• 634 Citations
  • 8 h-Index
20072015
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Publications 2007 2015

  • 634 Citations
  • 8 h-Index
  • 11 Article
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Article
2015
6 Citations (Scopus)

Acetylation of lysine 109 modulates pregnane X receptor DNA binding and transcriptional activity

Pasquel, D., Doricakova, A., Li, H., Kortagere, S., Krasowski, M. D., Biswas, A., Walton, W. G., Redinbo, M. R., Dvorak, Z. & Mani, S., Nov 18 2015, (Accepted/In press) In : Biochimica et Biophysica Acta - Gene Regulatory Mechanisms.

Research output: Contribution to journalArticle

Acetylation
Lysine
DNA
Xenobiotics
Metabolism
2014
39 Citations (Scopus)

Plant flavonol isorhamnetin attenuates chemically induced inflammatory bowel disease via a PXR-dependent pathway

Dou, W., Zhang, J., Li, H., Kortagere, S., Sun, K., Ding, L., Ren, G., Wang, Z. & Mani, S., 2014, In : Journal of Nutritional Biochemistry. 25, 9, p. 923-933 11 p.

Research output: Contribution to journalArticle

Inflammatory Bowel Diseases
Xenobiotics
Ligands
Metabolism
Interleukin-6
206 Citations (Scopus)

Symbiotic bacterial metabolites regulate gastrointestinal barrier function via the xenobiotic sensor PXR and toll-like receptor 4

Venkatesh, M., Mukherjee, S., Wang, H., Li, H., Sun, K., Benechet, A. P., Qiu, Z., Maher, L., Redinbo, M. R., Phillips, R. S., Fleet, J. C., Kortagere, S., Mukherjee, P., Fasano, A., Le Ven, J., Nicholson, J. K., Dumas, M. E., Khanna, K. M. & Mani, S., Aug 21 2014, In : Immunity. 41, 2, p. 296-310 15 p.

Research output: Contribution to journalArticle

Toll-Like Receptor 4
Xenobiotics
Indoles
Enterocytes
Toll-Like Receptors
2013
23 Citations (Scopus)

Novel yeast-based strategy unveils antagonist binding regions on the nuclear xenobiotic receptor PXR

Li, H., Redinbo, M. R., Venkatesh, M., Ekins, S., Chaudhry, A., Bloch, N., Negassa, A., Mukherjee, P., Kalpana, G. V. & Mani, S., May 10 2013, In : Journal of Biological Chemistry. 288, 19, p. 13655-13668 14 p.

Research output: Contribution to journalArticle

Ketoconazole
Xenobiotics
Cytoplasmic and Nuclear Receptors
Yeast
Yeasts
4 Citations (Scopus)
Two-Hybrid System Techniques
Cytoplasmic and Nuclear Receptors
Ketoconazole
Hybrid systems
Yeast
Two-Hybrid System Techniques
Cytoplasmic and Nuclear Receptors
Hybrid systems
Yeast
Assays
2012
58 Citations (Scopus)

Alleviation of gut inflammation by Cdx2/PXR pathway in a mouse model of chemical colitis

Dou, W., Mukherjee, S., Li, H., Venkatesh, M., Wang, H., Kortagere, S., Peleg, A., Chilimuri, S. S., Wang, Z. T., Feng, Y., Fearon, E. R. & Mani, S., Jul 16 2012, In : PLoS One. 7, 7, e36075.

Research output: Contribution to journalArticle

Chemical Models
colitis
Colitis
digestive system
inflammation
2011
86 Citations (Scopus)

Pregnane X receptor activation induces FGF19-dependent tumor aggressiveness in humans and mice

Wang, H., Venkatesh, M., Li, H., Goetz, R., Mukherjee, S., Biswas, A., Zhu, L., Kaubisch, A., Wang, L., Pullman, J. M., Whitney, K. D., Kuro-o, M., Roig, A. I., Shay, J. W., Mohammadi, M. & Mani, S., Aug 1 2011, In : Journal of Clinical Investigation. 121, 8, p. 3220-3232 13 p.

Research output: Contribution to journalArticle

Colon
Neoplasms
Colonic Neoplasms
Growth
Ligands
2009
45 Citations (Scopus)

Elucidating the 'Jekyll and Hyde' nature of PXR: The case for discovering antagonists or allosteric antagonists

Biswas, A., Mani, S., Redinbo, M. R., Krasowski, M. D., Li, H. & Ekins, S., Aug 2009, In : Pharmaceutical Research. 26, 8, p. 1807-1815 9 p.

Research output: Contribution to journalArticle

Detoxification
Cytoplasmic and Nuclear Receptors
Molecular modeling
Xenobiotics
Molecular Biology
2008
85 Citations (Scopus)

The phytoestrogen coumestrol is a naturally occurring antagonist of the human pregnane X receptor

Wang, H., Li, H., Moore, L. B., Johnson, M. D. L., Maglich, J. M., Goodwin, B., Ittoop, O. R. R., Wisely, B., Creech, K., Parks, D. J., Collins, J. L., Willson, T. M., Kalpana, G. V., Venkatesh, M., Xie, W., Cho, S. Y., Roboz, J., Redinbo, M., Moore, J. T. & Mani, S., Apr 2008, In : Molecular Endocrinology. 22, 4, p. 838-857 20 p.

Research output: Contribution to journalArticle

Coumestrol
Phytoestrogens
Cytoplasmic and Nuclear Receptors
Ligands
Hepatocytes
2007
82 Citations (Scopus)

Activated pregnenolone X-receptor is a target for ketoconazole and its analogs

Wang, H., Huang, H., Li, H., Teotico, D. G., Sinz, M., Baker, S. D., Staudinger, J., Kalpana, G. V., Redinbo, M. R. & Mani, S., Apr 15 2007, In : Clinical Cancer Research. 13, 8, p. 2488-2495 8 p.

Research output: Contribution to journalArticle

Ketoconazole
Paclitaxel
Azoles
Biotransformation
Ligands