• 180 Citations
  • 8 h-Index
20092020

Research output per year

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Publications

  • 180 Citations
  • 8 h-Index
  • 12 Article
  • 1 Review article
2009

The Ski protein can inhibit ligand induced RARα and HDAC3 degradation in the retinoic acid signaling pathway

Zhao, H. L., Ueki, N., Marcelain, K. & Hayman, M. J., May 22 2009, In : Biochemical and Biophysical Research Communications. 383, 1, p. 119-124 6 p.

Research output: Contribution to journalArticle

18 Scopus citations
2010

Combination of phosphorylated and truncated EGFR correlates with higher tumor and nodal stage in head and neck cancer

Keller, J., Shroyer, K. R., Batajoo, S. K., Zhao, H. L., Dong, L. M., Hayman, M. J. & Chan, E. L., Nov 1 2010, In : Cancer Investigation. 28, 10, p. 1054-1062 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

The Ski protein negatively regulates Siah2-mediated HDAC3 degradation

Zhao, H. L., Ueki, N. & Hayman, M. J., Sep 1 2010, In : Biochemical and Biophysical Research Communications. 399, 4, p. 623-628 6 p.

Research output: Contribution to journalArticle

23 Scopus citations
2011

Identification of Ski as a target for Aurora A kinase

Mosquera, J., Armisen, R., Zhao, H., Rojas, D. A., Maldonado, E., Tapia, J. C., Colombo, A., Hayman, M. J. & Marcelain, K., Jun 10 2011, In : Biochemical and Biophysical Research Communications. 409, 3, p. 539-543 5 p.

Research output: Contribution to journalArticle

9 Scopus citations
2013

PRb is an obesity suppressor in hypothalamus and high-fat diet inhibits pRb in this location

Lu, Z., Marcelin, G., Bauzon, F., Wang, H., Fu, H., Dun, S. L., Zhao, H., Li, X., Jo, Y. H., Wardlaw, S., Dun, N., Chua, S. & Zhu, L., Mar 20 2013, In : EMBO Journal. 32, 6, p. 844-857 14 p.

Research output: Contribution to journalArticle

11 Scopus citations

Skp2 Deletion Unmasks a p27 Safeguard that Blocks Tumorigenesis in the Absence of pRb and p53 Tumor Suppressors

Zhao, H., Bauzon, F., Fu, H., Lu, Z., Cui, J., Nakayama, K., Nakayama, K. I., Locker, J. & Zhu, L., Nov 11 2013, In : Cancer Cell. 24, 5, p. 645-659 15 p.

Research output: Contribution to journalArticle

44 Scopus citations
2014

Skp2 suppresses apoptosis in Rb1-deficient tumours by limiting E2F1 activity

Lu, Z., Bauzon, F., Fu, H., Cui, J., Zhao, H., Nakayama, K., Nakayama, K. I. & Zhu, L., Mar 17 2014, In : Nature communications. 5, 3463.

Research output: Contribution to journalArticle

27 Scopus citations
2015

Antitumor mechanisms when pRb and p53 are genetically inactivated

Zhu, L., Lu, Z. & Zhao, H., Aug 27 2015, In : Oncogene. 34, 35, p. 4547-4557 11 p.

Research output: Contribution to journalReview article

15 Scopus citations

Substituting threonine 187 with alanine in p27Kip1 prevents pituitary tumorigenesis by two-hit loss of RB1 and enhances humoral immunity in old age

Zhao, H., Bauzon, F., Bi, E., Yu, J. J., Fu, H., Lu, Z., Cui, J., Jeon, H., Zang, X., Ye, B. H. & Zhu, L., Feb 27 2015, In : Journal of Biological Chemistry. 290, 9, p. 5797-5809 13 p.

Research output: Contribution to journalArticle

7 Scopus citations
2016

Deletions of retinoblastoma 1 (Rb1) and its repressing target S phase kinase-associated protein 2 (Skp2) are synthetic lethal in mouse embryogenesis

Zhao, H., Wang, H., Bauzon, F., Lu, Z., Fu, H., Cui, J. & Zhu, L., May 6 2016, In : Journal of Biological Chemistry. 291, 19, p. 10201-10209 9 p.

Research output: Contribution to journalArticle

3 Scopus citations
2017

p27T187A knockin identifies Skp2/Cks1 pocket inhibitors for advanced prostate cancer

Zhao, H., Lu, Z., Bauzon, F., Fu, H., Cui, J., Locker, J. & Zhu, L., Jan 5 2017, In : Oncogene. 36, 1, p. 60-70 11 p.

Research output: Contribution to journalArticle

7 Scopus citations
2020

Skp2 Depletion Reduces Tumor-Initiating Properties and Promotes Apoptosis in Synovial Sarcoma

Wang, J., Sato, K., O'Donnell, E., Singla, A., Yaguare, S., Aldahamsheh, O., Batko, B., Borjihan, H., Tingling, J., Zhang, J., Weiser, D. A., Loeb, D. M., Gorlick, R., Schwartz, E. L., Yang, R., Zi, X., Zhao, H., Geller, D. S. & Hoang, B. H., Oct 2020, In : Translational Oncology. 13, 10, 100809.

Research output: Contribution to journalArticle

Open Access

Targeted Inhibition of the E3 Ligase SCFSkp2/Cks1 Has Antitumor Activity in RB1-Deficient Human and Mouse Small-Cell Lung Cancer

Zhao, H., Iqbal, N. J., Sukrithan, V., Nicholas, C., Xue, Y., Yu, C., Locker, J., Zou, J., Schwartz, E. L. & Zhu, L., Jun 1 2020, In : Cancer research. 80, 11, p. 2355-2367 13 p.

Research output: Contribution to journalArticle