminski, A., Lashmanova, E., Lezhnina, K., Liu, G. H., Longo, V., Mamoshina, P., Maslov, A., de Magalhaes, J. P., Mitchell, J., Mitnitski, A., Nikolsky, Y., Ozerov, I., Pasyukova, E., Peregudova, D., Popov, V., Proshkina, E., Putin, E., Rogaev, E., Rogina, B., Schastnaya, J., Seluanov, A., Shaposhnikov, M., Simm, A., Skulachev, V., Skulachev, M., Solovev, I., Spindler, S., Stefanova, N., Suh, Y., Swick, A., Tower, J., Gudkov, A. V., Vijg, J., Voronkov, A., West, M., Wagner, W., Yashin, A., Zemskaya, N., Zhumadilov, Z. & Zhavoronkov, A., 2017, In : Aging. 9, 1, p. 7-25 19 p.

Research output: Contribution to journalArticle

12 Scopus citations

"best-Guess" MRAD Provides Robust Evidence for a Limit to Human Lifespan: Reply to de Grey (Rejuvenation Res. 2017;20:261-262)

Milholland, B., Dong, X. & Vijg, J., Oct 1 2017, In : Rejuvenation Research. 20, 5, p. 437-440 4 p.

Research output: Contribution to journalArticle

4 Scopus citations

Development and validation of a targeted next generation DNA sequencing panel outperforming whole exome sequencing for the identification of clinically relevant genetic variants

Miller, E. M., Patterson, N. E., Zechmeister, J. M., Bejerano-Sagie, M., Delio, M., Patel, K., Ravi, N., Quispe-Tintaya, W., Maslov, A., Simmons, N., Castaldi, M., Vijg, J., Karabakhtsian, R. G., Greally, J. M., Kuo, D. Y. S. & Montagna, C., 2017, In : Oncotarget. 8, 60, p. 102033-102045 13 p.

Research output: Contribution to journalArticle

10 Scopus citations

Differences between germline and somatic mutation rates in humans and mice

Milholland, B., Dong, X., Zhang, L., Hao, X., Suh, Y. & Vijg, J., May 9 2017, In : Nature communications. 8, 15183.

Research output: Contribution to journalArticle

109 Scopus citations

Dong et al. reply

Dong, X., Milholland, B. & Vijg, J., Jun 28 2017, In : Nature. 546, 7660, p. E21

Research output: Contribution to journalComment/debate

Dong et al. reply

Dong, X., Milholland, B. & Vijg, J., Jun 28 2017, In : Nature. 546, 7660, p. E12

Research output: Contribution to journalArticle

Dong et al. reply

Dong, X., Milholland, B. & Vijg, J., Jun 28 2017, In : Nature. 546, 7660, p. E9-E10

Research output: Contribution to journalComment/debate

1 Scopus citations

Dong et al. reply

Dong, X., Milholland, B. & Vijg, J., Jun 28 2017, In : Nature. 546, 7660, p. E7

Research output: Contribution to journalLetter

1 Scopus citations

Dong et al. reply

Dong, X., Milholland, B. & Vijg, J., Jun 28 2017, In : Nature. 546, 7660, p. E14-E15

Research output: Contribution to journalLetter

1 Scopus citations

Genome instability: A conserved mechanism of ageing?

Vijg, J., Dong, X., Milholland, B. & Zhang, L., Jul 11 2017, In : Essays in Biochemistry. 61, 3, p. 305-315 11 p.

Research output: Contribution to journalReview article

13 Scopus citations

Genome instability and aging: Cause or effect?

Vijg, J. & Montagna, C., Oct 2017, In : Translational Medicine of Aging. 1, p. 5-11 7 p.

Research output: Contribution to journalReview article

Open Access
4 Scopus citations

Genome-wide, Single-Cell DNA Methylomics Reveals Increased Non-CpG Methylation during Human Oocyte Maturation

Yu, B., Dong, X., Gravina, S., Kartal, Ö., Schimmel, T., Cohen, J., Tortoriello, D., Zody, R., Hawkins, R. D. & Vijg, J., Jul 11 2017, In : Stem Cell Reports. 9, 1, p. 397-407 11 p.

Research output: Contribution to journalArticle

28 Scopus citations

The Future of Human Longevity: Time for a Reality Check

Le Bourg, E. & Vijg, J., Aug 22 2017, (Accepted/In press) In : Gerontology.

Research output: Contribution to journalArticle

4 Scopus citations
2016

Deep biomarkers of human aging: Application of deep neural networks to biomarker development

Putin, E., Mamoshina, P., Aliper, A., Korzinkin, M., Moskalev, A., Kolosov, A., Ostrovskiy, A., Cantor, C., Vijg, J. & Zhavoronkov, A., 2016, In : Aging. 8, 5, p. 1021-1033 13 p.

Research output: Contribution to journalArticle

100 Scopus citations

Do DNA Double-Strand Breaks Drive Aging?

White, R. R. & Vijg, J., Sep 1 2016, In : Molecular Cell. 63, 5, p. 729-738 10 p.

Research output: Contribution to journalReview article

67 Scopus citations

Evidence for a limit to human lifespan

Dong, X., Milholland, B. & Vijg, J., 2016, In : Nature. 538, 7624, p. 257-259 3 p.

Research output: Contribution to journalArticle

179 Scopus citations

In silico Pathway Activation Network Decomposition Analysis (iPANDA) as a method for biomarker development

Ozerov, I. V., Lezhnina, K. V., Izumchenko, E., Artemov, A. V., Medintsev, S., Vanhaelen, Q., Aliper, A., Vijg, J., Osipov, A. N., Labat, I., West, M. D., Buzdin, A., Cantor, C. R., Nikolsky, Y., Borisov, N., Irincheeva, I., Khokhlovich, E., Sidransky, D., Camargo, M. L. & Zhavoronkov, A., Nov 16 2016, In : Nature communications. 7, 13427.

Research output: Contribution to journalArticle

49 Scopus citations

Mechanisms and consequences of aneuploidy and chromosome instability in the aging brain

Andriani, G. A., Vijg, J. & Montagna, C., Feb 15 2016, (Accepted/In press) In : Mechanisms of Ageing and Development.

Research output: Contribution to journalArticle

19 Scopus citations

Mutation and catastrophe in the aging genome

Milholland, B., Suh, Y. & Vijg, J., Nov 9 2016, (Accepted/In press) In : Experimental Gerontology.

Research output: Contribution to journalArticle

7 Scopus citations

Quantitative detection of low-abundance somatic structural variants in normal cells by high-throughput sequencing

Quispe-Tintaya, W., Gorbacheva, T., Lee, M., Makhortov, S., Popov, V. N., Vijg, J. & Maslov, A., Jun 29 2016, In : Nature Methods. 13, 7, p. 584-586 3 p.

Research output: Contribution to journalArticle

5 Scopus citations

Restricted diet delays accelerated ageing and genomic stress in DNA-repair-deficient mice

Vermeij, W. P., Dollé, M. E. T., Reiling, E., Jaarsma, D., Payan-Gomez, C., Bombardieri, C. R., Wu, H., Roks, A. J. M., Botter, S. M., Van Der Eerden, B. C., Youssef, S. A., Kuiper, R. V., Nagarajah, B., Van Oostrom, C. T., Brandt, R. M. C., Barnhoorn, S., Imholz, S., Pennings, J. L. A., De Bruin, A., Gyenis & 4 others, Pothof, J., Vijg, J., Van Steeg, H. & Hoeijmakers, J. H. J., Aug 24 2016, In : Nature. 537, 7620, p. 427-431 5 p.

Research output: Contribution to journalArticle

86 Scopus citations

Sensitivity of primary fibroblasts in culture to atmospheric oxygen does not correlate with species lifespan

Patrick, A., Seluanov, M., Hwang, C., Tam, J., Khan, T., Morgenstern, A., Wiener, L., Vazquez, J. M., Zafar, H., Wen, R., Muratkalyeva, M., Doerig, K., Zagorulya, M., Cole, L., Catalano, S., Lobo Ladd, A. A. B., Coppi, A. A., Coskun, Y., Tian, X., Ablaeva, J. & 6 others, Nevo, E., Gladyshev, V. N., Zhang, Z. D., Vijg, J., Seluanov, A. & Gorbunova, V., 2016, In : Aging. 8, 5, p. 841-847 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

Single-cell genome-wide bisulfite sequencing uncovers extensive heterogeneity in the mouse liver methylome

Gravina, S., Dong, X., Yu, B. & Vijg, J., Jul 5 2016, In : Genome biology. 17, 1, 150.

Research output: Contribution to journalArticle

55 Scopus citations

Systems-level analysis of human aging genes shed new light on mechanisms of aging

Zhang, Q., Nogales-Cadenas, R., Lin, J. R., Zhang, W., Cai, Y., Vijg, J. & Zhang, Z. D., 2016, In : Human molecular genetics. 25, 14, p. 2934-2947 14 p.

Research output: Contribution to journalArticle

17 Scopus citations

The dark side of circulating nucleic acids

Gravina, S., Sedivy, J. M. & Vijg, J., Jun 1 2016, In : Aging cell. 15, 3, p. 398-399 2 p.

Research output: Contribution to journalReview article

24 Scopus citations

The Essence of Aging

Vijg, J. & Kennedy, B. K., Jun 15 2016, In : Gerontology. 62, 4, p. 381-385 5 p.

Research output: Contribution to journalReview article

12 Scopus citations

Whole chromosome aneuploidy in the brain of Bub1bH/H and Ercc1-/Δ7 mice

Andriani, G. A., Faggioli, F., Baker, D., Dollé, M. E. T., Sellers, R. S., Hébert, J. M., Van Steeg, H., Hoeijmakers, J., Vijg, J. & Montagna, C., 2016, In : Human molecular genetics. 25, 4, p. 755-765 11 p.

Research output: Contribution to journalArticle

7 Scopus citations

Whole chromosome instability induces senescence and promotes SASP

Andriani, G. A., Almeida, V. P., Faggioli, F., Mauro, M., Li Tsai, W., Santambrogio, L., Maslov, A., Gadina, M., Campisi, J., Vijg, J. & Montagna, C., Oct 12 2016, In : Scientific reports. 6, 35218.

Research output: Contribution to journalArticle

45 Scopus citations