• 12421 Citations
  • 57 h-Index
1983 …2023
If you made any changes in Pure, your changes will be visible here soon.

Publications 1983 2019

2019

A direct comparison of interphase FISH versus low-coverage single cell sequencing to detect aneuploidy reveals respective strengths and weaknesses

Andriani, G. A., Maggi, E., Piqué, D., Zimmerman, S. E., Lee, M., Quispe-Tintaya, W., Maslov, A., Campisi, J., Vijg, J., Mar, J. C. & Montagna, C., Dec 1 2019, In : Scientific Reports. 9, 1, 10508.

Research output: Contribution to journalArticle

Open Access
Interphase
Aneuploidy
Fluorescence In Situ Hybridization
Genome
Polyploidy

New Insights into Bioactive Compounds of Traditional Chinese Medicines for Insulin Resistance Based on Signaling Pathways

He, J., Wang, H. & Vijg, J., Sep 1 2019, In : Chemistry & biodiversity. 16, 9, p. e1900176

Research output: Contribution to journalReview article

Insulin
Chinese Traditional Medicine
Medical problems
Medicine
Insulin Resistance
2 Citations (Scopus)
Open Access
B-Lymphocytes
Genome
Mutation
Immunoglobulin Genes
Nucleic Acid Regulatory Sequences
4 Citations (Scopus)

SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species

Tian, X., Firsanov, D., Zhang, Z., Cheng, Y., Luo, L., Tombline, G., Tan, R., Simon, M., Henderson, S., Steffan, J., Goldfarb, A., Tam, J., Zheng, K., Cornwell, A., Johnson, A., Yang, J. N., Mao, Z., Manta, B., Dang, W., Zhang, Z. & 8 others, Vijg, J., Wolfe, A., Moody, K., Kennedy, B. K., Bohmann, D., Gladyshev, V. N., Seluanov, A. & Gorbunova, V., Apr 18 2019, In : Cell. 177, 3, p. 622-638.e22

Research output: Contribution to journalArticle

Double-Stranded DNA Breaks
Rodentia
Repair
DNA
2018
1 Citation (Scopus)

Bleomycin-induced genome structural variations in normal, non-tumor cells

Quispe-Tintaya, W., Lee, M., Dong, X., Weiser, D. A., Vijg, J. & Maslov, A., Dec 1 2018, In : Scientific Reports. 8, 1, 16523.

Research output: Contribution to journalArticle

Genomic Structural Variation
Bleomycin
Mutation
Neoplasms
Pharmaceutical Preparations
3 Citations (Scopus)

Cell Replacement to Reverse Brain Aging: Challenges, Pitfalls, and Opportunities

Hebert, J. M. & Vijg, J., Jan 1 2018, (Accepted/In press) In : Trends in Neurosciences.

Research output: Contribution to journalArticle

Neocortex
Brain
Cognition
Neurons
Therapeutics
4 Citations (Scopus)

Development of a method to implement whole-genome bisulfite sequencing of cfDNA from cancer patients and a mouse tumor model

Maggi, E. C., Gravina, S., Cheng, H., Piperdi, B., Yuan, Z., Dong, X., Libutti, S. K., Vijg, J. & Montagna, C., Jan 23 2018, In : Frontiers in Genetics. 9, JAN, 6.

Research output: Contribution to journalArticle

DNA Methylation
Genome
DNA
Neoplasms
Neuroendocrine Tumors
1 Citation (Scopus)

Global, integrated analysis of methylomes and transcriptomes from laser capture microdissected bronchial and alveolar cells in human lung

Dong, X., Shi, M., Lee, M., Toro, R., Gravina, S., Han, W., Yasuda, S., Wang, T., Zhang, Z., Vijg, J., Suh, Y. & Spivack, S. D., May 1 2018, (Accepted/In press) In : Epigenetics. p. 1-11 11 p.

Research output: Contribution to journalArticle

Alveolar Epithelial Cells
Gene Expression Profiling
Lasers
Lung
GTP Phosphohydrolases
18 Citations (Scopus)

Mechanisms of cancer resistance in long-lived mammals

Seluanov, A., Gladyshev, V. N., Vijg, J. & Gorbunova, V., Apr 5 2018, (Accepted/In press) In : Nature Reviews Cancer. p. 1-9 9 p.

Research output: Contribution to journalArticle

Mammals
Neoplasms
Mole Rats
Whales
Sciuridae
5 Citations (Scopus)

Nuclear Genomic Instability and Aging

Niedernhofer, L. J., Gurkar, A. U., Wang, Y., Vijg, J., Hoeijmakers, J. H. J. & Robbins, P. D., Jun 20 2018, In : Annual Review of Biochemistry. 87, p. 295-322 28 p.

Research output: Contribution to journalReview article

Genomic Instability
DNA Damage
Aging of materials
DNA
Mammals
10 Citations (Scopus)

Somatic mutagenesis in mammals and its implications for human disease and aging

Zhang, L. & Vijg, J., Nov 23 2018, In : Annual Review of Genetics. 52, p. 397-419 23 p.

Research output: Contribution to journalReview article

Mutagenesis
Mammals
Mutation
Mitosis
DNA Repair
2017
32 Citations (Scopus)

Accurate identification of single-nucleotide variants in whole-genome-amplified single cells

Dong, X., Zhang, L., Milholland, B., Lee, M., Maslov, A., Wang, T. & Vijg, J., Mar 20 2017, (Accepted/In press) In : Nature Methods.

Research output: Contribution to journalArticle

Amplification
Nucleotides
Genes
Genome
Single-Cell Analysis

Ageing: Biomarkers get physical

Dong, X. & Vijg, J., Jun 30 2017, In : Nature Biomedical Engineering. 1, 7, 0102.

Research output: Contribution to journalComment/debate

Biomarkers
Aging of materials
10 Citations (Scopus)

Aging and the Inevitable Limit to Human Life Span

Vijg, J. & Le Bourg, E., May 17 2017, (Accepted/In press) In : Gerontology.

Research output: Contribution to journalArticle

Life History Traits
1 Citation (Scopus)

A high-fidelity method for genomic sequencing of single somatic cells reveals a very high mutational burden

Vijg, J., Dong, X. & Zhang, L., Jul 1 2017, In : Experimental Biology and Medicine. 242, 13, p. 1318-1324 7 p.

Research output: Contribution to journalReview article

Genes
Mutation
Genome
Mutation Rate
Neoplasms
27 Citations (Scopus)

Analysis of individual cells identifies cell-to-cell variability following induction of cellular senescence

Wiley, C. D., Flynn, J. M., Morrissey, C., Lebofsky, R., Shuga, J., Dong, X., Unger, M. A., Vijg, J., Melov, S. & Campisi, J., 2017, (Accepted/In press) In : Aging Cell.

Research output: Contribution to journalArticle

Cell Aging
Genes
Transcriptome
Physiological Phenomena
Population
10 Citations (Scopus)

A review of the biomedical innovations for healthy longevity

Moskalev, A., Anisimov, V., Aliper, A., Artemov, A., Asadullah, K., Belsky, D., Baranova, A., de Grey, A., Dixit, V. D., Debonneuil, E., Dobrovolskaya, E., Fedichev, P., Fedintsev, A., Fraifeld, V., Franceschi, C., Freer, R., Fülöp, T., Feige, J., Gems, D., Gladyshev, V. & 50 others, Gorbunova, V., Irincheeva, I., Jager, S., Jazwinski, S. M., Kaeberlein, M., Kennedy, B., Khaltourina, D., Kovalchuk, I., Kovalchuk, O., Kozin, S., Kulminski, A., Lashmanova, E., Lezhnina, K., Liu, G. H., Longo, V., Mamoshina, P., Maslov, A., de Magalhaes, J. P., Mitchell, J., Mitnitski, A., Nikolsky, Y., Ozerov, I., Pasyukova, E., Peregudova, D., Popov, V., Proshkina, E., Putin, E., Rogaev, E., Rogina, B., Schastnaya, J., Seluanov, A., Shaposhnikov, M., Simm, A., Skulachev, V., Skulachev, M., Solovev, I., Spindler, S., Stefanova, N., Suh, Y., Swick, A., Tower, J., Gudkov, A. V., Vijg, J., Voronkov, A., West, M., Wagner, W., Yashin, A., Zemskaya, N., Zhumadilov, Z. & Zhavoronkov, A., 2017, In : Aging. 9, 1, p. 7-25 19 p.

Research output: Contribution to journalArticle

2 Citations (Scopus)

"best-Guess" MRAD Provides Robust Evidence for a Limit to Human Lifespan: Reply to de Grey (Rejuvenation Res. 2017;20:261-262)

Milholland, B., Dong, X. & Vijg, J., Oct 1 2017, In : Rejuvenation Research. 20, 5, p. 437-440 4 p.

Research output: Contribution to journalArticle

Rejuvenation
Linear Models
3 Citations (Scopus)

Development and validation of a targeted next generation DNA sequencing panel outperforming whole exome sequencing for the identification of clinically relevant genetic variants

Miller, E. M., Patterson, N. E., Zechmeister, J. M., Bejerano-Sagie, M., Delio, M., Patel, K., Ravi, N., Quispe-Tintaya, W., Maslov, A., Simmons, N., Castaldi, M., Vijg, J., Karabakhtsian, R. G., Greally, J. M., Kuo, D. Y-S. & Montagna, C., Jan 1 2017, In : Oncotarget. 8, 60, p. 102033-102045 13 p.

Research output: Contribution to journalArticle

Exome
DNA Sequence Analysis
Genome
Endometrial Neoplasms
Costs and Cost Analysis
62 Citations (Scopus)

Differences between germline and somatic mutation rates in humans and mice

Milholland, B., Dong, X., Zhang, L., Hao, X., Suh, Y. & Vijg, J., May 9 2017, In : Nature Communications. 8, 15183.

Research output: Contribution to journalArticle

Germ-Line Mutation
Mutation Rate
mutations
mice
Genes
1 Citation (Scopus)

Dong et al. reply

Dong, X., Milholland, B. & Vijg, J., Jun 28 2017, In : Nature. 546, 7660, p. E14-E15

Research output: Contribution to journalLetter

Dong et al. reply

Dong, X., Milholland, B. & Vijg, J., Jun 28 2017, In : Nature. 546, 7660, p. E12

Research output: Contribution to journalArticle

1 Citation (Scopus)

Dong et al. reply

Dong, X., Milholland, B. & Vijg, J., Jun 28 2017, In : Nature. 546, 7660, p. E7

Research output: Contribution to journalLetter

Dong et al. reply

Dong, X., Milholland, B. & Vijg, J., Jun 28 2017, In : Nature. 546, 7660, p. E21

Research output: Contribution to journalComment/debate

1 Citation (Scopus)

Dong et al. reply

Dong, X., Milholland, B. & Vijg, J., Jun 28 2017, In : Nature. 546, 7660, p. E9-E10

Research output: Contribution to journalComment/debate

13 Citations (Scopus)

Genome instability: A conserved mechanism of ageing?

Vijg, J., Dong, X., Milholland, B. & Zhang, L., Jul 11 2017, In : Essays in Biochemistry. 61, 3, p. 305-315 11 p.

Research output: Contribution to journalReview article

Genomic Instability
Substitution reactions
Genes
Aging of materials
Mutation
17 Citations (Scopus)

Genome-wide, Single-Cell DNA Methylomics Reveals Increased Non-CpG Methylation during Human Oocyte Maturation

Yu, B., Dong, X., Gravina, S., Kartal, Ö., Schimmel, T., Cohen, J., Tortoriello, D., Zody, R., Hawkins, R. D. & Vijg, J., Jan 23 2017, (Accepted/In press) In : Stem Cell Reports.

Research output: Contribution to journalArticle

Methylation
Oocytes
Genes
Genome
DNA
3 Citations (Scopus)

The Future of Human Longevity: Time for a Reality Check

Le Bourg, E. & Vijg, J., Aug 22 2017, (Accepted/In press) In : Gerontology.

Research output: Contribution to journalArticle

Geriatrics
Life History Traits
2016
69 Citations (Scopus)

Deep biomarkers of human aging: Application of deep neural networks to biomarker development

Putin, E., Mamoshina, P., Aliper, A., Korzinkin, M., Moskalev, A., Kolosov, A., Ostrovskiy, A., Cantor, C., Vijg, J. & Zhavoronkov, A., 2016, In : Aging. 8, 5, p. 1021-1033 13 p.

Research output: Contribution to journalArticle

Biomarkers
Online Systems
Blood Cell Count
Hematologic Tests
Biochemistry
38 Citations (Scopus)

Do DNA Double-Strand Breaks Drive Aging?

White, R. R. & Vijg, J., Sep 1 2016, In : Molecular Cell. 63, 5, p. 729-738 10 p.

Research output: Contribution to journalReview article

Double-Stranded DNA Breaks
DNA Damage
Pathology
Phenotype
Poisons
133 Citations (Scopus)

Evidence for a limit to human lifespan

Dong, X., Milholland, B. & Vijg, J., 2016, In : Nature. 538, 7624, p. 257-259 3 p.

Research output: Contribution to journalArticle

Demography
Life Expectancy
Survival
Mortality
Pharmaceutical Preparations
30 Citations (Scopus)

In silico Pathway Activation Network Decomposition Analysis (iPANDA) as a method for biomarker development

Ozerov, I. V., Lezhnina, K. V., Izumchenko, E., Artemov, A. V., Medintsev, S., Vanhaelen, Q., Aliper, A., Vijg, J., Osipov, A. N., Labat, I., West, M. D., Buzdin, A., Cantor, C. R., Nikolsky, Y., Borisov, N., Irincheeva, I., Khokhlovich, E., Sidransky, D., Camargo, M. L. & Zhavoronkov, A., Nov 16 2016, In : Nature Communications. 7, 13427.

Research output: Contribution to journalArticle

biomarkers
Biomarkers
Computer Simulation
Chemical activation
activation
14 Citations (Scopus)

Mechanisms and consequences of aneuploidy and chromosome instability in the aging brain

Andriani, G. A., Vijg, J. & Montagna, C., Feb 15 2016, (Accepted/In press) In : Mechanisms of Ageing and Development.

Research output: Contribution to journalArticle

Chromosomal Instability
Aneuploidy
Brain
Polyploidy
Genomic Instability
3 Citations (Scopus)

Mutation and catastrophe in the aging genome

Milholland, B., Suh, Y. & Vijg, J., Nov 9 2016, (Accepted/In press) In : Experimental Gerontology.

Research output: Contribution to journalArticle

Genes
Aging of materials
Genome
Mutation
Mortality
4 Citations (Scopus)

Quantitative detection of low-abundance somatic structural variants in normal cells by high-throughput sequencing

Quispe-Tintaya, W., Gorbacheva, T., Lee, M., Makhortov, S., Popov, V. N., Vijg, J. & Maslov, A., Jun 29 2016, In : Nature Methods. 13, 7, p. 584-586 3 p.

Research output: Contribution to journalArticle

Throughput
High-Throughput Nucleotide Sequencing
Mutation
DNA
Point Mutation
62 Citations (Scopus)

Restricted diet delays accelerated ageing and genomic stress in DNA-repair-deficient mice

Vermeij, W. P., Dollé, M. E. T., Reiling, E., Jaarsma, D., Payan-Gomez, C., Bombardieri, C. R., Wu, H., Roks, A. J. M., Botter, S. M., van der Eerden, B. C., Youssef, S. A., Kuiper, R. V., Nagarajah, B., van Oostrom, C. T., Brandt, R. M. C., Barnhoorn, S., Imholz, S., Pennings, J. L. A., de Bruin, A., Gyenis & 4 others, Pothof, J., Vijg, J., van Steeg, H. & Hoeijmakers, J. H. J., Aug 24 2016, (Accepted/In press) In : Nature.

Research output: Contribution to journalArticle

DNA Repair-Deficiency Disorders
Diet
DNA Damage
DNA Repair
Cockayne Syndrome
4 Citations (Scopus)

Sensitivity of primary fibroblasts in culture to atmospheric oxygen does not correlate with species lifespan

Patrick, A., Seluanov, M., Hwang, C., Tam, J., Khan, T., Morgenstern, A., Wiener, L., Vazquez, J. M., Zafar, H., Wen, R., Muratkalyeva, M., Doerig, K., Zagorulya, M., Cole, L., Catalano, S., Lobo Ladd, A. A. B., Coppi, A. A., Coskun, Y., Tian, X., Ablaeva, J. & 6 others, Nevo, E., Gladyshev, V. N., Zhang, Z., Vijg, J., Seluanov, A. & Gorbunova, V., 2016, In : Aging. 8, 5, p. 841-847 7 p.

Research output: Contribution to journalArticle

Fibroblasts
Oxygen
Mole Rats
Rodentia
Sciuridae
40 Citations (Scopus)

Single-cell genome-wide bisulfite sequencing uncovers extensive heterogeneity in the mouse liver methylome

Gravina, S., Dong, X., Yu, B. & Vijg, J., Jul 5 2016, In : Genome Biology. 17, 1, 150.

Research output: Contribution to journalArticle

bisulfites
genome
Genome
5-Methylcytosine
liver
11 Citations (Scopus)

Systems-level analysis of human aging genes shed new light on mechanisms of aging

Zhang, Q., Nogales-Cadenas, R., Lin, J. R., Zhang, W., Cai, Y., Vijg, J. & Zhang, Z., 2016, In : Human Molecular Genetics. 25, 14, p. 2934-2947 14 p.

Research output: Contribution to journalArticle

Genes
Protein Interaction Domains and Motifs
Gene Expression
Essential Genes
Communication
17 Citations (Scopus)

The dark side of circulating nucleic acids

Gravina, S., Sedivy, J. M. & Vijg, J., 2016, (Accepted/In press) In : Aging Cell.

Research output: Contribution to journalArticle

Nucleic Acids
DNA
Interspersed Repetitive Sequences
Cell Aging
Mutagenesis
5 Citations (Scopus)

Whole chromosome aneuploidy in the brain of Bub1bH/H and Ercc1-/Δ7 mice

Andriani, G. A., Faggioli, F., Baker, D., Dollé, M. E. T., Sellers, R. S., Hebert, J. M., Van Steeg, H., Hoeijmakers, J., Vijg, J. & Montagna, C., Feb 15 2016, In : Human Molecular Genetics. 25, 4, p. 755-765 11 p.

Research output: Contribution to journalArticle

Aneuploidy
Chromosomes
Brain
Cerebral Cortex
M Phase Cell Cycle Checkpoints
29 Citations (Scopus)

Whole chromosome instability induces senescence and promotes SASP

Andriani, G. A., Almeida, V. P., Faggioli, F., Mauro, M., Li Tsai, W., Santambrogio, L., Maslov, A., Gadina, M., Campisi, J., Vijg, J. & Montagna, C., Oct 12 2016, In : Scientific Reports. 6, 35218.

Research output: Contribution to journalArticle

Chromosomal Instability
Phenotype
Diploidy
Cell Aging
Secretory Component
2015
43 Citations (Scopus)

Age-related somatic mutations in the cancer genome

Milholland, B., Auton, A., Suh, Y. & Vijg, J., 2015, In : Oncotarget. 6, 28, p. 24627-24635 9 p.

Research output: Contribution to journalArticle

Genome
Mutation
Neoplasms
Atlases
Genomic Instability
21 Citations (Scopus)

Comparative analysis of genome maintenance genes in naked mole rat, mouse, and human

Macrae, S. L., Zhang, Q., Lemetre, C., Seim, I., Calder, R. B., Hoeijmakers, J., Suh, Y., Gladyshev, V. N., Seluanov, A., Gorbunova, V., Vijg, J. & Zhang, Z., Apr 1 2015, In : Aging Cell. 14, 2, p. 288-291 4 p.

Research output: Contribution to journalArticle

Mole Rats
Maintenance
Genome
Genes
Genomic Instability
35 Citations (Scopus)

Comprehensive transcriptional landscape of aging mouse liver

White, R. R., Milholland, B., MacRae, S. L., Lin, M., Zheng, D. & Vijg, J., Nov 5 2015, In : BMC Genomics. 16, 1, 899.

Research output: Contribution to journalArticle

Liver
Transcriptome
Long Noncoding RNA
Untranslated RNA
RNA
47 Citations (Scopus)

Controlled induction of DNA double-strand breaks in the mouse liver induces features of tissue ageing

White, R. R., Milholland, B., De Bruin, A., Curran, S., Laberge, R. M., Van Steeg, H., Campisi, J., Maslov, A. & Vijg, J., Apr 10 2015, In : Nature Communications. 6, 6790.

Research output: Contribution to journalArticle

Double-Stranded DNA Breaks
liver
Liver
strands
mice
9 Citations (Scopus)

Development of a targeted multi-disorder high-throughput sequencing assay for the effective identification of disease-causing variants

Delio, M., Patel, K., Maslov, A., Marion, R. W., McDonald, T. V., Cadoff, E. M., Golden, A., Greally, J. M., Vijg, J., Morrow, B. E. & Montagna, C., Jul 27 2015, In : PLoS One. 10, 7, 0133742.

Research output: Contribution to journalArticle

Assays
Throughput
assays
muscular dystrophy
testing
46 Citations (Scopus)

DNA repair in species with extreme lifespan differences

MacRae, S. L., Croken, M. M., Calder, R. B., Aliper, A., Milholland, B., White, R. R., Zhavoronkov, A., Gladyshev, V. N., Seluanov, A., Gorbunova, V., Zhang, Z. & Vijg, J., 2015, In : Aging. 7, 12, p. 1171-1184 14 p.

Research output: Contribution to journalArticle

DNA Repair
Mole Rats
Transcriptome
Genes
Genomics

Editorial

Vijg, J., Feb 1 2015, In : Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 772, p. A2-A3

Research output: Contribution to journalArticle

Mutagenesis
Biomedical Research
Mutation
27 Citations (Scopus)

Genetic evidence for common pathways in human age-related diseases

Johnson, S. C., Dong, X., Vijg, J. & Suh, Y., Oct 1 2015, In : Aging Cell. 14, 5, p. 809-817 9 p.

Research output: Contribution to journalArticle

Gene Ontology
Genes
Chronic Disease
Maintenance
Genome